Research Topics
Genomes and Genes
Species | Mimi C YuSummaryAffiliation: University of Southern California Country: USA Publications
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Detail Information
Publications
Plasma isoflavone levels versus self-reported soy isoflavone levels in Asian-American women in Los Angeles CountyAnna H Wu
Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles 90089 9175, USA
Carcinogenesis 25:77-81. 2004..These results further strengthen our previous observation of an inverse association between soy intake and breast cancer risk in the Los Angeles Asian Breast Cancer Study...- Tea intake, COMT genotype, and breast cancer in Asian-American womenAnna H Wu
Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
Cancer Res 63:7526-9. 2003..Reduction in risk was strongest among persons who had the low activity COMT alleles, suggesting these individuals were less efficient in eliminating tea catechins and may derive the most benefit from these compounds... - Alkylaniline-hemoglobin adducts and risk of non-smoking-related bladder cancerJinping Gan
Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
J Natl Cancer Inst 96:1425-31. 2004..Because arylamines may account for a substantial proportion of bladder cancers among the general population, identification of environmental sources of these compounds is needed... - Tea and circulating estrogen levels in postmenopausal Chinese women in SingaporeAnna H Wu
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9175, USA
Carcinogenesis 26:976-80. 2005..Larger studies are needed to confirm results from this cross-sectional study and to better understand the potentially differing effect of black and green tea on circulating estrogen levels and ultimately on the risk of breast cancer... - Epidemiology of nasopharyngeal carcinomaMimi C Yu
Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
Semin Cancer Biol 12:421-9. 2002..Other recognized risk factors for NPC are cigarette smoking, and occupational exposure to formaldehyde and wood dust... - Arylamine exposures and bladder cancer riskMimi C Yu
Keck School of Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
Mutat Res 506:21-8. 2002..Furthermore, women may experience higher bladder cancer risk than men from comparable arylamine exposure, possibly due in part to women's higher propensity for arylamine activation relative to men... - Environmental factors and risk for hepatocellular carcinomaMimi C Yu
Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Gastroenterology 127:S72-8. 2004..In summary, risk factors for HCC are identifiable in most patients and primarily are associated with chronic hepatic injury... - Carotenoids/vitamin C and smoking-related bladder cancerJ Esteban Castelao
USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089 9181, USA
Int J Cancer 110:417-23. 2004..The carotenoid-bladder cancer association was not affected by the GSTM1, GSTT1 and GSTP1 genotypes... - A new single nucleotide polymorphism in the insulin-like growth factor I regulatory region associates with colorectal cancer risk in singapore chineseHui Lee Wong
University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA
Cancer Epidemiol Biomarkers Prev 14:144-51. 2005..In conclusion, we report a novel SNP in the IGF-I regulatory region that is associated with colorectal cancer risk... - Green tea intake, ACE gene polymorphism and breast cancer risk among Chinese women in SingaporeJian Min Yuan
USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, MC 9175, Los Angeles, CA 90089 9181, USA
Carcinogenesis 26:1389-94. 2005..The findings of the present study highlight the importance of genetically determined factors in evaluating the role of green tea intake in the development of breast cancer... - Marine n-3 fatty acid intake, glutathione S-transferase polymorphisms and breast cancer risk in post-menopausal Chinese women in SingaporeManuela Gago-Dominguez
USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033 0800, USA
Carcinogenesis 25:2143-7. 2004..36, 95% CI = 0.14, 0.94). A similar relationship was observed among women with the combined GSTT1 null and GSTP1 AB/BB genotypes (OR = 0.26, 95% CI = 0.08, 0.78)... - Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese womenGiske Ursin
University of Southern California, Los Angeles, CA 90089, USA
Nutr Cancer 56:128-35. 2006..Our results suggest that the effect of soy intake on percent mammographic density is moderate but possibly of clinical relevance... 
Dietary isothiocyanates, glutathione S-transferase M1 (GSTM1), and lung cancer risk in African Americans and Caucasians from Los Angeles County, CaliforniaCatherine L Carpenter
David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1742, USA
Nutr Cancer 61:492-9. 2009..52). Reduced lung cancer risk with higher isothiocyanate intake may be slightly stronger among subjects with deletion of GSTM1...- Dietary patterns and breast cancer risk in Asian American womenAnna H Wu
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
Am J Clin Nutr 89:1145-54. 2009..The role of diet as a cause of breast cancer in Asian Americans has not been adequately studied... - Beta-cryptoxanthin and lung cancer in Shanghai, China--an examination of potential confounding with cigarette smoking using urinary cotinine as a biomarker for true tobacco exposureDaniel O Stram
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Nutr Cancer 57:123-9. 2007.... 
Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health StudyMariana C Stern
Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA
J Nutrigenet Nutrigenomics 2:273-9. 2009..003). Our results suggest a positive association between high intake of marine n-3 PUFA and rectal cancer risk among carriers of at least one PARP codon 762 Ala allele (odds ratio=1.7, 95% confidence interval=1.1-2.7)...- Green tea, soy, and mammographic density in Singapore Chinese womenAnna H Wu
Department of Preventive Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
Cancer Epidemiol Biomarkers Prev 17:3358-65. 2008..52). Our findings suggest that both regular green tea and high soy intake may have beneficial effects on the breast; the effect of green tea on PMD may be stronger than the effect of soy... - Prediagnostic levels of serum micronutrients in relation to risk of gastric cancer in Shanghai, ChinaJian Min Yuan
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, MC 9175, 1441 Eastlake Avenue, Los Angeles, CA 90033 0800, USA
Cancer Epidemiol Biomarkers Prev 13:1772-80. 2004..The present study implicates that dietary carotenes, lycopene, and vitamin C are potential chemopreventive agents for gastric cancer in humans... - Anthropometric, dietary, and hormonal correlates of serum adiponectin in Asian American womenAnna H Wu
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
Nutr Cancer 63:549-57. 2011..0001) and the ratios of total testosterone (T)/total estradiol (E2) (P trend <0.004) after adjustment for BMI and WHR. Confirmation of our findings on green tea and adiponectin is needed... - Diabetes and risk of breast cancer in Asian-American womenAnna H Wu
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
Carcinogenesis 28:1561-6. 2007..08) than women without such a history after adjusting for BMI and WHR. Our results support the hypothesis that diabetes may have a role in the development of breast cancer, influencing risk via both sex hormone and insulin pathways... - Genetic variation in peroxisome proliferator-activated receptor gamma, soy, and mammographic density in Singapore Chinese womenEunjung Lee
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, Norris Cancer Center, Los Angeles, CA 90089, USA
Cancer Epidemiol Biomarkers Prev 21:635-44. 2012..We investigated the interrelations of soy, PPARγ, and mammographic density, a biomarker of breast cancer risk in a cross-sectional study of 2,038 women who were members of the population-based Singapore Chinese Health Study Cohort... - Body size, hormone therapy and risk of breast cancer in Asian-American womenAnna H Wu
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Int J Cancer 120:844-52. 2007..017). The increased risk associated with high body weight was observed irrespective of HT use. Use of HT and high body size might have contributed to the rapid increase of breast cancer in Asian-Americans... - Sleep duration, melatonin and breast cancer among Chinese women in SingaporeAnna H Wu
Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
Carcinogenesis 29:1244-8. 2008..However, data are inconclusive from the three studies conducted in Western populations on sleep duration and breast cancer risk... - Dietary soy and increased risk of bladder cancer: the Singapore Chinese Health StudyCan Lan Sun
USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
Cancer Epidemiol Biomarkers Prev 11:1674-7. 2002..To our knowledge, this is the first epidemiological report on the effect of dietary soy on bladder cancer risk... - DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health StudyMariana C Stern
Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Room 5421A, Los Angeles, CA 90089, USA
Cancer Epidemiol Biomarkers Prev 16:2363-72. 2007..8; 95% CI, 1.0-8.1). Our results support a role for reactive oxygen species as relevant genotoxins that may account for the effects of both smoking and alcohol on colorectal cancer risk... - Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.SJian Min Yuan
Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles 90089 9176, USA
Cancer 101:1009-17. 2004..Heavy alcohol consumption, viral hepatitis, and diabetes are risk factors for hepatocellular carcinoma (HCC). However, to the authors' knowledge, the information concerning their interaction effect in patients with risk of HCC is sparse... - Dietary cryptoxanthin and reduced risk of lung cancer: the Singapore Chinese Health StudyJian Min Yuan
Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033 0800, USA
Cancer Epidemiol Biomarkers Prev 12:890-8. 2003..The present study lends additional credence to prior experimental and epidemiological data in support of the hypothesis that dietary beta-cryptoxanthin is a chemopreventive agent for lung cancer in humans... - Vitamin D receptor start codon polymorphism and colorectal cancer risk: effect modification by dietary calcium and fat in Singapore ChineseHui Lee Wong
USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
Carcinogenesis 24:1091-5. 2003..5-fold increased risk that was statistically significant. There was little evidence of a VDR genotype-colorectal cancer association among subjects with higher than median values of either dietary fat or calcium... - DNA methylation as a biomarker for cardiovascular disease riskMyungjin Kim
Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
PLoS ONE 5:e9692. 2010..This may reflect a reduced systemic remethylation capacity, which would be expected to cause decreased genomic DNA methylation in peripheral blood leukocytes (PBL)... - Comparison of prostate-specific antigen and hormone levels among men in Singapore and the United StatesIona Cheng
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA, 90089 9175, USA
Cancer Epidemiol Biomarkers Prev 14:1692-6. 2005..Given that the overall mortality rate of prostate cancer in Singapore is low, these undiagnosed cancers may be of nonaggressive type. Alternatively, PSA may be a poor marker of prostate cancer in this low-risk population... - Dietary soy and increased risk of bladder cancer: a prospective cohort study of men in Shanghai, ChinaCan Lan Sun
USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033 9176, USA
Int J Cancer 112:319-23. 2004..The soy-bladder cancer risk associations in smokers and non-smokers were comparable. The soy-bladder cancer relationship became stronger when the analysis was restricted to subjects with 2 or more years of follow-up... - Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2Manuela Gago-Dominguez
USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033 0800, USA
Carcinogenesis 24:483-9. 2003..On the other hand, individuals of NAT1*10 genotype exhibited no such associations... - Sleep duration, spot urinary 6-sulfatoxymelatonin levels and risk of breast cancer among Chinese women in SingaporeAnna H Wu
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9175, USA
Int J Cancer 132:891-6. 2013..Melatonin levels derived from randomly timed spot urine are unrelated to breast cancer. Randomly timed, spot urine-derived melatonin levels are noninformative as surrogates of nocturnal melatonin production... - Environmental tobacco smoke and bladder cancer risk in never smokers of Los Angeles CountyXuejuan Jiang
Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
Cancer Res 67:7540-5. 2007..ETS exposure was associated with neither bladder cancer risk nor 4-ABP-Hb adduct levels in male lifelong nonsmokers. In conclusion, ETS is a risk factor for bladder cancer in women who were lifelong nonusers of any tobacco products... - Green tea and risk of breast cancer in Asian AmericansAnna H Wu
Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
Int J Cancer 106:574-9. 2003..In summary, our results point to an important role of both green tea and soy intake in relation to breast cancer risk in Asian-American women... - Lipid peroxidation: a novel and unifying concept of the etiology of renal cell carcinoma (United States)Manuela Gago-Dominguez
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90089 9176, USA
Cancer Causes Control 13:287-93. 2002..Our hypothesis may also explain the roles of other risk (oophorectomy/hysterectomy, parity, smoking, diabetes) and protective factors (dietary antioxidants) for renal cell cancer... - HSD17B1 and CYP17 polymorphisms and breast cancer risk among Chinese women in SingaporeAnna H Wu
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Int J Cancer 104:450-7. 2003..41, 95% CI=1.56-3.72; RR=4.39, 95% CI=1.71-11.30, respectively). The latter gene-parity effects were especially pronounced in postmenopausal women... - Tea, hormone-related cancers and endogenous hormone levelsAnna H Wu
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9175, USA
Mol Nutr Food Res 50:160-9. 2006..We pay special attention to some of the limitations of the human studies and discuss future research needs... - Sex differential in methylation patterns of selected genes in Singapore ChineseBarbara Sarter
Kenneth Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
Hum Genet 117:402-3. 2005..13 and 0.96, respectively). Our data suggest that gender is at least as strong a predictor of methylation level in the four genes under study as age, with males showing higher PMRs... - GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancerEunjung Lee
Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9176, USA
Cancer Res 66:7849-53. 2006..82; P = 0.010). The use of GRP78 as a predictor for chemoresponsiveness and the potential interaction of GRP78 and/or the UPR pathways with taxanes warrant larger studies... - Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in Shanghai, ChinaCan Lan Sun
USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
Carcinogenesis 23:1497-503. 2002..The present study provides direct evidence that tea polyphenols may act as chemopreventive agents against gastric and esophageal cancer development... - A modified reduced-temperature antigen retrieval protocol effective for use with a polyclonal antibody to cyclooxygenase-2 (PG 27)Shan-Rong Shi
Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
Appl Immunohistochem Mol Morphol 10:368-73. 2002..In conclusion, use of the test battery approach allowed development of a modified antigen retrieval technique that provides a more reliable, much simpler approach for the demonstration of cyclooxygenase-2 in archival tissues... - Adolescent and adult soy intake and risk of breast cancer in Asian-AmericansAnna H Wu
Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
Carcinogenesis 23:1491-6. 2002..These results show that high soy intake in childhood in Asian-Americans is associated with reduced breast cancer risk. Risk may be further reduced by intake as an adult... - Detection of residual subclinical ovarian carcinoma after completion of adjuvant chemotherapyMory Nouriani
Division of Gynecologic Oncology, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
Clin Cancer Res 10:2681-6. 2004.... - Cancer, culture, and health disparities: time to chart a new course?Marjorie Kagawa-Singer
Department of Asian American Studies, Senior Editor, AAPI Nexus Journal, Los Angeles, California 90095 1772, USA
CA Cancer J Clin 60:12-39. 2010..The authors conclude with suggestions for clinical practice to eliminate the disconnection between evidence-based, quality, cancer care and its delivery to diverse population groups... - Combination of molecular alterations and smoking intensity predicts bladder cancer outcome: A report from the Los Angeles Cancer Surveillance ProgramAnirban P Mitra
Department of Pathology, University of Southern California, Los Angeles, California Center for Personalized Medicine, University of Southern California, Los Angeles, California
Cancer 119:756-65. 2013.... - A case-control study of cyclin D1 CCND1 870A-->G polymorphism and bladder cancerVictoria K Cortessis
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, MC 9175, Los Angeles, CA 90033, USA
Carcinogenesis 24:1645-50. 2003..90, 95% confidence interval 0.60-1.33). The null association was not appreciably modified by bladder cancer risk factors, including lifetime smoking history, or by histopathologic classification... - Soy intake and other lifestyle determinants of serum estrogen levels among postmenopausal Chinese women in SingaporeAnna H Wu
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
Cancer Epidemiol Biomarkers Prev 11:844-51. 2002..Current smokers showed significantly higher E(2) levels (28%) than nonsmokers (P = 0.04). These findings are discussed in relation to the recent doubling of breast cancer incidence among Chinese women in Singapore... - Effect of reproductive hormones on ovarian epithelial tumors: II. Effect on angiogenic activityChen Chen
Deportment of Pathology USC/Norris Comprehensive Concer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Cancer Biol Ther 1:307-12. 2002..Therapeutic use of progestins may be most effective when administered in combination with an anti-angiogenic agent, at least against a subset of ovarian carcinomas... - Hepatitis C in a Los Angeles public hepatitis clinic: demographic and biochemical differences associated with race-ethnicityAnne F Celona
Keck School of Medicine, University of Southern California, Los Angeles, California 94115, USA
Clin Gastroenterol Hepatol 2:459-62. 2004..Further studies are required to determine the possible causes for these biochemical differences... - Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancerJan Stoehlmacher
Department of Medical Oncology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90033, USA
J Natl Cancer Inst 94:936-42. 2002.... - Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levelsBinh N Trinh
Department of Surgery, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9176, USA
Hum Genet 111:299-302. 2002..These genetic determinants of plasma folate and homocysteine levels may be useful in identifying individuals at increased risk for cardiovascular disease... - Incense use and respiratory tract carcinomas: a prospective cohort studyJeppe T Friborg
The Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
Cancer 113:1676-84. 2008..Therefore, the relation between incense use and the risk of respiratory tract carcinomas was analyzed in a prospective cohort study... - Urinary total isothiocyanates and colorectal cancer: a prospective study of men in Shanghai, ChinaKristin A Moy
The Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
Cancer Epidemiol Biomarkers Prev 17:1354-9. 2008..25-0.83), respectively, for risk of colorectal cancer (P for trend = 0.006). The present study suggests that dietary ITCs may exert tumor inhibitory effects, especially during earlier stages of the multistage process of carcinogenesis... - Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancerJian Min Yuan
The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Carcinogenesis 29:1386-93. 2008..12-3.69, P = 0.02). The effect of NAT2 slow acetylation was even stronger in the presence of two or more null/low-activity GST genotypes. There were no associations between bladder cancer risk and NAT1 genotype or CYP1A2 phenotype... - Association of metabolic gene polymorphisms with tobacco consumption in healthy controlsKim M Smits
University Maastricht, Maastricht, The Netherlands
Int J Cancer 110:266-70. 2004..No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected... - Alcohol, tobacco, and diet in relation to esophageal cancer: the Shanghai Cohort StudyYunhua Fan
The Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
Nutr Cancer 60:354-63. 2008..low consumers after adjustment for cigarette smoking, alcohol drinking, and other confounders... - Differential effects of black versus green tea on risk of Parkinson's disease in the Singapore Chinese Health StudyLouis C Tan
Department of Neurology, National Neuroscience Institute, Singapore
Am J Epidemiol 167:553-60. 2008..Green tea drinking was unrelated to Parkinson's disease risk. Diet had no strong influence on risk. Ingredients of black tea other than caffeine appear to be responsible for the beverage's inverse association with Parkinson's disease... - Dietary fiber and reduced cough with phlegm: a cohort study in SingaporeLesley M Butler
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
Am J Respir Crit Care Med 170:279-87. 2004..These data suggest that a diet high in fiber from fruit and, possibly, soyfoods may reduce the incidence of chronic respiratory symptoms. Associated nutrients, such as flavonoids, may contribute to this association... - Effect of glutathione-S-transferase polymorphisms on the cancer preventive potential of isothiocyanates: an epidemiological perspectiveAdeline Seow
Department of Community, Occupational and Family Medicine, National University of Singapore, 16 Medical Drive, MD3, Singapore 117597, Singapore
Mutat Res 592:58-67. 2005.... - Coffee, tea, and incident type 2 diabetes: the Singapore Chinese Health StudyAndrew O Odegaard
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA
Am J Clin Nutr 88:979-85. 2008..Increasing coffee intake was inversely associated with risk of type 2 diabetes in populations of European descent; however, data from high-risk Asian populations are lacking as are data on tea intake in general... - Determinants of circulating insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations in a cohort of Singapore men and womenNicole M Probst-Hensch
University Hospital Zurich, Cancer Registry Zürich, Zurich, Switzerland
Cancer Epidemiol Biomarkers Prev 12:739-46. 2003..The results of this study lend additional support to the hypothesis that circulating IGF-I concentrations increase the risk of prostate, bladder, colorectal, and breast cancer... - Diet, reproductive factors and lung cancer risk among Chinese women in Singapore: evidence for a protective effect of soy in nonsmokersAdeline Seow
Department of Community, Occupational and Family Medicine, Faculty of Medicine MD3, National University of Singapore, 16 Medical Drive, 117597 Singapore
Int J Cancer 97:365-71. 2002..These findings are consistent with other evidence suggesting an involvement of estrogen-related pathways in lung cancer among non-smoking women... - Nonsmoking-related arylamine exposure and bladder cancer riskPaul L Skipper
Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Cancer Epidemiol Biomarkers Prev 12:503-7. 2003.... - Angiotensin I-converting enzyme (ACE) gene polymorphism and breast cancer risk among Chinese women in SingaporeWoon Puay Koh
Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore 117597
Cancer Res 63:573-8. 2003..27-0.81). Our findings support experimental data implicating ACE and angiotensin II in breast cancer, and suggest that the renin-angiotensin system may serve as a therapeutic target for breast cancer treatment and prevention... - Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health StudyAdeline Seow
Department of Community, Occupational and Family Medicine, Faculty of Medicine, National University of Singapore, Singapore
Carcinogenesis 23:2055-61. 2002..Further, this gene-diet interaction may be important in studies evaluating the effect of risk-enhancing compounds in the colorectum... - Mammographic parenchymal patterns and self-reported soy intake in Singapore Chinese womenRupert W Jakes
National Medical Research Council Clinical Trials and Epidemiology Research Unit, Singapore 169039
Cancer Epidemiol Biomarkers Prev 11:608-13. 2002..20-0.98). The association between high soy intake and a reduced risk of mammographic parenchymal patterns that are associated with high breast cancer risk may have important implications in breast cancer prevention... - Insulin-like growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in ChinaStephanie J London
Epidemiology Branch and Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
J Natl Cancer Inst 94:749-54. 2002..In a prospective study of men in Shanghai, China, we examined the association between serum levels of IGF-I and IGFBP-3 and the subsequent risk of lung cancer... - Morbidity and mortality in relation to smoking among women and men of Chinese ethnicity: the Singapore Chinese Health StudyAnoop Shankar
Department of Community, Occupational, and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Eur J Cancer 44:100-9. 2008..We examined the association among cigarette smoking, smoking cessation and a broad range of cancer incidence and all cause and cause-specific mortality in a population-based cohort of adults of Chinese ethnicity in Singapore... - Green tea and black tea consumption in relation to colorectal cancer risk: the Singapore Chinese Health StudyCan Lan Sun
Division of Population Sciences, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA
Carcinogenesis 28:2143-8. 2007..75, 95% CI = 1.24-2.46; P for trend < 0.0001). Irrespective of gender, intake of black tea was not associated with risk of colorectal cancer (RR = 0.92, 95% CI = 0.79-1.07) in this Asian population... - 249ser p53 mutation in the serum of black southern African patients with hepatocellular carcinomaGerald C Kimbi
MRC/University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
J Gastroenterol Hepatol 20:1185-90. 2005.... - Middle-aged and older Chinese men and women in Singapore who smoke have less healthy diets and lifestyles than nonsmokersWoon Puay Koh
Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore
J Nutr 135:2473-7. 2005..Our results are consistent with findings among Western populations, and suggest that the unhealthy diet and lifestyle in smokers occur across diverse cultures... - Diabetes mellitus and risk of colorectal cancer in the Singapore Chinese Health StudyAdeline Seow
Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore
J Natl Cancer Inst 98:135-8. 2006..Our results support the hypothesis that hyperinsulinemia may play a role in colorectal carcinogenesis, even in a relatively lean population... - Association between circulating white blood cell count and cancer mortality: a population-based cohort studyAnoop Shankar
Division of Epidemiology, Department of Community, Occupational, and Family Medicine and the Centre for Molecular Epidemiology, National University of Singapore, Singapore
Arch Intern Med 166:188-94. 2006..However, it is not clear whether systemic markers of inflammation predict cancer. We examined the prospective relationship between circulating white blood cell (WBC) count and cancer mortality... - The effect of cyclin D1 (CCND1) G870A-polymorphism on breast cancer risk is modified by oxidative stress among Chinese women in SingaporeMichela Ceschi
Cancer Registry and Molecular Epidemiology, University Hospital, Vogelsangstrasse 10, 8091 Zurich, Switzerland
Carcinogenesis 26:1457-64. 2005..The results of this study are compatible with the hypothesis that the oxidant-antioxidant balance in cells is an important determinant of the direction of the cyclin D1 effect, leading either to cell proliferation or cell death... - Peroxisome proliferator-activated receptor (PPAR) gamma gene polymorphisms and colorectal cancer risk among Chinese in SingaporeWoon Puay Koh
Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Carcinogenesis 27:1797-802. 2006..72 (0.49-1.07) among subjects possessing one low-risk genotype (either PPARgamma2 or PPARgamma3), and the comparable figure among subjects possessing both low-risk genotypes was 0.19 (0.07-0.51)... - Prediagnostic level of serum retinol in relation to reduced risk of hepatocellular carcinomaJian Min Yuan
The Cancer Center, University of Minnesota, Minneapolis, MN, USA
J Natl Cancer Inst 98:482-90. 2006.... - Dietary factors and cancers of the renal pelvis and ureterKaye E Brock
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Executive Plaza South, Room 8024, 6120 Executive Boulevard, MSC 7244, Bethesda, MD 20892-7244, USA
Cancer Epidemiol Biomarkers Prev 15:1051-3. 2006 - Vapor, dust, and smoke exposure in relation to adult-onset asthma and chronic respiratory symptoms: the Singapore Chinese Health StudyTricia D LeVan
Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA
Am J Epidemiol 163:1118-28. 2006..These data support the role of occupational exposures in the etiology of respiratory illness in a population-based cohort in Singapore with a low prevalence of atopic illness... - The effect of the cyclin D1 (CCND1) A870G polymorphism on colorectal cancer risk is modified by glutathione-S-transferase polymorphisms and isothiocyanate intake in the Singapore Chinese Health StudyNicole M Probst-Hensch
Molecular Epidemiology Cancer Registry, Institutes of Social and Preventive Medicine Surgical Pathology, University Hospital Zurich Zurich, Switzerland
Carcinogenesis 27:2475-82. 2006..The results of our current study on CRC and those of our previous breast cancer study are compatible with the notion of oxidative stress in target cells as important determinant of direction and magnitude of the CCND1 effect... - Increased hepatocarcinogenic potential of hepatitis B virus genotype A in Bantu-speaking sub-saharan AfricansMichael C Kew
MRC CANSA University Molecular Hepatology Research Unit, Department of Medicine, Medical School, University of the Witwatersrand, 7 York Road, Parktown 2193, Johannesburg, South Africa
J Med Virol 75:513-21. 2005..Genotype A has a greater hepatocarcinogenic potential than non-A genotypes in Bantu-speaking sub-saharan Africans and this is entirely attributable to subgenotype A1... - Urinary biomarkers of tea polyphenols and risk of colorectal cancer in the Shanghai Cohort StudyJian Min Yuan
The Cancer Center, University of Minnesota, 1300 South 2nd Street, Minneapolis, MN 55454, USA
Int J Cancer 120:1344-50. 2007..Urinary levels of tea polyphenols and their metabolites were not associated with rectal cancer risk. The present study supports the notion of tea catechins as chemopreventive agents against the development of colon cancer in humans... - Effect of cytokine genotypes on the hepatitis B virus-hepatocellular carcinoma associationAlexandra Nieters
Department of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
Cancer 103:740-8. 2005..However, only a minority of HBV carriers eventually develop hepatocellular carcinoma. The authors hypothesized that cytokine genotypes may be important codeterminants of the risk of HBV-related hepatocellular carcinoma... - Polymorphisms in angiotensin II type 1 receptor and angiotensin I-converting enzyme genes and breast cancer risk among Chinese women in SingaporeWoon Puay Koh
Department of Community, Occupational and Family Medicine, National University of Singapore, 16 Medical Drive, Singapore 117597, Singapore
Carcinogenesis 26:459-64. 2005..Our findings suggest that pharmacological inhibition of the angiotensin II effect by blockade of ACE and/or AGTR1 could be potential targets for the prevention and treatment of breast cancer... - Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinomaJian Min Yuan
The Cancer Center, University of Minnesota, Minneapolis, Minnesota 55454, USA
Hepatology 46:749-58. 2007..CONCLUSION: This study supports the hypothesis that reduced MTHFR activity and enhanced TYMS activity, both of which are essential elements in minimizing uracil misincorporation into DNA, may protect against the development of HCC... - Effects of cruciferous vegetable consumption on urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in singapore chineseStephen S Hecht
University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware St SE, Minneapolis, MN 55455, USA
Cancer Epidemiol Biomarkers Prev 13:997-1004. 2004..The results of this study demonstrate the complexities in assessing effects of cruciferous vegetables on carcinogen metabolism... - Tobacco smoking and urinary levels of 2-amino-9H-pyrido[2,3-b]indole in men of Shanghai, ChinaRobert J Turesky
Wadsworth Center, New York State Department of Health, Albany, New York, Empire State Plaza, P O Box 509, Albany, NY 12201 0509, USA
Cancer Epidemiol Biomarkers Prev 16:1554-60. 2007..Our data indicate that AalphaC represents a major HAA exposure in adult men of Shanghai, China, and that tobacco smoke is an important point source of their AalphaC exposure...