Habib Zaghouani

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. pmc Delayed maturation of an IL-12-producing dendritic cell subset explains the early Th2 bias in neonatal immunity
    Hyun Hee Lee
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Exp Med 205:2269-80. 2008
  2. pmc Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells
    Habib Zaghouani
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Trends Immunol 30:585-91. 2009
  3. pmc APCs expressing high levels of programmed death ligand 2 sustain the development of CD4 T cell memory
    Jason S Ellis
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Immunol 185:3149-57. 2010
  4. pmc Antigen-specific effector CD4 T lymphocytes school lamina propria dendritic cells to transfer innate tolerance
    Jason A Cascio
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Immunol 190:6004-14. 2013
  5. pmc Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production
    Renu Jain
    Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO 65212, USA
    J Exp Med 205:207-18. 2008
  6. ncbi request reprint In trans T cell tolerance diminishes autoantibody responses and exacerbates experimental allergic encephalomyelitis
    J Jeremiah Bell
    Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, MO 65212, USA
    J Immunol 180:1508-16. 2008
  7. pmc FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetes
    Danielle M Tartar
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Immunol 184:3377-85. 2010
  8. ncbi request reprint IL-10 diminishes CTLA-4 expression on islet-resident T cells and sustains their activation rather than tolerance
    Randal K Gregg
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Immunol 174:662-70. 2005
  9. pmc T cell dynamics during induction of tolerance and suppression of experimental allergic encephalomyelitis
    Rohit D Divekar
    Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO 65212, USA
    J Immunol 187:3979-86. 2011
  10. pmc Recovery from overt type 1 diabetes ensues when immune tolerance and β-cell formation are coupled with regeneration of endothelial cells in the pancreatic islets
    Xiaoxiao Wan
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA
    Diabetes 62:2879-89. 2013

Collaborators

  • Ping Yu
  • Beixue Gao
  • Mary Collins
  • Becky Adkins
  • Hanspeter Waldner
  • An Chen
  • Booki Min
  • Michael W McBurney
  • Jason A Cascio
  • Christine M Hoeman
  • Xiaoxiao Wan
  • Jason S Ellis
  • Danielle M Tartar
  • Mermagya Dhakal
  • F Betul Guloglu
  • Cara L Haymaker
  • J Jeremiah Bell
  • Renu Jain
  • Hyun Hee Lee
  • Rohit D Divekar
  • Linda M Rowland
  • Randal K Gregg
  • Amie M Vanmorlan
  • Marie Therese Khairallah
  • Weirong Chen
  • Sarah Zaghouani
  • Rohit Divekar
  • John C Hardaway
  • Helen Braley-Mullen
  • Christine Hoeman
  • Craig L Franklin
  • Jinping Zhang
  • Jacque C Caprio-Young
  • Scott J Schoenleber
  • Lequn Li
  • Mindy M Miller
  • So Hee Hong
  • Adam A Zaghouani
  • Betul F Guloglu
  • Mark J Miller
  • Jennifer N Lynch
  • Bernd H Zinselmeyer
  • Mohamed Oukka
  • Seung Hi Yahng
  • Amie VanMorlan
  • Amie M van Morlan
  • Sang Myeong Lee
  • Stephen Shannon
  • Deyu Fang
  • Weimin Chen
  • Gary Sayler
  • Danielle Nast
  • Jason Ellis
  • Andre Gessner

Detail Information

Publications26

  1. pmc Delayed maturation of an IL-12-producing dendritic cell subset explains the early Th2 bias in neonatal immunity
    Hyun Hee Lee
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Exp Med 205:2269-80. 2008
    ....
  2. pmc Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells
    Habib Zaghouani
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Trends Immunol 30:585-91. 2009
    ..Upon re-challenge, Th2 cells rapidly produce IL-4 which utilizes the heteroreceptor to drive apoptosis of Th1 cells, thus yielding the Th2 bias of neonatal immunity...
  3. pmc APCs expressing high levels of programmed death ligand 2 sustain the development of CD4 T cell memory
    Jason S Ellis
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Immunol 185:3149-57. 2010
    ..These previously unrecognized findings suggest that targeting specific APCs for Ag presentation during vaccination could prove effective against microbial infections...
  4. pmc Antigen-specific effector CD4 T lymphocytes school lamina propria dendritic cells to transfer innate tolerance
    Jason A Cascio
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Immunol 190:6004-14. 2013
    ..This previously unrecognized attribute potentiates DCs against autoimmunity...
  5. pmc Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production
    Renu Jain
    Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO 65212, USA
    J Exp Med 205:207-18. 2008
    ..Thus, IFNgamma induced by an adjuvant free antigen, contrary to its usual inflammatory function, restores normoglycemia, most likely by localized bystander suppression of pathogenic IL-17-producing cells...
  6. ncbi request reprint In trans T cell tolerance diminishes autoantibody responses and exacerbates experimental allergic encephalomyelitis
    J Jeremiah Bell
    Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, MO 65212, USA
    J Immunol 180:1508-16. 2008
    ..Thus, in trans T cell tolerance, which should be operative in polymorphic systems, can aggravate rather than ameliorate autoimmunity. This phenomenon possibly takes place through interference with protective humoral immunity...
  7. pmc FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetes
    Danielle M Tartar
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Immunol 184:3377-85. 2010
    ....
  8. ncbi request reprint IL-10 diminishes CTLA-4 expression on islet-resident T cells and sustains their activation rather than tolerance
    Randal K Gregg
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Immunol 174:662-70. 2005
    ..Therefore, IL-10 supports T cell tolerance in the periphery, but its interplay with CTLA-4 sustains activation within the islets. As a result, IL-10 displays opposite functions against diabetes in young vs older insulitis-positive mice...
  9. pmc T cell dynamics during induction of tolerance and suppression of experimental allergic encephalomyelitis
    Rohit D Divekar
    Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO 65212, USA
    J Immunol 187:3979-86. 2011
    ..Therefore, both Th1 immunity and Th2 tolerance alter T cell migration on Ag recognition, but the kinetics of this effect differ among the subsets...
  10. pmc Recovery from overt type 1 diabetes ensues when immune tolerance and β-cell formation are coupled with regeneration of endothelial cells in the pancreatic islets
    Xiaoxiao Wan
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA
    Diabetes 62:2879-89. 2013
    ..Thus, overcoming T1D requires both immune modulation and repair of the islet vascular niche to preserve newly formed β-cells. ..
  11. pmc Developmental expression of IL-12Rβ2 on murine naive neonatal T cells counters the upregulation of IL-13Rα1 on primary Th1 cells and balances immunity in the newborn
    Christine M Hoeman
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Immunol 190:6155-63. 2013
    ..Thus, in neonatal mice, IL-12, which accumulates in the environment progressively, uses IL-12Rβ2 to counter IL-13Rα1 expression in addition to promoting Th1 differentiation...
  12. pmc Mechanisms underlying antigen-specific tolerance of stable and convertible Th17 cells during suppression of autoimmune diabetes
    Xiaoxiao Wan
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA
    Diabetes 61:2054-65. 2012
    ..These findings suggest that effective strategies against type 1 diabetes will require regimens that could drive both mechanisms of tolerance to overcome the disease...
  13. ncbi request reprint Early effector T cells producing significant IFN-gamma develop into memory
    J Jeremiah Bell
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Immunol 180:179-87. 2008
    ..Thus, highly activated early effectors generated under short exposure to optimal Ag in vivo develop into memory, and such transition is dependent on a significant production of the cell's signature cytokine, IFN-gamma...
  14. pmc The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice
    Jinping Zhang
    Department of Otolaryngology Head and Neck Surgery, University of Missouri, Columbia, MO 65212, USA
    J Clin Invest 119:3048-58. 2009
    ..These findings provide insight into the molecular mechanisms of T cell activation and anergy, and we suggest that activators of Sirt1 may be useful as therapeutic agents for the treatment and/or prevention of autoimmune diseases...
  15. ncbi request reprint Specific T regulatory cells display broad suppressive functions against experimental allergic encephalomyelitis upon activation with cognate antigen
    Ping Yu
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, 65212, USA
    J Immunol 174:6772-80. 2005
    ..Thus, it is suggested that activation of Treg cells by the cognate autoantigen is necessary for operation of broad suppressive functions...
  16. pmc Fetal exposure to high-avidity TCR ligand enhances expansion of peripheral T regulatory cells
    Ping Yu
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MD 65212, USA
    J Immunol 181:73-80. 2008
    ..Thus, contrary to pathogenic T cells, Tregs require avid TCR-ligand interaction to undergo thymic development and maturation...
  17. pmc Antigen-free adjuvant assists late effector CD4 T cells to transit to memory in lymphopenic hosts
    F Betul Guloglu
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Immunol 191:1126-35. 2013
    ..These findings uncover the mechanism by which late effector CD4 T cells are driven to transit to memory and suggest that timely boosts with adjuvant may enhance vaccine efficacy. ..
  18. pmc Bone marrow-derived IL-13Rα1-positive thymic progenitors are restricted to the myeloid lineage
    Cara L Haymaker
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Immunol 188:3208-16. 2012
    ..Thus, IL-13Rα1 defines a new class of myeloid restricted ETPs yielding APCs that could contribute to development of T cells and the control of immunity and autoimmunity...
  19. doi request reprint In trans T cell tolerance exacerbates experimental allergic encephalomyelitis by interfering with protective antibody responses
    Jason A Cascio
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, M616 Medical Sciences Building, Columbia, MO 65212, USA
    J Neuroimmunol 266:49-55. 2014
    ..These findings reveal a potential self-limiting regulatory mechanism involving auto-antibodies in MOG EAE. ..
  20. ncbi request reprint neonatally primed lymph node, but not splenic T cells, display a Gly-Gly motif within the TCR beta-chain complementarity-determining region 3 that controls affinity and may affect lymphoid organ retention
    Jacque C Caprio-Young
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Immunol 176:357-64. 2006
    ..Also, it is suggested that a higher TCR affinity may be a contributing factor for the development of the neonatal Th1 response in the spleen...
  21. pmc Reduced effectiveness of CD4+Foxp3+ regulatory T cells in CD28-deficient NOD.H-2h4 mice leads to increased severity of spontaneous autoimmune thyroiditis
    Jason S Ellis
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212
    J Immunol 191:4940-9. 2013
    ..B cell-deficient (B(-/-)) NOD.H-2h4 mice are resistant to ISAT, but CD28(-/-)B(-/-) mice develop ISAT comparable to WT mice and have reduced numbers of Tregs compared with WT B(-/-) mice. ..
  22. ncbi request reprint A sudden decline in active membrane-bound TGF-beta impairs both T regulatory cell function and protection against autoimmune diabetes
    Randal K Gregg
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Immunol 173:7308-16. 2004
    ..Thus, a developmental decline in active mTGF-beta nullifies Treg function, leading to a break in tolerance and the onset of diabetes...
  23. ncbi request reprint IL-4 utilizes an alternative receptor to drive apoptosis of Th1 cells and skews neonatal immunity toward Th2
    Lequn Li
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, M616 Medical Sciences Building, Columbia, MO 65212 USA
    Immunity 20:429-40. 2004
    ..These observations indicate that developmental expression of IL-13Ralpha1 along with IL-4Ralpha provides a receptor through which IL-4 induces death of Th1 cells and skews neonatal immunity toward Th2...
  24. ncbi request reprint Overcoming dendritic cell tardiness to triumph over IL-13 receptor: a strategy for the development of effective pediatric vaccines
    Christine Hoeman
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Discov Med 9:554-9. 2010
    ..Accordingly, the neonate would have balanced Th1/Th2 immunity and withstand both microbes and allergens. Such approaches could open new avenues for better pediatric vaccines and allergy therapies...
  25. ncbi request reprint T-regulatory/T-helper 17: promiscuous signals and fear of commitment
    Danielle M Tartar
    University of Missouri School of Medicine, Department of Molecular Microbiology and Immunology, M616 Medical Sciences Building, Columbia, MO 65212, USA
    Immunotherapy 1:27-9. 2009
    ..This suggests that T-cell differentiation does not necessarily follow a one-way road, but that traffic may flow in both directions...
  26. ncbi request reprint Break of neonatal Th1 tolerance and exacerbation of experimental allergic encephalomyelitis by interference with B7 costimulation
    J Jeremiah Bell
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Immunol 171:1801-8. 2003
    ..Thus, recovery from neonatally induced T cell anergy requires B7 molecules to serve double functions, namely, costimulation and induction of cytokine production by APCs...