Chun Su Yuan

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint Gastric effects of mu-, delta- and kappa-opioid receptor agonists on brainstem unitary responses in the neonatal rat
    C S Yuan
    Committee on Clinical Pharmacology, University of Chicago Medical Center, IL 60637, USA
    Eur J Pharmacol 314:27-32. 1996
  2. ncbi request reprint Gastric effects of galanin and its interaction with leptin on brainstem neuronal activity
    Chun Su Yuan
    Committee on Clinical Pharmacology, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, USA
    J Pharmacol Exp Ther 301:488-93. 2002
  3. ncbi request reprint Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: a double-blind randomized placebo-controlled trial
    Chun Su Yuan
    Committee on Clinical Pharmacology, University of Chicago, Chicago, Illinois 60637, USA
    J Pharmacol Exp Ther 300:118-23. 2002
  4. ncbi request reprint Herbal medicines and perioperative care
    M K Ang-Lee
    Department of Anesthesia and Critical Care, University of Chicago, 5841 S Maryland Ave, MC 4028, Chicago, IL 60637, USA
    JAMA 286:208-16. 2001
  5. ncbi request reprint Effects of Panax quinquefolius L. on brainstem neuronal activities: comparison between Wisconsin-cultivated and Illinois-cultivated roots
    C S Yuan
    Tang Center for Herbal Medicine Research, Pritzker School of Medicine, The University of Chicago, Illinois, USA
    Phytomedicine 8:178-83. 2001
  6. ncbi request reprint Effects of enteric-coated methylnaltrexone in preventing opioid-induced delay in oral-cecal transit time
    C S Yuan
    Department of Anesthesia and Critical Care, University of Chicago, IL 60637, USA
    Clin Pharmacol Ther 67:398-404. 2000
  7. ncbi request reprint Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial
    C S Yuan
    Committee on Clinical Pharmacology, Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Ill 60637, USA
    JAMA 283:367-72. 2000
  8. ncbi request reprint Effects of intravenous methylnaltrexone on opioid-induced gut motility and transit time changes in subjects receiving chronic methadone therapy: a pilot study
    C S Yuan
    Committee on Clinical Pharmacology and the Department of Anesthesia and Critical Care, The University of Chicago, IL 60637, USA
    Pain 83:631-5. 1999
  9. ncbi request reprint Peripheral gastric leptin modulates brain stem neuronal activity in neonates
    C S Yuan
    Committee on Clinical Pharmacology, The Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol 277:G626-30. 1999
  10. ncbi request reprint The safety and efficacy of oral methylnaltrexone in preventing morphine-induced delay in oral-cecal transit time
    C S Yuan
    Department of Anesthesia and Critical Care, University of Chicago, IL 60637, USA
    Clin Pharmacol Ther 61:467-75. 1997

Collaborators

Detail Information

Publications120 found, 100 shown here

  1. ncbi request reprint Gastric effects of mu-, delta- and kappa-opioid receptor agonists on brainstem unitary responses in the neonatal rat
    C S Yuan
    Committee on Clinical Pharmacology, University of Chicago Medical Center, IL 60637, USA
    Eur J Pharmacol 314:27-32. 1996
    ..These results suggest that the mu- and kappa-opioid receptors of the distal stomach are important in modulation of brainstem neuronal activity and may play a role in regulating the digestive process...
  2. ncbi request reprint Gastric effects of galanin and its interaction with leptin on brainstem neuronal activity
    Chun Su Yuan
    Committee on Clinical Pharmacology, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, USA
    J Pharmacol Exp Ther 301:488-93. 2002
    ..05 compared with leptin alone; P < 0.01 compared with galanin alone, 55.1 +/- 3.2%). Our data suggest that galanin modulates the leptin signals, which regulate the ingestive process in neonates...
  3. ncbi request reprint Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: a double-blind randomized placebo-controlled trial
    Chun Su Yuan
    Committee on Clinical Pharmacology, University of Chicago, Chicago, Illinois 60637, USA
    J Pharmacol Exp Ther 300:118-23. 2002
    ..Our results suggest that subcutaneous methylnaltrexone may have clinical utility in treating opioid-induced constipation and reducing opioid-induced unpleasant subjective symptoms...
  4. ncbi request reprint Herbal medicines and perioperative care
    M K Ang-Lee
    Department of Anesthesia and Critical Care, University of Chicago, 5841 S Maryland Ave, MC 4028, Chicago, IL 60637, USA
    JAMA 286:208-16. 2001
    ..Widespread use of herbal medications among the presurgical population may have a negative impact on perioperative patient care...
  5. ncbi request reprint Effects of Panax quinquefolius L. on brainstem neuronal activities: comparison between Wisconsin-cultivated and Illinois-cultivated roots
    C S Yuan
    Tang Center for Herbal Medicine Research, Pritzker School of Medicine, The University of Chicago, Illinois, USA
    Phytomedicine 8:178-83. 2001
    ..Data from our high performance liquid chromatography ginsenoside analysis suggest that this increase in inhibitory effects by Illinois-cultivated P. quinquefolius may be due to its different ginsenoside profile...
  6. ncbi request reprint Effects of enteric-coated methylnaltrexone in preventing opioid-induced delay in oral-cecal transit time
    C S Yuan
    Department of Anesthesia and Critical Care, University of Chicago, IL 60637, USA
    Clin Pharmacol Ther 67:398-404. 2000
    ..In previous human volunteer trials, we demonstrated that oral uncoated methylnaltrexone prevented morphine-induced delay in gastrointestinal transit time...
  7. ncbi request reprint Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial
    C S Yuan
    Committee on Clinical Pharmacology, Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Ill 60637, USA
    JAMA 283:367-72. 2000
    ....
  8. ncbi request reprint Effects of intravenous methylnaltrexone on opioid-induced gut motility and transit time changes in subjects receiving chronic methadone therapy: a pilot study
    C S Yuan
    Committee on Clinical Pharmacology and the Department of Anesthesia and Critical Care, The University of Chicago, IL 60637, USA
    Pain 83:631-5. 1999
    ....
  9. ncbi request reprint Peripheral gastric leptin modulates brain stem neuronal activity in neonates
    C S Yuan
    Committee on Clinical Pharmacology, The Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol 277:G626-30. 1999
    ..01). Our data demonstrate that peripheral gastric leptin modulates brain stem neuronal activity and suggest that gastric leptin has a significantly stronger effect in the 7- to 8-day-old animals than in the younger neonates...
  10. ncbi request reprint The safety and efficacy of oral methylnaltrexone in preventing morphine-induced delay in oral-cecal transit time
    C S Yuan
    Department of Anesthesia and Critical Care, University of Chicago, IL 60637, USA
    Clin Pharmacol Ther 61:467-75. 1997
    ..Oral methylnaltrexone may have a clinical value in the prevention and treatment of constipation induced by long-term opioid use...
  11. ncbi request reprint Kavalactones and dihydrokavain modulate GABAergic activity in a rat gastric-brainstem preparation
    Chun Su Yuan
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago 60637, USA
    Planta Med 68:1092-6. 2002
    ..Our results demonstrated modulation of brainstem GABAergic mechanism by kavalactones and dihydrokavain, and suggested that these compounds may play an important role in regulation of GABAergic neurotransmission...
  12. ncbi request reprint Dose-related effects of oral acetaminophen on cold-induced pain: a double-blind, randomized, placebo-controlled trial
    C S Yuan
    Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Illinois 60637, USA
    Clin Pharmacol Ther 63:379-83. 1998
    ..Results from our study suggest that the cold-pressor method may have clinical value in evaluating nonopioid analgesic agents...
  13. ncbi request reprint GABAergic effects on nucleus tractus solitarius neurons receiving gastric vagal inputs
    C S Yuan
    Committee on Clinical Pharmacology and the Department of Anesthesia and Critical Care, The Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Pharmacol Exp Ther 286:736-41. 1998
    ..Our results demonstrated that both GABAA and GABAB receptors in the stomach and brainstem play an important role in activity modulation of the medial NTS neurons receiving gastric vagal inputs in neonatal rats...
  14. ncbi request reprint Efficacy of orally administered methylnaltrexone in decreasing subjective effects after intravenous morphine
    C S Yuan
    Department of Anesthesia and Critical Care, Pritzer School of Medicine, University of Chicago, IL 60637, USA
    Drug Alcohol Depend 52:161-5. 1998
    ..Our results suggested that methylnaltrexone has a potential therapeutic value in decreasing some undesirable subjective effects associated with opioid medications...
  15. ncbi request reprint Gastric effects of methylnaltrexone on mu, kappa, and delta opioid agonists induced brainstem unitary responses
    C S Yuan
    Department of Anesthesia and Critical Care, The Pritzker School of Medicine, The University of Chicago, IL 60637, USA
    Neuropharmacology 38:425-32. 1999
    ..5+/-2.1%) of the NTS neurons receiving subdiaphragmatic vagal inputs, suggesting an endogenous gastric opioid action in the modulation of brainstem neuronal activities...
  16. ncbi request reprint Modulation of American ginseng on brainstem GABAergic effects in rats
    C S Yuan
    Department of Anesthesia and Critical Care, The Pritzker School of Medicine, The University of Chicago, IL 60637, USA
    J Ethnopharmacol 62:215-22. 1998
    ..Our data suggest that the regulation of GABAergic neurotransmission may be an important action of Panax quinquefolium L...
  17. ncbi request reprint Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component
    Anoja S Attele
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Diabetes 51:1851-8. 2002
    ..This antidiabetic effect of ginsenoside Re was not associated with body weight changes, suggesting that other constituents in the extract have distinct pharmacological mechanisms on energy metabolism...
  18. ncbi request reprint Polyphenol contents in grape-seed extracts correlate with antipica effects in cisplatin-treated rats
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, Pritzker School of Medicine, University of Chicago, IL 60637, USA
    J Altern Complement Med 11:1059-65. 2005
    ..Grape-seed (Vitis spp.) extract (GSE) is a widely used antioxidant dietary supplement. Chemotherapeutic agents such as cisplatin induce oxidative damage in the gastrointestinal tract and cause nausea and vomiting...
  19. ncbi request reprint Grape seed proanthocyanidin extract attenuates oxidant injury in cardiomyocytes
    Zuo Hui Shao
    Department of Medicine, Section of Emergency Medicine, University of Chicago, 5841 S Maryland Avenue, MC 5068, Chicago, IL 60637, USA
    Pharmacol Res 47:463-9. 2003
    ..Its effect does not require PKC, mito K(ATP) channel, or NO synthase, presumably because it acts by reactive oxygen species scavenging and iron chelating directly...
  20. ncbi request reprint Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytes
    Zuo Hui Shao
    Tang Center for Herbal Medicine Research, Emergency Resuscitation Research Center, and Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
    Cardiovasc Toxicol 3:331-9. 2003
    ..Consumers may take higher doses of dietary supplements in the belief that natural herbs have no major side effects. This study demonstrates that dosages of GSPE should be optimized to avoid potential harmful pro-oxidant effects...
  21. pmc Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cells
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, The University of Chicago, Chicago, IL 60637, USA
    Cancer Chemother Pharmacol 60:69-79. 2007
    ..In this study, using HCT-116 human colorectal cancer cell line, we investigated the possible synergistic anti-cancer effects between notoginseng flower extract (NGF) and 5-FU on colon cancer cells...
  22. pmc Paraptosis and NF-κB activation are associated with protopanaxadiol-induced cancer chemoprevention
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL, USA
    BMC Complement Altern Med 13:2. 2013
    ..PPD possesses anticancer potential via caspase-dependent apoptosis. Whether paraptosis, a type of the caspase-independent cell death, is also induced by PPD has not been evaluated...
  23. ncbi request reprint Antihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng
    Jing Tian Xie
    Tang Center for Herbal Medicine Research the Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Acta Pharmacol Sin 26:1104-10. 2005
    ..The antihyperglycemic effects of the total ginsenosides in Chinese ginseng (TGCG), extracted from leaves and the stem, were evaluated in diabetic C57BL/6J ob/ob mice...
  24. ncbi request reprint Effects of antioxidant herbs on chemotherapy-induced nausea and vomiting in a rat-pica model
    Sangeeta R Mehendale
    Tang Center for Herbal Medicine Research, and Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Am J Chin Med 32:897-905. 2004
    ..We conclude that herbal antioxidants may have a role in attenuating cisplatin-induced nausea and vomiting...
  25. doi request reprint Asian ginseng enhances the anti-proliferative effect of 5-fluorouracil on human colorectal cancer: comparison between white and red ginseng
    Anna B Fishbein
    Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL, 60637, USA
    Arch Pharm Res 32:505-13. 2009
    ..Rd and Rg3 showed positive anti-proliferative effect. Our data suggested a potential for RG as an adjuvant therapy in the treatment of colorectal cancer, via a synergistic action...
  26. ncbi request reprint American ginseng leaf: ginsenoside analysis and hypoglycemic activity
    Jing Tian Xie
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, 5841 S Maryland Avenue, MC 4028, Chicago, IL 60637, USA
    Pharmacol Res 49:113-7. 2004
    ..05). Our results suggest that AGLE possesses a significant anti-hyperglycemic and thermogenic activity and may prove to be beneficial in improving the management of type 2 diabetes...
  27. ncbi request reprint American ginseng berry extract and ginsenoside Re attenuate cisplatin-induced kaolin intake in rats
    Sangeeta Mehendale
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, IL 60637, USA
    Cancer Chemother Pharmacol 56:63-9. 2005
    ....
  28. ncbi request reprint Synergistic effect of Scutellaria baicalensis and grape seed proanthocyanidins on scavenging reactive oxygen species in vitro
    Zuo Hui Shao
    Tang Center for Herbal Medicine Research, Emergency Medicine and Emergency Resuscitation Center, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
    Am J Chin Med 32:89-95. 2004
    ..This has the advantage of avoiding possible side effects that may arise when higher doses of a single herb are used in an attempt to achieve a maximum degree of antioxidant activity...
  29. ncbi request reprint Antioxidant effects of ginsenoside Re in cardiomyocytes
    Jing Tian Xie
    Tang Center for Herbal Medicine Research, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Eur J Pharmacol 532:201-7. 2006
    ....
  30. pmc The effects of ginsenoside Rb1 on JNK in oxidative injury in cardiomyocytes
    Jing Li
    Department of Emergency Medicine, University of Illinois Hospital and Health Sciences System, Chicago, IL 60612, USA
    Arch Pharm Res 35:1259-67. 2012
    ..Collectively, our results suggest that gRb1 conferred cardioprotection that was mediated via attenuating ROS and suppressing ROS-induced JNK activation...
  31. pmc Antiproliferative effects of different plant parts of Panax notoginseng on SW480 human colorectal cancer cells
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Phytother Res 23:6-13. 2009
    ..Remarkably apoptosis induction activities of notoginseng extracts were observed with the flower extract possessing the most potent effect, supporting the antiproliferative effect...
  32. ncbi request reprint Antioxidant effects of American ginseng berry extract in cardiomyocytes exposed to acute oxidant stress
    Zuo Hui Shao
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, The University of Chicago, IL 60637, USA
    Biochim Biophys Acta 1670:165-71. 2004
    ..We conclude that AGBE is a potent antioxidant that protects cardiomyocytes against oxidant-mediated injury and this protection is partly mediated by its free radical scavenging properties...
  33. ncbi request reprint Effects of American ginseng berry extract on blood glucose levels in ob/ob mice
    Jing Tian Xie
    Tang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Illinois 60637, USA
    Am J Chin Med 30:187-94. 2002
    ..01 compared to day 0) was noticeable. Our results support in vivo antihyperglycemic and antiobese activity of American ginseng berry extract that may prove to be of clinical importance in the prevention and treatment of Type 2 diabetes...
  34. ncbi request reprint Scutellaria baicalensis extract decreases cisplatin-induced pica in rats
    Han H Aung
    Tang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cancer Chemother Pharmacol 52:453-8. 2003
    ..In this study, we investigated the effects of Scutellaria baicalensis, an antioxidant herbal medicine, on cisplatin-induced nausea using a rat model...
  35. ncbi request reprint Chronic pretreatment with American ginseng berry and its polyphenolic constituents attenuate oxidant stress in cardiomyocytes
    Sangeeta R Mehendale
    Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA
    Eur J Pharmacol 553:209-14. 2006
    ..The results suggest that pretreatment with AGBE upregulates peroxide detoxifying mechanisms, which could affect intracellular oxidant dynamics in cardiomyocytes...
  36. pmc Caspase-mediated pro-apoptotic interaction of panaxadiol and irinotecan in human colorectal cancer cells
    Guang Jian Du
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Pharm Pharmacol 64:727-34. 2012
    ..In this study, we have investigated the possible synergistic anticancer effects of panaxadiol and irinotecan on human colorectal cancer cells and explored the potential role of apoptosis in their synergistic activity...
  37. ncbi request reprint Steamed American ginseng berry: ginsenoside analyses and anticancer activities
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, MC 4028, Chicago, Illinois 60637, USA
    J Agric Food Chem 54:9936-42. 2006
    ..The steaming of American ginseng berries augments ginsenoside Rg3 content and increases the antiproliferative effects on two human colorectal cancer cell lines...
  38. ncbi request reprint Effects of ganoderma lucidum extract on chemotherapy-induced nausea and vomiting in a rat model
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Am J Chin Med 33:807-15. 2005
    ..01), suggesting a supportive effect of the extract on general body condition. Future controlled clinical trials are needed to evaluate the safety and effectiveness of this herbal medication...
  39. pmc Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, and Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Int J Oncol 42:1018-26. 2013
    ....
  40. pmc Chemopreventive effects of heat-processed Panax quinquefolius root on human breast cancer cells
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Anticancer Res 28:2545-51. 2008
    ..In this study, the chemical constituents of both untreated and heat-processed American ginseng and their antiproliferative activities on human breast cancer cells were evaluated...
  41. pmc Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Phytomedicine 17:63-8. 2010
    ..These combined phytochemical and biological data provide evidence for further chemopreventive studies of the baicalin-deprived SbE on breast cancer...
  42. pmc The mitochondrial pathway is involved in American ginseng-induced apoptosis of SW-480 colon cancer cells
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Oncol Rep 21:577-84. 2009
    ..The mitochondrial pathway may play a key role in American ginseng-mediated cancer cell apoptosis...
  43. pmc Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cells
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, and Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Int J Oncol 31:1149-56. 2007
    ..Further in vivo and human trials are warranted to test whether notoginseng is a valuable chemo-adjuvant with clinical validity...
  44. pmc Identification of potential anticancer compounds from Oplopanax horridus
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, and Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Phytomedicine 20:999-1006. 2013
    ..Results from this study supplied valuable information for future semi-synthesis of polyyne derivatives to develop novel cancer chemopreventive agents...
  45. ncbi request reprint Baicalein attenuates oxidant stress in cardiomyocytes
    Zuo Hui Shao
    Section of Emergency Medicine, Department of Medicine, University of Chicago, Illinois 60637, USA
    Am J Physiol Heart Circ Physiol 282:H999-H1006. 2002
    ..We conclude that baicalein can scavenge ROS generation in cardiomyocytes and that it protects against cell death in an ischemia-reperfusion model when given only at reperfusion...
  46. ncbi request reprint Methylnaltrexone prevents morphine-induced kaolin intake in the rat
    Han H Aung
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Life Sci 74:2685-91. 2004
    ..Morphine and methylnaltrexone did not significantly affect food intake and body weight in the experimental animals. Our data suggest that methylnaltrexone has therapeutic value in treating opioid-induced nausea and vomiting...
  47. ncbi request reprint Anti-diabetic effects of Gymnema yunnanense extract
    Jing Tian Xie
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, The University of Chicago Medical Center, 5841 S Maryland Avenue, MC 4028, Chicago, IL 60637, USA
    Pharmacol Res 47:323-9. 2003
    ..8+/-1.1g on Day 12 (P<0.05). Our results support an in vivo anti-hyperglycemic and body weight reduction activity of G. yunnanense extract that may prove to be of clinical importance in improving the management of type 2 diabetes...
  48. ncbi request reprint The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity
    Chun Su Yuan
    Department of Anesthesia and Critical Care, Tang Center for Herbal Medicine Research, and Committee on Clinical Pharmacology and Pharmacogenomics, Pritzker School of Medicine, University of Chicago, Illinois 60637, USA
    Anesth Analg 98:353-8, table of contents. 2004
    ..Thus, valerian may potentiate the sedative effects of anesthetics and other medications that act on GABA receptors, and presurgical valerian use may cause a valerian-anesthetic interaction...
  49. pmc Red American ginseng: ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius roots
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, University of Chicago, Chicago, Illinois 60637, USA
    Planta Med 73:669-74. 2007
    ..Five representative ginsenosides, Rb1, Rd, Re, Rg2 and Rg3, were studied. Ginsenoside Rg3 had the most potent effect. The antiproliferative activities of red American ginseng are augmented when ginsenoside Rg3 is increased...
  50. pmc Cisplatin's tumoricidal effect on human breast carcinoma MCF-7 cells was not attenuated by American ginseng
    Han H Aung
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, 5841 S Maryland Avenue, MC 4028, Chicago, IL 60637, USA
    Cancer Chemother Pharmacol 59:369-74. 2007
    ..In this study, we explored if the ginseng extract and its constituents, ginsenosides Rb1, Rb3, and Re, alter tumoricidal activity of cisplatin in human cancer cells...
  51. pmc The synergistic apoptotic interaction of panaxadiol and epigallocatechin gallate in human colorectal cancer cells
    Guang Jian Du
    Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA
    Phytother Res 27:272-7. 2013
    ..Data from this study suggested that apoptosis might play an important role in the EGCG-enhanced antiproliferative effects of PD on human colorectal cancer cells...
  52. ncbi request reprint Methylnaltrexone, a peripherally acting opioid receptor antagonist, enhances tumoricidal effects of 5-Fu on human carcinoma cells
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Anticancer Res 29:2927-32. 2009
    ..Its effects on the activities of chemotherapeutic agents, however, have not been evaluated. In this study, the effect of methylnaltrexone on the action of 5-fluorouracil (5-FU) was tested in three human cancer cell lines...
  53. ncbi request reprint In vitro and in vivo anticancer effects of American ginseng berry: exploring representative compounds
    Jing Tian Xie
    Tang Center for Herbal Medicine Research, University of Chicago, IL 60637, USA
    Biol Pharm Bull 32:1552-8. 2009
    ..Our results suggested that S-AGE inhibited the colorectal cancer growth both in vitro and in vivo, and this inhibition might be achieved through cell cycle arrest and induced apoptosis in the cells...
  54. pmc High performance liquid chromatographic analysis and anticancer potential of Oplopanax horridus: comparison of stem and berry extracts
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Fitoterapia 81:132-9. 2010
    ..1 mg/ml of stem extract for 72 h, apoptotic cells were increased to 45.2%, while control was 9.6%. The cell cycle arrest and induction of apoptosis may play a critical role in cancer chemoprevention by Oplopanax horridus stem extract...
  55. pmc Salvia miltiorrhiza (dan shen) significantly ameliorates colon inflammation in dextran sulfate sodium induced colitis
    Xiao Dong Wen
    State Key Laboratory of Natural Medicines, China Pharmaceutical University Nanjing 210009, China, Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA, Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Am J Chin Med 41:1097-108. 2013
    ..05). Colitis histological data supported the pharmacological observations. Thus, Salvia miltiorrhiza could be a promising candidate in preventing and treating colitis and in reducing the risks of inflammation-associated colorectal cancer...
  56. ncbi request reprint Anti-diabetic effect of ginsenoside Re in ob/ob mice
    Jing Tian Xie
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, The University of Chicago, MC 4028, IL 60637, USA
    Biochim Biophys Acta 1740:319-25. 2005
    ..Preliminary microarray analysis revealed differential expression of skeletal muscle genes associated with lipid metabolism and muscle function. The results suggest that ginsenoside Re may prove to be useful in treating type 2 diabetes...
  57. pmc Scutellaria baicalensis and a constituent flavonoid, baicalein, attenuate ritonavir-induced gastrointestinal side-effects
    Sangeeta Mehendale
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Pharm Pharmacol 59:1567-72. 2007
    ..baicalensis and the constituent baicalein reduce the gastrointestinal dysfunction caused by ritonavir. It is concluded that S. baicalensis may potentially have a role to play in reducing drug-induced adverse effects...
  58. ncbi request reprint Effects of Corydalis yanhusuo and Angelicae dahuricae on cold pressor-induced pain in humans: a controlled trial
    Chun Su Yuan
    Tang Center for Herbal Medicine Research, Committee on Clinical Pharmacology, and Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Illinois 60637, USA
    J Clin Pharmacol 44:1323-7. 2004
    ..01). Dose-related analgesic effect was also observed. Results from this study suggest that C. yanhusuo and A. dahuricae may have a potential clinical value for treating mild to moderate pain...
  59. pmc Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, and Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Int J Oncol 40:1970-6. 2012
    ..C-K, but not its parent ginsenoside Rb1, showed significant anti-proliferative and pro-apoptotic effects in human colorectal cancer cells. These results suggest that C-K could be a potentially effective anti-colorectal cancer agent...
  60. doi request reprint Panaxadiol, a purified ginseng component, enhances the anti-cancer effects of 5-fluorouracil in human colorectal cancer cells
    Xiao Li Li
    Department of Anesthesia and Critical Care, Tang Center for Herbal Medicine Research, University of Chicago, 5841 South Maryland Avenue, MC 4028, Chicago, IL 60637, USA
    Cancer Chemother Pharmacol 64:1097-104. 2009
    ..Panaxadiol (PD) is the purified sapogenin of ginseng saponins, which exhibit anti-tumor activity. In this study, we investigated the possible synergistic anti-cancer effects of PD and 5-FU on a human colorectal cancer cell line, HCT-116...
  61. pmc Improving anticancer activities of Oplopanax horridus root bark extract by removing water-soluble components
    Shi Sun
    Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Tang Center for Herbal Medicine Research, Chicago, IL 60637, USA
    Phytother Res 24:1166-74. 2010
    ..Data from this study suggested that the 70% and 100% ethanol fractions are active antiproliferative fractions and that induction of apoptosis is the mechanism involved in the antiproliferative effect observed...
  62. pmc Botanical flavonoids on coronary heart disease
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research and Departments of Anesthesia and Critical Care, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Chin Med 39:661-71. 2011
    ..In this article, we will discuss two herbs containing potent flavonoids, Scutellaria baicalensis and grape seed proanthocyanidin, which can potentially offer cardiac protection against ischemic heart disease...
  63. pmc Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53
    Binghui Li
    Ben May Department for Cancer Research, The University of Chicago, IL 60637, United States
    Cancer Lett 301:185-92. 2011
    ..Blockage of ROS by NAC or catalase inhibited the activation of NF-κB signaling and enhanced Rh2-induced cell death, suggesting that the anti-cancer effect of Rh2 can be enhanced by antioxidants...
  64. ncbi request reprint Bioactivity of American ginseng by knockout extract preparation using monoclonal antibody
    Chun Su Yuan
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, The University of Chicago, 5841 S Maryland Avenue, MC 4028, Chicago, IL 60637, USA
    Curr Drug Discov Technol 8:32-41. 2011
    ..The monoclonal antibody technique can be used to prepare botanical knockout extracts for bioactivity studies...
  65. pmc Effects of Oplopanax horridus on human colorectal cancer cells
    Xiao Li Li
    Tang Center for Herbal Medicine Research, and Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Anticancer Res 30:295-302. 2010
    ....
  66. pmc Epigallocatechin Gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea
    Guang Jian Du
    Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA
    Nutrients 4:1679-91. 2012
    ..The gallic acid group significantly enhanced catechin's anticancer potential. This property could be utilized in future semi-synthesis of flavonoid derivatives to develop novel anticancer agents...
  67. pmc Metabolism of ginseng and its interactions with drugs
    Lian Wen Qi
    Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, The Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, MC 4028, Chicago, Illinois 60637, USA
    Curr Drug Metab 12:818-22. 2011
    ..Thus, further investigation of ginseng metabolites is needed for predicting the therapeutic outcome with ginseng...
  68. pmc Hydrophobic constituents and their potential anticancer activities from Devil's Club (Oplopanax horridus Miq.)
    Shi Sun
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Ethnopharmacol 132:280-5. 2010
    ..It is widely used for external and internal infections as well as arthritis, respiratory ailments, digestive tract ailments, broken bones, fever, headaches, and cancer...
  69. pmc Detection of adulteration of notoginseng root extract with other panax species by quantitative HPLC coupled with PCA
    Chong Zhi Wang
    Department of Anesthesia and Critical Care, Tang Center for Herbal Medicine Research, Cancer Research Center, University of Chicago, Chicago, Illinois 60637, USA
    J Agric Food Chem 57:2363-7. 2009
    ..The HPLC-PCA assay distinguished notoginseng root extract not only from the extract of other plant parts of notoginseng but also from the extract of Asian or American ginseng plant parts...
  70. ncbi request reprint Methylnaltrexone potentiates body weight and fat reduction with leptin
    Chun Su Yuan
    Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Illinois, USA
    J Opioid Manag 5:373-8. 2009
    ..In this study, the authors evaluated the effects of naloxone (a nonselective opioid antagonist) and methylnaltrexone (a peripherally acting opioid antagonist) on the action of leptin in neonatal rats...
  71. pmc Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells
    Xiaoji Luo
    Molecular Oncology Laboratory, Department of Surgery, The University of Chicago, Chicago, IL 60637, USA
    Int J Oncol 32:975-83. 2008
    ..Although further studies are needed to elucidate the mechanisms of action, our findings should expand the understanding of the molecular framework of American ginseng as an anti-cancer agent...
  72. pmc Herbal medicines as adjuvants for cancer therapeutics
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, Pritzker School of Medicine, University of Chicago, Illinois 60637, USA
    Am J Chin Med 40:657-69. 2012
    ..Controlled clinical studies are warranted to verify the clinical utility of the botanicals in cancer chemoprevention...
  73. pmc Antioxidants potentiate American ginseng-induced killing of colorectal cancer cells
    Binghui Li
    Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, United States
    Cancer Lett 289:62-70. 2010
    ..These results further suggest that the anti-cancer effect of steamed ginseng can be enhanced by antioxidants or inhibitors of the NF-kappaB pathway...
  74. ncbi request reprint Curry leaf (Murraya koenigii Spreng.) reduces blood cholesterol and glucose levels in ob/ob mice
    Jing Tian Xie
    Tang Center for Herbal Medicine Research, Pritzker School of Medicine, University of Chicago, IL 60637, USA
    Am J Chin Med 34:279-84. 2006
    ..01). In addition, body weight was reduced after extract treatment. Our data suggest that curry leaf may be proved to be of clinical importance in improving the management of high cholesterol level and type 2 diabetes...
  75. pmc Antioxidant protection by American ginseng in pancreatic beta-cells
    Elaine Lin
    Tang Center for Herbal Medicine Research, The University of Chicago, Chicago, IL 60637, USA
    Am J Chin Med 36:981-8. 2008
    ..Our data suggest that the observed ability of ginseng to reduce blood glucose levels may be linked to its antioxidant effects on pancreatic beta-cells...
  76. pmc Synthesis of protopanaxadiol derivatives and evaluation of their anticancer activities
    Guang Jian Du
    Department of Anesthesia and Critical Care, Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA
    Anticancer Drugs 22:35-45. 2011
    ..A flow cytometric assay indicated that compounds 1, 3, and 5 arrested cell cycle progression in the G1 phase and significantly induced apoptosis of cancer cells...
  77. ncbi request reprint Methylnaltrexone reduced body weight gain in ob/ob mice
    Chun Su Yuan
    Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Illinois, USA
    J Opioid Manag 5:213-8. 2009
    ..In this study, the authors evaluated the effects of a peripherally acting opioid receptor antagonist, methylnaltrexone, on weight changes in adult obese ob/ob mice...
  78. ncbi request reprint Safety and tolerability of Ganoderma lucidum in healthy subjects: a double-blind randomized placebo-controlled trial
    Sheila M Wicks
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Chin Med 35:407-14. 2007
    ..It appears that an additional long-term safety and tolerance trial with herbal dose-escalating design is warranted...
  79. pmc Commonly used antioxidant botanicals: active constituents and their potential role in cardiovascular illness
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Chin Med 35:543-58. 2007
    ..Data obtained from future studies will have the potential for translation into practical benefits for human health...
  80. pmc Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions
    Zhiyu Zhang
    Tang Center for Herbal Medicine Research, Pritzker School of Medicine, University of Chicago, 5841 S Maryland Ave, MC 4028, Chicago, IL 60637, USA
    Int J Mol Sci 14:2980-95. 2013
    ..These results indicate that CK inhibits transcriptional activation of multiple tumor-promoting pathways in CRC, suggesting that CK could be an active compound in the prevention or treatment of CRC...
  81. pmc Analysis of Panax notoginseng metabolites in rat bile by liquid chromatography-quadrupole time-of-flight mass spectrometry with microdialysis sampling
    Xiao Dong Wen
    Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 895:162-8. 2012
    ..Data from this study suggest that this microdialysis technique could be used in notoginseng saponin metabolic animal studies...
  82. pmc Baicalein protects against doxorubicin-induced cardiotoxicity by attenuation of mitochondrial oxidant injury and JNK activation
    Wei Tien Chang
    Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Cell Biochem 112:2873-81. 2011
    ..In conclusion, baicalein adjunct treatment confers anti-apoptotic protection against doxorubicin-induced cardiotoxicity without compromising its anti-cancer efficacy...
  83. ncbi request reprint Brief communication: American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled Trial
    Chun Su Yuan
    Tang Center for Herbal Medicine Research, Committee on Clinical Pharmacology and Pharmacogenomics, Anticoagulation Consult Service, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Ann Intern Med 141:23-7. 2004
    ..People using prescription medication often concurrently take herbal supplements. In a case report, the anticoagulant effect of warfarin decreased after patients consumed ginseng...
  84. pmc Effects of Triterpenoid Glycosides from Fresh Ginseng Berry on SW480 Human Colorectal Cancer Cell Line
    Jing Tian Xie
    Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL, USA
    Cancer Res Treat 43:49-55. 2011
    ..In this study, we investigated the antiproliferative effects of fresh American ginseng berry extract (AGBE) and its representative triterpenoid glycosides using the human colorectal cancer cell line SW480...
  85. ncbi request reprint American ginseng berry enhances chemopreventive effect of 5-FU on human colorectal cancer cells
    Xiao Li Li
    Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Oncol Rep 22:943-52. 2009
    ..The enhancement of S and G2/M phase arrest, rather than cell apoptosis, should be the mechanism of synergistic effects of AGBE on 5-FU. Further in vivo and clinical trials are needed to test AGBE as a valuable chemo-adjuvant...
  86. ncbi request reprint American ginseng: potential structure-function relationship in cancer chemoprevention
    Lian Wen Qi
    Tang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, The Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, MC 4028, Chicago, IL 60637, United States
    Biochem Pharmacol 80:947-54. 2010
    ..Understanding these relationships may produce insights into chemical and pharmacological approaches for enhancing the chemopreventive effects of ginsenoside and for developing novel anticancer agents...
  87. pmc Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes
    Wei Tien Chang
    Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA, and Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC
    Eur J Pharmacol 566:58-66. 2007
    ..Flavonoids possess specific but differential radical scavenging capacity, which, in conjunction with the timing of treatment, affects their protective efficacy in cardiomyocytes exposed to ischemia/reperfusion...
  88. ncbi request reprint Methylnaltrexone, a novel peripheral opioid receptor antagonist for the treatment of opioid side effects
    Chun Su Yuan
    Pritzker School of Medicine, Department of Anesthesia and Critical Care, The University of Chicago, 5841 S Maryland Avenue, MC 4028, Chicago, IL 60637, USA
    Expert Opin Investig Drugs 15:541-52. 2006
    ..This article reviews preclinical studies and clinical opioid bowel dysfunction trial data, and briefly discusses other potential roles of this compound in clinical practice...
  89. pmc Isolation and analysis of ginseng: advances and challenges
    Lian Wen Qi
    Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, The Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Nat Prod Rep 28:467-95. 2011
    ..The aim of this review is to illustrate the recent advances in the isolation and analysis of ginseng, and to highlight new applications and challenges. Emphasis is placed on recent trends and emerging techniques...
  90. doi request reprint Reversal of opioid-induced gastric dysfunction in a critically ill burn patient after methylnaltrexone
    Michael Woo
    Department Anesthesia and Critical Care, The University of Chicago, 5841 S Maryland Ave, MC 4028, Chicago, IL 60637, USA
    Anesth Analg 107:1965-7. 2008
    ..Gastric residuals markedly decreased and enteral feeding increased after administration of i.v. methylnaltrexone. The patient's ileus resolved coincident with the first injection...
  91. ncbi request reprint Clinical status of methylnaltrexone, a new agent to prevent and manage opioid-induced side effects
    Chun Su Yuan
    Department of Anesthesia and Critical Care, Pritzker School of Medicine, The University of Chicago, 5841 S Maryland Avenue, MC 4028, Chicago, IL 60637, USA
    J Support Oncol 2:111-7; discussion 119-22. 2004
    ..This article reviews existing clinical data on methylnaltrexone, focusing on the antagonism of opioid-induced adverse effects in the gut...
  92. pmc American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR
    Urszula Dougherty
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    BMC Complement Altern Med 11:111. 2011
    ..In this study we asked if ginseng could inhibit Western diet (20% fat) promoted colonic tumorigenesis and if compound K, a microbial metabolite of ginseng could suppress colon cancer xenograft growth...
  93. pmc Ginsenosides from American ginseng: chemical and pharmacological diversity
    Lian Wen Qi
    Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, The Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Phytochemistry 72:689-99. 2011
    ..The goal is that this article is a useful reference to chemists and biologists researching American ginseng, and will open the door to agents in drug discovery...
  94. ncbi request reprint Methylnaltrexone mechanisms of action and effects on opioid bowel dysfunction and other opioid adverse effects
    Chun Su Yuan
    Department of Anesthesia and Critical Care, Pritzker School of Medicine, The University of Chicago, 5841 S Maryland Ave, MC 4028, Chicago, IL 60637, USA
    Ann Pharmacother 41:984-93. 2007
    ..To review the mechanisms of action of methylnaltrexone and its effects on opioid bowel dysfunction, as well as its effects on other opioid-induced adverse effects (ADEs), and its potential roles in clinical practice...
  95. doi request reprint Anti-diabetic effect of American ginseng may not be linked to antioxidant activity: comparison between American ginseng and Scutellaria baicalensis using an ob/ob mice model
    Jing Tian Xie
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Fitoterapia 80:306-11. 2009
    ..The mechanisms of American ginseng's effects on reducing high blood glucose levels and body weight remain to be investigated in future experiments...
  96. pmc Protease inhibitor-induced nausea and vomiting is attenuated by a peripherally acting, opioid-receptor antagonist in a rat model
    Chun Su Yuan
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, USA
    AIDS Res Ther 6:19. 2009
    ..CONCLUSION: These results suggest that methylnaltrexone may have potential clinical utility in reducing nausea and vomiting in HIV patients who take ritonavir...
  97. ncbi request reprint Tolerability, gut effects, and pharmacokinetics of methylnaltrexone following repeated intravenous administration in humans
    Chun Su Yuan
    Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, 5841 S Maryland Avenue, MC 4028, Chicago, IL 60637, USA
    J Clin Pharmacol 45:538-46. 2005
    ..The observation of a significant reduction in the gut transit time after repeated administration of methylnaltrexone to these opioid-naive volunteers suggests that endogenous opioids modulate human gut motility...
  98. ncbi request reprint Grape seed proanthocyanidins protect cardiomyocytes from ischemia and reperfusion injury via Akt-NOS signaling
    Zuo Hui Shao
    Department of Medicine, Emergency Resuscitation Center, University of Chicago, Illinois 60637, USA
    J Cell Biochem 107:697-705. 2009
    ..GSPE offers an alternative approach to therapeutic cardioprotection against I/R injury and may offer unique opportunities to improve cardiovascular health by enhancing NO production and increasing Akt-eNOS signaling...
  99. ncbi request reprint Transcutaneous electrical acupoint stimulation potentiates analgesic effect of morphine
    Chun Su Yuan
    Tang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, University of Chicago, Illinois 60637, USA
    J Clin Pharmacol 42:899-903. 2002
    ..01). The results support the efficacy of TEAS analgesia and suggest that combination of TEAS with low-dose morphine can achieve better pain control in a variety of clinical settings...
  100. ncbi request reprint Saponins composition in American ginseng leaf and berry assayed by high-performance liquid chromatography
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, The University of Chicago, Chicago, Illnois 60637, USA
    J Agric Food Chem 54:2261-6. 2006
    ..Ginsenoside Rb3 was quantified as 4.71% in American ginseng leaves and 5.35% in berries, suggesting that American ginseng leaves and berries are new sources of ginsenoside Rb3...
  101. ncbi request reprint Determination of methylnaltrexone in clinical samples by solid-phase extraction and high-performance liquid chromatography for a pharmacokinetics study
    Joachim Osinski
    Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL 60637, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 780:251-9. 2002
    ..7 (+/-10.8) and 20.0 (+/-9.5) min, respectively. The method is simple, yet sensitive for the detection and determination of methylnaltrexone in biological samples at the level of the physiological response...