Research Topics
Genomes and Genes
| Hongtao YuSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
The Smc complexes in DNA damage responseNan Wu
Department of Pharmacology, Howard Hughes Medical Institute, 6001 Forest Park Road, Dallas, TX 75390, USA
Cell Biosci 2:5. 2012....
Bub1 multitasking in mitosisHongtao Yu
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Cell Cycle 4:262-5. 2005..Therefore, Bub1 performs multiple tasks in mitosis that ensure the proper inheritance of chromosomes...- Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template modelHongtao Yu
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
J Cell Biol 173:153-7. 2006..I review the recent structural, biochemical, and cell biological data on Mad2, discuss the differences between the two models, and propose experiments that test their key principles... - Chk1: a double agent in cell cycle checkpointsHongtao Yu
Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA
Dev Cell 12:167-8. 2007..In this issue of Developmental Cell, Zachos et al.(2007) present evidence to indicate that Chk1 also plays a critical role in the spindle checkpoint, suggesting an interplay between the DNA damage and spindle checkpoints... - Cdc20: a WD40 activator for a cell cycle degradation machineHongtao Yu
Department of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390 9041, USA
Mol Cell 27:3-16. 2007..This review summarizes recent progress toward the understanding of the functions of Cdc20, the mechanisms by which it activates APC/C, and its regulation by phosphorylation and by association with its binding proteins... - PP2A as a mercenary for warring kinases in the eggHongtao Yu
Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA
Proc Natl Acad Sci U S A 104:17245-6. 2007 - Regulation of APC-Cdc20 by the spindle checkpointHongtao Yu
Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9041, USA
Curr Opin Cell Biol 14:706-14. 2002..Therefore, the checkpoint proteins form a complex intracellular signalling network to inhibit the anaphase-promoting complex... - Tango between ubiquitin ligase and deubiquitinase keeps cyclin A tag freeHongtao Yu
Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA
Mol Cell 42:409-10. 2011..In this issue of Molecular Cell, Huang et al. (2011) provide a counterintuitive example of a USP residing in an E3 complex, and establish Usp37 as a gatekeeper of APC/C-mediated ubiquitination of cyclin A... - Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimerMaojun Yang
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
PLoS Biol 6:e50. 2008..Collectively, our results establish the existence of a symmetric Mad2 dimer and provide insights into Mad1-assisted conformational activation of Mad2 in the spindle checkpoint... - p31comet blocks Mad2 activation through structural mimicryMaojun Yang
Department of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA
Cell 131:744-55. 2007..p31(comet) adopts a fold strikingly similar to that of Mad2 and binds at the dimerization interface of Mad2. Thus, p31(comet) exploits the two-state behavior of Mad2 to block its activation by acting as an "anti-Mad2.".. - Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1Wei Qi
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
Mol Biol Cell 17:3705-16. 2006..Our results suggest that phosphorylation of Bub1 at T609 by Cdk1 creates a docking site for the PBD of Plk1 and facilitates the kinetochore recruitment of Plk1... - Human MMS21/NSE2 is a SUMO ligase required for DNA repairPatrick Ryan Potts
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, 75390 9041, USA
Mol Cell Biol 25:7021-32. 2005..Our findings suggest that the human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells... - Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transitionSoonjoung Kim
Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390 9041, USA
Proc Natl Acad Sci U S A 107:19772-7. 2010..Our results indicate that Mad2 phosphorylation inhibits its function through differentially regulating its binding to Mad1 and Cdc20 and establish that the conformational change of Mad2 is regulated by posttranslational mechanisms... - Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cellsJungseog Kang
Department of Pharmacology, Howard Hughes Medical Institute, USA
Mol Biol Cell 22:1181-90. 2011.... - Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpointGuohong Xia
Department of Pharmacology, The University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
EMBO J 23:3133-43. 2004..Therefore, our results suggest that p31(comet) counteracts the function of Mad2 and is required for the silencing of the spindle checkpoint... - Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31(comet)Luying Jia
Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Mol Biol Cell 22:4227-35. 2011..Thus both p31(comet) and ubiquitination of Cdc20 are critical mechanisms of checkpoint inactivation. They act redundantly to promote Mad2 dissociation from Cdc20... - PP2A is required for centromeric localization of Sgo1 and proper chromosome segregationZhanyun Tang
Department of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, USA
Dev Cell 10:575-85. 2006..Our findings suggest that Bub1 targets PP2A to centromeres, which in turn maintains Sgo1 at centromeres by counteracting Plk1-mediated chromosome removal of Sgo1... - Structure and substrate recruitment of the human spindle checkpoint kinase Bub1Jungseog Kang
Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA
Mol Cell 32:394-405. 2008..The KEN boxes of Bub1 are required for the spindle checkpoint in human cells. Therefore, its unusual active-site conformation and mode of substrate recruitment suggest that Bub1 has an exquisitely tuned specificity for Cdc20... - Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosisHong Liu
Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, USA
Nat Cell Biol 15:40-9. 2013..PP2A-orchestrated, site-selective dephosphorylation of cohesin and its regulators underlies centromeric cohesion protection... - Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting WaplNan Wu
Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Genes Dev 26:1473-85. 2012..We propose that Scc1 sumoylation by Mms21 promotes SCR by antagonizing Wapl at a step after cohesin loading at DSBs and in a way not solely dependent on Smc3 acetylation... - Kinase signaling in the spindle checkpointJungseog Kang
Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 284:15359-63. 2009..Increasing evidence also indicates that the checkpoint kinases not only help to generate the wait anaphase signal but also actively correct kinetochore-microtubule attachment defects... - Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosisZhanyun Tang
Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9041, USA
Proc Natl Acad Sci U S A 101:18012-7. 2004..Bub1 maintains the steady-state levels and centromeric localization of Sgo1. Therefore, Bub1 protects centromeric cohesion through Shugoshin in mitosis... - Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpointZhanyun Tang
Department of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Mol Cell 16:387-97. 2004..We speculate that inhibition of APC/C(Cdc20) by Bub1 in a catalytic fashion may partly account for the exquisite sensitivity of the spindle checkpoint... - The Mad2 spindle checkpoint protein has two distinct natively folded statesXuelian Luo
Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Nat Struct Mol Biol 11:338-45. 2004..Our results suggest that the unusual two-state behavior of Mad2 is critical for spindle checkpoint signaling... - ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingersChristian B Gocke
Howard Hughes Medical Institute, Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
PLoS ONE 3:e3255. 2008.... - PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolutionYuwen Ke
Deparment of Pharmacology, Howard Hughes Medical Institute, Dallas, TX, USA
EMBO J 30:3309-21. 2011.... - Multiple anaphase-promoting complex/cyclosome degrons mediate the degradation of human Sgo1Zemfira Karamysheva
Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, 75390, USA
J Biol Chem 284:1772-80. 2009..Finally, we show that the spindle checkpoint kinase Bub1 contributes to the maintenance of Sgo1 steady-state protein levels in an APC/C-independent mechanism... - Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaksPatrick Ryan Potts
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
EMBO J 25:3377-88. 2006..Our results establish a mechanism by which the hSMC5/6 complex promotes DNA repair and suggest a novel strategy to improve the efficiency of gene targeting in mammalian somatic cells... - Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligasesEngin Ozkan
Department of Biochemistry and Pharmacology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 102:18890-5. 2005..Our studies reveal structural determinants for communication between distal functional sites of E2s and suggest that RING-type E3s activate E2s allosterically... - Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targetingSoonjoung Kim
Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 109:6549-54. 2012..Our results indicate that CTD is a part of an extensive kinetochore-binding interface of Mad1, and rationalize graded kinetochore targeting of Mad1 during checkpoint signaling... - Purification and assay of Mad2: a two-state inhibitor of anaphase-promoting complex/cyclosomeXuelian Luo
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
Methods Enzymol 398:246-55. 2005..This article describes methods for the purification of the two Mad2 conformers and for the analysis of their activities in APC/C inhibition in Xenopus egg extracts... - Identification of two novel components of the human NDC80 kinetochore complexRajnish Bharadwaj
Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Biol Chem 279:13076-85. 2004..Thus, hSPC25 is an essential kinetochore component that plays a significant role in proper execution of mitotic events... - Structural analysis of human Cdc20 supports multisite degron recognition by APC/CWei Tian
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 109:18419-24. 2012..We propose that low-cooperativity, multisite target recognition enables APC/C to robustly ubiquitinate diverse substrates and helps to drive cell cycle oscillations... - Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activityJungseog Kang
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
BMC Biochem 7:5. 2006..The myocyte enhancer factor 2 (MEF2) family of transcription factors plays an important role in regulating gene expression during myogenesis and has been recently shown to be sumoylated... - The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteinsPatrick Ryan Potts
Department of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390 9041, USA
Nat Struct Mol Biol 14:581-90. 2007..Thus, the SMC5/6 complex facilitates telomere HR and elongation in ALT cells by promoting APB formation through SUMOylation of telomere-binding proteins... - Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylaseMaojun Yang
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Mol Cell 23:377-87. 2006..This spatially separated, multivalent nucleosome binding mode may apply to other chromatin-modifying enzymes that generally contain multiple nucleosome binding modules... - Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpointJungseog Kang
Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390 9041, USA
Proc Natl Acad Sci U S A 104:20232-7. 2007..We speculate that the kinetochore localization of Mps1 raises its local concentration, leading to its activation during mitosis through more efficient trans autophosphorylation... - KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosomeWei Qi
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
J Biol Chem 282:3672-9. 2007..Nevertheless, our study clearly demonstrates that Bub1, an APC/C inhibitor, is also an APC/C substrate. The antagonistic relationship between Bub1 and APC/C may help to prevent the premature accumulation of Bub1 during G1... - Structural basis of histone demethylation by LSD1 revealed by suicide inactivationMaojun Yang
Department of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, USA
Nat Struct Mol Biol 14:535-9. 2007..The unusual backbone conformation of LSD1-bound H3 suggests a strategy for designing potent LSD1 inhibitors with therapeutic potential... - Protein metamorphosis: the two-state behavior of Mad2Xuelian Luo
Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA
Structure 16:1616-25. 2008..This review summarizes recent structural and biochemical studies on the two-state behavior of Mad2 and discusses the generality and implications of structural malleability of proteins... - Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamineMaojun Yang
Departments of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, USA
Biochemistry 46:8058-65. 2007..This study thus provides the basis for designing more potent inhibitors of LSD1 that contain substitutions on the phenyl ring of PCPA to fully engage neighboring residues... - Mutual regulation between the spindle checkpoint and APC/CSoonjoung Kim
Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States
Semin Cell Dev Biol 22:551-8. 2011.... - Functional analysis of the spindle-checkpoint proteins using an in vitro ubiquitination assayZhanyun Tang
Department of Pharmacology, UT Southwestern Medical Center, Dallas, USA
Methods Mol Biol 281:227-42. 2004..This assay is extremely useful in dissecting the biochemical functions of various spindle-checkpoint proteins... - Systematic identification and analysis of mammalian small ubiquitin-like modifier substratesChristian B Gocke
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 280:5004-12. 2005..Therefore, sumoylation appears to regulate the functions of its substrates through multiple, context-dependent mechanisms... 
Identification of SUMO targets through in vitro expression cloningChristian B Gocke
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
Methods Mol Biol 497:51-61. 2009..IVEC allows for immediate validation and analysis of substrates through in vitro reconstitution. Furthermore, this method can be easily adapted to identify substrates of specific SUMO ligases...- Mitosis: short-circuiting spindle checkpoint signalingXuelian Luo
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Curr Biol 22:R128-30. 2012..Using clever genetic experiments in the budding yeast, Lau and Murray define the endpoint of checkpoint signaling and provide key mechanistic insights into checkpoint inhibition of APC/C... - Cohesin: a multi-purpose chromatin glueLaura A Diaz-Martinez
Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Mol Cell Biol 1:58-60. 2009..Recent discoveries point to cohesin having a role in transcription regulation by mediating long-distance intra-chromosomal interactions... - Crm1-mediated nuclear export of Cdc14 is required for the completion of cytokinesis in budding yeastJoshua Bembenek
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Cell Cycle 4:961-71. 2005..Our results suggest a requirement for Crm1p-dependent nuclear export of Cdc14p in coordinating mitotic exit and cytokinesis in budding yeast... - The spindle checkpoint, aneuploidy, and cancerRajnish Bharadwaj
Department of Pharmacology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9041, USA
Oncogene 23:2016-27. 2004..We review recent progress toward the understanding of the molecular mechanism of the spindle checkpoint and its role in guarding genome integrity at the chromosome level... - The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20Xuelian Luo
Department of Biochemistry, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Mol Cell 9:59-71. 2002..Our data suggest that, upon checkpoint activation, Mad1 recruits Mad2 to unattached kinetochores and may promote binding of Mad2 to Cdc20... - Nucleoporin levels regulate cell cycle progression and phase-specific gene expressionPapia Chakraborty
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Dev Cell 15:657-67. 2008..Thus, Nup96 levels regulate differential gene expression in a phase-specific manner, setting the stage for proper cell cycle progression... - FWD1-mediated degradation of FREQUENCY in Neurospora establishes a conserved mechanism for circadian clock regulationQun He
Department of Physiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
EMBO J 22:4421-30. 2003.... - ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasomeChang-Wei Liu
Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Mol Cell 24:39-50. 2006..These results indicate that 26S proteasome-catalyzed degradation of polyubiquitylated proteins involves mechanistic coupling of several processes and that such coupling imposes an energy requirement not apparent for any isolated process... - Regulation of CDC14: pathways and checkpoints of mitotic exitJoshua Bembenek
Department of Pharmacology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9041, USA
Front Biosci 8:d1275-87. 2003..We review recent discoveries in several model systems that have shed light on the function of Cdc14 and propose a general framework within which Cdc14 plays conserved roles in regulating the exit from mitosis and cytokinesis... - Structural insights into histone lysine demethylationHaifeng Hou
Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA
Curr Opin Struct Biol 20:739-48. 2010..Here, we review these exciting advances in the structure biology of histone demethylases and discuss the general principles applicable to other histone-modifying enzymes... - Cdh1 Is a HECT of an ActivatorLuying Jia
Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA
Mol Cell 44:681-3. 2011..In this issue of Molecular Cell, Wan et al. (2011) report an APC/C-independent role of Cdh1 during development as an activator for Smurf1, a HECT-type ubiquitin ligase... - Kinetic and mechanistic studies of a cell cycle protein phosphatase Cdc14Wei-Qing Wang
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Biol Chem 279:30459-68. 2004..We also identified several residues including Asp50, Asp129, Glu168, Glu171, and Asp177 in the Cdc14 active site cleft that are required for efficient dephosphorylation of hCdh1... - A novel motif governs APC-dependent degradation of Drosophila ORC1 in vivoMarito Araki
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Genes Dev 19:2458-65. 2005.... - A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpointRui Hong Wang
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:17108-13. 2004..These data reveal a role of BRCA1 in maintaining genome integrity by interplaying with p53 and genes that are involved in the spindle checkpoint and apoptosis... - Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregationYoung H Kang
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Mol Cell 24:409-22. 2006..Thus, Plk1 self-regulates the Plk1-PBIP1 interaction to timely localize to the kinetochores and promote proper chromosome segregation... - Two distinct pathways for inhibiting pds1 ubiquitination in response to DNA damageRitu Agarwal
Laboratory of Molecular and Cellular Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 278:45027-33. 2003..Finally, we show that once the DNA damage is repaired, Pds1 dephosphorylation is involved in the recovery from the checkpoint induced cell cycle arrest... - HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of scheduleBaoying Liu
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Proc Natl Acad Sci U S A 102:63-8. 2005..Unscheduled activation of APC(Cdc20) by Tax provides an explanation for the mitotic abnormalities in HTLV-I-infected cells and is likely to play an important role in the development of adult T cell leukemia... - Degradation of origin recognition complex large subunit by the anaphase-promoting complex in DrosophilaMarito Araki
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
EMBO J 22:6115-26. 2003..These observations suggest that in Drosophila, ORC1 regulates origin utilization much as does Cdc6 in budding yeast...
Research Grants
- Regulation of the Anaphase-Promoting Complex by the Spindle CheckpointHongtao Yu; Fiscal Year: 2009..Experiments in this proposal will shed light on the molecular basis of the spindle checkpoint, which might eventually lead to new strategies to treat human cancers. ..
- Protection of Centromeric Cohesion by Bub1 and Sgo1Hongtao Yu; Fiscal Year: 2010....
- Protection of Centromeric Cohesion by Bub1 and Sgo1Hongtao Yu; Fiscal Year: 2009..abstract_text> ..
- Regulation of the Anaphase-Promoting Complex by the Spindle CheckpointHongtao Yu; Fiscal Year: 2009..Experiments in this proposal will shed light on the molecular basis of the spindle checkpoint, which might eventually lead to new strategies to treat human cancers. ..
- Protection of Centromeric Cohesion by Bub1 and Sgo1Hongtao Yu; Fiscal Year: 2007....
- Regulation of the Anaphase-Promoting ComplexHongtao Yu; Fiscal Year: 2005..Research on the regulation of APCcdh1 will provide insights into how the mitotic checkpoint halts the cell cycle and present novel molecular targets for the design of agents that interfere with this pathway. ..
- Regulation of the Anaphase-Promoting Complex by the Spindle CheckpointHongtao Yu; Fiscal Year: 2010..Experiments in this proposal will shed light on the molecular basis of the spindle checkpoint, which might eventually lead to new strategies to treat human cancers. ..