Jae Hyuk Yu

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc A novel regulator couples sporogenesis and trehalose biogenesis in Aspergillus nidulans
    Min Ni
    Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 2:e970. 2007
  2. pmc Gβ-like CpcB plays a crucial role for growth and development of Aspergillus nidulans and Aspergillus fumigatus
    Qing Kong
    School of Food Science and Engineering, Ocean University of China, Qingdao, Shandong, PR China
    PLoS ONE 8:e70355. 2013
  3. pmc The role, interaction and regulation of the velvet regulator VelB in Aspergillus nidulans
    Hee Soo Park
    Department of Bacteriology and Genetics, University of Wisconsin, Madison, Wisconsin, USA
    PLoS ONE 7:e45935. 2012
  4. pmc The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-κB
    Yasar Luqman Ahmed
    Department of Molecular Structural Biology, Institute of Microbiology and Genetics, Georg August University, Gottingen, Germany
    PLoS Biol 11:e1001750. 2013
  5. ncbi request reprint Upstream regulation of mycotoxin biosynthesis
    Fahad Alkhayyat
    University of Wisconsin Madison, Madison, Wisconsin, USA Electronic address
    Adv Appl Microbiol 86:251-78. 2014
  6. ncbi request reprint Double-joint PCR: a PCR-based molecular tool for gene manipulations in filamentous fungi
    Jae Hyuk Yu
    Department of Food Microbiology and Toxicology, The University of Wisconsin, Madison, WI 53706, USA
    Fungal Genet Biol 41:973-81. 2004
  7. pmc Growth and developmental control in the model and pathogenic aspergilli
    Jae Hyuk Yu
    Department of Food Microbiology and Toxicology and Food Research Institute, University of Wisconsin, Madison, Madison, WI 53706, USA
    Eukaryot Cell 5:1577-84. 2006
  8. ncbi request reprint Regulation of secondary metabolism in filamentous fungi
    Jae Hyuk Yu
    Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Annu Rev Phytopathol 43:437-58. 2005
  9. ncbi request reprint Heterotrimeric G protein signaling and RGSs in Aspergillus nidulans
    Jae Hyuk Yu
    Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, WI 53706, USA
    J Microbiol 44:145-54. 2006
  10. ncbi request reprint Regulators of G-protein signalling in Aspergillus nidulans: RgsA downregulates stress response and stimulates asexual sporulation through attenuation of GanB (Galpha) signalling
    Kap Hoon Han
    Department of Food Microbiology and Toxicology and Food Research Institute, University of Wisconsin, Madison, WI 53706, USA
    Mol Microbiol 53:529-40. 2004

Collaborators

Detail Information

Publications35

  1. pmc A novel regulator couples sporogenesis and trehalose biogenesis in Aspergillus nidulans
    Min Ni
    Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 2:e970. 2007
    ..VosA is conserved in most fungi and may define a new fungus-specific transcription factor family...
  2. pmc Gβ-like CpcB plays a crucial role for growth and development of Aspergillus nidulans and Aspergillus fumigatus
    Qing Kong
    School of Food Science and Engineering, Ocean University of China, Qingdao, Shandong, PR China
    PLoS ONE 8:e70355. 2013
    ..A speculative model summarizing the roles of CpcB in conjunction with SfaD in A. nidulans is presented. ..
  3. pmc The role, interaction and regulation of the velvet regulator VelB in Aspergillus nidulans
    Hee Soo Park
    Department of Bacteriology and Genetics, University of Wisconsin, Madison, Wisconsin, USA
    PLoS ONE 7:e45935. 2012
    ..In summary, VelB acts as a positive regulator of asexual development and regulates spore maturation, focal trehalose biogenesis and germination by interacting with VosA in A. nidulans...
  4. pmc The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-κB
    Yasar Luqman Ahmed
    Department of Molecular Structural Biology, Institute of Microbiology and Genetics, Georg August University, Gottingen, Germany
    PLoS Biol 11:e1001750. 2013
    ..These findings suggest that defence mechanisms of both fungi and animals might be governed by structurally related DNA-binding transcription factors. ..
  5. ncbi request reprint Upstream regulation of mycotoxin biosynthesis
    Fahad Alkhayyat
    University of Wisconsin Madison, Madison, Wisconsin, USA Electronic address
    Adv Appl Microbiol 86:251-78. 2014
    ..This review presents a concise summary of the regulation of mycotoxin biosynthesis, focusing on the roles of the upstream regulatory elements governing biosynthesis of aflatoxin and sterigmatocystin in Aspergillus. ..
  6. ncbi request reprint Double-joint PCR: a PCR-based molecular tool for gene manipulations in filamentous fungi
    Jae Hyuk Yu
    Department of Food Microbiology and Toxicology, The University of Wisconsin, Madison, WI 53706, USA
    Fungal Genet Biol 41:973-81. 2004
    ..To stream line the analysis of the transformants a relatively simple procedure for genomic DNA or total RNA isolation achieving approximately 100 samples/person/day is also presented...
  7. pmc Growth and developmental control in the model and pathogenic aspergilli
    Jae Hyuk Yu
    Department of Food Microbiology and Toxicology and Food Research Institute, University of Wisconsin, Madison, Madison, WI 53706, USA
    Eukaryot Cell 5:1577-84. 2006
  8. ncbi request reprint Regulation of secondary metabolism in filamentous fungi
    Jae Hyuk Yu
    Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Annu Rev Phytopathol 43:437-58. 2005
    ..Particularly, the roles of G protein signaling components and developmental regulators in the mycotoxin sterigmatocystin biosynthesis in the model fungus Aspergillus nidulans are discussed in depth...
  9. ncbi request reprint Heterotrimeric G protein signaling and RGSs in Aspergillus nidulans
    Jae Hyuk Yu
    Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, WI 53706, USA
    J Microbiol 44:145-54. 2006
    ..In particular, their functions in controlling hyphal proliferation, asexual spore formation, sexual fruiting, and the mycotoxin sterigmatocystin production are discussed...
  10. ncbi request reprint Regulators of G-protein signalling in Aspergillus nidulans: RgsA downregulates stress response and stimulates asexual sporulation through attenuation of GanB (Galpha) signalling
    Kap Hoon Han
    Department of Food Microbiology and Toxicology and Food Research Institute, University of Wisconsin, Madison, WI 53706, USA
    Mol Microbiol 53:529-40. 2004
    ..Our findings define a second and specific RGS-Galpha pair in A. nidulans, which may govern upstream regulation of fungal cellular responses to environmental changes...
  11. pmc The phosducin-like protein PhnA is required for Gbetagamma-mediated signaling for vegetative growth, developmental control, and toxin biosynthesis in Aspergillus nidulans
    Jeong Ah Seo
    Department of Food Microbiology and Toxicology, Food Research Institute, University of Wisconsin, Madison, WI 53706, USA
    Eukaryot Cell 5:400-10. 2006
    ..Potential differential roles of FadA, Gbetagamma, and FlbA in controlling ST biosynthesis are further discussed...
  12. pmc LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity
    Ozlem Sarikaya Bayram
    Institute of Microbiology and Genetics, Department of Molecular Microbiology and Genetics, Georg August University, Gottingen, Germany
    PLoS Genet 6:e1001226. 2010
    ..This suggests that LaeA controls Hülle cells. In summary, LaeA plays a dynamic role in fungal morphological and chemical development, and it controls expression, interactions, and modification of the velvet regulators...
  13. pmc Multiple roles of a heterotrimeric G-protein gamma-subunit in governing growth and development of Aspergillus nidulans
    Jeong Ah Seo
    Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 171:81-9. 2005
    ..We propose that GpgA is the only A. nidulans G gamma-subunit and is required for normal vegetative growth as well as proper asexual and sexual developmental progression...
  14. doi request reprint Characterization of the velvet regulators in Aspergillus fumigatus
    Hee Soo Park
    Department of Bacteriology, University of Wisconsin, Madison, WI, USA
    Mol Microbiol 86:937-53. 2012
    ..A model depicting the similar yet different roles of the velvet regulators governing conidiation and sporogenesis in A. fumigatus is presented...
  15. ncbi request reprint A putative G protein-coupled receptor negatively controls sexual development in Aspergillus nidulans
    Kap Hoon Han
    Department of Food Microbiology and Toxicology and Food Research Institute, Molecular and Environmental Toxicology Center, 1925 Willow Drive, University of Wisconsin, Madison, 53706, USA
    Mol Microbiol 51:1333-45. 2004
    ..We propose that the GprD-mediated signalling cascade negatively regulates sexual development, which is required for proper proliferation of A. nidulans...
  16. pmc The putative guanine nucleotide exchange factor RicA mediates upstream signaling for growth and development in Aspergillus
    Nak Jung Kwon
    Departments of Bacteriology and Genetics, University of Wisconsin, Madison, WI, USA
    Eukaryot Cell 11:1399-412. 2012
    ..These findings suggest that the commencement of asexual development requires unknown RicA-mediated signaling input in A. nidulans...
  17. ncbi request reprint VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism
    Özgür Bayram
    Institute of Microbiology and Genetics, Georg August University, D 37077 Gottingen, Germany
    Science 320:1504-6. 2008
    ..VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either velB or veA results in defects in both sexual fruiting-body formation and the production of secondary metabolites...
  18. pmc Upstream and downstream regulation of asexual development in Aspergillus fumigatus
    Jae Hyung Mah
    Department of Food Microbiology and Toxicology and Food Research Institute, University of Wisconsin, Madison, Madison, WI 53706, USA
    Eukaryot Cell 5:1585-95. 2006
    ..Finally, both AffluG and AfflbA mutants showed reduced conidiation and delayed expression of AfbrlA in synchronized developmental induction, indicating that these upstream regulators contribute to the proper progression of conidiation...
  19. pmc The pkaB gene encoding the secondary protein kinase A catalytic subunit has a synthetic lethal interaction with pkaA and plays overlapping and opposite roles in Aspergillus nidulans
    Min Ni
    Department of Food Microbiology and Toxicology, Food Research Institute, University of Wisconsin, Madison, WI 53706, USA
    Eukaryot Cell 4:1465-76. 2005
    ..nidulans...
  20. doi request reprint FlbC is a putative nuclear C2H2 transcription factor regulating development in Aspergillus nidulans
    Nak Jung Kwon
    Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA
    Mol Microbiol 77:1203-19. 2010
    ..In summary, FlbC is a putative nuclear transcription factor necessary for proper activation of conidiation, and its balanced activity is crucial for governing growth and development in A. nidulans...
  21. ncbi request reprint The gprA and gprB genes encode putative G protein-coupled receptors required for self-fertilization in Aspergillus nidulans
    Jeong Ah Seo
    Department of Food Microbiology and Toxicology, Food Research Institute, University of Wisconsin, Madison, WI 53706, USA
    Mol Microbiol 53:1611-23. 2004
    ..Deletion of gprA and/or gprB suppressed growth defects caused by DeltagprD, implying that GprA/B function downstream of GprD-mediated negative control of sexual development...
  22. pmc Suppressor mutations bypass the requirement of fluG for asexual sporulation and sterigmatocystin production in Aspergillus nidulans
    Jeong Ah Seo
    Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin 53706 1187, USA
    Genetics 165:1083-93. 2003
    ..The fact that at least four loci are defined by recessive sfg mutations indicates that multiple genes negatively regulate conidiation downstream of fluG and that the activity of fluG is required to remove such repressive effects...
  23. doi request reprint AbaA and WetA govern distinct stages of Aspergillus fumigatus development
    Li Tao
    Departments of Bacteriology and Genetics, University of Wisconsin, Madison, WI 53706, USA
    Microbiology 157:313-26. 2011
    ..A genetic model depicting the regulation of conidiation in A. fumigatus is proposed...
  24. doi request reprint Characterization of the developmental regulator FlbE in Aspergillus fumigatus and Aspergillus nidulans
    Nak Jung Kwon
    Department of Bacteriology and Genetics, University of Wisconsin, Madison, WI 53706, USA
    Fungal Genet Biol 47:981-93. 2010
    ..Finally, overexpression of flbD, but not flbB or flbC, restores conidiation in A. nidulans ΔflbE, generally supporting the current genetic model for developmental regulation...
  25. pmc FluG-dependent asexual development in Aspergillus nidulans occurs via derepression
    Jeong Ah Seo
    Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 172:1535-44. 2006
    ..Genetic analyses demonstrated that SfgA functions downstream of FluG but upstream of transcriptional activators (FlbD, FlbC, FlbB, and BrlA) necessary for normal conidiation...
  26. ncbi request reprint VelC positively controls sexual development in Aspergillus nidulans
    Hee Soo Park
    Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 9:e89883. 2014
    ....
  27. doi request reprint Genetic control of asexual sporulation in filamentous fungi
    Hee Soo Park
    Departments of Bacteriology and Genetics, and Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI 53706, USA
    Curr Opin Microbiol 15:669-77. 2012
    ..Here, we summarize genetic control of conidiation including the light-responding mechanisms in the two model fungi...
  28. ncbi request reprint NsdD is a key repressor of asexual development in Aspergillus nidulans
    Mi Kyung Lee
    Departments of Bacteriology and Genetics, University of Wisconsin, Madison, Wisconsin 53706
    Genetics 197:159-73. 2014
    ..Collectively, NsdD is a key negative regulator of conidiation and likely exerts its repressive role via downregulating brlA. ..
  29. doi request reprint Multi-copy genetic screen in Aspergillus nidulans
    Hee Soo Park
    Molecular and Environmental Toxicology Center, University of Wisconsin Madison, Madison, WI, USA
    Methods Mol Biol 944:183-90. 2012
    ..Here, we describe a working protocol for the identification of novel regulators in Aspergillus nidulans...
  30. ncbi request reprint G-protein and cAMP-mediated signaling in aspergilli: a genomic perspective
    Anne Lafon
    Unité Postulante Biologie et Pathogénicité Fongiques INRA USC 2019, Institut Pasteur, Paris, France
    Fungal Genet Biol 43:490-502. 2006
    ..This may reflect the abilities of these fungi to adapt to various ecological niches and to integrate diverse environmental cues into highly conserved cellular processes...
  31. ncbi request reprint Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
    William C Nierman
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    Nature 438:1151-6. 2005
    ..The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus...
  32. pmc The heterotrimeric G-protein GanB(alpha)-SfaD(beta)-GpgA(gamma) is a carbon source sensor involved in early cAMP-dependent germination in Aspergillus nidulans
    Anne Lafon
    Unité Postulante Biologie et Pathogénicité Fongiques, INRA USC2019, Institut Pasteur, Paris, France
    Genetics 171:71-80. 2005
    ..Furthermore, GanB may function in sensing various carbon sources and subsequent activation of downstream signaling for germination...
  33. ncbi request reprint aflT, a MFS transporter-encoding gene located in the aflatoxin gene cluster, does not have a significant role in aflatoxin secretion
    Perng Kuang Chang
    Southern Regional Research Center, Agricultural Research Service, US Department of Agriculture, 1100 Robert E Lee Boulevard, New Orleans, LA 70124, USA
    Fungal Genet Biol 41:911-20. 2004
    ..The FadA-dependent G-protein signaling pathway previously shown to govern aflatoxin biosynthesis and sporulation plays a role in the regulation of aflT expression...
  34. pmc Basic-zipper-type transcription factor FlbB controls asexual development in Aspergillus nidulans
    Oier Etxebeste
    University of the Basque Country, Biochemistry II, Manuel de Lardizabal 3, 20018, San Sebastian, Spain
    Eukaryot Cell 7:38-48. 2008
    ..We also present evidence that FlbB activation results in the production of a second diffusible signal, acting downstream from the FluG factor, to induce conidiation...