Dorothy Yuan

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint The role of adjuvant on the regulatory effects of NK cells on B cell responses as revealed by a new model of NK cell deficiency
    Dorothy Yuan
    Laboratory of Molecular Pathology, Department of Pathology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Int Immunol 16:707-16. 2004
  2. ncbi request reprint Lipopolysaccharide deacylation by an endogenous lipase controls innate antibody responses to Gram-negative bacteria
    Mingfang Lu
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nat Immunol 6:989-94. 2005
  3. doi request reprint The role of NK cells in the development of autoantibodies
    Dorothy Yuan
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Autoimmunity 44:641-51. 2011
  4. pmc Antigen-specific responses and ANA production in B6.Sle1b mice: a role for SAP
    Paula Jennings
    Department of Molecular Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Autoimmun 31:345-53. 2008
  5. doi request reprint Requirements for the natural killer cell-mediated induction of IgG1 and IgG2a expression in B lymphocytes
    Ning Gao
    Laboratory of Molecular Pathology, Department of Molecular Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Int Immunol 20:645-57. 2008
  6. ncbi request reprint B cell induction of IL-13 expression in NK cells: role of CD244 and SLAM-associated protein
    Ning Gao
    Department of Molecular Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 176:2758-64. 2006
  7. doi request reprint NK cell enhancement of antigen presentation by B lymphocytes
    Paula Jennings
    Graduate Program in Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 182:2879-87. 2009
  8. doi request reprint Mechanism of induction of NK activation by 2B4 (CD244) via its cognate ligand
    Suwan Kumar Sinha
    Department of Molecular Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 185:5205-10. 2010
  9. pmc IFN type I and type II independent enhancement of B cell TLR7 expression by natural killer cells
    Suwan Sinha
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Leukoc Biol 92:713-22. 2012
  10. doi request reprint Regulatory role of natural killer (NK) cells on antibody responses to Brucella abortus
    Ning Gao
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, TX 75390, USA
    Innate Immun 17:152-63. 2011

Collaborators

  • Xin J Zhou
  • Robert S Munford
  • Wesley Dunnick
  • B R Blazar
  • Lily I Jiang
  • Ning Gao
  • Paula Jennings
  • Yuhong Guo
  • Suwan Sinha
  • Biyan Duan
  • Suwan Kumar Sinha
  • Subhadra Nandakumar
  • Pamela Schwartzberg
  • Mingfang Lu
  • Hong Ren
  • Suwannee Thet
  • Paul C Sternweis
  • Julie Collins
  • Eva L Sadat
  • Richard Davis
  • Uday Kumaraguru
  • Barry T Rouse
  • Edward K Wakeland
  • Alice Chan
  • Stacie N Woolard
  • Julie A Wilder
  • John T Collins
  • Mei Zhang
  • Akira Takashima
  • Xiang Hong Li
  • Jerrold Weiss
  • Michael A Apicella
  • Tam Dang
  • Richard B Gaynor
  • Aurelia Schmalstieg

Detail Information

Publications17

  1. ncbi request reprint The role of adjuvant on the regulatory effects of NK cells on B cell responses as revealed by a new model of NK cell deficiency
    Dorothy Yuan
    Laboratory of Molecular Pathology, Department of Pathology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Int Immunol 16:707-16. 2004
    ..Since NKT cells are not depleted, the effect cannot be attributed to this subpopulation. These results help to resolve differences in previous findings regarding the role of NK cells in antibody responses...
  2. ncbi request reprint Lipopolysaccharide deacylation by an endogenous lipase controls innate antibody responses to Gram-negative bacteria
    Mingfang Lu
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nat Immunol 6:989-94. 2005
    ..Control of lipopolysaccharide activation by acyloxyacyl hydrolase indicates that mammals can regulate immune responses to bacterial infection by chemical modification of a Toll-like receptor agonist...
  3. doi request reprint The role of NK cells in the development of autoantibodies
    Dorothy Yuan
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Autoimmunity 44:641-51. 2011
    ..Further experiments provide a possible mechanism for the NK-cell dependence...
  4. pmc Antigen-specific responses and ANA production in B6.Sle1b mice: a role for SAP
    Paula Jennings
    Department of Molecular Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Autoimmun 31:345-53. 2008
    ..The results of these studies of responses to non-self-antigens provide further insight into the mechanism by which responses to self-antigens might be initiated in the context of specific genetic alterations...
  5. doi request reprint Requirements for the natural killer cell-mediated induction of IgG1 and IgG2a expression in B lymphocytes
    Ning Gao
    Laboratory of Molecular Pathology, Department of Molecular Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Int Immunol 20:645-57. 2008
    ..This in vitro analysis provides a mechanistic basis for understanding the documented NK cell effects on T-independent B cell responses in vivo...
  6. ncbi request reprint B cell induction of IL-13 expression in NK cells: role of CD244 and SLAM-associated protein
    Ning Gao
    Department of Molecular Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 176:2758-64. 2006
    ..The induction of IL-13 mRNA by B cells may account for the effect of NK cells on the generation of Th2-type responses in the presence of some adjuvants...
  7. doi request reprint NK cell enhancement of antigen presentation by B lymphocytes
    Paula Jennings
    Graduate Program in Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 182:2879-87. 2009
    ..These results show, for the first time, that the rapid activation of a component of the innate response can even exert effects on the Ag-specific memory response...
  8. doi request reprint Mechanism of induction of NK activation by 2B4 (CD244) via its cognate ligand
    Suwan Kumar Sinha
    Department of Molecular Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 185:5205-10. 2010
    ..By the use of double CD2/2B4 knockout mice, we have also shown that the induction of NK cell activation by anti-CD48 or by B cells is not due to the release of inhibitory effects of 2B4...
  9. pmc IFN type I and type II independent enhancement of B cell TLR7 expression by natural killer cells
    Suwan Sinha
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Leukoc Biol 92:713-22. 2012
    ..This increased expression allows B cells to respond more readily upon stimulation by its ligand and may increase in vivo responses to other TLR7 ligands, such as autoantigens, prior to or jointly with stimulation by other cytokines...
  10. doi request reprint Regulatory role of natural killer (NK) cells on antibody responses to Brucella abortus
    Ning Gao
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, TX 75390, USA
    Innate Immun 17:152-63. 2011
    ..These findings have therapeutic implications in that the induction of polyclonal Ig production may be more important for altering the chronic phase rather than the acute stage of infection by B. abortus...
  11. ncbi request reprint Receptors and counterreceptors involved in NK-B cell interactions
    Ning Gao
    Department of Molecular Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 174:4113-9. 2005
    ....
  12. pmc Distinct roles of adenylyl cyclase VII in regulating the immune responses in mice
    Biyan Duan
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 185:335-44. 2010
    ..These results are the first to ascribe specific functions to an AC isoform in the immune system and emphasize the importance of cAMP synthesis by this isoform in shaping the immune responses...
  13. doi request reprint Enhancement of Antigen-Specific Immunoglobulin G Responses by Anti-CD48
    Dorothy Yuan
    Department of Pathology, UT Southwestern Medical Center, Dallas, Tex, USA
    J Innate Immun 5:174-84. 2013
    ..These results provide a pathway by which CD48, when appropriately activated, can influence the course of an antigen-specific antibody response via the innate system...
  14. ncbi request reprint Interactions between NK cells and B lymphocytes
    Dorothy Yuan
    Laboratory of Molecular Pathology, Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Adv Immunol 84:1-42. 2004
  15. ncbi request reprint I-kappa B kinase beta is critical for B cell proliferation and antibody response
    Hong Ren
    Division of Hematology Oncology, Department of Medicine, Harold Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 168:577-87. 2002
    ..These results suggest that IKKbeta is critical for the proliferation of B cells and the control of some aspects of the humoral response...
  16. pmc Natural killer cells as novel helpers in anti-herpes simplex virus immune response
    Subhadra Nandakumar
    Department of Microbiology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Virol 82:10820-31. 2008
    ..Hence, NK cells may well be exploited for enhancing and rescuing the T-cell response in situations where the CD4 helper response is affected...
  17. ncbi request reprint Comment on "Molecular basis of the dual functions of 2B4 (CD244)"
    Dorothy Yuan
    J Immunol 181:5181; author reply 5181. 2008