Affiliation: University of Missouri
Barik S, Cattin Roy A, Miller M, Ukah T, Zaghouani H. IL-4 and IL-13 Guide Early Thymic Progenitors To Mature toward Dendritic Cells. J Immunol. 2018;201:2947-2958 pubmed publisher
Dhakal M, Miller M, Zaghouani A, Sherman M, Zaghouani H. Neonatal Basophils Stifle the Function of Early-Life Dendritic Cells To Curtail Th1 Immunity in Newborn Mice. J Immunol. 2015;195:507-18 pubmed publisher
..The resulting Th1/Th2 imbalance impacts childhood immunity culminating in sensitivity to allergic reactions, susceptibility to microbial infection and perhaps poor efficacy of pediatric vaccines. ..
Sherman M, Pritzl C, Xia C, Miller M, Zaghouani H, Hahm B. Lactoferrin acts as an adjuvant during influenza vaccination of neonatal mice. Biochem Biophys Res Commun. 2015;467:766-70 pubmed publisher
..01). Controls had no anti-H1N1 antibody. Neonates given lactoferrin had no anaphylaxis when challenged four weeks later. Lactoferrin is a safe and effective adjuvant for inducing antibody against influenza in neonates. ..
Barik S, Miller M, Cattin Roy A, Ukah T, Zaghouani H. A distinct dendritic cell population arises in the thymus of IL-13R?1-sufficient but not IL-13R?1-deficient mice. Cell Immunol. 2018;331:130-136 pubmed publisher
Chen W, Wan X, Ukah T, Miller M, Barik S, Cattin Roy A, et al
. Antigen-Specific Immune Modulation Targets mTORC1 Function To Drive Chemokine Receptor-Mediated T Cell Tolerance. J Immunol. 2016;197:3554-3565 pubmed
..Thus, mTORC1 component of the metabolic pathway serves as a target for chemokine receptor-mediated T cell tolerance and suppression of T1D. ..
Ukah T, Cattin Roy A, Chen W, Miller M, Barik S, Zaghouani H. On the Role IL-4/IL-13 Heteroreceptor Plays in Regulation of Type 1 Diabetes. J Immunol. 2017;199:894-902 pubmed publisher
..These findings reveal new insights as to the role environmental IL-4/IL-13 and the HR play in peripheral tolerance and the development of T1D. ..
Barik S, Ellis J, Cascio J, Miller M, Ukah T, Cattin Roy A, et al
. IL-4/IL-13 Heteroreceptor Influences Th17 Cell Conversion and Sensitivity to Regulatory T Cell Suppression To Restrain Experimental Allergic Encephalomyelitis. J Immunol. 2017;199:2236-2248 pubmed publisher
..These previously unrecognized findings shed light on the intricacies underlying the contribution of cytokines to peripheral tolerance and control of autoimmunity. ..
Barik S, Miller M, Cattin Roy A, Ukah T, Chen W, Zaghouani H. IL-4/IL-13 Signaling Inhibits the Potential of Early Thymic Progenitors To Commit to the T Cell Lineage. J Immunol. 2017;199:2767-2776 pubmed publisher
..These observations indicate that environmental cytokines play a role in conditioning ETP lineage choice, which would impact T cell development. ..