Christopher J Yuskaitis

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome
    Christopher J Yuskaitis
    Department of Psychiatry and Behavioral Neurobiology, 1720 7th Ave South, Sparks Center 1057, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Biochem Pharmacol 79:632-46. 2010
  2. pmc Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of Fragile X syndrome
    Christopher J Yuskaitis
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Biochim Biophys Acta 1802:1006-12. 2010
  3. pmc GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism
    Marjelo A Mines
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 5:e9706. 2010
  4. pmc Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity
    Christopher J Yuskaitis
    Department of Psychiatry and Behavioral Neurobiology, 1720 Seventh Avenue South, Sparks Center 1057, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Cell Signal 21:264-73. 2009
  5. pmc Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics
    Richard S Jope
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Sparks Center 1057, 1720 Seventh Avenue South, Birmingham, AL 35294 0017, USA
    Neurochem Res 32:577-95. 2007

Detail Information

Publications5

  1. pmc Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome
    Christopher J Yuskaitis
    Department of Psychiatry and Behavioral Neurobiology, 1720 7th Ave South, Sparks Center 1057, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Biochem Pharmacol 79:632-46. 2010
    ..These findings support the hypothesis that impaired inhibition of GSK3 contributes to the pathogenesis of FXS and support GSK3 as a potential therapeutic target...
  2. pmc Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of Fragile X syndrome
    Christopher J Yuskaitis
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Biochim Biophys Acta 1802:1006-12. 2010
    ..These results provide further evidence of the involvement of dysregulated GSK3 in FXS, and demonstrate that lithium administration reduces macroorchidism and reactive astrocytes in Fmr1 knockout mice...
  3. pmc GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism
    Marjelo A Mines
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 5:e9706. 2010
    ..This used two mouse models with disrupted regulation of GSK3, Fmr1 knockout mice and GSK3 knockin mice, in which inhibitory serines of the two isoforms of GSK3, GSK3alpha and GSK3beta, are mutated to alanines, leaving GSK3 fully active...
  4. pmc Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity
    Christopher J Yuskaitis
    Department of Psychiatry and Behavioral Neurobiology, 1720 Seventh Avenue South, Sparks Center 1057, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Cell Signal 21:264-73. 2009
    ..These findings demonstrate that GSK3 promotes microglial responses to inflammation and that the utilization of GSK3 inhibitors provides a means to limit the inflammatory actions of microglia...
  5. pmc Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics
    Richard S Jope
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Sparks Center 1057, 1720 Seventh Avenue South, Birmingham, AL 35294 0017, USA
    Neurochem Res 32:577-95. 2007
    ..Thus, GSK3 may contribute not only to primary pathologies in these diseases, but also to the associated inflammation, suggesting that GSK3 inhibitors may have multiple effects influencing these conditions...