Steven A Yukl

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Latently-infected CD4+ T cells are enriched for HIV-1 Tat variants with impaired transactivation activity
    Steven Yukl
    University of California, San Francisco UCSF and San Francisco VA Medical Center SFVAMC, 4150 Clement Street, 111W3, San Francisco, CA 94121, USA
    Virology 387:98-108. 2009
  2. pmc Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy
    Steven A Yukl
    San Francisco VA Medical Center SFVAMC and University of California, San Francisco UCSF, San Francisco, California, USA
    AIDS 24:2451-60. 2010
  3. pmc Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy
    Steven A Yukl
    San Francisco Veterans Affairs Medical Center, San Francisco, California, USA
    J Infect Dis 202:1553-61. 2010
  4. pmc Modification of the Abbott RealTime assay for detection of HIV-1 plasma RNA viral loads less than one copy per milliliter
    Steven A Yukl
    San Francisco VA Medical Center, San Francisco, CA 94121, USA
    J Virol Methods 175:261-5. 2011
  5. pmc Discordance between peripheral and colonic markers of inflammation during suppressive ART
    Richard M Dunham
    HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, NC Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA P ng Loke is now with the Department of Microbiology, Division of Parasitology, New York University Medical Center, New York, NY Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA Division of Infectious Diseases, Department of Medicine, University of California, San Francisco and San Francisco VA Medical Center, San Francisco, CA Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, Cleveland, OH Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA and Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA
    J Acquir Immune Defic Syndr 65:133-41. 2014
  6. doi request reprint A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells
    Steven A Yukl
    aSan Francisco Veterans Affairs Medical Center bUniversity of California, San Francisco UCSF, California, USA
    AIDS 28:439-42. 2014
  7. ncbi request reprint Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers
    Hiroyu Hatano
    aDepartment of Medicine bDepartment of Epidemiology and Biostatistics, University of California cSan Francisco Veterans Affairs Medical Center, San Francisco, California, USA
    AIDS 27:2255-60. 2013
  8. pmc Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers
    Hiroyu Hatano
    Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 9:e1003691. 2013
  9. ncbi request reprint Advantages of using the QIAshredder instead of restriction digestion to prepare DNA for droplet digital PCR
    Steven A Yukl
    San Francisco VA Medical Center, San Francisco, CA University of California, San Francisco UCSF, San Francisco, CA
    Biotechniques 56:194-6. 2014

Collaborators

Detail Information

Publications9

  1. doi request reprint Latently-infected CD4+ T cells are enriched for HIV-1 Tat variants with impaired transactivation activity
    Steven Yukl
    University of California, San Francisco UCSF and San Francisco VA Medical Center SFVAMC, 4150 Clement Street, 111W3, San Francisco, CA 94121, USA
    Virology 387:98-108. 2009
    ..These findings suggest that impaired activity in the Tat-TAR axis may contribute to the establishment of latent infection in CD4+ T cells...
  2. pmc Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy
    Steven A Yukl
    San Francisco VA Medical Center SFVAMC and University of California, San Francisco UCSF, San Francisco, California, USA
    AIDS 24:2451-60. 2010
    ..To determine whether raltegravir-containing antiretroviral therapy (ART) intensification reduces HIV levels in the gut...
  3. pmc Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy
    Steven A Yukl
    San Francisco Veterans Affairs Medical Center, San Francisco, California, USA
    J Infect Dis 202:1553-61. 2010
    ..The gut is a major reservoir for human immunodeficiency virus (HIV) in patients receiving antiretroviral therapy (ART). We hypothesized that distinct immune environments within the gut may support varying levels of HIV...
  4. pmc Modification of the Abbott RealTime assay for detection of HIV-1 plasma RNA viral loads less than one copy per milliliter
    Steven A Yukl
    San Francisco VA Medical Center, San Francisco, CA 94121, USA
    J Virol Methods 175:261-5. 2011
    ..77 copy/ml; 95% CI 0.86-4.68 copy/ml). The measured viral load correlated inversely (r = -0.78; p = 0.028) with the total duration of viral suppression (viral load<40 copies/ml)...
  5. pmc Discordance between peripheral and colonic markers of inflammation during suppressive ART
    Richard M Dunham
    HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, NC Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA P ng Loke is now with the Department of Microbiology, Division of Parasitology, New York University Medical Center, New York, NY Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA Division of Infectious Diseases, Department of Medicine, University of California, San Francisco and San Francisco VA Medical Center, San Francisco, CA Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, Cleveland, OH Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA and Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA
    J Acquir Immune Defic Syndr 65:133-41. 2014
    ..In this study, we sought to understand whether such systemic inflammation is also associated with detectable signs of inflammation in biopsies from the rectosigmoid colon...
  6. doi request reprint A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells
    Steven A Yukl
    aSan Francisco Veterans Affairs Medical Center bUniversity of California, San Francisco UCSF, California, USA
    AIDS 28:439-42. 2014
    ..HIV DNA levels in total rectal cells were greater than those predicted from levels in sorted CD4 T cells, suggesting a reservoir in non-CD4 T cells, and HIV DNA was detected in sorted myeloid cells (7/7 subjects)...
  7. ncbi request reprint Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers
    Hiroyu Hatano
    aDepartment of Medicine bDepartment of Epidemiology and Biostatistics, University of California cSan Francisco Veterans Affairs Medical Center, San Francisco, California, USA
    AIDS 27:2255-60. 2013
    ..HIV-infected controllers have provided novel insights into mechanisms of viral control. We investigated the degree to which HIV DNA and RNA are present in gut-associated lymphoid tissue (GALT) of controllers...
  8. pmc Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers
    Hiroyu Hatano
    Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 9:e1003691. 2013
    ..These data confirm that HIV replication persists in controllers and contributes to a chronic inflammatory state. ART should be considered for these individuals (ClinicalTrials.gov NCT01025427). ..
  9. ncbi request reprint Advantages of using the QIAshredder instead of restriction digestion to prepare DNA for droplet digital PCR
    Steven A Yukl
    San Francisco VA Medical Center, San Francisco, CA University of California, San Francisco UCSF, San Francisco, CA
    Biotechniques 56:194-6. 2014
    ..35-fold compared with BsaJI; P < 0.0001), even for inputs as high as 1.8 μg or dilution down to the single copy level. ..