Jian Min Yuan

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Tea and cancer prevention: epidemiological studies
    Jian Min Yuan
    The Masonic Cancer Center, and Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 425 East River Road, 554 MCRB, Minneapolis, MN 55455, USA
    Pharmacol Res 64:123-35. 2011
  2. pmc Green tea and prevention of esophageal and lung cancers
    Jian Min Yuan
    University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA
    Mol Nutr Food Res 55:886-904. 2011
  3. pmc Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer
    Jian Min Yuan
    The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Carcinogenesis 29:1386-93. 2008
  4. pmc Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma
    Jian Min Yuan
    The Cancer Center, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Hepatology 46:749-58. 2007
  5. ncbi request reprint Urinary biomarkers of tea polyphenols and risk of colorectal cancer in the Shanghai Cohort Study
    Jian Min Yuan
    The Cancer Center, University of Minnesota, 1300 South 2nd Street, Minneapolis, MN 55454, USA
    Int J Cancer 120:1344-50. 2007
  6. pmc Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers
    Jian Min Yuan
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Carcinogenesis 32:1366-71. 2011
  7. ncbi request reprint Prediagnostic level of serum retinol in relation to reduced risk of hepatocellular carcinoma
    Jian Min Yuan
    The Cancer Center, University of Minnesota, Minneapolis, MN, USA
    J Natl Cancer Inst 98:482-90. 2006
  8. pmc Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers
    Jian Min Yuan
    Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Res 69:2990-5. 2009
  9. pmc Prospective evaluation of hepatitis B 1762(T)/1764(A) mutations on hepatocellular carcinoma development in Shanghai, China
    Jian Min Yuan
    The Masonic Cancer Center and Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
    Cancer Epidemiol Biomarkers Prev 18:590-4. 2009
  10. ncbi request reprint Urinary tobacco smoke-constituent biomarkers for assessing risk of lung cancer
    Jian Min Yuan
    Authors Affiliations Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota
    Cancer Res 74:401-11. 2014

Detail Information

Publications75

  1. pmc Tea and cancer prevention: epidemiological studies
    Jian Min Yuan
    The Masonic Cancer Center, and Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 425 East River Road, 554 MCRB, Minneapolis, MN 55455, USA
    Pharmacol Res 64:123-35. 2011
    ..Future prospective observational studies with biomarkers of exposure and phase III clinical trials are required to provide definitive evidence for the hypothesized beneficial effect of tea consumption on cancer formation in humans...
  2. pmc Green tea and prevention of esophageal and lung cancers
    Jian Min Yuan
    University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA
    Mol Nutr Food Res 55:886-904. 2011
    ....
  3. pmc Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer
    Jian Min Yuan
    The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Carcinogenesis 29:1386-93. 2008
    ..12-3.69, P = 0.02). The effect of NAT2 slow acetylation was even stronger in the presence of two or more null/low-activity GST genotypes. There were no associations between bladder cancer risk and NAT1 genotype or CYP1A2 phenotype...
  4. pmc Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma
    Jian Min Yuan
    The Cancer Center, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Hepatology 46:749-58. 2007
    ..003). Individuals possessing the maximum number of mutant alleles (i.e., 4) had an odds ratio of 0.46 (95% confidence interval = 0.23-0.93) for HCC compared with those with no or only 1 mutant allele...
  5. ncbi request reprint Urinary biomarkers of tea polyphenols and risk of colorectal cancer in the Shanghai Cohort Study
    Jian Min Yuan
    The Cancer Center, University of Minnesota, 1300 South 2nd Street, Minneapolis, MN 55454, USA
    Int J Cancer 120:1344-50. 2007
    ..Urinary levels of tea polyphenols and their metabolites were not associated with rectal cancer risk. The present study supports the notion of tea catechins as chemopreventive agents against the development of colon cancer in humans...
  6. pmc Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers
    Jian Min Yuan
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Carcinogenesis 32:1366-71. 2011
    ..These findings along with results of previous studies in laboratory animals support a significant and unique role of NNN in esophageal carcinogenesis in humans...
  7. ncbi request reprint Prediagnostic level of serum retinol in relation to reduced risk of hepatocellular carcinoma
    Jian Min Yuan
    The Cancer Center, University of Minnesota, Minneapolis, MN, USA
    J Natl Cancer Inst 98:482-90. 2006
    ....
  8. pmc Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers
    Jian Min Yuan
    Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Res 69:2990-5. 2009
    ..Findings of the present study directly link NNK exposure to lung cancer development in humans...
  9. pmc Prospective evaluation of hepatitis B 1762(T)/1764(A) mutations on hepatocellular carcinoma development in Shanghai, China
    Jian Min Yuan
    The Masonic Cancer Center and Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
    Cancer Epidemiol Biomarkers Prev 18:590-4. 2009
    ..57 (95% confidence interval, 2.41-87.98) relative to those without the double mutations (P(trend) = 0.004). Thus, the HBV 1762(T)/1764(A) double mutation is a codeterminant of HCC risk for people chronically infected with HBV...
  10. ncbi request reprint Urinary tobacco smoke-constituent biomarkers for assessing risk of lung cancer
    Jian Min Yuan
    Authors Affiliations Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota
    Cancer Res 74:401-11. 2014
    ....
  11. ncbi request reprint Tobacco-specific N-nitrosamine exposures and cancer risk in the Shanghai Cohort Study: remarkable coherence with rat tumor sites
    Irina Stepanov
    Division of Environmental Health Sciences, University of Minnesota, Minneapolis, MN Masonic Cancer Center, University of Minnesota, Minneapolis, MN
    Int J Cancer 134:2278-83. 2014
    ....
  12. pmc Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and gastric cancer risk: a prospective study of men in Shanghai, China
    Kristin A Moy
    The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Int J Cancer 125:2652-9. 2009
    ..The protection may be stronger for individuals genetically deficient in enzymes that metabolize these chemopreventive compounds...
  13. pmc Urinary levels of cigarette smoke constituent metabolites are prospectively associated with lung cancer development in smokers
    Jian Min Yuan
    Masonic Cancer Center, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    Cancer Res 71:6749-57. 2011
    ..023) after adjustment for self-reported smoking intensity and duration and urinary total NNAL and total cotinine. This study also confirmed that urinary total NNAL and total cotinine are independently related to lung cancer risk...
  14. pmc Combined lifestyle factors and cardiovascular disease mortality in Chinese men and women: the Singapore Chinese health study
    Andrew O Odegaard
    MPH, University of Minnesota, School of Public Health, Division of Epidemiology and Community Health, 1300 S 2nd St, Ste 300, Minneapolis MN, 55454, USA
    Circulation 124:2847-54. 2011
    ..Lifestyle factors directly influence cardiovascular disease (CVD) risk, yet little research has examined the association of combined lifestyle factors with CVD mortality, especially in Asian populations...
  15. pmc Alcohol, tobacco, and diet in relation to esophageal cancer: the Shanghai Cohort Study
    Yunhua Fan
    The Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Nutr Cancer 60:354-63. 2008
    ..low consumers after adjustment for cigarette smoking, alcohol drinking, and other confounders...
  16. pmc Alcohol and tobacco use in relation to gastric cancer: a prospective study of men in Shanghai, China
    Kristin A Moy
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Masonic Cancer Center, Minneapolis, Minnesota 55455, USA
    Cancer Epidemiol Biomarkers Prev 19:2287-97. 2010
    ..Epidemiologic findings of tobacco and alcohol use in relation to gastric cancer are inconsistent. Well-designed prospective studies examining their relationship are sparse...
  17. pmc Age at menarche and cardiovascular disease mortality in Singaporean Chinese women: the Singapore Chinese Health Study
    Noel T Mueller
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454, USA
    Ann Epidemiol 22:717-22. 2012
    ..To examine whether age at menarche was inversely associated with cardiovascular disease (CVD) mortality in Singaporean Chinese women...
  18. pmc Dietary patterns and incident type 2 diabetes in chinese men and women: the singapore chinese health study
    Andrew O Odegaard
    Division of Epidemiology and CommunityHealth, University ofMinnesota, Minneapolis, Minnesota, USA
    Diabetes Care 34:880-5. 2011
    ..To empirically derive dietary patterns and examine their association with incident type 2 diabetes...
  19. pmc Coffee consumption and reduced risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study
    Shane Johnson
    The Masonic Cancer Center, MMC 806, University of Minnesota, 425 East River Road, Minneapolis, MN 55455, USA
    Cancer Causes Control 22:503-10. 2011
    ..Data on the association between coffee consumption and risk of hepatocellular carcinoma (HCC), especially in high-risk populations, are sparse...
  20. ncbi request reprint A prospective study of tobacco and alcohol use as risk factors for pharyngeal carcinomas in Singapore Chinese
    Jeppe T Friborg
    The Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    Cancer 109:1183-91. 2007
    ..Therefore, the authors analyzed this relation in a cohort of Singapore Chinese, which is a population with a high incidence of NPC...
  21. pmc Soy intake and risk of type 2 diabetes in Chinese Singaporeans [corrected]
    Noel T Mueller
    Division of Epidemiology and Community Health, University of Minnesota, 1300 South 2nd St, Suite 300, Minneapolis, MN 55454, USA
    Eur J Nutr 51:1033-40. 2012
    ..To examine the association between soy products and their components, isoflavones and protein, and incident type 2 diabetes in a population with varied soy intake and high rates of diabetes...
  22. ncbi request reprint Western-style fast food intake and cardiometabolic risk in an Eastern country
    Andrew O Odegaard
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, 55454, USA
    Circulation 126:182-8. 2012
    ..Western-style fast food contributes to a dietary pattern portending poor cardiometabolic health in the United States. With globalization, this way of eating is becoming more common in developing and recently developed populations...
  23. pmc Cytochrome P4501A2 phenotype and bladder cancer risk: The Shanghai bladder cancer study
    Li Tao
    Masonic Cancer Center, University of Minnesota, MN, USA
    Int J Cancer 130:1174-83. 2012
    ..The findings of our study demonstrate that CYP1A2 phenotype may be an important contributing factor in the development of smoking-related bladder cancer in humans...
  24. pmc Coffee intake and risk of colorectal cancer among Chinese in Singapore: the Singapore Chinese Health Study
    Sabrina Peterson
    University of Minnesota, St Paul, Minnesota 55108, USA
    Nutr Cancer 62:21-9. 2010
    ..Although there is a null association between coffee intake and risk of colorectal cancer overall, coffee may protect against smoking related advanced colon cancer...
  25. pmc Omega-3 fatty acids and incident type 2 diabetes: the Singapore Chinese Health Study
    Diana P Brostow
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA
    Am J Clin Nutr 94:520-6. 2011
    ..The role of omega-3 (n-3) fatty acids (FAs) in the development of type 2 diabetes is uncertain, especially with regard to any differential influence of α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)...
  26. ncbi request reprint Antiviral therapy for adults with chronic hepatitis B: a systematic review for a National Institutes of Health Consensus Development Conference
    Tatyana A Shamliyan
    Minnesota Evidence based Practice Center, Division of Health Policy and Management, University of Minnesota School of Public Health, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Ann Intern Med 150:111-24. 2009
    ..Chronic hepatitis B infection can lead to liver failure, hepatocellular carcinoma, and death...
  27. ncbi request reprint Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore
    Kim Robien
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55455, USA
    Br J Nutr 109:493-502. 2013
    ..Dietary vitamin D intake, hours spent indoors at work and genetic variation in CYP2R1, CYP3A4 and GC are significant predictors of 25(OH)D concentrations among Singapore Chinese...
  28. pmc Mitochondrial DNA copy number is associated with breast cancer risk
    Bharat Thyagarajan
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 8:e65968. 2013
    ..Future studies are warranted to confirm these findings and to elucidate the biological role of mtDNA copy number in breast cancer risk...
  29. ncbi request reprint Green tea, black tea and colorectal cancer risk: a meta-analysis of epidemiologic studies
    Can Lan Sun
    The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Carcinogenesis 27:1301-9. 2006
    ....
  30. pmc Elevated levels of volatile organic carcinogen and toxicant biomarkers in Chinese women who regularly cook at home
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, School of Public Health, MMC 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 19:1185-92. 2010
    ..Our goal was to quantify carcinogen and toxicant biomarkers in Chinese women who reported regularly doing home cooking compared with women randomly selected from the Singapore Chinese Health Study as controls...
  31. pmc Body mass index and risk of colorectal cancer in Chinese Singaporeans: the Singapore Chinese Health Study
    Andrew O Odegaard
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Cancer 117:3841-9. 2011
    ..5 kg/m(2)) in any population...
  32. pmc Urinary total isothiocyanates and colorectal cancer: a prospective study of men in Shanghai, China
    Kristin A Moy
    The Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    Cancer Epidemiol Biomarkers Prev 17:1354-9. 2008
    ..25-0.83), respectively, for risk of colorectal cancer (P for trend = 0.006). The present study suggests that dietary ITCs may exert tumor inhibitory effects, especially during earlier stages of the multistage process of carcinogenesis...
  33. pmc Systematic review of the literature on comparative effectiveness of antiviral treatments for chronic hepatitis B infection
    Tatyana A Shamliyan
    Division of Health Policy and Management, Minnesota Evidence based Practice Center, University of Minnesota School of Public Health, 420 Delaware Street SE, D330 5 Mayo MMC 729, Minneapolis, MN 55455, USA
    J Gen Intern Med 26:326-39. 2011
    ..To evaluate the comparative effectiveness of antiviral drugs in adults with chronic hepatitis B monoinfection for evidence-based decision-making...
  34. pmc Combined lifestyle factors and risk of incident colorectal cancer in a Chinese population
    Andrew O Odegaard
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454, USA
    Cancer Prev Res (Phila) 6:360-7. 2013
    ..Conversely, there was no association with rectal cancer risk. An increasing protective lifestyle factor index score is associated with a marked decreased risk of developing colon cancer in Chinese men and women...
  35. pmc Alcohol, cofactors and the genetics of hepatocellular carcinoma
    Mimi C Yu
    Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Gastroenterol Hepatol 23:S92-7. 2008
    ....
  36. pmc Genetic polymorphisms in the cytokine genes and risk of hepatocellular carcinoma in low-risk non-Asians of USA
    Simona Ognjanovic
    Department of Pediatrics, Division of Pediatric Epidemiology and Clinical Research, University of Minnesota, MMC 715, 420 Delaware Street S E, Minneapolis, MN 55455, USA
    Carcinogenesis 30:758-62. 2009
    ..98, 95% CI = 0.50-7.84, P = 0.08). In contrast to high-risk Chinese, Th1 and Th2 genotypes did not impact in a major way on risk of HCC in USA non-Asians...
  37. ncbi request reprint Green tea, black tea and breast cancer risk: a meta-analysis of epidemiological studies
    Can Lan Sun
    The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Carcinogenesis 27:1310-5. 2006
    ..15, 95% CI = 1.02-1.31). The results of this meta-analysis indicate a lower risk for breast cancer with green tea consumption. Available data suggest a possible late-stage, promotional effect of black tea on breast carcinogenesis...
  38. pmc Incense use and respiratory tract carcinomas: a prospective cohort study
    Jeppe T Friborg
    The Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    Cancer 113:1676-84. 2008
    ..Therefore, the relation between incense use and the risk of respiratory tract carcinomas was analyzed in a prospective cohort study...
  39. pmc Mitochondrial copy number is associated with colorectal cancer risk
    Bharat Thyagarajan
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 21:1574-81. 2012
    ..Quantitative changes in human mitochondrial DNA (mtDNA) copy number have been implicated in various cancer types. Data from prospective cohort studies on mtDNA copy number and colorectal cancer risk have been lacking...
  40. pmc Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 23:1001-8. 2010
    ....
  41. pmc Environmental tobacco smoke in relation to bladder cancer risk--the Shanghai bladder cancer study [corrected]
    Li Tao
    Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Epidemiol Biomarkers Prev 19:3087-95. 2010
    ..Hepatic cytochrome P450 (CYP) 1A2 and N-acetyltransferase (NAT2) are important isoenzymes in activation and detoxification, respectively, of tobacco carcinogens. Data on ETS and bladder cancer risk are sparse...
  42. pmc BMI, all-cause and cause-specific mortality in Chinese Singaporean men and women: the Singapore Chinese health study
    Andrew O Odegaard
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 5:e14000. 2010
    ..We aimed to examine the association between body mass index (BMI), all cause and cause-specific mortality to determine the optimal range of BMI in relation to mortality in Chinese men and women in Singapore...
  43. ncbi request reprint Coffee intake and gastric cancer risk: the Singapore Chinese health study
    Cheryl E Ainslie-Waldman
    Authors Affiliations Division of Epidemiology and Community Health, University of Minnesota, Minneapolis Department of Food Science and Nutrition, University of Minnesota, Saint Paul, Minnesota Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania Duke NUS Graduate Medical School Singapore, Singapore Saw Swee Hock School of Public Health and Department of Medicine, National University of Singapore, Singapore National Registry of Diseases Office, Health Promotion Board and Department of Gastroenterology and Hepatology, National University Health System, Singapore
    Cancer Epidemiol Biomarkers Prev 23:638-47. 2014
    ..Observational data are lacking among high-risk populations with sufficient regular coffee consumption...
  44. pmc Genetic variation in folylpolyglutamate synthase and gamma-glutamyl hydrolase and plasma homocysteine levels in the Singapore Chinese Health Study
    Sarah J Oppeneer
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
    Mol Genet Metab 105:73-8. 2012
    ..Since this is one of the first studies to assess FPGS and GGH genetic variants in relation to plasma homocysteine, further research is needed to confirm these findings and characterize the functional effects of these variants...
  45. pmc Diabetes and risk of bladder cancer among postmenopausal women in the Iowa Women's Health Study
    Anna E Prizment
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S Second Street, Suite 300, Minneapolis, MN 55454 1015, USA
    Cancer Causes Control 24:603-8. 2013
    ..We re-examined the diabetes-bladder cancer risk association by accounting for 12 more years of follow-up and assessed whether the association varied by diabetes duration, body mass index, or waist-to-hip ratio (WHR)...
  46. ncbi request reprint Knowledge and behaviors toward hepatitis B and the hepatitis B vaccine in the Laotian community in Minnesota
    Ma Xiong
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 S 2nd Street, Suite 300, Minneapolis, MN 55454, USA
    J Immigr Minor Health 15:771-8. 2013
    ..8 %) of those individuals received all three doses. This study outlines gaps in knowledge and resources that could address the staggering HBV disparity in this community. ..
  47. doi request reprint Clinical outcomes in adults with chronic hepatitis B in association with patient and viral characteristics: A systematic review of evidence
    Brent C Taylor
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Hepatology 49:S85-95. 2009
    ..Baseline patient and disease characteristics provide important information about the risk of clinical outcomes and should be incorporated into monitoring or treatment decisions...
  48. ncbi request reprint Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033 0800, USA
    Carcinogenesis 24:483-9. 2003
    ..On the other hand, individuals of NAT1*10 genotype exhibited no such associations...
  49. ncbi request reprint Angiotensin I-converting enzyme (ACE) gene polymorphism and breast cancer risk among Chinese women in Singapore
    Woon Puay Koh
    Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore 117597
    Cancer Res 63:573-8. 2003
    ..27-0.81). Our findings support experimental data implicating ACE and angiotensin II in breast cancer, and suggest that the renin-angiotensin system may serve as a therapeutic target for breast cancer treatment and prevention...
  50. ncbi request reprint Dietary cryptoxanthin and reduced risk of lung cancer: the Singapore Chinese Health Study
    Jian Min Yuan
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033 0800, USA
    Cancer Epidemiol Biomarkers Prev 12:890-8. 2003
    ..The present study lends additional credence to prior experimental and epidemiological data in support of the hypothesis that dietary beta-cryptoxanthin is a chemopreventive agent for lung cancer in humans...
  51. ncbi request reprint Dietary soy and increased risk of bladder cancer: the Singapore Chinese Health Study
    Can Lan Sun
    USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
    Cancer Epidemiol Biomarkers Prev 11:1674-7. 2002
    ..To our knowledge, this is the first epidemiological report on the effect of dietary soy on bladder cancer risk...
  52. ncbi request reprint Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study
    Adeline Seow
    Department of Community, Occupational and Family Medicine, Faculty of Medicine, National University of Singapore, Singapore
    Carcinogenesis 23:2055-61. 2002
    ..Further, this gene-diet interaction may be important in studies evaluating the effect of risk-enhancing compounds in the colorectum...
  53. ncbi request reprint Carotenoids/vitamin C and smoking-related bladder cancer
    J Esteban Castelao
    USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089 9181, USA
    Int J Cancer 110:417-23. 2004
    ..The carotenoid-bladder cancer association was not affected by the GSTM1, GSTT1 and GSTP1 genotypes...
  54. ncbi request reprint Tobacco smoking and urinary levels of 2-amino-9H-pyrido[2,3-b]indole in men of Shanghai, China
    Robert J Turesky
    Wadsworth Center, New York State Department of Health, Albany, New York, Empire State Plaza, P O Box 509, Albany, NY 12201 0509, USA
    Cancer Epidemiol Biomarkers Prev 16:1554-60. 2007
    ..Our data indicate that AalphaC represents a major HAA exposure in adult men of Shanghai, China, and that tobacco smoke is an important point source of their AalphaC exposure...
  55. ncbi request reprint Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in Shanghai, China
    Can Lan Sun
    USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
    Carcinogenesis 23:1497-503. 2002
    ..The present study provides direct evidence that tea polyphenols may act as chemopreventive agents against gastric and esophageal cancer development...
  56. ncbi request reprint Insulin-like growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China
    Stephanie J London
    Epidemiology Branch and Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Natl Cancer Inst 94:749-54. 2002
    ..In a prospective study of men in Shanghai, China, we examined the association between serum levels of IGF-I and IGFBP-3 and the subsequent risk of lung cancer...
  57. ncbi request reprint Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S
    Jian Min Yuan
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles 90089 9176, USA
    Cancer 101:1009-17. 2004
    ..Heavy alcohol consumption, viral hepatitis, and diabetes are risk factors for hepatocellular carcinoma (HCC). However, to the authors' knowledge, the information concerning their interaction effect in patients with risk of HCC is sparse...
  58. ncbi request reprint Dietary soy and increased risk of bladder cancer: a prospective cohort study of men in Shanghai, China
    Can Lan Sun
    USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033 9176, USA
    Int J Cancer 112:319-23. 2004
    ..The soy-bladder cancer risk associations in smokers and non-smokers were comparable. The soy-bladder cancer relationship became stronger when the analysis was restricted to subjects with 2 or more years of follow-up...
  59. ncbi request reprint Polymorphisms in angiotensin II type 1 receptor and angiotensin I-converting enzyme genes and breast cancer risk among Chinese women in Singapore
    Woon Puay Koh
    Department of Community, Occupational and Family Medicine, National University of Singapore, 16 Medical Drive, Singapore 117597, Singapore
    Carcinogenesis 26:459-64. 2005
    ..Our findings suggest that pharmacological inhibition of the angiotensin II effect by blockade of ACE and/or AGTR1 could be potential targets for the prevention and treatment of breast cancer...
  60. ncbi request reprint DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Room 5421A, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 16:2363-72. 2007
    ..8; 95% CI, 1.0-8.1). Our results support a role for reactive oxygen species as relevant genotoxins that may account for the effects of both smoking and alcohol on colorectal cancer risk...
  61. pmc Differential effects of black versus green tea on risk of Parkinson's disease in the Singapore Chinese Health Study
    Louis C Tan
    Department of Neurology, National Neuroscience Institute, Singapore
    Am J Epidemiol 167:553-60. 2008
    ..Green tea drinking was unrelated to Parkinson's disease risk. Diet had no strong influence on risk. Ingredients of black tea other than caffeine appear to be responsible for the beverage's inverse association with Parkinson's disease...
  62. ncbi request reprint Green tea and black tea consumption in relation to colorectal cancer risk: the Singapore Chinese Health Study
    Can Lan Sun
    Division of Population Sciences, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA
    Carcinogenesis 28:2143-8. 2007
    ..75, 95% CI = 1.24-2.46; P for trend < 0.0001). Irrespective of gender, intake of black tea was not associated with risk of colorectal cancer (RR = 0.92, 95% CI = 0.79-1.07) in this Asian population...
  63. ncbi request reprint Beta-cryptoxanthin and lung cancer in Shanghai, China--an examination of potential confounding with cigarette smoking using urinary cotinine as a biomarker for true tobacco exposure
    Daniel O Stram
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Nutr Cancer 57:123-9. 2007
    ....
  64. ncbi request reprint Peroxisome proliferator-activated receptor (PPAR) gamma gene polymorphisms and colorectal cancer risk among Chinese in Singapore
    Woon Puay Koh
    Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Carcinogenesis 27:1797-802. 2006
    ..72 (0.49-1.07) among subjects possessing one low-risk genotype (either PPARgamma2 or PPARgamma3), and the comparable figure among subjects possessing both low-risk genotypes was 0.19 (0.07-0.51)...
  65. ncbi request reprint Diabetes mellitus and risk of colorectal cancer in the Singapore Chinese Health Study
    Adeline Seow
    Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore
    J Natl Cancer Inst 98:135-8. 2006
    ..Our results support the hypothesis that hyperinsulinemia may play a role in colorectal carcinogenesis, even in a relatively lean population...
  66. ncbi request reprint [A prospective cohort study on body mass index and mortality among middle-aged and elderly men in urban Shanghai]
    Jun Wang
    The Department of Epidemiology, Shanghai Cancer Institute, Shanghai 200032, China
    Zhonghua Liu Xing Bing Xue Za Zhi 26:394-9. 2005
    ..To examine the association between body mass index (BMI) and mortality as well as the effect of age on it among middle-aged and elderly men in urban area of Shanghai...
  67. ncbi request reprint Green tea intake, ACE gene polymorphism and breast cancer risk among Chinese women in Singapore
    Jian Min Yuan
    USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, MC 9175, Los Angeles, CA 90089 9181, USA
    Carcinogenesis 26:1389-94. 2005
    ..The findings of the present study highlight the importance of genetically determined factors in evaluating the role of green tea intake in the development of breast cancer...
  68. ncbi request reprint Effect of cytokine genotypes on the hepatitis B virus-hepatocellular carcinoma association
    Alexandra Nieters
    Department of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer 103:740-8. 2005
    ..However, only a minority of HBV carriers eventually develop hepatocellular carcinoma. The authors hypothesized that cytokine genotypes may be important codeterminants of the risk of HBV-related hepatocellular carcinoma...
  69. ncbi request reprint [Cigarette smoking and cancer mortality: a prospective cohort study in urban males in Shanghai]
    Jun Wang
    Shanghai Cancer Institute, Shanghai 200032, China
    Zhonghua Liu Xing Bing Xue Za Zhi 25:837-40. 2004
    ..To investigate the association between cigarette smoking and cancer mortality in urban men in Shanghai and its impact when smoking habit changed during the follow-up period...
  70. ncbi request reprint Prediagnostic levels of serum micronutrients in relation to risk of gastric cancer in Shanghai, China
    Jian Min Yuan
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, MC 9175, 1441 Eastlake Avenue, Los Angeles, CA 90033 0800, USA
    Cancer Epidemiol Biomarkers Prev 13:1772-80. 2004
    ..The present study implicates that dietary carotenes, lycopene, and vitamin C are potential chemopreventive agents for gastric cancer in humans...
  71. ncbi request reprint Environmental factors and risk for hepatocellular carcinoma
    Mimi C Yu
    Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Gastroenterology 127:S72-8. 2004
    ..In summary, risk factors for HCC are identifiable in most patients and primarily are associated with chronic hepatic injury...
  72. pmc Morbidity and mortality in relation to smoking among women and men of Chinese ethnicity: the Singapore Chinese Health Study
    Anoop Shankar
    Department of Community, Occupational, and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Eur J Cancer 44:100-9. 2008
    ..We examined the association among cigarette smoking, smoking cessation and a broad range of cancer incidence and all cause and cause-specific mortality in a population-based cohort of adults of Chinese ethnicity in Singapore...
  73. ncbi request reprint Middle-aged and older Chinese men and women in Singapore who smoke have less healthy diets and lifestyles than nonsmokers
    Woon Puay Koh
    Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore
    J Nutr 135:2473-7. 2005
    ..Our results are consistent with findings among Western populations, and suggest that the unhealthy diet and lifestyle in smokers occur across diverse cultures...
  74. ncbi request reprint Epidemiology of nasopharyngeal carcinoma
    Mimi C Yu
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
    Semin Cancer Biol 12:421-9. 2002
    ..Other recognized risk factors for NPC are cigarette smoking, and occupational exposure to formaldehyde and wood dust...
  75. ncbi request reprint Lipid peroxidation: a novel and unifying concept of the etiology of renal cell carcinoma (United States)
    Manuela Gago-Dominguez
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90089 9176, USA
    Cancer Causes Control 13:287-93. 2002
    ..Our hypothesis may also explain the roles of other risk (oophorectomy/hysterectomy, parity, smoking, diabetes) and protective factors (dietary antioxidants) for renal cell cancer...

Research Grants16

  1. Dietary Factors in the Etiology of Colorectal Cancer
    Jian Min Yuan; Fiscal Year: 2004
    ..The potential modifying effects of HAA activating genes and tea polyphenols on the HAA-colorectal cancer association will be explored. ..
  2. Biomarkers of NNK in prediction of lung cancer development in smokers
    Jian Min Yuan; Fiscal Year: 2010
    ..The findings of the proposed study will have great influence on lung cancer incidence and mortality. ..
  3. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2010
    ..The findings of the proposed study will have great impact on reducing incidence and mortality of lung and liver cancers in humans. ..
  4. Randomized trial of PEITC as a modifier of NNK metabolism in smokers
    Jian Min Yuan; Fiscal Year: 2010
    ..The major strengths include the need for a randomized, placebo-controlled trial of PEITC, the qualification of the investigators, and the feasibility of the proposed studies. ..
  5. Biomarkers of NNK in prediction of lung cancer development in smokers
    Jian Min Yuan; Fiscal Year: 2009
    ..The findings of the proposed study will have great influence on lung cancer incidence and mortality. ..
  6. THE SINGAPORE COHORT STUDY OF DIET AND CANCER
    Jian Min Yuan; Fiscal Year: 2009
    ....
  7. Randomized trial of PEITC as a modifier of NNK metabolism in smokers
    Jian Min Yuan; Fiscal Year: 2009
    ..The major strengths include the need for a randomized, placebo-controlled trial of PEITC, the qualification of the investigators, and the feasibility of the proposed studies. ..
  8. Dietary Factors in the Etiology of Colorectal Cancer
    Jian Min Yuan; Fiscal Year: 2007
    ..The potential modifying effects of HAA activating genes and tea polyphenols on the HAA-colorectal cancer association will be explored. ..
  9. Dietary Factors in the Etiology of Colorectal Cancer
    Jian Min Yuan; Fiscal Year: 2005
    ..The potential modifying effects of HAA activating genes and tea polyphenols on the HAA-colorectal cancer association will be explored. ..
  10. DIETARY FACTORS IN THE ETIOLOGY OF CANCER IN SHANGHAI
    Jian Min Yuan; Fiscal Year: 2006
    ..In all instances of diet-cancer investigations, relevant genes with potential modifying effects on the respective diet-cancer associations will be included in the investigations. ..
  11. Dietary Factors in the Etiology of Colorectal Cancer
    Jian Min Yuan; Fiscal Year: 2006
    ..The potential modifying effects of HAA activating genes and tea polyphenols on the HAA-colorectal cancer association will be explored. ..
  12. Dietary Factors in the Etiology of Colorectal Cancer
    Jian Min Yuan; Fiscal Year: 2005
    ..The potential modifying effects of HAA activating genes and tea polyphenols on the HAA-colorectal cancer association will be explored. ..
  13. THE SINGAPORE COHORT STUDY OF DIET AND CANCER
    Jian Min Yuan; Fiscal Year: 2009
    ....