Jianxin Yu

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Stereoselective synthesis of 1,2:4,5-di-O-isopropylidene-3-C-(5-phenyl-1,2,4-oxadiazol-3-yl)-beta-D-psicopyranose and its X-ray crystallographic analysis
    Jianxin Yu
    Department of Chemistry, Xinjiang University, Wulumqi 830046, China
    Carbohydr Res 338:257-61. 2003
  2. pmc 6-Trifluoromethylpyridoxine: novel (19)F NMR pH indicator for in vivo detection
    Jian Xin Yu
    Advanced Radiological Sciences, Department of Radiology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9058, United States
    J Med Chem 55:6814-21. 2012
  3. ncbi request reprint Stereoselective synthesis, structural characterization, and properties of 1,2-O-isopropylidene-3-C-(5-phenyl-1,2,4-oxadiazol-3-yl)-beta-D-psicopyranose
    Jianxin Yu
    Advanced Radiological Sciences, Department of Radiology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9058, USA
    Bioorg Med Chem 13:353-61. 2005
  4. ncbi request reprint Synthesis and evaluation of a novel gene reporter molecule: detection of beta-galactosidase activity using 19F NMR of a fluorinated vitamin B6 conjugate+
    Jianxin Yu
    Department of Radiology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, 75390 9058, USA
    Med Chem 1:255-62. 2005
  5. ncbi request reprint Imaging beta-galactosidase activity using 19F chemical shift imaging of LacZ gene-reporter molecule 2-fluoro-4-nitrophenol-beta-D-galactopyranoside
    Vikram D Kodibagkar
    Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9058, USA
    Magn Reson Imaging 24:959-62. 2006
  6. ncbi request reprint Synthesis and evaluation of novel enhanced gene reporter molecules: detection of beta-galactosidase activity using 19F NMR of trifluoromethylated aryl beta-D-galactopyranosides
    Jianxin Yu
    Department of Radiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Bioorg Med Chem 14:326-33. 2006
  7. pmc Synthesis and characterization of novel lacZ gene reporter molecules: detection of beta-galactosidase activity by 19F nuclear magnetic resonance of polyglycosylated fluorinated vitamin B6
    Jianxin Yu
    Department of Radiology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9058, USA
    J Med Chem 49:1991-9. 2006
  8. ncbi request reprint Novel NMR platform for detecting gene transfection: synthesis and evaluation of fluorinated phenyl beta-D-galactosides with potential application for assessing LacZ gene expression
    Jianxin Yu
    Department Radiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9058, USA
    Bioconjug Chem 15:1334-41. 2004
  9. ncbi request reprint Novel NMR approach to assessing gene transfection: 4-fluoro-2-nitrophenyl-beta-D-galactopyranoside as a prototype reporter molecule for beta-galactosidase
    Weina Cui
    Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9058, USA
    Magn Reson Med 51:616-20. 2004

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Stereoselective synthesis of 1,2:4,5-di-O-isopropylidene-3-C-(5-phenyl-1,2,4-oxadiazol-3-yl)-beta-D-psicopyranose and its X-ray crystallographic analysis
    Jianxin Yu
    Department of Chemistry, Xinjiang University, Wulumqi 830046, China
    Carbohydr Res 338:257-61. 2003
    ..A possible mechanism is reported. The structure has been determined by spectroscopic data and X-ray crystallographic analysis...
  2. pmc 6-Trifluoromethylpyridoxine: novel (19)F NMR pH indicator for in vivo detection
    Jian Xin Yu
    Advanced Radiological Sciences, Department of Radiology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9058, United States
    J Med Chem 55:6814-21. 2012
    ....
  3. ncbi request reprint Stereoselective synthesis, structural characterization, and properties of 1,2-O-isopropylidene-3-C-(5-phenyl-1,2,4-oxadiazol-3-yl)-beta-D-psicopyranose
    Jianxin Yu
    Advanced Radiological Sciences, Department of Radiology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9058, USA
    Bioorg Med Chem 13:353-61. 2005
    ..A possible mechanism, as well as structural analysis and bioactivity are described...
  4. ncbi request reprint Synthesis and evaluation of a novel gene reporter molecule: detection of beta-galactosidase activity using 19F NMR of a fluorinated vitamin B6 conjugate+
    Jianxin Yu
    Department of Radiology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, 75390 9058, USA
    Med Chem 1:255-62. 2005
    ..00 ppm); (b) minimal toxicity for substrate or aglycone; (c) good water solubility; (d) good blood stability; (e) pH responsiveness of aglycone...
  5. ncbi request reprint Imaging beta-galactosidase activity using 19F chemical shift imaging of LacZ gene-reporter molecule 2-fluoro-4-nitrophenol-beta-D-galactopyranoside
    Vikram D Kodibagkar
    Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9058, USA
    Magn Reson Imaging 24:959-62. 2006
    ..19F CSI studies of enzyme activity and lacZ gene expression in 9L-glioma and MCF7 breast cancer cells are presented, providing further evidence for the utility of OFPNPG as a gene-reporter molecule for future in vivo studies...
  6. ncbi request reprint Synthesis and evaluation of novel enhanced gene reporter molecules: detection of beta-galactosidase activity using 19F NMR of trifluoromethylated aryl beta-D-galactopyranosides
    Jianxin Yu
    Department of Radiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Bioorg Med Chem 14:326-33. 2006
    ..14 ppm) in breast cancer cells transfected to stably express lacZ...
  7. pmc Synthesis and characterization of novel lacZ gene reporter molecules: detection of beta-galactosidase activity by 19F nuclear magnetic resonance of polyglycosylated fluorinated vitamin B6
    Jianxin Yu
    Department of Radiology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9058, USA
    J Med Chem 49:1991-9. 2006
    ..0 approximately 9.4 ppm), minimal toxicity for substrate or aglycon, and good water solubility. However, the differential glycosylation of 12 and 13 appears more advantageous for assessing lacZ gene expression in vivo...
  8. ncbi request reprint Novel NMR platform for detecting gene transfection: synthesis and evaluation of fluorinated phenyl beta-D-galactosides with potential application for assessing LacZ gene expression
    Jianxin Yu
    Department Radiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9058, USA
    Bioconjug Chem 15:1334-41. 2004
    ..This class of molecules presents a new strategy for assaying gene expression with a highly versatile molecular structural platform...
  9. ncbi request reprint Novel NMR approach to assessing gene transfection: 4-fluoro-2-nitrophenyl-beta-D-galactopyranoside as a prototype reporter molecule for beta-galactosidase
    Weina Cui
    Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9058, USA
    Magn Reson Med 51:616-20. 2004
    ..Molecular and 19F NMR characteristics of PFONPG in solution, blood, and prostate tumor cells are presented. This prototype molecule facilitates a novel approach for assaying gene activity in vivo...