Research Topics
Genomes and Genes | Jae Hyuk YuSummaryAffiliation: University of Wisconsin Country: USA Publications
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Detail Information
Publications
A novel regulator couples sporogenesis and trehalose biogenesis in Aspergillus nidulansMin Ni
Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, United States of America
PLoS ONE 2:e970. 2007..VosA is conserved in most fungi and may define a new fungus-specific transcription factor family...
Heterotrimeric G protein signaling and RGSs in Aspergillus nidulansJae Hyuk Yu
Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, WI 53706, USA
J Microbiol 44:145-54. 2006..In particular, their functions in controlling hyphal proliferation, asexual spore formation, sexual fruiting, and the mycotoxin sterigmatocystin production are discussed...- Regulation of secondary metabolism in filamentous fungiJae Hyuk Yu
Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin 53706, USA
Annu Rev Phytopathol 43:437-58. 2005..Particularly, the roles of G protein signaling components and developmental regulators in the mycotoxin sterigmatocystin biosynthesis in the model fungus Aspergillus nidulans are discussed in depth... 
Growth and developmental control in the model and pathogenic aspergilliJae-Hyuk Yu
Department of Food Microbiology and Toxicology and Food Research Institute, University of Wisconsin, Madison, Madison, WI 53706, USA
Eukaryot Cell 5:1577-84. 2006- Double-joint PCR: a PCR-based molecular tool for gene manipulations in filamentous fungiJae Hyuk Yu
Department of Food Microbiology and Toxicology, The University of Wisconsin, Madison, WI 53706, USA
Fungal Genet Biol 41:973-81. 2004..To stream line the analysis of the transformants a relatively simple procedure for genomic DNA or total RNA isolation achieving approximately 100 samples/person/day is also presented... 
FlbC is a putative nuclear C2H2 transcription factor regulating development in Aspergillus nidulansNak Jung Kwon
Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA
Mol Microbiol 77:1203-19. 2010..In summary, FlbC is a putative nuclear transcription factor necessary for proper activation of conidiation, and its balanced activity is crucial for governing growth and development in A. nidulans...- FluG-dependent asexual development in Aspergillus nidulans occurs via derepressionJeong Ah Seo
Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin 53706, USA
Genetics 172:1535-44. 2006..Genetic analyses demonstrated that SfgA functions downstream of FluG but upstream of transcriptional activators (FlbD, FlbC, FlbB, and BrlA) necessary for normal conidiation... - AbaA and WetA govern distinct stages of Aspergillus fumigatus developmentLi Tao
Departments of Bacteriology and Genetics, University of Wisconsin, Madison, WI 53706, USA
Microbiology 157:313-26. 2011..A genetic model depicting the regulation of conidiation in A. fumigatus is proposed... - Multiple roles of a heterotrimeric G-protein gamma-subunit in governing growth and development of Aspergillus nidulansJeong-Ah Seo
Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin 53706, USA
Genetics 171:81-9. 2005..We propose that GpgA is the only A. nidulans G gamma-subunit and is required for normal vegetative growth as well as proper asexual and sexual developmental progression... - Regulators of G-protein signalling in Aspergillus nidulans: RgsA downregulates stress response and stimulates asexual sporulation through attenuation of GanB (Galpha) signallingKap-Hoon Han
Department of Food Microbiology and Toxicology and Food Research Institute, University of Wisconsin, Madison, WI 53706, USA
Mol Microbiol 53:529-40. 2004..Our findings define a second and specific RGS-Galpha pair in A. nidulans, which may govern upstream regulation of fungal cellular responses to environmental changes... - The phosducin-like protein PhnA is required for Gbetagamma-mediated signaling for vegetative growth, developmental control, and toxin biosynthesis in Aspergillus nidulansJeong-Ah Seo
Department of Food Microbiology and Toxicology, Food Research Institute, University of Wisconsin, Madison, WI 53706, USA
Eukaryot Cell 5:400-10. 2006..Potential differential roles of FadA, Gbetagamma, and FlbA in controlling ST biosynthesis are further discussed... - A putative G protein-coupled receptor negatively controls sexual development in Aspergillus nidulansKap-Hoon Han
Department of Food Microbiology and Toxicology and Food Research Institute, Molecular and Environmental Toxicology Center, 1925 Willow Drive, University of Wisconsin, Madison, 53706, USA
Mol Microbiol 51:1333-45. 2004..We propose that the GprD-mediated signalling cascade negatively regulates sexual development, which is required for proper proliferation of A. nidulans... - Upstream and downstream regulation of asexual development in Aspergillus fumigatusJae-Hyung Mah
Department of Food Microbiology and Toxicology and Food Research Institute, University of Wisconsin, Madison, Madison, WI 53706, USA
Eukaryot Cell 5:1585-95. 2006..Finally, both AffluG and AfflbA mutants showed reduced conidiation and delayed expression of AfbrlA in synchronized developmental induction, indicating that these upstream regulators contribute to the proper progression of conidiation... - Characterization of the developmental regulator FlbE in Aspergillus fumigatus and Aspergillus nidulansNak Jung Kwon
Department of Bacteriology and Genetics, University of Wisconsin, Madison, WI 53706, USA
Fungal Genet Biol 47:981-93. 2010..Finally, overexpression of flbD, but not flbB or flbC, restores conidiation in A. nidulans ΔflbE, generally supporting the current genetic model for developmental regulation... - The pkaB gene encoding the secondary protein kinase A catalytic subunit has a synthetic lethal interaction with pkaA and plays overlapping and opposite roles in Aspergillus nidulansMin Ni
Department of Food Microbiology and Toxicology, Food Research Institute, University of Wisconsin, Madison, WI 53706, USA
Eukaryot Cell 4:1465-76. 2005..nidulans... - Genetic control of asexual sporulation in filamentous fungiHee Soo Park
Departments of Bacteriology and Genetics, and Molecular and Environmental Toxicology Center, University of Wisconsin, 1550 Linden Drive, Madison, WI 53706, USA
Curr Opin Microbiol 15:669-77. 2012..Here, we summarize genetic control of conidiation including the light-responding mechanisms in the two model fungi... - The role, interaction and regulation of the velvet regulator VelB in Aspergillus nidulansHee Soo Park
Department of Bacteriology and Genetics, University of Wisconsin, Madison, Wisconsin, USA
PLoS ONE 7:e45935. 2012..In summary, VelB acts as a positive regulator of asexual development and regulates spore maturation, focal trehalose biogenesis and germination by interacting with VosA in A. nidulans... - Multi-Copy Genetic Screen in Aspergillus nidulansHee Soo Park
Molecular and Environmental Toxicology Center, University of Wisconsin Madison, Madison, WI, USA
Methods Mol Biol 944:183-90. 2012..Here, we describe a working protocol for the identification of novel regulators in Aspergillus nidulans... - Suppressor mutations bypass the requirement of fluG for asexual sporulation and sterigmatocystin production in Aspergillus nidulansJeong-Ah Seo
Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin 53706-1187, USA
Genetics 165:1083-93. 2003..The fact that at least four loci are defined by recessive sfg mutations indicates that multiple genes negatively regulate conidiation downstream of fluG and that the activity of fluG is required to remove such repressive effects... - The gprA and gprB genes encode putative G protein-coupled receptors required for self-fertilization in Aspergillus nidulansJeong-Ah Seo
Department of Food Microbiology and Toxicology, Food Research Institute, University of Wisconsin, Madison, WI 53706, USA
Mol Microbiol 53:1611-23. 2004..Deletion of gprA and/or gprB suppressed growth defects caused by DeltagprD, implying that GprA/B function downstream of GprD-mediated negative control of sexual development... - Basic-zipper-type transcription factor FlbB controls asexual development in Aspergillus nidulansOier Etxebeste
University of the Basque Country, Biochemistry II, Manuel de Lardizabal 3, 20018, San Sebastian, Spain
Eukaryot Cell 7:38-48. 2008..We also present evidence that FlbB activation results in the production of a second diffusible signal, acting downstream from the FluG factor, to induce conidiation... - VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolismÖzgür Bayram
Institute of Microbiology and Genetics, Georg August University, D 37077 Gottingen, Germany
Science 320:1504-6. 2008..VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either velB or veA results in defects in both sexual fruiting-body formation and the production of secondary metabolites... - Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatusWilliam C Nierman
The Institute for Genomic Research, Rockville, Maryland 20850, USA
Nature 438:1151-6. 2005..The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus... - The heterotrimeric G-protein GanB(alpha)-SfaD(beta)-GpgA(gamma) is a carbon source sensor involved in early cAMP-dependent germination in Aspergillus nidulansAnne Lafon
, INRA USC2019, Institut Pasteur, Paris, France
Genetics 171:71-80. 2005..Furthermore, GanB may function in sensing various carbon sources and subsequent activation of downstream signaling for germination... - aflT, a MFS transporter-encoding gene located in the aflatoxin gene cluster, does not have a significant role in aflatoxin secretionPerng Kuang Chang
Southern Regional Research Center, Agricultural Research Service, US Department of Agriculture, 1100 Robert E Lee Boulevard, New Orleans, LA 70124, USA
Fungal Genet Biol 41:911-20. 2004..The FadA-dependent G-protein signaling pathway previously shown to govern aflatoxin biosynthesis and sporulation plays a role in the regulation of aflT expression... - G-protein and cAMP-mediated signaling in aspergilli: a genomic perspectiveAnne Lafon
, Institut Pasteur, Paris, France
Fungal Genet Biol 43:490-502. 2006..This may reflect the abilities of these fungi to adapt to various ecological niches and to integrate diverse environmental cues into highly conserved cellular processes...