Martin Zand

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Functionally Distinct Subpopulations of CpG-Activated Memory B Cells
    Alicia D Henn
    Sci Rep 2:345. 2012
  2. pmc Tofacitinab in renal transplantation
    Martin S Zand
    Department of Medicine, Division of Nephrology, University of Rochester Medical Center, Box 675, Rochester, NY 14642, USA
    Transplant Rev (Orlando) 27:85-9. 2013
  3. pmc An age-dependent branching process model for the analysis of CFSE-labeling experiments
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biol Direct 5:41. 2010
  4. doi request reprint High mortality in orthotopic liver transplant recipients who require hemodialysis
    Martin S Zand
    Division of Nephrology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Clin Transplant 25:213-21. 2011
  5. ncbi request reprint B-cell activity of polyclonal antithymocyte globulins
    Martin S Zand
    Division of Nephrology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Transplantation 82:1387-95. 2006
  6. ncbi request reprint Interleukin-2 and interferon-gamma double knockout mice reject heterotopic cardiac allografts
    M S Zand
    Division of Immunology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Transplantation 70:1378-81. 2000
  7. ncbi request reprint Immunosuppression and immune monitoring after renal transplantation
    Martin S Zand
    Nephrology Unit, Kidney and Pancreas Transplant Programs, University of Rochester Medical Center, Rochester, New York 14642, USA
    Semin Dial 18:511-9. 2005
  8. pmc Apoptosis and complement-mediated lysis of myeloma cells by polyclonal rabbit antithymocyte globulin
    Martin S Zand
    Division of Nephrology, University of Rochester Medical Center, 601 Elmwood Ave, Box 675, Rochester, NY 14642, USA
    Blood 107:2895-903. 2006
  9. ncbi request reprint Polyclonal rabbit antithymocyte globulin triggers B-cell and plasma cell apoptosis by multiple pathways
    Martin S Zand
    Nephrology Unit, University of Rochester Medical Center, Rochester, NY 14642, USA
    Transplantation 79:1507-15. 2005
  10. ncbi request reprint Screening a living kidney donor for polycystic kidney disease using heavily T2-weighted MRI
    M S Zand
    Department of Medicine, Nephrology Unit, Division of Solid Organ Transplantation, University of Rochester Medical Center, Rochester, NY, USA
    Am J Kidney Dis 37:612-9. 2001

Collaborators

Detail Information

Publications28

  1. pmc Functionally Distinct Subpopulations of CpG-Activated Memory B Cells
    Alicia D Henn
    Sci Rep 2:345. 2012
    ..Transcriptome analysis suggested a gene regulatory network for CD27(lo) and CD27(hi) Bc differentiation...
  2. pmc Tofacitinab in renal transplantation
    Martin S Zand
    Department of Medicine, Division of Nephrology, University of Rochester Medical Center, Box 675, Rochester, NY 14642, USA
    Transplant Rev (Orlando) 27:85-9. 2013
    ....
  3. pmc An age-dependent branching process model for the analysis of CFSE-labeling experiments
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biol Direct 5:41. 2010
    ..Several mathematical models have been presented in the literature to describe cell kinetics during these experiments...
  4. doi request reprint High mortality in orthotopic liver transplant recipients who require hemodialysis
    Martin S Zand
    Division of Nephrology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Clin Transplant 25:213-21. 2011
    ..5, and male gender. We conclude that renal failure requiring hemodialysis post liver transplant, irrespective of pre-transplant dialysis status, is a profound risk factor for death in liver transplant recipients...
  5. ncbi request reprint B-cell activity of polyclonal antithymocyte globulins
    Martin S Zand
    Division of Nephrology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Transplantation 82:1387-95. 2006
    ..In this paper, the experimental and clinical evidence supporting the B-cell activity of AThG preparations, and their mechanisms of action, are reviewed...
  6. ncbi request reprint Interleukin-2 and interferon-gamma double knockout mice reject heterotopic cardiac allografts
    M S Zand
    Division of Immunology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Transplantation 70:1378-81. 2000
    ..Several studies suggest that MHC-mismatched allografts reject with a Th1 or Th2 immune response, but these models all have low-level expression of the Th1 cytokines interleukin (IL)-2 and interferon-gamma (IFN-gamma)...
  7. ncbi request reprint Immunosuppression and immune monitoring after renal transplantation
    Martin S Zand
    Nephrology Unit, Kidney and Pancreas Transplant Programs, University of Rochester Medical Center, Rochester, New York 14642, USA
    Semin Dial 18:511-9. 2005
    ..Monitoring assays are discussed, as well as the frequency of monitoring and patient visits. Finally, we discuss several common clinical scenarios that often require adjustment of immunosuppression medications or regimens...
  8. pmc Apoptosis and complement-mediated lysis of myeloma cells by polyclonal rabbit antithymocyte globulin
    Martin S Zand
    Division of Nephrology, University of Rochester Medical Center, 601 Elmwood Ave, Box 675, Rochester, NY 14642, USA
    Blood 107:2895-903. 2006
    ..We conclude that rATG is an effective agent for in vitro induction of apoptosis in multiple myeloma, and that exploratory clinical trials may be warranted...
  9. ncbi request reprint Polyclonal rabbit antithymocyte globulin triggers B-cell and plasma cell apoptosis by multiple pathways
    Martin S Zand
    Nephrology Unit, University of Rochester Medical Center, Rochester, NY 14642, USA
    Transplantation 79:1507-15. 2005
    ..The authors recently demonstrated that rabbit (r) ATG can be used in combination with plasmapheresis to effectively treat antibody-mediated renal allograft rejection. This observation suggested that rATG may have anti-B cell activity...
  10. ncbi request reprint Screening a living kidney donor for polycystic kidney disease using heavily T2-weighted MRI
    M S Zand
    Department of Medicine, Nephrology Unit, Division of Solid Organ Transplantation, University of Rochester Medical Center, Rochester, NY, USA
    Am J Kidney Dis 37:612-9. 2001
    ..We conclude that ultrasound is not a sufficiently sensitive screening test for ADPKD in younger living related renal donors. HT2MRI has improved sensitivity and may be the best screening test for ADPKD in this population...
  11. ncbi request reprint A renewable source of donor cells for repetitive monitoring of T- and B-cell alloreactivity
    Martin S Zand
    Nephrology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    Am J Transplant 5:76-86. 2005
    ..We conclude that sBc are a renewable source of donor-specific target/stimulator cells for use in repetitive and coordinate assays of B- and T-cell alloreactivity...
  12. ncbi request reprint Discrete event modeling of CD4+ memory T cell generation
    Martin S Zand
    Nephrology Unit, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 173:3763-72. 2004
    ....
  13. doi request reprint Minimizing morbidity of organ donation: analysis of factors for perioperative complications after living-donor nephrectomy in the United States
    Siddharth Patel
    Division of Transplantation, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA
    Transplantation 85:561-5. 2008
    ..Wide variability exists in reported donor complications, and associated risk factors are ill defined. Use of administrative data can overcome the bias of single-center studies and identify variables associated with untoward events...
  14. pmc Modulation of single-cell IgG secretion frequency and rates in human memory B cells by CpG DNA, CD40L, IL-21, and cell division
    Alicia D Henn
    Division of Nephrology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 183:3177-87. 2009
    ..Finally, these data support a mixture model of IgG secretion in which IgG secreted over time is modulated by the frequency of IgG-SC and the distribution of their IgG secretion rates...
  15. ncbi request reprint Impact of hepatitis C viral infection in primary cadaveric liver allograft versus primary living-donor allograft in 100 consecutive liver transplant recipients receiving tacrolimus
    Adel Bozorgzadeh
    Department of Surgery, University of Rochester, Rochester, New York 14642, USA
    Transplantation 77:1066-70. 2004
    ..This study examines the survival outcome and HCV recurrence in CLTx versus LLTx performed at a single institution...
  16. ncbi request reprint Modification of a biventricular assist device to facilitate preservative infusion and organ recovery in a nonheart-beating donor
    Ron Angona
    Department of Surgery, Division of Cardiothoracic Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Extra Corpor Technol 38:157-60. 2006
    ..This report discusses the technical aspects of this potentially beneficial procedure...
  17. ncbi request reprint Treatment of C4d-positive acute humoral rejection with plasmapheresis and rabbit polyclonal antithymocyte globulin
    Amish Shah
    Nephrology Unit, University of Rochester Medical Center, Rochester, New York 14642, USA
    Transplantation 77:1399-405. 2004
    ..We describe a series of seven patients with C4d positive AHR who received combined therapy with PPH and polyclonal rabbit antithymocyte globulin (rATG)...
  18. pmc Interpreting CFSE obtained division histories of B cells in vitro with Smith-Martin and cyton type models
    Ha Youn Lee
    Department of Biostatistics and Computational Biology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Bull Math Biol 71:1649-70. 2009
    ..The most profound effect of the presence of IL-4 was decreased death rates for smaller division classes, which supports a role of IL-4 in the protection of B cells from apoptosis...
  19. ncbi request reprint Mini-BEAM and autologous hematopoietic stem-cell transplant for treatment of post-transplant lymphoproliferative disorders
    Rami S Komrokji
    Department of Medicine, University of Cincinnati and Veterans Administration Medical Center, Cincinnati, Ohio 45267, USA
    Am J Hematol 79:211-5. 2005
    ..With over 30 months of follow-up, both patients remain in complete remission with excellent allograft function...
  20. pmc CpG DNA activation and plasma-cell differentiation of CD27- naive human B cells
    Jennifer Huggins
    Department of Pathology, James P Wilmot Cancer Center, University of Rochester Medical Center, NY 14642, USA
    Blood 109:1611-9. 2007
    ..In addition to its immunologic significance, this system should be a valuable method to interrogate the antigenic specificity of naive B cells...
  21. pmc Simulation and prediction of the adaptive immune response to influenza A virus infection
    Ha Youn Lee
    Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York 14642, USA
    J Virol 83:7151-65. 2009
    ..We further compared alternative model structures, for example, B-cell activation directly by the virus versus that through professional antigen-presenting cells or dendritic cell licensing of CD8 T cells...
  22. doi request reprint Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cells
    Shuya Y Kyu
    Division of Pulmonary and Critical Care Medicine, NY 14642, USA
    J Immunol Methods 340:42-7. 2009
    ..43, 0.28, 0.28 respectively). These results demonstrate feasibility of testing whether antigen-specific ASC from frozen PBMC are an early biomarker of long-term antibody responses in multi-center vaccine trials...
  23. ncbi request reprint Elevated calcium phosphate product after renal transplantation is a risk factor for graft failure
    Ogo I Egbuna
    Division of Nephrology, Beth Israel Deaconess Medical Center, and Division of Endocrinology and Hypertension Calcium and Parathyroid Physiology Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Transplant 21:558-66. 2007
    ..The effect of these abnormalities on recipient and graft survival after renal transplantation is unknown...
  24. ncbi request reprint De novo thrombotic microangiopathy in renal transplant recipients: a comparison of hemolytic uremic syndrome with localized renal thrombotic microangiopathy
    Joshua Schwimmer
    Department of Medicine, Nephrology Unit, University of Rochester Medical Center, Rochester, NY, USA
    Am J Kidney Dis 41:471-9. 2003
    ..Thrombotic microangiopathy (TMA) is a well-recognized and serious complication of renal transplantation, affecting 3% to 14% of patients administered calcineurin-inhibitor-based immunosuppression...
  25. pmc Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza A virus
    Hongyu Miao
    Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York 146421, USA
    J Virol 84:6687-98. 2010
    ..Also, simulation studies were performed to understand the relative contributions of biological parameters to IAV clearance. This study provides a basis to better understand and predict influenza virus immunity...
  26. ncbi request reprint Home glucometer monitoring markedly improves diagnosis of post renal transplant diabetes mellitus in renal transplant recipients
    Amish Shah
    Division of Nephrology, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Transplantation 80:775-81. 2005
    ..Most patients are monitored for PTDM by 12-hour FPG levels drawn for clinic visits. In contrast, we describe the diagnosis of PTDM by home glucometer monitoring..
  27. ncbi request reprint Pretransplant cellular alloimmunity as assessed by a panel of reactive T cells assay correlates with acute renal graft rejection
    Emilio D Poggio
    Department of Nephrology and Hypertension, Transplant Center, Cleveland Clinic, Cleveland, OH 44195, USA
    Transplantation 83:847-52. 2007
    ....
  28. ncbi request reprint Zonal distribution of glomerular collapse in renal allografts: possible role of vascular changes
    Tibor Nadasdy
    Department of Pathology, The Johns Hopkins University, Baltimore, MD, USA
    Hum Pathol 33:437-41. 2002
    ..Among other factors, hemodynamic disturbance may play a role in the development of the pattern of CG in renal allografts...

Research Grants5

  1. TRANSPLANT IMMUNOLOGY OF IL2 IFNY DOUBLE KNOCKOUT MICE
    Martin Zand; Fiscal Year: 2002
    ..In contrast, if the DKO mice are tolerant to islet allografts, we will determine the mechanism by adoptive transfer of tolerance inducing T lymphocyte subsets. ..
  2. Branching Stochastic Process Modeling of Human Plasma Cell Differentiation
    Martin Zand; Fiscal Year: 2007
    ..The stochastic branching process model developed in Aim 1 will be used to predict experimental outcomes and compare them with in vitro data. ..
  3. Branching Stochastic Process Modeling of Human Plasma Cell Differentiation
    Martin Zand; Fiscal Year: 2009
    ..The stochastic branching process model developed in Aim 1 will be used to predict experimental outcomes and compare them with in vitro data. ..
  4. Branching Stochastic Process Modeling of Human Plasma Cell Differentiation
    Martin S Zand; Fiscal Year: 2010
    ..The stochastic branching process model developed in Aim 1 will be used to predict experimental outcomes and compare them with in vitro data. ..