Research Topics
| Grazyna ZarebaSummaryAffiliation: University of Rochester Country: USA Publications
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Detail Information
Publications
Pregabalin: a new agent for the treatment of neuropathic painGrazyna Zareba
Department of Environmental Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
Drugs Today (Barc) 41:509-16. 2005..Furthermore, pregabalin has proven efficacy in adjunctive therapy of refractory partial seizures and in the treatment of acute pain, generalized anxiety disorder and social phobia...
Validity of methyl mercury hair analysis: mercury monitoring in human scalp/nude mouse modelGrazyna Zareba
Department of Environmental Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, USA
J Appl Toxicol 28:535-42. 2008..The grafting of human scalp hair was used as a new application of this method to explore methyl mercury incorporation into human hair and to validate this model for mercury monitoring in hair...
Phytotherapy for pain reliefGrazyna Zareba
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Drugs Today (Barc) 45:445-67. 2009....
Idursulfase in Hunter syndrome treatmentGrazyna Zareba
Department of Environmental Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA
Drugs Today (Barc) 43:759-67. 2007..Clinical studies demonstrate that idursulfase may be the first successful symptomatic therapy that can benefit patients with MPS II by addressing the enzymatic defect...
Thimerosal distribution and metabolism in neonatal mice: comparison with methyl mercuryGrazyna Zareba
Department of Environmental Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, USA
J Appl Toxicol 27:511-8. 2007..The data showing significant kinetic differences in tissue distribution and metabolism of mercury species challenge the assumption that ethyl mercury is toxicologically identical to methyl mercury...
A new combination vaccine for measles, mumps, rubella and varicellaGrazyna Zareba
Department of Environmental Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
Drugs Today (Barc) 42:321-9. 2006..The ProQuad combination vaccine facilitates implementation of varicella vaccination into routine childhood immunization schedules and will help to protect children against these four potentially serious diseases...
Torcetrapib and atorvastatin: a novel combination therapy for dyslipidemiaGrazyna Zareba
Department of Environmental Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
Drugs Today (Barc) 42:95-102. 2006....
Rotigotine: a novel dopamine agonist for the transdermal treatment of Parkinson's diseaseGrazyna Zareba
Department of Environmental Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
Drugs Today (Barc) 42:21-8. 2006..Clinical studies on rotigotine, the first transdermally delivered dopamine agonist, are now in progress, and regulatory approval is expected in the near future...
Zonisamide: review of its use in epilepsy therapyGrazyna Zareba
Department of Environmental Medicine, University of Rochester, School of Medicine and Dentistry, 575 Elmwood Ave, Box EHSC, New York 14642, USA
Drugs Today (Barc) 41:589-97. 2005..It has a good pharmacokinetic profile and a low drug interaction potential. Zonisamide is considered as a drug that effectively reduces the frequency of partial seizures...
Percutaneous absorption studies of octamethylcyclotetrasiloxane using the human skin/nude mouse modelGrazyna Zareba
Department of Environmental Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, USA
Skin Pharmacol Appl Skin Physiol 15:184-94. 2002..The fraction of the percutaneous dose of D(4) absorbed in this model was found to be consistent with results reported by others using different experimental approaches...
Fish consumption and prenatal methylmercury exposure: cognitive and behavioral outcomes in the main cohort at 17 years from the Seychelles child development studyPhilip W Davidson
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Neurotoxicology 32:711-7. 2011..For some endpoints we found performance improved with increasing prenatal exposure to MeHg. Follow up studies indicate this association is related to the beneficial nutrients present in fish...
Mercury levels in premature and low birth weight newborn infants after receipt of thimerosal-containing vaccinesMichael E Pichichero
University of Rochester, Rochester, NY, USA
J Pediatr 155:495-9. 2009..We conducted a population-based pharmacokinetic study to assess blood levels and elimination of mercury after vaccination of premature infants born at > or =32 and <37 weeks of gestation and with birth weight > or =2000 but <3000 g...
Prenatal exposure to dental amalgam: evidence from the Seychelles Child Development Study main cohortGENE E WATSON
Eastman Institute for Oral Health, Department of Environmental Medicine, and Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester, N Y, USA
J Am Dent Assoc 142:1283-94. 2011..Controversy surrounds whether fetal exposure to mercury vapor resulting from maternal dental amalgam restorations has neurodevelopmental consequences...
Sex-specific alterations of cerebral cortical cell size in rats exposed prenatally to dioxinRieko Hojo
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Appl Toxicol 26:25-34. 2006..These findings demonstrate that prenatal exposure to TCDD alters the normal patterns of cortical cell asymmetry in a manner consistent with our previous data on thickness patterns...
Organic and inorganic mercury in neonatal rat brain after prenatal exposure to methylmercury and mercury vaporHiromi Ishitobi
Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
Environ Health Perspect 118:242-8. 2010..Most of our knowledge of the neurotoxicity of Hg is based on research devoted to studying only one form at a time, mostly MeHg...
Sexually dimorphic alterations of brain cortical dominance in rats prenatally exposed to TCDDGrazyna Zareba
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
J Appl Toxicol 22:129-37. 2002..These data demonstrate that prenatal exposure to TCDD reduces cortical thickness and alters the normal pattern of cortical asymmetry, a finding consistent with the sexually dimorphic behavioral effects induced by this agent...
Prenatal exposure to dental amalgam in the Seychelles Child Development Nutrition Study: associations with neurodevelopmental outcomes at 9 and 30 monthsGENE E WATSON
Eastman Institute for Oral Health, and Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA
Neurotoxicology 33:1511-7. 2012..Maternal amalgams expose the developing fetus to mercury vapor. Mercury vapor can be toxic, but uncertainty remains whether prenatal amalgam exposure is associated with neurodevelopmental consequences in offspring...
Mercury levels in newborns and infants after receipt of thimerosal-containing vaccinesMichael E Pichichero
Department of Microbiology Immunology, Pediatrics, and Medicine, University of Rochester, Rochester, New York 14642, USA
Pediatrics 121:e208-14. 2008..We conducted a pharmacokinetic study to assess blood levels and elimination of ethyl mercury after vaccination of infants with thimerosal-containing vaccines...
Fish consumption, mercury exposure, and their associations with scholastic achievement in the Seychelles Child Development StudyPhilip W Davidson
University of Rochester, School of Medicine and Dentistry, Department of Pediatrics, Rochester, NY 14642, USA
Neurotoxicology 31:439-47. 2010..The adverse association of educational measures with postnatal exposure in males is intriguing, but will need to be confirmed by further studies examining factors that influence scholastic achievement...
Sexually dimorphic behavioral responses to prenatal dioxin exposureRieko Hojo
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Environ Health Perspect 110:247-54. 2002..02 ng/kg. The corresponding ED(01) was 0.30 ng/kg with a 95% lower bound of 0.20 ng/kg. These values fall close to, but below, current estimates of human body burdens of 13 ng/kg, based on TCDD toxic equivalents...
