Victor L Yu
Affiliation: University of Pittsburgh
- Distribution of Legionella species and serogroups isolated by culture in patients with sporadic community-acquired legionellosis: an international collaborative surveyVictor L Yu
Veterans Affairs Medical Center, Infectious Disease Section, Pittsburgh, Pennsylvania 15240, USA
J Infect Dis 186:127-8. 2002..9%) and L. bozemanii (2.4%), followed by L. micdadei, L. dumoffii, L. feeleii, L. wadsworthii, and L. anisa (2.2% combined). L. longbeachae constituted 30.4% of the community-acquired Legionella isolates in Australia and New Zealand...
- An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered, and clinical outcomeVictor L Yu
Division of Infectious Disease, University of Pittsburgh, PA, USA
Clin Infect Dis 37:230-7. 2003..beta-Lactam antibiotics should still be useful for treatment of pneumococcal infections that do not involve cerebrospinal fluid, regardless of in vitro susceptibility, as determined by current NCCLS breakpoints...
- Staphylococcus aureus bacteremia: recurrence and the impact of antibiotic treatment in a prospective multicenter studyFeng Yee Chang
VA Medical Center, Infectious Disease Section, University Drive C, Pittsburgh, PA 15240, USA
Medicine (Baltimore) 82:333-9. 2003..Duration of antistaphylococcal therapy was not associated with relapse, but type of antibiotic therapy was. Nafcillin was superior to vancomycin in efficacy in patients with MSSA bacteremia...
- Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamasesDavid L Paterson
Infectious Disease Section, VA Medical Center, Pittsburgh, Pennsylvania 15240, USA
Clin Infect Dis 39:31-7. 2004..Antibiotic choice is particularly important in seriously ill patients with infections due to ESBL-producing K. pneumoniae...
- Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infectionsVictor L Yu
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Emerg Infect Dis 13:986-93. 2007..001). Differences in clinical features of bacteremic infection with K. pneumoniae are due to the virulence factors expressed by the organism...
- Role of environmental surveillance in determining the risk of hospital-acquired legionellosis: a national surveillance study with clinical correlationsJanet E Stout
VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
Infect Control Hosp Epidemiol 28:818-24. 2007..None of these hospitals had previously experienced endemic hospital-acquired Legionella pneumonia...
- Effect of pipe corrosion scales on chlorine dioxide consumption in drinking water distribution systemsZhe Zhang
Department of Civil and Environmental Engineering, School of Engineering, University of Pittsburgh, 943 Benedum Hall, Pittsburgh, PA 15261, USA
Water Res 42:129-36. 2008..Based on these results, it can be concluded that the corrosion scale will cause much more significant ClO(2) loss in corroded iron pipes of the distribution system than the total organic carbon that may be present in finished water...
- Isolation of Staphylococcus aureus from the urinary tract: association of isolation with symptomatic urinary tract infection and subsequent staphylococcal bacteremiaRobert R Muder
Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
Clin Infect Dis 42:46-50. 2006..The significance of staphylococcal bacteriuria is uncertain. We hypothesized that S. aureus is a urinary pathogen and that colonized urine could be a source of future staphylococcal infection...
- Computer keyboard covers impregnated with a novel antimicrobial polymer significantly reduce microbial contaminationNatalie N D'Antonio
Special Pathogens Laboratory, Pittsburgh, PA, USA
Am J Infect Control 41:337-9. 2013..This study aimed to determine whether plastic keyboard covers containing HM 4100 effectively minimize the survival of bacterial species commonly present on health care environmental surfaces...
- Comparative activity of quinolones, macrolides and ketolides against Legionella species using in vitro broth dilution and intracellular susceptibility testingJanet E Stout
VA Pittsburgh Healthcare System, VA Medical Center, Infectious Disease Section, University Drive C, Pittsburgh, PA 15240, USA
Int J Antimicrob Agents 25:302-7. 2005..The rank order of intracellular activity against L. pneumophila serogroup 1 was quinolones>ketolides>macrolides. Clinical trials to determine the clinical efficacy of ketolides for the treatment of Legionnaires' disease are warranted...
- Safety and efficacy of chlorine dioxide for Legionella control in a hospital water systemZhe Zhang
Department of Civil and Environmental Engineering, School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA
Infect Control Hosp Epidemiol 28:1009-12. 2007..Use of chlorine dioxide was safe, based on Environmental Protection Agency limits regarding maximum concentrations of chlorine dioxide and chlorite...
- Revisiting the hand wipe versus gel rub debate: is a higher-ethanol content hand wipe more effective than an ethanol gel rub?Natalie N D'Antonio
Special Pathogens Laboratory, Pittsburgh, PA, USA
Am J Infect Control 38:678-82. 2010..The objective of this study was to determine whether a hand wipe with higher ethanol content (65.9%) is as effective as an ethanol hand rub or antimicrobial soap in removing bacteria and spores from hands...
- Rapid diagnostic testing for community-acquired pneumonia: can innovative technology for clinical microbiology be exploited?Victor L Yu
University of Pittsburgh and Special Pathogens Laboratory, Pittsburgh, PA 15219, USA
Chest 136:1618-21. 2009..To reduce antimicrobial overuse with subsequent antimicrobial resistance, these basic principles must be applied in concert with traditional and newer tests in the clinical microbiology laboratory...
- Quantitative cultures for diagnosing ventilator-associated pneumonia: a critiqueShigeki Fujitani
Infectious Disease Section, West Los Angeles Healthcare Center, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
Clin Infect Dis 43:S106-13. 2006..The variability in both the methods and reference criteria in the studies reviewed show that the quantitation approach is neither standardized nor evidence based...
- Outcomes of central nervous system cryptococcosis vary with host immune function: results from a multi-center, prospective studyM Hong Nguyen
The University of Florida, College of Medicine, Gainesville, FL, USA
J Infect 61:419-26. 2010..Central nervous system (CNS) cryptococcosis is most commonly encountered among HIV-infected and other immunosuppressed hosts but is less well-characterized among non-immunosuppressed patients...
- Pneumonia due to Pseudomonas aeruginosa: part II: antimicrobial resistance, pharmacodynamic concepts, and antibiotic therapyHsin Yun Sun
Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
Chest 139:1172-85. 2011....
- Pneumonia due to Pseudomonas aeruginosa: part I: epidemiology, clinical diagnosis, and sourceShigeki Fujitani
Department of Emergency and Critical Care Medicine, St Marianna University, Kanagawa, Japan
Chest 139:909-19. 2011..The source of the P aeruginosa may be endogenous (from respiratory or GI tract colonization) or exogenous from tap water in hospital-acquired pneumonia. The latter source is amenable to preventive measures...
- Legionnaires' disease in long-term care facilities: overview and proposed solutionsMeena H Seenivasan
Department of Veterans Affairs Pittsburgh Healthcare System and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Am Geriatr Soc 53:875-80. 2005..pneumophila serogroup 1 be found...
- Linezolid-associated peripheral and optic neuropathy, lactic acidosis, and serotonin syndromeMasashi Narita
Infectious Disease Section, University of Pittsburgh, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240, USA
Pharmacotherapy 27:1189-97. 2007..Linezolid should be discontinued immediately in patients experiencing these adverse effects. Patients receiving linezolid for more than 28 days should be monitored for signs of peripheral and optic neuropathy...
- Experiences of the first 16 hospitals using copper-silver ionization for Legionella control: implications for the evaluation of other disinfection modalitiesJanet E Stout
Special Pathogens Laboratory, Veterans Affairs Medical Center, Pittsburg, Pennsylvania 15240, USA
Infect Control Hosp Epidemiol 24:563-8. 2003..A standardized, evidence-based approach to assist hospitals with decision making concerning the possible purchase of a disinfection system is presented...
- Levofloxacin efficacy in the treatment of community-acquired legionellosisVictor L Yu
VAMC and University of Pittsburgh, Pittsburgh, PA, USA
Chest 125:2135-9. 2004..Even fewer studies have applied rigorous criteria for diagnosis of community-acquired Legionnaires disease, including culture of respiratory secretions on selective media...
- International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum beta-lactamase production in nosocomial InfectionsDavid L Paterson
Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15240, USA
Ann Intern Med 140:26-32. 2004..Commonly encountered nosocomially acquired gram-negative bacteria, especially Klebsiella pneumoniae, produce extended-spectrum beta-lactamases (ESBLs) as an antibiotic resistance mechanism...
- Prospective observational study of chronic rhinosinusitis: environmental triggers and antibiotic implicationsBerrylin J Ferguson
Department of Otolaryngology, University of Pittsburgh, Pennsylvania, USA
Clin Infect Dis 54:62-8. 2012..We examined differences in clinical manifestations and underlying conditions in patients with symptoms typical for CRS. CT scan abnormality of the sinuses was the gold standard for diagnosis of CRS...
- Legionnaires's disease in a transplant recipient acquired from the patient's home: implications for managementNina Singh
VA Medical Center, University of Pittsburgh, PA, USA
Transplantation 74:755-6. 2002
- Diagnosis of ventilator-associated pneumonia: focus on nonbronchoscopic techniques (nonbronchoscopic bronchoalveolar lavage, including mini-BAL, blinded protected specimen brush, and blinded bronchial sampling) and endotracheal aspiratesShigeki Fujitani
Department of Critical Care Medicine, University of Pittsburgh, PA 15240, USA
J Intensive Care Med 21:17-21. 2006..Pending future studies, use of endotracheal aspirates without the use of quantitation seems to be a reasonable approach for clinicians who are not committed to an invasive procedure...
- Infection due to Legionella species other than L. pneumophilaRobert R Muder
Infectious Diseases Section, VA Pittsburgh Healthcare System and University of Pittsburgh School of Medicine, Pittsburgh, PA 15240, USA
Clin Infect Dis 35:990-8. 2002..Application of appropriate culture methodology to the etiologic diagnosis of pneumonia is needed to further define the role of these organisms in disease in humans...
- Mycobacterium monacense: a mycobacterial pathogen that causes infection of the handAurele Taieb
Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
J Hand Surg Am 33:94-6. 2008..The organism was identified as Mycobacterium monacense, a newly described species. The patient was cured with a 6-week course of clarithromycin and levofloxacin...
- Similar hematologic effects of long-term linezolid and vancomycin therapy in a prospective observational study of patients with orthopedic infectionsNalini Rao
Division of Infectious Disease, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15232, USA
Clin Infect Dis 38:1058-64. 2004..In conclusion, hematologic effects were detectable through weekly monitoring and were reversible; therefore, concern about myelosuppression need not preclude linezolid use for orthopedic infections requiring long-term therapy...
- Severing the Gordian knot of prevention of cytomegalovirus in liver transplant recipients: the principle is the swordNina Singh
Veterans Affairs Medical Center Infectious Diseases Section, Pittsburgh, PA 15240, USA
Liver Transpl 11:891-4. 2005
- A prospective multicenter study of Staphylococcus aureus bacteremia: incidence of endocarditis, risk factors for mortality, and clinical impact of methicillin resistanceFeng Yee Chang
VA Medical Center, Infectious Disease Section, University Drive C, Pittsburgh, PA 15240, USA
Medicine (Baltimore) 82:322-32. 2003..MRSA as the infecting organism should be added to the list of risk factors for consideration of valvular resection in cases of endocarditis...
- Guidelines for hospital-acquired pneumonia and health-care-associated pneumonia: a vulnerability, a pitfall, and a fatal flawVictor L Yu
Special Pathogens Laboratory and Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Lancet Infect Dis 11:248-52. 2011..Emphasis should be placed on defining the microbial cause of the pneumonia rather than reflex administration of empirical combination therapy...
- Community-acquired legionnaires disease: implications for underdiagnosis and laboratory testingVictor L Yu
Clin Infect Dis 46:1365-7. 2008
- Community-acquired Klebsiella pneumoniae bacteremia: global differences in clinical patternsWen Chien Ko
National Cheng Kung University Medical College, Taiwan
Emerg Infect Dis 8:160-6. 2002..A distinctive form of K. pneumoniae infection, often causing liver abscess, was identified, almost exclusively in Taiwan...
- Streptococcus pneumoniae bacteraemia: pharmacodynamic correlations with outcome and macrolide resistance--a controlled studyJerome J Schentag
CPL Associates, LLC, 3980 Sheridan Drive, Suite 501, Amherst, NY 14226 1727, USA
Int J Antimicrob Agents 30:264-9. 2007....
- Severe pneumococcal pneumonia: new strategies for managementChristine C C Chiou
Department of Pediatrics, Veterans General Hospital Kaohsiung, Kaohsiung, Taiwan
Curr Opin Crit Care 12:470-6. 2006..Bacteremic pneumococcal pneumonia is an advanced stage of severe pneumococcal pneumonia. Improvement in the management of bacteremic pneumococcal pneumonia has the potential for improving the survival for severe pneumococcal pneumonia...
- No impact of penicillin resistance on mortalityKeith P Klugman
Clin Infect Dis 43:261; author reply 261-2. 2006
- The role of Klebsiella pneumoniae in lung abscesses: a geographic phenomenon (for now!)Victor L Yu
Clin Infect Dis 42:152-3; author reply 153-4. 2006
- Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremiaLarry M Baddour
Mayo Clinic, Rochester, NY, USA
Am J Respir Crit Care Med 170:440-4. 2004..Combination antibiotic therapy improved survival among critically ill patients with bacteremic pneumococcal illness...
- Infection by drug-resistant Streptococcus pneumoniae is not linked to increased mortalityVictor L Yu
Clin Infect Dis 39:1086-7; author reply 1087-8. 2004
- Bacteraemic pneumococcal pneumonia: impact of HIV on clinical presentation and outcomeCharles Feldman
Division of Pulmonology, Department of Medicine, Johannesburg Hospital, University of the Witwatersrand, Medical School, 7 York Road, Parktown 2193, Johannesburg, South Africa
J Infect 55:125-35. 2007....
- Hospital-acquired legionellosis: solutions for a preventable infectionMiguel Sabria
Hospital Universitario Germans Trias I Pujol and the Autonomous University of Barcelona, Badalona, Spain
Lancet Infect Dis 2:368-73. 2002..There is a need for public-health agencies to educate the public and media that discovery of cases identifies those hospitals as providers of superior care, and that such hospitals are not negligent...
- Legionella anisa and hospital water systemsVictor L Yu
J Infect Chemother 10:133; author reply 134. 2004
- Legionnaires disease and the updated IDSA guidelines for community-acquired pneumoniaVictor L Yu
Clin Infect Dis 39:1734-7; author reply 1737-8. 2004
- Management of nonsevere pneumonia in military trainees with the urinary antigen test for Streptococcus pneumoniae: an innovative approach to targeted therapyIgor A Guchev
Pulmonary Medicine Department, Smolensk Military Hospital, Smolensk, Russia
Clin Infect Dis 40:1608-16. 2005..Our purpose was to assess the usefulness of a strategy of targeted antimicrobial therapy based on the results of a rapid urinary antigen test for S. pneumoniae...
- Fluconazole MIC and the fluconazole dose/MIC ratio correlate with therapeutic response among patients with candidemiaCornelius J Clancy
University of Florida College of Medicine, P O Box 100277, JHMHC, Gainesville, FL 32610, USA
Antimicrob Agents Chemother 49:3171-7. 2005..In clinical practice, dose/MIC ratio might prove easier to interpret than breakpoint MICs, since it quantitates the effects of increasing fluconazole doses that are alluded to in the S-DD designation...
- Preemptive therapy for cytomegalovirusNina Singh
Liver Transpl 12:327. 2006
- Problem pathogens: paediatric legionellosis--implications for improved diagnosisDavid Greenberg
Soroka University Medical Center, Beer Sheeva, Israel
Lancet Infect Dis 6:529-35. 2006..As legionella diagnostic tests become more widely applied, we predict that legionellosis may appear as an emerging infectious disease in children...
- Negative effect of high pH on biocidal efficacy of copper and silver ions in controlling Legionella pneumophilaYu Sen E Lin
Graduate Institute of Environmental Education, National Kaohsiung Normal University, Kaohsiung, Taiwan
Appl Environ Microbiol 68:2711-5. 2002..Precipitation of insoluble copper complexes was observed at a pH above 6.0. These results suggest that pH may be an important factor in the efficacy of copper-silver ionization in controlling Legionella in water systems...