Liping Yu

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Rituximab selectively suppresses specific islet antibodies
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 60:2560-5. 2011
  2. pmc Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetes
    Taylor M Triolo
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Health Science Center, Aurora, CO 80045, USA
    J Clin Endocrinol Metab 94:4517-23. 2009
  3. pmc Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
    Maki Nakayama
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Nature 435:220-3. 2005
  4. doi request reprint Triple chimeric islet autoantigen IA2-ZnT8WR to facilitate islet autoantibody determination
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, United States
    J Immunol Methods 353:20-3. 2010
  5. ncbi request reprint Comparative study of oral versus subcutaneous B:9-23 insulin peptide in Balb/c mice as an experimental model for autoimmune diabetes
    Devasenan Devendra
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Ann N Y Acad Sci 1029:331-3. 2004
  6. ncbi request reprint Genetic differentiation of poly I:C from B:9-23 peptide induced experimental autoimmune diabetes
    Johanna Paronen
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B140, Denver, CO 80262, USA
    J Autoimmun 22:307-13. 2004
  7. doi request reprint SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Ann N Y Acad Sci 1150:256-9. 2008
  8. pmc Murine high specificity/sensitivity competitive europium insulin autoantibody assay
    Naru Babaya
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado 80045 6511, USA
    Diabetes Technol Ther 11:227-33. 2009
  9. ncbi request reprint Nondepleting anti-CD4 monoclonal antibody prevents diabetes and blocks induction of insulin autoantibodies following insulin peptide B:9-23 immunization in the NOD mouse
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B140, Denver, CO 80262, USA
    J Autoimmun 21:213-9. 2003
  10. pmc Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes Care 34:1397-9. 2011

Collaborators

Detail Information

Publications46

  1. pmc Rituximab selectively suppresses specific islet antibodies
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 60:2560-5. 2011
    ..Rituximab decreased the loss of C-peptide over the first year of follow-up and markedly depleted B lymphocytes for 6 months after administration. This article analyzes the specific effect of rituximab on multiple islet autoantibodies...
  2. pmc Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetes
    Taylor M Triolo
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Health Science Center, Aurora, CO 80045, USA
    J Clin Endocrinol Metab 94:4517-23. 2009
    ..Subjects with type 1 diabetes (T1D) are at increased risk for AD. Genetic factors including HLA-DRB1*0404 and MICA have been associated with AD in populations with and without T1D...
  3. pmc Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
    Maki Nakayama
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Nature 435:220-3. 2005
    ....
  4. doi request reprint Triple chimeric islet autoantigen IA2-ZnT8WR to facilitate islet autoantibody determination
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, United States
    J Immunol Methods 353:20-3. 2010
    ..The chimeric assay provides an efficient and economical technique to screen for islet autoantibodies reacting with IA-2 and ZnT8...
  5. ncbi request reprint Comparative study of oral versus subcutaneous B:9-23 insulin peptide in Balb/c mice as an experimental model for autoimmune diabetes
    Devasenan Devendra
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Ann N Y Acad Sci 1029:331-3. 2004
    ..The insulin autoantibodies induced react with insulin and not the immunizing peptide. Oral administration of insulin as well as subcutaneous insulin can sensitize to insulin...
  6. ncbi request reprint Genetic differentiation of poly I:C from B:9-23 peptide induced experimental autoimmune diabetes
    Johanna Paronen
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B140, Denver, CO 80262, USA
    J Autoimmun 22:307-13. 2004
    ..Interaction of genes and environment (antigenic epitope and viral mimic) can be important in the pathogenesis of immune mediated diabetes and activation of the innate immune system (e.g. Poly I:C) may be one key determinant...
  7. doi request reprint SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Ann N Y Acad Sci 1150:256-9. 2008
    ..We conclude that SLC30A8 provides an important additional and independent predictive marker for T1D...
  8. pmc Murine high specificity/sensitivity competitive europium insulin autoantibody assay
    Naru Babaya
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado 80045 6511, USA
    Diabetes Technol Ther 11:227-33. 2009
    ..There is thus a need for simpler assay formats that do not utilize radioactivity, yet retain the high specificity and sensitivity of radioassays...
  9. ncbi request reprint Nondepleting anti-CD4 monoclonal antibody prevents diabetes and blocks induction of insulin autoantibodies following insulin peptide B:9-23 immunization in the NOD mouse
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B140, Denver, CO 80262, USA
    J Autoimmun 21:213-9. 2003
    ..Furthermore, recent experience has demonstrated the potential dangers of disease exacerbation or anaphylaxis with peptide immunotherapy...
  10. pmc Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes Care 34:1397-9. 2011
    ..We evaluated predictors of progression to diabetes in children with high-risk HLA genotypes and persistent islet autoantibodies...
  11. pmc Conserved T cell receptor alpha-chain induces insulin autoantibodies
    Masakazu Kobayashi
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 105:10090-4. 2008
    ..We suggest that a major part of the mystery as to why islet autoimmunity develops relates to recognition of a primary insulin peptide by a conserved alpha chain T cell receptor...
  12. ncbi request reprint HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY population
    Erin E Baschal
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045 6511, USA
    Diabetes 56:2405-9. 2007
    ....
  13. doi request reprint Comparison of insulin autoantibody: polyethylene glycol and micro-IAA 1-day and 7-day assays
    Naru Babaya
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045 6511, USA
    Diabetes Metab Res Rev 25:665-70. 2009
    ..Our standard micro-IAA assay (mIAA) utilizes precipitation with proteins A/G and 1-day incubation (1-day mIAA), but is less sensitive compared to the CIAA assay...
  14. ncbi request reprint Type 1 diabetes: chronic progressive autoimmune disease
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, CO 80010, USA
    Novartis Found Symp 292:85-94; discussion 94-8, 122-9, 202-3. 2008
    ..Given the ability to predict type 1A diabetes trials at all stages of the disorder to prevent beta cell destruction are now possible...
  15. pmc A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 57:2693-7. 2008
    ..The type 2 diabetes nonsynonymous single nucleotide polymorphism (SNP) affecting aa(325) lies within the region of highest ZnT8 autoantibody (ZnT8A) binding, prompting an investigation of its relationship to type 1 diabetes...
  16. ncbi request reprint Role of autoantibodies in type 1 diabetes
    Dongmei Miao
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 1775 N Ursula Street, Aurora, Colorado 80010, USA
    Front Biosci 12:1889-98. 2007
    ..The ability to detect specific anti-islet autoantibodies provides the foundation for developing and testing these preventive therapies...
  17. pmc Extreme genetic risk for type 1A diabetes
    Theresa A Aly
    Barbara Davis Center for Childhood Diabetes and Human Medical Genetics Program, University Colorado Health Sciences Center, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 103:14074-9. 2006
    ..A subset of siblings at extremely high risk for T1D can now be identified at birth for trials to prevent islet autoimmunity...
  18. ncbi request reprint Differential immune induction with subcutaneous versus oral administration of a diabetogenic insulin peptide in the NOD mouse
    Devasenan Devendra
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Ann N Y Acad Sci 1029:328-30. 2004
    ..Given in oral form with multiple different vehicles, it did not alter expression of insulin autoantibodies in contrast to subcutaneous administration...
  19. ncbi request reprint Prevalence of autoantibody-negative diabetes is not rare at all ages and increases with older age and obesity
    Jian Wang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, PO Box 6511, Mail Stop B140, Aurora, Colorado 80045 6511, USA
    J Clin Endocrinol Metab 92:88-92. 2007
    ..A significant percentage of nonautoimmune forms of diabetes presents among children in all age groups, with a remarkable increase with age...
  20. ncbi request reprint Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout
    Jean M Jasinski
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P O Box 6511, MS B140, Aurora, CO 80045 6511, USA
    Diabetes 55:1978-84. 2006
    ..scid mouse. The current study demonstrates that the BDC12-4.1 TCR is sufficient to cause diabetes at NOD backcross 1, bypassing polygenic inhibition of insulitis and diabetogenesis...
  21. ncbi request reprint Animal models of insulin-dependent diabetes
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
    Methods Mol Med 102:195-212. 2004
    ..In summary, animal models have become necessary in the study of type 1 diabetes and provide researchers important tools to conduct studies that could not otherwise be performed in humans...
  22. pmc Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver, Aurora, Colorado, USA
    Diabetes Care 35:1213-8. 2012
    ....
  23. doi request reprint Predicting the onset of Addison's disease: ACTH, renin, cortisol and 21-hydroxylase autoantibodies
    Peter R Baker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, USA
    Clin Endocrinol (Oxf) 76:617-24. 2012
    ..Autoantibodies to 21-hydroxylase (21OH-AA) precede onset of autoimmune Addison's disease (AD). Progression to AD can take months to years, and early detection of metabolic decompensation may prevent morbidity and mortality...
  24. ncbi request reprint Genetic prediction of autoimmunity: initial oligogenic prediction of anti-islet autoimmunity amongst DR3/DR4-DQ8 relatives of patients with type 1A diabetes
    Theresa A Aly
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue B 140, Denver, CO 80262, USA
    J Autoimmun 25:40-5. 2005
    ..These results highlight the multiplicative risk of combined high-risk genotypes at different loci in terms of time to autoantibody and autoimmune disease development...
  25. pmc Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes
    Jeesuk Yu
    University of Colorado Health Sciences Center, Aurora, Colorado, USA
    J Clin Endocrinol Metab 94:504-10. 2009
    ..There is controversy as to whether type 2 diabetes genetic susceptibility contributes to type 1 diabetes, and it is not known what proportion of islet autoantibody-negative new onset subjects have type 2 diabetes risk alleles...
  26. pmc Distinguishing persistent insulin autoantibodies with differential risk: nonradioactive bivalent proinsulin/insulin autoantibody assay
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 61:179-86. 2012
    ..We hypothesize that factors related to the mechanism of loss of tolerance leading to diabetes determine high affinity and MSD-IAA reactivity...
  27. pmc Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 110:1021-7. 2002
    ..Thus, the insulin peptides B:9-23 and B:13-23, even when administered subcutaneously in the absence of adjuvant, can induce a dramatic humoral response leading to fatal anaphylaxis in NOD mice...
  28. pmc A report on the International Transglutaminase Autoantibody Workshop for Celiac Disease
    Marcella Li
    University of Colorado Denver, Anshultz Medical Campus, Aurora, CO 80010, USA
    Am J Gastroenterol 104:154-63. 2009
    ..The primary aim of this workshop is to compare TGAA assays among various research and clinical laboratories to examine assay concordance and improve (and eventually standardize) the TGAA assay...
  29. pmc The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, 1775 North Ursula Street, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 104:17040-5. 2007
    ..The combination of bioinformatics and molecular engineering used here will potentially generate other diabetes autoimmunity markers and is also broadly applicable to other autoimmune disorders...
  30. ncbi request reprint Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 89:3896-902. 2004
    ..Predictive value of autoantibodies increases with blinded duplicate and independent sample retesting and incorporation of the level of autoantibody in the predictive algorithm...
  31. pmc Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8
    Mylinh Dang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 186:6056-63. 2011
    ....
  32. pmc Genetic determinants of 21-hydroxylase autoantibodies amongst patients of the Type 1 Diabetes Genetics Consortium
    Peter Baker
    Barbara Davis Center for Childhood Diabetes, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 97:E1573-8. 2012
    ..Screening for 21OH-AA in newly diagnosed T1DM patients is a valuable prognostic tool, made stronger when MHC genotype is considered...
  33. ncbi request reprint Insulin autoimmunity: prediction/precipitation/prevention type 1A diabetes
    George S Eisenbarth
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 140, Denver, CO 80262, USA
    Autoimmun Rev 1:139-45. 2002
    ..An expanding set of resources are now available for the development and testing in man of therapies to prevent type 1 diabetes, and a number of trials utilizing insulin peptides are now underway...
  34. ncbi request reprint Humoral autoimmunity
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Health Sciences Center, Denver, USA
    Adv Exp Med Biol 552:247-67. 2004
  35. pmc Additional autoimmune disease found in 33% of patients at type 1 diabetes onset
    Taylor M Triolo
    Barbara Davis Center for Childhood Diabetes, Aurora, Colorado, USA
    Diabetes Care 34:1211-3. 2011
    ..We sought to define the prevalence of nonislet, organ-specific autoantibodies at diagnosis of type 1 diabetes and to determine the prevalence of comorbid autoimmune diseases...
  36. ncbi request reprint Expression of beta-cell autoimmunity does not differ between potential dizygotic twins and siblings of patients with type 1 diabetes
    Maria J Redondo
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East Ninth Avenue B 140, Denver, CO 80262, USA
    J Autoimmun 23:275-9. 2004
    ....
  37. ncbi request reprint Endocrine and immunogenetic testing in individuals with type 1 diabetes and 21-hydroxylase autoantibodies: Addison's disease in a high-risk population
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 140, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 90:128-34. 2005
    ..1 had AD-free survival of 60% compared with 100% AD-free survival in those who were not homozygous for MICA5.1. Homozygosity for MICA5.1 may increase progression to overt AD among 21-OHAA-positive individuals...
  38. ncbi request reprint Diabetes Prevention Trial 1: prevalence of GAD and ICA512 (IA-2) autoantibodies by relationship to proband
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Ann N Y Acad Sci 958:254-8. 2002
    ..0001). We conclude that the prevalence of anti-islet cell autoantibodies is affected by multiple levels of relationship to the proband...
  39. ncbi request reprint Absence of the T-bet gene coding for the Th1-related transcription factor does not affect diabetes-associated phenotypes in Balb/c mice
    Evie Melanitou
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, Denver, Colorado 80262, USA
    Ann N Y Acad Sci 1005:187-91. 2003
    ..We have therefore investigated whether absence of the T-bet gene influences diabetes-related phenotypes in Balb/c T-bet KO mice...
  40. pmc Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide
    Hiroaki Moriyama
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 99:5539-44. 2002
    ..These first PolyIC/insulin-induced murine models should provide an important tool to study the pathogenesis of type 1 diabetes with experimental autoimmune diabetes...
  41. ncbi request reprint Heterophile antibodies masquerade as interferon-alpha in subjects with new-onset type 1 diabetes
    Theresa Aly
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Diabetes Care 27:1205-6. 2004
  42. pmc Celiac disease and HLA in a Bedouin kindred
    Elise Eller
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Hum Immunol 67:940-50. 2006
    ..0098). There were no other significant results, including the HLA region or any other previously reported regions. This could reflect the reduced power of family-based linkage and association analyses in isolated inbred populations...
  43. ncbi request reprint The second murine autoantibody workshop: remarkable interlaboratory concordance for radiobinding assays to identify insulin autoantibodies in nonobese diabetic mice
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Ann N Y Acad Sci 1005:1-12. 2003
    ..In sum, this workshop continued to support the notion that IAA, as determined by RIA, could provide a sensitive and specific marker of anti-beta cell immunity in NOD mice...
  44. ncbi request reprint Endocrine autoantibodies
    Devasenan Devendra
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B140, Denver, CO 80262, USA
    Clin Lab Med 24:275-303. 2004
    ..The availability of highly sensitive and specific autoantibody assays for the various endocrine disorders can allow physicians to better diagnose and promptly treat these conditions...
  45. ncbi request reprint Anti-dsDNA antibody assay: high specificity and sensitivity with a filtration radioassay in comparison to low specificity with the standard ELISA
    Liping Yu
    Barbara Davis Center for Childhood Diabetes and the Division of Rheumatology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Rheumatol 34:734-9. 2007
    ..To evaluate whether a new fluid-phase filtration radioassay possesses both high sensitivity and specificity compared with the currently used ELISA and Farr assays...
  46. ncbi request reprint ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodies
    Dongmei Miao
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver 80262, USA
    J Autoimmun 18:191-6. 2002
    ....