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Genomes and Genes | Liping YuSummaryAffiliation: University of Colorado Denver Country: USA Publications
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Publications
Rituximab selectively suppresses specific islet antibodiesLiping Yu
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
Diabetes 60:2560-5. 2011..Rituximab decreased the loss of C-peptide over the first year of follow-up and markedly depleted B lymphocytes for 6 months after administration. This article analyzes the specific effect of rituximab on multiple islet autoantibodies...- Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetesTaylor M Triolo
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Health Science Center, Aurora, CO 80045, USA
J Clin Endocrinol Metab 94:4517-23. 2009..Subjects with type 1 diabetes (T1D) are at increased risk for AD. Genetic factors including HLA-DRB1*0404 and MICA have been associated with AD in populations with and without T1D... - Prime role for an insulin epitope in the development of type 1 diabetes in NOD miceMaki Nakayama
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Nature 435:220-3. 2005.... 
Triple chimeric islet autoantigen IA2-ZnT8WR to facilitate islet autoantibody determinationLiping Yu
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, United States
J Immunol Methods 353:20-3. 2010..The chimeric assay provides an efficient and economical technique to screen for islet autoantibodies reacting with IA-2 and ZnT8...
Comparative study of oral versus subcutaneous B:9-23 insulin peptide in Balb/c mice as an experimental model for autoimmune diabetesDevasenan Devendra
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Ann N Y Acad Sci 1029:331-3. 2004..The insulin autoantibodies induced react with insulin and not the immunizing peptide. Oral administration of insulin as well as subcutaneous insulin can sensitize to insulin...- Genetic differentiation of poly I:C from B:9-23 peptide induced experimental autoimmune diabetesJohanna Paronen
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B140, Denver, CO 80262, USA
J Autoimmun 22:307-13. 2004..Interaction of genes and environment (antigenic epitope and viral mimic) can be important in the pathogenesis of immune mediated diabetes and activation of the innate immune system (e.g. Poly I:C) may be one key determinant... - SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetesJanet M Wenzlau
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
Ann N Y Acad Sci 1150:256-9. 2008..We conclude that SLC30A8 provides an important additional and independent predictive marker for T1D... - Murine high specificity/sensitivity competitive europium insulin autoantibody assayNaru Babaya
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado 80045 6511, USA
Diabetes Technol Ther 11:227-33. 2009..There is thus a need for simpler assay formats that do not utilize radioactivity, yet retain the high specificity and sensitivity of radioassays... - Nondepleting anti-CD4 monoclonal antibody prevents diabetes and blocks induction of insulin autoantibodies following insulin peptide B:9-23 immunization in the NOD mouseEdwin Liu
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B140, Denver, CO 80262, USA
J Autoimmun 21:213-9. 2003..9) in NOD mice confers long-term protection from diabetes and insulitis and profoundly blocks spontaneous and B:9-23 peptide-induced insulin autoantibodies... - Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the youngAndrea K Steck
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
Diabetes Care 34:1397-9. 2011..We evaluated predictors of progression to diabetes in children with high-risk HLA genotypes and persistent islet autoantibodies... - Conserved T cell receptor alpha-chain induces insulin autoantibodiesMasakazu Kobayashi
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 105:10090-4. 2008..We suggest that a major part of the mystery as to why islet autoimmunity develops relates to recognition of a primary insulin peptide by a conserved alpha chain T cell receptor... - HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY populationErin E Baschal
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045 6511, USA
Diabetes 56:2405-9. 2007.... - Comparison of insulin autoantibody: polyethylene glycol and micro-IAA 1-day and 7-day assaysNaru Babaya
Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045 6511, USA
Diabetes Metab Res Rev 25:665-70. 2009..Our standard micro-IAA assay (mIAA) utilizes precipitation with proteins A/G and 1-day incubation (1-day mIAA), but is less sensitive compared to the CIAA assay... - Type 1 diabetes: chronic progressive autoimmune diseaseLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, CO 80010, USA
Novartis Found Symp 292:85-94; discussion 94-8, 122-9, 202-3. 2008..Given the ability to predict type 1A diabetes trials at all stages of the disorder to prevent beta cell destruction are now possible... - A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetesJanet M Wenzlau
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
Diabetes 57:2693-7. 2008..The type 2 diabetes nonsynonymous single nucleotide polymorphism (SNP) affecting aa(325) lies within the region of highest ZnT8 autoantibody (ZnT8A) binding, prompting an investigation of its relationship to type 1 diabetes... - Role of autoantibodies in type 1 diabetesDongmei Miao
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 1775 N Ursula Street, Aurora, Colorado 80010, USA
Front Biosci 12:1889-98. 2007..The ability to detect specific anti-islet autoantibodies provides the foundation for developing and testing these preventive therapies... - Extreme genetic risk for type 1A diabetesTheresa A Aly
Barbara Davis Center for Childhood Diabetes and Human Medical Genetics Program, University Colorado Health Sciences Center, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 103:14074-9. 2006..A subset of siblings at extremely high risk for T1D can now be identified at birth for trials to prevent islet autoimmunity... - Differential immune induction with subcutaneous versus oral administration of a diabetogenic insulin peptide in the NOD mouseDevasenan Devendra
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Ann N Y Acad Sci 1029:328-30. 2004..Given in oral form with multiple different vehicles, it did not alter expression of insulin autoantibodies in contrast to subcutaneous administration... - Prevalence of autoantibody-negative diabetes is not rare at all ages and increases with older age and obesityJian Wang
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, PO Box 6511, Mail Stop B140, Aurora, Colorado 80045 6511, USA
J Clin Endocrinol Metab 92:88-92. 2007..A significant percentage of nonautoimmune forms of diabetes presents among children in all age groups, with a remarkable increase with age... - Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockoutJean M Jasinski
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P O Box 6511, MS B140, Aurora, CO 80045 6511, USA
Diabetes 55:1978-84. 2006..scid mouse. The current study demonstrates that the BDC12-4.1 TCR is sufficient to cause diabetes at NOD backcross 1, bypassing polygenic inhibition of insulitis and diabetogenesis... - Animal models of insulin-dependent diabetesEdwin Liu
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
Methods Mol Med 102:195-212. 2004..In summary, animal models have become necessary in the study of type 1 diabetes and provide researchers important tools to conduct studies that could not otherwise be performed in humans... - Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodiesLiping Yu
Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver, Aurora, Colorado, USA
Diabetes Care 35:1213-8. 2012.... - Predicting the onset of Addison's disease: ACTH, renin, cortisol and 21-hydroxylase autoantibodiesPeter R Baker
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, USA
Clin Endocrinol (Oxf) 76:617-24. 2012..Autoantibodies to 21-hydroxylase (21OH-AA) precede onset of autoimmune Addison's disease (AD). Progression to AD can take months to years, and early detection of metabolic decompensation may prevent morbidity and mortality... - Genetic prediction of autoimmunity: initial oligogenic prediction of anti-islet autoimmunity amongst DR3/DR4-DQ8 relatives of patients with type 1A diabetesTheresa A Aly
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue B 140, Denver, CO 80262, USA
J Autoimmun 25:40-5. 2005..These results highlight the multiplicative risk of combined high-risk genotypes at different loci in terms of time to autoantibody and autoimmune disease development... - Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetesJeesuk Yu
University of Colorado Health Sciences Center, Aurora, Colorado, USA
J Clin Endocrinol Metab 94:504-10. 2009..There is controversy as to whether type 2 diabetes genetic susceptibility contributes to type 1 diabetes, and it is not known what proportion of islet autoantibody-negative new onset subjects have type 2 diabetes risk alleles... - Distinguishing persistent insulin autoantibodies with differential risk: nonradioactive bivalent proinsulin/insulin autoantibody assayLiping Yu
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
Diabetes 61:179-86. 2012..We hypothesize that factors related to the mechanism of loss of tolerance leading to diabetes determine high affinity and MSD-IAA reactivity... - Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23Edwin Liu
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA
J Clin Invest 110:1021-7. 2002..Thus, the insulin peptides B:9-23 and B:13-23, even when administered subcutaneously in the absence of adjuvant, can induce a dramatic humoral response leading to fatal anaphylaxis in NOD mice... - A report on the International Transglutaminase Autoantibody Workshop for Celiac DiseaseMarcella Li
University of Colorado Denver, Anshultz Medical Campus, Aurora, CO 80010, USA
Am J Gastroenterol 104:154-63. 2009..The primary aim of this workshop is to compare TGAA assays among various research and clinical laboratories to examine assay concordance and improve (and eventually standardize) the TGAA assay... - The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetesJanet M Wenzlau
Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, 1775 North Ursula Street, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 104:17040-5. 2007..The combination of bioinformatics and molecular engineering used here will potentially generate other diabetes autoimmunity markers and is also broadly applicable to other autoimmune disorders... - Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)Jennifer M Barker
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Clin Endocrinol Metab 89:3896-902. 2004..Predictive value of autoantibodies increases with blinded duplicate and independent sample retesting and incorporation of the level of autoantibody in the predictive algorithm... - Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8Mylinh Dang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
J Immunol 186:6056-63. 2011.... - Genetic determinants of 21-hydroxylase autoantibodies amongst patients of the Type 1 Diabetes Genetics ConsortiumPeter Baker
Barbara Davis Center for Childhood Diabetes, Aurora, Colorado 80045, USA
J Clin Endocrinol Metab 97:E1573-8. 2012..Screening for 21OH-AA in newly diagnosed T1DM patients is a valuable prognostic tool, made stronger when MHC genotype is considered... - Insulin autoimmunity: prediction/precipitation/prevention type 1A diabetesGeorge S Eisenbarth
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 140, Denver, CO 80262, USA
Autoimmun Rev 1:139-45. 2002..An expanding set of resources are now available for the development and testing in man of therapies to prevent type 1 diabetes, and a number of trials utilizing insulin peptides are now underway... - Humoral autoimmunityLiping Yu
Barbara Davis Center for Childhood Diabetes, University of Colorado, Health Sciences Center, Denver, USA
Adv Exp Med Biol 552:247-67. 2004 - Additional autoimmune disease found in 33% of patients at type 1 diabetes onsetTaylor M Triolo
Barbara Davis Center for Childhood Diabetes, Aurora, Colorado, USA
Diabetes Care 34:1211-3. 2011..We sought to define the prevalence of nonislet, organ-specific autoantibodies at diagnosis of type 1 diabetes and to determine the prevalence of comorbid autoimmune diseases... - Expression of beta-cell autoimmunity does not differ between potential dizygotic twins and siblings of patients with type 1 diabetesMaria J Redondo
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East Ninth Avenue B-140, Denver, CO 80262, USA
J Autoimmun 23:275-9. 2004.... - Endocrine and immunogenetic testing in individuals with type 1 diabetes and 21-hydroxylase autoantibodies: Addison's disease in a high-risk populationJennifer M Barker
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 140, Denver, Colorado 80262, USA
J Clin Endocrinol Metab 90:128-34. 2005..1 had AD-free survival of 60% compared with 100% AD-free survival in those who were not homozygous for MICA5.1. Homozygosity for MICA5.1 may increase progression to overt AD among 21-OHAA-positive individuals... - Diabetes Prevention Trial 1: prevalence of GAD and ICA512 (IA-2) autoantibodies by relationship to probandLiping Yu
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Ann N Y Acad Sci 958:254-8. 2002..0001). We conclude that the prevalence of anti-islet cell autoantibodies is affected by multiple levels of relationship to the proband... - Absence of the T-bet gene coding for the Th1-related transcription factor does not affect diabetes-associated phenotypes in Balb/c miceEvie Melanitou
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, Denver, Colorado 80262, USA
Ann N Y Acad Sci 1005:187-91. 2003..We have therefore investigated whether absence of the T-bet gene influences diabetes-related phenotypes in Balb/c T-bet KO mice... - Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptideHiroaki Moriyama
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 99:5539-44. 2002..These first PolyIC/insulin-induced murine models should provide an important tool to study the pathogenesis of type 1 diabetes with experimental autoimmune diabetes... - Heterophile antibodies masquerade as interferon-alpha in subjects with new-onset type 1 diabetesTheresa Aly
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Diabetes Care 27:1205-6. 2004 - Celiac disease and HLA in a Bedouin kindredElise Eller
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
Hum Immunol 67:940-50. 2006..0098). There were no other significant results, including the HLA region or any other previously reported regions. This could reflect the reduced power of family-based linkage and association analyses in isolated inbred populations... - The second murine autoantibody workshop: remarkable interlaboratory concordance for radiobinding assays to identify insulin autoantibodies in nonobese diabetic miceLiping Yu
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA
Ann N Y Acad Sci 1005:1-12. 2003..In sum, this workshop continued to support the notion that IAA, as determined by RIA, could provide a sensitive and specific marker of anti-beta cell immunity in NOD mice... - Endocrine autoantibodiesDevasenan Devendra
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B140, Denver, CO 80262, USA
Clin Lab Med 24:275-303. 2004..The availability of highly sensitive and specific autoantibody assays for the various endocrine disorders can allow physicians to better diagnose and promptly treat these conditions... - Anti-dsDNA antibody assay: high specificity and sensitivity with a filtration radioassay in comparison to low specificity with the standard ELISALiping Yu
Barbara Davis Center for Childhood Diabetes and the Division of Rheumatology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
J Rheumatol 34:734-9. 2007..To evaluate whether a new fluid-phase filtration radioassay possesses both high sensitivity and specificity compared with the currently used ELISA and Farr assays... - ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodiesDongmei Miao
Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver 80262, USA
J Autoimmun 18:191-6. 2002....