Y P Yu

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Phosphorylation and interaction of myopodin by integrin-link kinase lead to suppression of cell growth and motility in prostate cancer cells
    Y P Yu
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Oncogene 30:4855-63. 2011
  2. ncbi request reprint Pathological factors evaluating prostate cancer
    Y P Yu
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Histol Histopathol 22:1291-300. 2007
  3. ncbi request reprint Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin
    Yan Ping Yu
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Cancer Res 66:7414-9. 2006
  4. doi request reprint Inhibition of prostate cancer growth and metastasis using small interference RNA specific for minichromosome complex maintenance component 7
    Y K Shi
    Department of Pathology and Biostatistics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Cancer Gene Ther 17:694-9. 2010
  5. pmc Identification of a novel gene with increasing rate of suppression in high grade prostate cancers
    Y P Yu
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Am J Pathol 158:19-24. 2001
  6. ncbi request reprint MCM7 amplification and overexpression are associated with prostate cancer progression
    B Ren
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Oncogene 25:1090-8. 2006
  7. pmc Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers
    F Lin
    Department of Pathology, School of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Am J Pathol 159:1603-12. 2001
  8. pmc CSR1 induces cell death through inactivation of CPSF3
    Z H Zhu
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Oncogene 28:41-51. 2009
  9. ncbi request reprint Gene expression analysis of prostate cancers
    Jian Hua Luo
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pensylvania 15261, USA
    Mol Carcinog 33:25-35. 2002
  10. ncbi request reprint Inactivation of myopodin expression associated with prostate cancer relapse
    Yan Ping Yu
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Urology 68:578-82. 2006

Collaborators

Detail Information

Publications16

  1. pmc Phosphorylation and interaction of myopodin by integrin-link kinase lead to suppression of cell growth and motility in prostate cancer cells
    Y P Yu
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Oncogene 30:4855-63. 2011
    ..A mutant of myopodin lacking the ILK interaction motif is inactive in suppressing the growth and motility of PC3 cells. As a result, this study showed a novel and critical signaling pathway that leads to activation of myopodin...
  2. ncbi request reprint Pathological factors evaluating prostate cancer
    Y P Yu
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Histol Histopathol 22:1291-300. 2007
    ..In addition, this review will cover a brief overview on conventional morphological evaluation of prostate cancer differentiation...
  3. ncbi request reprint Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin
    Yan Ping Yu
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Cancer Res 66:7414-9. 2006
    ..The motility and invasion suppression activity of myopodin were significantly weakened in myopodin mutants lacking this sequence. Thus, our studies suggest that zyxin may be a critical functional regulator of myopodin...
  4. doi request reprint Inhibition of prostate cancer growth and metastasis using small interference RNA specific for minichromosome complex maintenance component 7
    Y K Shi
    Department of Pathology and Biostatistics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Cancer Gene Ther 17:694-9. 2010
    ..As a result, intervention of MCM7 expression using siRNA approach may hold the promise for treating androgen refractory prostate cancer...
  5. pmc Identification of a novel gene with increasing rate of suppression in high grade prostate cancers
    Y P Yu
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Am J Pathol 158:19-24. 2001
    ..The selective inactivation in the more aggressive prostate cancers holds promise for SAPC as a potential prognostic marker for high grade prostate cancer...
  6. ncbi request reprint MCM7 amplification and overexpression are associated with prostate cancer progression
    B Ren
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Oncogene 25:1090-8. 2006
    ..These studies implicate MCM7, and the DNA replication licensing gene family, in prostate cancer progression, growth and invasion...
  7. pmc Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers
    F Lin
    Department of Pathology, School of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Am J Pathol 159:1603-12. 2001
    ..Statistical analysis indicates that deletion of myopodin is highly correlated with the invasiveness of prostate cancers, and thus may hold promise as an important prognostic marker for prostate cancers...
  8. pmc CSR1 induces cell death through inactivation of CPSF3
    Z H Zhu
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Oncogene 28:41-51. 2009
    ..In summary, CSR1 appears to induce cell death through a novel mechanism by hijacking a critical RNA processing enzyme...
  9. ncbi request reprint Gene expression analysis of prostate cancers
    Jian Hua Luo
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pensylvania 15261, USA
    Mol Carcinog 33:25-35. 2002
    ..Cluster analysis using the 84-gene list showed that the highly aggressive prostate cancers contained gene-expression patterns that were distinct from organ-confined prostate cancers...
  10. ncbi request reprint Inactivation of myopodin expression associated with prostate cancer relapse
    Yan Ping Yu
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Urology 68:578-82. 2006
    ..In this study, we conducted a large-scale analysis of myopodin expression in prostate cancer samples to examine the relationship between myopodin expression and prostate cancer grade and stage and the probability of clinical relapse...
  11. pmc Expression of myopodin induces suppression of tumor growth and metastasis
    Ling Jing
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Pathol 164:1799-806. 2004
    ..All these results support the hypothesis that myopodin functions as a tumor suppressor gene to limit the growth and to inhibit the metastasis of cancer cells...
  12. pmc CSR1 suppresses tumor growth and metastasis of prostate cancer
    Guoying Yu
    Department of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Am J Pathol 168:597-607. 2006
    ..Expression of CSR1 in PC3 cell xenografts produced a dramatic reduction (>8-fold) in tumor size, rate of invasion (0 versus 31%), and mortality (13 versus 100%). The present findings suggest that CSR1 is a potent tumor sup-pressor gene...
  13. ncbi request reprint Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy
    Yan Ping Yu
    University of Pittsburgh Cancer Institute and Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Oncol 22:2790-9. 2004
    ..Identification of the genes and patterns of gene expression will provide a more cohesive picture of prostate cancer biology...
  14. ncbi request reprint Genetic factors underlying prostate cancer
    Jian Hua Luo
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Expert Rev Mol Med 5:1-26. 2003
    ..This review summarises some of the important findings in the areas of genome and gene expression abnormalities in prostate cancer, and aims to provide a comprehensive view of new developments in these areas...
  15. ncbi request reprint High throughput screening of methylation status of genes in prostate cancer using an oligonucleotide methylation array
    Yan Ping Yu
    Department of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Carcinogenesis 26:471-9. 2005
    ....
  16. ncbi request reprint Gene expression analysis of human soft tissue leiomyosarcomas
    Baoguo Ren
    Department of Pathology, University of Pittsburgh School of Medicine, PA 15361, USA
    Hum Pathol 34:549-58. 2003
    ....