Research Topics
| Chun Su YuanSummaryAffiliation: University of Chicago Country: USA Publications
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Publications
Scutellaria baicalensis and a constituent flavonoid, baicalein, attenuate ritonavir-induced gastrointestinal side-effectsSangeeta Mehendale
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
J Pharm Pharmacol 59:1567-72. 2007..baicalensis and the constituent baicalein reduce the gastrointestinal dysfunction caused by ritonavir. It is concluded that S. baicalensis may potentially have a role to play in reducing drug-induced adverse effects...
Brief communication: American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled TrialChun Su Yuan
Tang Center for Herbal Medicine Research, Committee on Clinical Pharmacology and Pharmacogenomics, Anticoagulation Consult Service, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
Ann Intern Med 141:23-7. 2004..People using prescription medication often concurrently take herbal supplements. In a case report, the anticoagulant effect of warfarin decreased after patients consumed ginseng...- Methylnaltrexone, a novel peripheral opioid receptor antagonist for the treatment of opioid side effectsChun Su Yuan
Pritzker School of Medicine, Department of Anesthesia and Critical Care, The University of Chicago, 5841 S Maryland Avenue, MC 4028, Chicago, IL 60637, USA
Expert Opin Investig Drugs 15:541-52. 2006..This article reviews preclinical studies and clinical opioid bowel dysfunction trial data, and briefly discusses other potential roles of this compound in clinical practice... - Methylnaltrexone mechanisms of action and effects on opioid bowel dysfunction and other opioid adverse effectsChun Su Yuan
Department of Anesthesia and Critical Care, Pritzker School of Medicine, The University of Chicago, 5841 S Maryland Ave, MC 4028, Chicago, IL 60637, USA
Ann Pharmacother 41:984-93. 2007..To review the mechanisms of action of methylnaltrexone and its effects on opioid bowel dysfunction, as well as its effects on other opioid-induced adverse effects (ADEs), and its potential roles in clinical practice... - Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cellsChong Zhi Wang
Tang Center for Herbal Medicine Research, The University of Chicago, Chicago, IL 60637, USA
Cancer Chemother Pharmacol 60:69-79. 2007..In this study, using HCT-116 human colorectal cancer cell line, we investigated the possible synergistic anti-cancer effects between notoginseng flower extract (NGF) and 5-FU on colon cancer cells... - Chronic pretreatment with American ginseng berry and its polyphenolic constituents attenuate oxidant stress in cardiomyocytesSangeeta R Mehendale
Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA
Eur J Pharmacol 553:209-14. 2006..The results suggest that pretreatment with AGBE upregulates peroxide detoxifying mechanisms, which could affect intracellular oxidant dynamics in cardiomyocytes... 
Asian ginseng enhances the anti-proliferative effect of 5-fluorouracil on human colorectal cancer: comparison between white and red ginsengAnna B Fishbein
Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL, 60637, USA
Arch Pharm Res 32:505-13. 2009..Rd and Rg3 showed positive anti-proliferative effect. Our data suggested a potential for RG as an adjuvant therapy in the treatment of colorectal cancer, via a synergistic action...- The effects of ginsenoside Rb1 on JNK in oxidative injury in cardiomyocytesJing Li
Department of Emergency Medicine, University of Illinois Hospital and Health Sciences System, Chicago, IL 60612, USA
Arch Pharm Res 35:1259-67. 2012..Collectively, our results suggest that gRb1 conferred cardioprotection that was mediated via attenuating ROS and suppressing ROS-induced JNK activation... - Antiproliferative effects of different plant parts of Panax notoginseng on SW480 human colorectal cancer cellsChong Zhi Wang
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
Phytother Res 23:6-13. 2009..Remarkably apoptosis induction activities of notoginseng extracts were observed with the flower extract possessing the most potent effect, supporting the antiproliferative effect... - Caspase-mediated pro-apoptotic interaction of panaxadiol and irinotecan in human colorectal cancer cellsGuang Jian Du
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
J Pharm Pharmacol 64:727-34. 2012..In this study, we have investigated the possible synergistic anticancer effects of panaxadiol and irinotecan on human colorectal cancer cells and explored the potential role of apoptosis in their synergistic activity... - Kavalactones and dihydrokavain modulate GABAergic activity in a rat gastric-brainstem preparationChun Su Yuan
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago 60637, USA
Planta Med 68:1092-6. 2002..Our results demonstrated modulation of brainstem GABAergic mechanism by kavalactones and dihydrokavain, and suggested that these compounds may play an important role in regulation of GABAergic neurotransmission... - The mitochondrial pathway is involved in American ginseng-induced apoptosis of SW-480 colon cancer cellsChong Zhi Wang
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
Oncol Rep 21:577-84. 2009..The mitochondrial pathway may play a key role in American ginseng-mediated cancer cell apoptosis... - Cisplatin's tumoricidal effect on human breast carcinoma MCF-7 cells was not attenuated by American ginsengHan H Aung
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, 5841 S Maryland Avenue, MC 4028, Chicago, IL 60637, USA
Cancer Chemother Pharmacol 59:369-74. 2007..In this study, we explored if the ginseng extract and its constituents, ginsenosides Rb1, Rb3, and Re, alter tumoricidal activity of cisplatin in human cancer cells... - Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cellsChong Zhi Wang
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
Phytomedicine 17:63-8. 2010..These combined phytochemical and biological data provide evidence for further chemopreventive studies of the baicalin-deprived SbE on breast cancer... - Chemopreventive effects of heat-processed Panax quinquefolius root on human breast cancer cellsChong Zhi Wang
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
Anticancer Res 28:2545-51. 2008..In this study, the chemical constituents of both untreated and heat-processed American ginseng and their antiproliferative activities on human breast cancer cells were evaluated... - Red American ginseng: ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius rootsChong Zhi Wang
Tang Center for Herbal Medicine Research, University of Chicago, Chicago, Illinois 60637, USA
Planta Med 73:669-74. 2007..Five representative ginsenosides, Rb1, Rd, Re, Rg2 and Rg3, were studied. Ginsenoside Rg3 had the most potent effect. The antiproliferative activities of red American ginseng are augmented when ginsenoside Rg3 is increased... - Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cellsChong Zhi Wang
Tang Center for Herbal Medicine Research, and Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Int J Oncol 31:1149-56. 2007..Further in vivo and human trials are warranted to test whether notoginseng is a valuable chemo-adjuvant with clinical validity... - Anti-diabetic effects of Gymnema yunnanense extractJing Tian Xie
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, The University of Chicago Medical Center, 5841 S Maryland Avenue, MC 4028, Chicago, IL 60637, USA
Pharmacol Res 47:323-9. 2003..8+/-1.1g on Day 12 (P<0.05). Our results support an in vivo anti-hyperglycemic and body weight reduction activity of G. yunnanense extract that may prove to be of clinical importance in improving the management of type 2 diabetes... - In vitro and in vivo anticancer effects of American ginseng berry: exploring representative compoundsJing Tian Xie
Tang Center for Herbal Medicine Research, University of Chicago, IL 60637, USA
Biol Pharm Bull 32:1552-8. 2009..Our results suggested that S-AGE inhibited the colorectal cancer growth both in vitro and in vivo, and this inhibition might be achieved through cell cycle arrest and induced apoptosis in the cells... - High performance liquid chromatographic analysis and anticancer potential of Oplopanax horridus: comparison of stem and berry extractsChong Zhi Wang
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
Fitoterapia 81:132-9. 2010..1 mg/ml of stem extract for 72 h, apoptotic cells were increased to 45.2%, while control was 9.6%. The cell cycle arrest and induction of apoptosis may play a critical role in cancer chemoprevention by Oplopanax horridus stem extract... - Methylnaltrexone, a peripherally acting opioid receptor antagonist, enhances tumoricidal effects of 5-Fu on human carcinoma cellsChong Zhi Wang
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
Anticancer Res 29:2927-32. 2009..Its effects on the activities of chemotherapeutic agents, however, have not been evaluated. In this study, the effect of methylnaltrexone on the action of 5-fluorouracil (5-FU) was tested in three human cancer cell lines... - Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancerChong Zhi Wang
Tang Center for Herbal Medicine Research, and Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
Int J Oncol 40:1970-6. 2012..C-K, but not its parent ginsenoside Rb1, showed significant anti-proliferative and pro-apoptotic effects in human colorectal cancer cells. These results suggest that C-K could be a potentially effective anti-colorectal cancer agent... - Improving anticancer activities of Oplopanax horridus root bark extract by removing water-soluble componentsShi Sun
Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Tang Center for Herbal Medicine Research, Chicago, IL 60637, USA
Phytother Res 24:1166-74. 2010..Data from this study suggested that the 70% and 100% ethanol fractions are active antiproliferative fractions and that induction of apoptosis is the mechanism involved in the antiproliferative effect observed... - Botanical flavonoids on coronary heart diseaseChong Zhi Wang
Tang Center for Herbal Medicine Research and Departments of Anesthesia and Critical Care, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
Am J Chin Med 39:661-71. 2011..In this article, we will discuss two herbs containing potent flavonoids, Scutellaria baicalensis and grape seed proanthocyanidin, which can potentially offer cardiac protection against ischemic heart disease... - Effects of Oplopanax horridus on human colorectal cancer cellsXiao Li Li
Tang Center for Herbal Medicine Research, and Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
Anticancer Res 30:295-302. 2010.... - Panaxadiol, a purified ginseng component, enhances the anti-cancer effects of 5-fluorouracil in human colorectal cancer cellsXiao Li Li
Department of Anesthesia and Critical Care, Tang Center for Herbal Medicine Research, University of Chicago, 5841 South Maryland Avenue, MC 4028, Chicago, IL 60637, USA
Cancer Chemother Pharmacol 64:1097-104. 2009..Panaxadiol (PD) is the purified sapogenin of ginseng saponins, which exhibit anti-tumor activity. In this study, we investigated the possible synergistic anti-cancer effects of PD and 5-FU on a human colorectal cancer cell line, HCT-116... - Bioactivity of American ginseng by knockout extract preparation using monoclonal antibodyChun Su Yuan
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, The University of Chicago, 5841 S Maryland Avenue, MC 4028, Chicago, IL 60637, USA
Curr Drug Discov Technol 8:32-41. 2011..The monoclonal antibody technique can be used to prepare botanical knockout extracts for bioactivity studies... - Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53Binghui Li
Ben May Department for Cancer Research, The University of Chicago, IL 60637, United States
Cancer Lett 301:185-92. 2011..Blockage of ROS by NAC or catalase inhibited the activation of NF-κB signaling and enhanced Rh2-induced cell death, suggesting that the anti-cancer effect of Rh2 can be enhanced by antioxidants... - Metabolism of ginseng and its interactions with drugsLian Wen Qi
Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, The Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, MC 4028, Chicago, Illinois 60637, USA
Curr Drug Metab 12:818-22. 2011..Thus, further investigation of ginseng metabolites is needed for predicting the therapeutic outcome with ginseng... - Gastric effects of galanin and its interaction with leptin on brainstem neuronal activityChun Su Yuan
Committee on Clinical Pharmacology, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, USA
J Pharmacol Exp Ther 301:488-93. 2002..05 compared with leptin alone; P < 0.01 compared with galanin alone, 55.1 +/- 3.2%). Our data suggest that galanin modulates the leptin signals, which regulate the ingestive process in neonates... - Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cellsXiaoji Luo
Molecular Oncology Laboratory, Department of Surgery, The University of Chicago, Chicago, IL 60637, USA
Int J Oncol 32:975-83. 2008..Although further studies are needed to elucidate the mechanisms of action, our findings should expand the understanding of the molecular framework of American ginseng as an anti-cancer agent... - Hydrophobic constituents and their potential anticancer activities from Devil's Club (Oplopanax horridus Miq.)Shi Sun
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
J Ethnopharmacol 132:280-5. 2010..It is widely used for external and internal infections as well as arthritis, respiratory ailments, digestive tract ailments, broken bones, fever, headaches, and cancer... - Herbal medicines as adjuvants for cancer therapeuticsChong Zhi Wang
Tang Center for Herbal Medicine Research, Pritzker School of Medicine, University of Chicago, Illinois 60637, USA
Am J Chin Med 40:657-69. 2012..Controlled clinical studies are warranted to verify the clinical utility of the botanicals in cancer chemoprevention... - Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: a double-blind randomized placebo-controlled trialChun Su Yuan
Committee on Clinical Pharmacology, University of Chicago, Chicago, Illinois 60637, USA
J Pharmacol Exp Ther 300:118-23. 2002..Our results suggest that subcutaneous methylnaltrexone may have clinical utility in treating opioid-induced constipation and reducing opioid-induced unpleasant subjective symptoms... - Commonly used antioxidant botanicals: active constituents and their potential role in cardiovascular illnessChong Zhi Wang
Tang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, The University of Chicago, Chicago, Illinois 60637, USA
Am J Chin Med 35:543-58. 2007..Data obtained from future studies will have the potential for translation into practical benefits for human health... - Curry leaf (Murraya koenigii Spreng.) reduces blood cholesterol and glucose levels in ob/ob miceJing Tian Xie
Tang Center for Herbal Medicine Research, Pritzker School of Medicine, University of Chicago, IL 60637, USA
Am J Chin Med 34:279-84. 2006..01). In addition, body weight was reduced after extract treatment. Our data suggest that curry leaf may be proved to be of clinical importance in improving the management of high cholesterol level and type 2 diabetes... - Detection of adulteration of notoginseng root extract with other panax species by quantitative HPLC coupled with PCAChong Zhi Wang
Department of Anesthesia and Critical Care, Tang Center for Herbal Medicine Research, Cancer Research Center, University of Chicago, Chicago, Illinois 60637, USA
J Agric Food Chem 57:2363-7. 2009..The HPLC-PCA assay distinguished notoginseng root extract not only from the extract of other plant parts of notoginseng but also from the extract of Asian or American ginseng plant parts... - Methylnaltrexone potentiates body weight and fat reduction with leptinChun Su Yuan
Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Illinois, USA
J Opioid Manag 5:373-8. 2009..In this study, the authors evaluated the effects of naloxone (a nonselective opioid antagonist) and methylnaltrexone (a peripherally acting opioid antagonist) on the action of leptin in neonatal rats... - Synthesis of protopanaxadiol derivatives and evaluation of their anticancer activitiesGuang Jian Du
Department of Anesthesia and Critical Care, Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA
Anticancer Drugs 22:35-45. 2011..A flow cytometric assay indicated that compounds 1, 3, and 5 arrested cell cycle progression in the G1 phase and significantly induced apoptosis of cancer cells... - Antioxidant protection by American ginseng in pancreatic beta-cellsElaine Lin
Tang Center for Herbal Medicine Research, The University of Chicago, Chicago, IL 60637, USA
Am J Chin Med 36:981-8. 2008..Our data suggest that the observed ability of ginseng to reduce blood glucose levels may be linked to its antioxidant effects on pancreatic beta-cells... - Antioxidants potentiate American ginseng-induced killing of colorectal cancer cellsBinghui Li
Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, United States
Cancer Lett 289:62-70. 2010..These results further suggest that the anti-cancer effect of steamed ginseng can be enhanced by antioxidants or inhibitors of the NF-kappaB pathway... - Analysis of Panax notoginseng metabolites in rat bile by liquid chromatography-quadrupole time-of-flight mass spectrometry with microdialysis samplingXiao Dong Wen
Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
J Chromatogr B Analyt Technol Biomed Life Sci 895:162-8. 2012..Data from this study suggest that this microdialysis technique could be used in notoginseng saponin metabolic animal studies... - Baicalein protects against doxorubicin-induced cardiotoxicity by attenuation of mitochondrial oxidant injury and JNK activationWei Tien Chang
Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
J Cell Biochem 112:2873-81. 2011..In conclusion, baicalein adjunct treatment confers anti-apoptotic protection against doxorubicin-induced cardiotoxicity without compromising its anti-cancer efficacy... - Safety and tolerability of Ganoderma lucidum in healthy subjects: a double-blind randomized placebo-controlled trialSheila M Wicks
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
Am J Chin Med 35:407-14. 2007..It appears that an additional long-term safety and tolerance trial with herbal dose-escalating design is warranted... - Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytesWei Tien Chang
Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA, and Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC
Eur J Pharmacol 566:58-66. 2007..Flavonoids possess specific but differential radical scavenging capacity, which, in conjunction with the timing of treatment, affects their protective efficacy in cardiomyocytes exposed to ischemia/reperfusion... - Effects of Triterpenoid Glycosides from Fresh Ginseng Berry on SW480 Human Colorectal Cancer Cell LineJing Tian Xie
Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL, USA
Cancer Res Treat 43:49-55. 2011..In this study, we investigated the antiproliferative effects of fresh American ginseng berry extract (AGBE) and its representative triterpenoid glycosides using the human colorectal cancer cell line SW480... - American ginseng berry enhances chemopreventive effect of 5-FU on human colorectal cancer cellsXiao Li Li
Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
Oncol Rep 22:943-52. 2009..The enhancement of S and G2/M phase arrest, rather than cell apoptosis, should be the mechanism of synergistic effects of AGBE on 5-FU. Further in vivo and clinical trials are needed to test AGBE as a valuable chemo-adjuvant... - Chemical and pharmacological studies of Oplopanax horridus, a North American botanicalTyler Calway
Tang Center for Herbal Medicine Research, and Department of Anesthesia and Critical Care, University of Chicago, 5841 South Maryland Avenue, MC 4028, Chicago, IL 60637, USA
J Nat Med 66:249-56. 2012..Our recent study has focused more on the anticancer effects of OH and the involved mechanisms of action. In this review, we will summarize the research status in the botany, phytochemistry, and pharmacology of OH... - Identification of metabolites of Buyang Huanwu decoction in rat urine using liquid chromatography-quadrupole time-of-flight mass spectrometryXiao Dong Wen
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
J Pharm Biomed Anal 67:114-22. 2012..Furthermore, the results of this work have demonstrated the feasibility of the RRLC/ESI-Q-TOF-MS approach for rapid and reliable characterization of metabolites from herbal medicines... - Methylnaltrexone reduced body weight gain in ob/ob miceChun Su Yuan
Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Illinois, USA
J Opioid Manag 5:213-8. 2009..In this study, the authors evaluated the effects of a peripherally acting opioid receptor antagonist, methylnaltrexone, on weight changes in adult obese ob/ob mice... - American ginseng: potential structure-function relationship in cancer chemopreventionLian Wen Qi
Tang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, The Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, MC 4028, Chicago, IL 60637, United States
Biochem Pharmacol 80:947-54. 2010..Understanding these relationships may produce insights into chemical and pharmacological approaches for enhancing the chemopreventive effects of ginsenoside and for developing novel anticancer agents... - The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activityChun Su Yuan
Department of Anesthesia and Critical Care, Tang Center for Herbal Medicine Research, and Committee on Clinical Pharmacology and Pharmacogenomics, Pritzker School of Medicine, University of Chicago, Illinois 60637, USA
Anesth Analg 98:353-8, table of contents. 2004..Thus, valerian may potentiate the effects of anesthetics that act on GABA receptors, and presurgical valerian use may cause a valerian-anesthetic interaction... - Isolation and analysis of ginseng: advances and challengesLian Wen Qi
Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, The Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
Nat Prod Rep 28:467-95. 2011..The aim of this review is to illustrate the recent advances in the isolation and analysis of ginseng, and to highlight new applications and challenges. Emphasis is placed on recent trends and emerging techniques... - Epigallocatechin Gallate (EGCG) Is the Most Effective Cancer Chemopreventive Polyphenol in Green TeaGuang Jian Du
Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA
Nutrients 4:1679-91. 2012..The gallic acid group significantly enhanced catechin's anticancer potential. This property could be utilized in future semi-synthesis of flavonoid derivatives to develop novel anticancer agents... - American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFRUrszula Dougherty
Department of Medicine, University of Chicago, Chicago, IL 60637, USA
BMC Complement Altern Med 11:111. 2011..In this study we asked if ginseng could inhibit Western diet (20% fat) promoted colonic tumorigenesis and if compound K, a microbial metabolite of ginseng could suppress colon cancer xenograft growth... - Clinical status of methylnaltrexone, a new agent to prevent and manage opioid-induced side effectsChun Su Yuan
Department of Anesthesia and Critical Care, Pritzker School of Medicine, The University of Chicago, 5841 S Maryland Avenue, MC 4028, Chicago, IL 60637, USA
J Support Oncol 2:111-7; discussion 119-22. 2004..This article reviews existing clinical data on methylnaltrexone, focusing on the antagonism of opioid-induced adverse effects in the gut... - Ginsenosides from American ginseng: chemical and pharmacological diversityLian Wen Qi
Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, The Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
Phytochemistry 72:689-99. 2011..The goal is that this article is a useful reference to chemists and biologists researching American ginseng, and will open the door to agents in drug discovery... - Reversal of opioid-induced gastric dysfunction in a critically ill burn patient after methylnaltrexoneMichael Woo
Department Anesthesia and Critical Care, The University of Chicago, 5841 S Maryland Ave, MC 4028, Chicago, IL 60637, USA
Anesth Analg 107:1965-7. 2008..Gastric residuals markedly decreased and enteral feeding increased after administration of i.v. methylnaltrexone. The patient's ileus resolved coincident with the first injection... - Ultra-performance liquid chromatography and time-of-flight mass spectrometry analysis of ginsenoside metabolites in human plasmaChong Zhi Wang
Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, University of Chicago, IL 60637, USA
Am J Chin Med 39:1161-71. 2011..4 ng⋅h/ml for C-K, respectively. The gradual decrease of Rb1 levels and the delayed increase in levels of C-K observed in human subjects supported previous reports that enteric microbiota played a key role in transforming Rb1 to C-K... - Potential role of ginseng in the treatment of colorectal cancerChong Zhi Wang
Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, The University of Chicago, Chicago, Illinois 60637, USA
Am J Chin Med 36:1019-28. 2008..This heat treatment process may increase the role of ginseng in treating colorectal cancer... - Diagnostic ion filtering to characterize ginseng saponins by rapid liquid chromatography with time-of-flight mass spectrometryLian Wen Qi
State Key Laboratory of Natural Medicines China Pharmaceutical University, No 24 Tongjia Lane, Nanjing 210009, China
J Chromatogr A 1230:93-9. 2012..We characterized 70 saponins in the samples. Our strategy can be extended to screen and characterize other rare ginseng saponins and their metabolites... - Trends in scientific publications of chinese medicineChong Zhi Wang
Tang Center for Herbal Medicine Research, The University of Chicago, Chicago, Illinois 60637, USA, Department of Anesthesia and Critical Care, The University of Chicago, Chicago, Illinois 60637, USA
Am J Chin Med 40:1099-108. 2012..These data are not only important to the scientific community for recognition of trends in TCM research, but also for providing information to TCM researchers who are targeting potentially highly cited studies... - Protease inhibitor-induced nausea and vomiting is attenuated by a peripherally acting, opioid-receptor antagonist in a rat modelChun Su Yuan
Department of Anesthesia and Critical Care, University of Chicago, Chicago, USA
AIDS Res Ther 6:19. 2009..CONCLUSION: These results suggest that methylnaltrexone may have potential clinical utility in reducing nausea and vomiting in HIV patients who take ritonavir... - Opioid-induced immunosuppression: is it centrally mediated or peripherally mediated?Gang Wei
Department of Anesthesia and Critical Care, The University of Chicago, 5841 S Maryland Avenue, MC 4028, Chicago, IL 60637, USA
Biochem Pharmacol 65:1761-6. 2003.... - Anti-diabetic effect of American ginseng may not be linked to antioxidant activity: comparison between American ginseng and Scutellaria baicalensis using an ob/ob mice modelJing Tian Xie
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
Fitoterapia 80:306-11. 2009..The mechanisms of American ginseng's effects on reducing high blood glucose levels and body weight remain to be investigated in future experiments... - Grape seed proanthocyanidins protect cardiomyocytes from ischemia and reperfusion injury via Akt-NOS signalingZuo Hui Shao
Department of Medicine, Emergency Resuscitation Center, University of Chicago, Illinois 60637, USA
J Cell Biochem 107:697-705. 2009..GSPE offers an alternative approach to therapeutic cardioprotection against I/R injury and may offer unique opportunities to improve cardiovascular health by enhancing NO production and increasing Akt-eNOS signaling... - Leptin, gut, and food intakeAnoja S Attele
Department of Anesthesia and Critical Care, The University of Chicago, 5841 S. Maryland Avenue, MC 4028, Chicago, IL 60637, USA
Biochem Pharmacol 63:1579-83. 2002..Based on currently available data, some potential future studies are suggested... - Baicalein attenuates oxidant stress in cardiomyocytesZuo-Hui Shao
Section of Emergency Medicine, Department of Medicine, University of Chicago, Illinois 60637, USA
Am J Physiol Heart Circ Physiol 282:H999-H1006. 2002..We conclude that baicalein can scavenge ROS generation in cardiomyocytes and that it protects against cell death in an ischemia-reperfusion model when given only at reperfusion... - Ginsenoside variability in American ginseng samplesChun-Su Yuan
Am J Clin Nutr 75:600-1. 2002 - Antidiabetic effects of Panax ginseng berry extract and the identification of an effective componentAnoja S Attele
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
Diabetes 51:1851-8. 2002..This antidiabetic effect of ginsenoside Re was not associated with body weight changes, suggesting that other constituents in the extract have distinct pharmacological mechanisms on energy metabolism... - Methylnaltrexone prevents morphine-induced kaolin intake in the ratHan H Aung
Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
Life Sci 74:2685-91. 2004..Morphine and methylnaltrexone did not significantly affect food intake and body weight in the experimental animals. Our data suggest that methylnaltrexone has therapeutic value in treating opioid-induced nausea and vomiting... - Flavones from Scutellaria baicalensis Georgi attenuate apoptosis and protein oxidation in neuronal cell linesJoungil Choi
Molecular Aging Unit, Department of Molecular Biology and Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
Biochim Biophys Acta 1571:201-10. 2002..These data support the idea that flavones in SbE can attenuate oxidant stress and protect cells from lethal oxidant damage... - American ginseng leaf: ginsenoside analysis and hypoglycemic activityJing-Tian Xie
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, 5841 S. Maryland Avenue, MC 4028, Chicago, IL 60637, USA
Pharmacol Res 49:113-7. 2004..05). Our results suggest that AGLE possesses a significant anti-hyperglycemic and thermogenic activity and may prove to be beneficial in improving the management of type 2 diabetes... - Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytesZuo-Hui Shao
Tang Center for Herbal Medicine Research, Emergency Resuscitation Research Center, and Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
Cardiovasc Toxicol 3:331-9. 2003..Consumers may take higher doses of dietary supplements in the belief that natural herbs have no major side effects. This study demonstrates that dosages of GSPE should be optimized to avoid potential harmful pro-oxidant effects... - Effects of antioxidant herbs on chemotherapy-induced nausea and vomiting in a rat-pica modelSangeeta R Mehendale
Tang Center for Herbal Medicine Research, and Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
Am J Chin Med 32:897-905. 2004..We conclude that herbal antioxidants may have a role in attenuating cisplatin-induced nausea and vomiting... - American ginseng berry extract and ginsenoside Re attenuate cisplatin-induced kaolin intake in ratsSangeeta Mehendale
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, IL 60637, USA
Cancer Chemother Pharmacol 56:63-9. 2005..Significant recovery of food intake further strengthens the conclusion that AGBE may exert an antinausea/antiemetic effect... - Tolerability, gut effects, and pharmacokinetics of methylnaltrexone following repeated intravenous administration in humansChun-Su Yuan
Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, 5841 S. Maryland Avenue, MC 4028, Chicago, IL 60637, USA
J Clin Pharmacol 45:538-46. 2005..The observation of a significant reduction in the gut transit time after repeated administration of methylnaltrexone to these opioid-naive volunteers suggests that endogenous opioids modulate human gut motility... - Saponins composition in American ginseng leaf and berry assayed by high-performance liquid chromatographyChong-Zhi Wang
Tang Center for Herbal Medicine Research, The University of Chicago, Chicago, Illnois 60637, USA
J Agric Food Chem 54:2261-6. 2006..Ginsenoside Rb3 was quantified as 4.71% in American ginseng leaves and 5.35% in berries, suggesting that American ginseng leaves and berries are new sources of ginsenoside Rb3... - Antioxidant effects of ginsenoside Re in cardiomyocytesJing-Tian Xie
Tang Center for Herbal Medicine Research, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
Eur J Pharmacol 532:201-7. 2006.... - Antioxidant effects of American ginseng berry extract in cardiomyocytes exposed to acute oxidant stressZuo-Hui Shao
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, The University of Chicago, IL 60637, USA
Biochim Biophys Acta 1670:165-71. 2004..We conclude that AGBE is a potent antioxidant that protects cardiomyocytes against oxidant-mediated injury and this protection is partly mediated by its free radical scavenging properties... - Methylnaltrexone antagonizes opioid-mediated enhancement of HIV infection of human blood mononuclear phagocytesWen-Zhe Ho
Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Pharmacol Exp Ther 307:1158-62. 2003..The ability of MNTX to block opioid-induced CCR5 expression and HIV replication at clinically relevant doses may have additional benefit for opioid abusers with HIV infection, or patients with AIDS pain receiving opioids... - Effects of Corydalis yanhusuo and Angelicae dahuricae on cold pressor-induced pain in humans: a controlled trialChun-Su Yuan
Tang Center for Herbal Medicine Research, Committee on Clinical Pharmacology, and Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Illinois 60637, USA
J Clin Pharmacol 44:1323-7. 2004..01). Dose-related analgesic effect was also observed. Results from this study suggest that C. yanhusuo and A. dahuricae may have a potential clinical value for treating mild to moderate pain... - Determination of major ginsenosides in Panax quinquefolius (American ginseng) using high-performance liquid chromatographyAnbao Wang
Tang Center for Herbal Medicine Research, The University of Chicago, Chicago, IL 60637, USA
Phytochem Anal 16:272-7. 2005..The amounts of Re in 5- and 7-year Illinois-cultivated samples were greater than those found in ginseng cultivated for 3 or 4 years in Wisconsin, whereas the levels of Rb1 were greater in the younger Wisconsin samples... - Transcutaneous electrical acupoint stimulation potentiates analgesic effect of morphineChun-Su Yuan
Tang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, University of Chicago, Illinois 60637, USA
J Clin Pharmacol 42:899-903. 2002..01). The results support the efficacy of TEAS analgesia and suggest that combination of TEAS with low-dose morphine can achieve better pain control in a variety of clinical settings... - Effects of American ginseng berry extract on blood glucose levels in ob/ob miceJing-Tian Xie
Tang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Illinois 60637, USA
Am J Chin Med 30:187-94. 2002..01 compared to day 0) was noticeable. Our results support in vivo antihyperglycemic and antiobese activity of American ginseng berry extract that may prove to be of clinical importance in the prevention and treatment of Type 2 diabetes... - Grape seed proanthocyanidin extract attenuates oxidant injury in cardiomyocytesZuo-Hui Shao
Department of Medicine, Section of Emergency Medicine, University of Chicago, 5841 S. Maryland Avenue, MC 5068, Chicago, IL 60637, USA
Pharmacol Res 47:463-9. 2003..Its effect does not require PKC, mito K(ATP) channel, or NO synthase, presumably because it acts by reactive oxygen species scavenging and iron chelating directly... - Polyphenol contents in grape-seed extracts correlate with antipica effects in cisplatin-treated ratsChong-Zhi Wang
Tang Center for Herbal Medicine Research, Pritzker School of Medicine, University of Chicago, IL 60637, USA
J Altern Complement Med 11:1059-65. 2005..Results from this study suggest that an appropriate dose of GSE has therapeutic value in treating cisplatin-induced emesis... - Determination of methylnaltrexone in clinical samples by solid-phase extraction and high-performance liquid chromatography for a pharmacokinetics studyJoachim Osinski
Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL 60637, USA
J Chromatogr B Analyt Technol Biomed Life Sci 780:251-9. 2002..7 (+/-10.8) and 20.0 (+/-9.5) min, respectively. The method is simple, yet sensitive for the detection and determination of methylnaltrexone in biological samples at the level of the physiological response... - Anti-diabetic and anti-obese effects of ginseng berry extract: comparison between intraperitoneal and oral administrationsLucy Dey
Am J Chin Med 30:645-7. 2002 - Synergistic effect of Scutellaria baicalensis and grape seed proanthocyanidins on scavenging reactive oxygen species in vitroZuo-Hui Shao
Tang Center for Herbal Medicine Research, Emergency Medicine and Emergency Resuscitation Center, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
Am J Chin Med 32:89-95. 2004..This has the advantage of avoiding possible side effects that may arise when higher doses of a single herb are used in an attempt to achieve a maximum degree of antioxidant activity... - Selective postoperative inhibition of gastrointestinal opioid receptorsJonathan Moss
N Engl J Med 346:455. 2002 - Isolation of ginsenoside Rb1 from Kalopanax pictus by eastern blotting using anti-ginsenoside Rb1 monoclonal antibodyHiroyuki Tanaka
Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Phytother Res 19:255-8. 2005..The result provided evidence that a combination of two immunoassays using monoclonal antibodies against ginsenosides is a powerful means of surveying new ginsenoside resources... - Nucleus accumbens receives gastric vagal inputsSangeeta Mehendale
Department of Anesthesia and Critical Care, and Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
Acta Pharmacol Sin 25:271-5. 2004..CONCLUSION: The present study localized and characterized gastric vagally evoked responses in the nucleus accumbens, which suggest that the nucleus accumbens may process gastric signals concerned with the ingestive process... - Ginseng and diabetesJing-Tian Xie
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
Am J Chin Med 33:397-404. 2005..Ginseng has also been commonly used in Oriental medicine to treat diabetes-like conditions. The present review discusses the research on the anti-diabetic effects of ginseng and the possible mechanisms of its anti-diabetic actions... - Analgesic effects of different acupoint stimulation frequencies in humansAnoja S Attele
Tang Center for Herbal Medicine Research, Committee on Clinical Pharmacology and Department of Anesthesia and Critical Care The University of Chicago, Chicago IL 60637, USA
Am J Chin Med 31:157-62. 2003..01). Our data support the efficacy of TEAS analgesia. However, there was no significant difference between pain scores at 4 Hz and 32 Hz stimulation... - Alternative therapies for type 2 diabetesLucy Dey
Tang Center for Herbal Medicine Research and Department of Anethesia and Critical Care, The Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA
Altern Med Rev 7:45-58. 2002..Commonly used herbs and other alternative therapies, less likely to have the side effects of conventional approaches for type 2 diabetes, are reviewed... - Regional anesthesia in the anticoagulated patient: defining the risks (the second ASRA Consensus Conference on Neuraxial Anesthesia and Anticoagulation)Terese T Horlocker
Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
Reg Anesth Pain Med 28:172-97. 2003 - Steamed American ginseng berry: ginsenoside analyses and anticancer activitiesChong-Zhi Wang
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, MC 4028, Chicago, Illinois 60637, USA
J Agric Food Chem 54:9936-42. 2006..The steaming of American ginseng berries augments ginsenoside Rg3 content and increases the antiproliferative effects on two human colorectal cancer cell lines... - Cardioprotective effects of grape seed proanthocyanidins, baicalin and wogonin: comparison between acute and chronic treatmentsWei-Tien Chang
Am J Chin Med 34:363-5. 2006 - Opioid-induced gastrointestinal dysfunctionSangeeta R Mehendale
Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
Dig Dis 24:105-12. 2006..A better understanding of the pathophysiological mechanisms of opioid-induced bowel dysfunction should lead to the development of newer opioid analgesics and improved regimens resulting in reduced gastrointestinal adverse effects... - Identification of Fritillaria pallidiflora using diagnostic PCR and PCR-RFLP based on nuclear ribosomal DNA internal transcribed spacer sequencesChong-Zhi Wang
Key Laboratory of Modern Traditional Chinese Medicines, and Department of Pharmacognosy, School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing, Jiangsu Province, PR China
Planta Med 71:384-6. 2005..pallidiflora. PCR-RFLP analysis was established to differentiate F. pallidiflora from the other species of Fritillaria. These methods provide effective and accurate identification of F. pallidiflora...