Research Topics
| Guoqiang YuSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
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Detail Information
Publications
Frequency-domain multiplexing system for in vivo diffuse light measurements of rapid cerebral hemodynamicsGuoqiang Yu
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Appl Opt 42:2931-9. 2003..We evaluate the performance of the instrument with tissue phantoms, and then employ the system to measure in vivo cerebral blood oxygenation during forepaw stimulation of a rat's brain...- Real-time in situ monitoring of human prostate photodynamic therapy with diffuse lightGuoqiang Yu
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA
Photochem Photobiol 82:1279-84. 2006.... - Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopiesGuoqiang Yu
University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 10:024027. 2005..The instrument thus provides a method for evaluation of microcirculation and muscle metabolism in patients with vascular diseases... - Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacyGuoqiang Yu
Department of Physics and Astronomy, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Clin Cancer Res 11:3543-52. 2005..To monitor tumor blood flow noninvasively during photodynamic therapy (PDT) and to correlate flow responses with therapeutic efficacy... 
Direct measurement of tissue blood flow and metabolism with diffuse opticsRickson C Mesquita
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
Philos Trans A Math Phys Eng Sci 369:4390-406. 2011....- Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activationTurgut Durduran
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Opt Lett 29:1766-8. 2004..The feasibility for noninvasive optical measurement of blood flow through the skull of an adult brain is thus demonstrated, and the clinical potential of this hybrid, all-optical noninvasive, methodology can now be explored... - Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adultsMeeri N Kim
Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104, USA
Neurocrit Care 12:173-80. 2010.... - Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapyTheresa M Busch
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, B13 Anatomy and Chemistry, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
Photochem Photobiol Sci 8:1683-93. 2009..This research suggests that the benefits of low-fluence-rate PDT are mediated in part by a reduction in intratumor heterogeneity in hypoxic, vascular and cytotoxic responses... - Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injuryChao Zhou
University of Pennsylvania, Department of Physics, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 14:034015. 2009..In total, the investigation corraborates potential of the optical methods for bedside monitoring of pediatric and adult human patients in the neurointensive care unit... - Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapyChao Zhou
University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 12:051903. 2007..The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms... - Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetryTurgut Durduran
Departments of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
J Cereb Blood Flow Metab 24:518-25. 2004.... - Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patientsTurgut Durduran
Departments of Radiology, University of Pennsylvania, PA, USA
Opt Express 17:3884-902. 2009..Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere... - Diffuse optical measurement of blood flow in breast tumorsTurgut Durduran
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Opt Lett 30:2915-7. 2005..Increased blood flow was observed in tumor regions relative to healthy tissue, and control subjects did not exhibit significant blood flow heterogeneity. The measurements introduce a new optical contrast for diffuse optical mammography... - Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasoundErin M Buckley
Department of Physics and Astronomy, University of Pennsylvania, 209 S 33rd St, Philadelphia, PA 19104, USA
Opt Express 17:12571-81. 2009.... - Increasing damage to tumor blood vessels during motexafin lutetium-PDT through use of low fluence rateTheresa M Busch
Department of Radiation Oncology, School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania 19104, USA
Radiat Res 174:331-40. 2010..Further study of low fluence rate as a means to improve responses to PDT under conditions designed to predominantly damage vasculature is warranted... - Acute functional recovery of cerebral blood flow after forebrain ischemia in ratChao Zhou
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Cereb Blood Flow Metab 28:1275-84. 2008..4+/-0.2 secs before ischemia to 3.6+/-0.1 secs at 20 mins into reperfusion (P<0.001); the delay was reduced gradually to 2.9+/-0.2 secs after 3 h, which was still significantly greater than that observed before the insult (P=0.04)... - Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot studyUlas Sunar
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6396, USA
J Biomed Opt 11:064021. 2006..0+/-8.1) [microM] at the end of the fourth week of therapy. These preliminary results suggest daily diffuse-optics-based therapy monitoring is feasible during the first two weeks and may have clinical promise... - Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defectsTurgut Durduran
ICFO Institut de Ciencies Fotoniques, Av Canal Olimpic s n, Castelldefels 08860, Spain
J Biomed Opt 15:037004. 2010..7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population... - Tumor vascular microenvironment determines responsiveness to photodynamic therapyAmanda L Maas
Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Res 72:2079-88. 2012..The vascular basement membrane is thus identified to be a determinant of therapeutic outcome in PDT of tumors... - Transabdominal near infrared oximetry of hypoxic stress in fetal sheep brain in uteroRegine Choe
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 100:12950-4. 2003..Fetal hypoxia was detected. Good agreement was found between fetal blood saturation determined by the transabdominal NIR method and arterial and venous fetal blood saturation quantified from fetal blood samples by using a hemoximeter... - Surface property and in vitro biodegradation of microspheres fabricated by poly(epsilon-caprolactone-b-ethylene oxide) diblock copolymersGuoqiang Yu
CAS Key Laboratory of Engineering Plastics, Joint Laboratory of Polymer Sciences and Materials, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China
J Biomed Mater Res A 84:926-39. 2008..These microspheres with controllable surface morphology and amino functional groups are expected to be promising alternatives for the further biomimetic modification to promote cell growth on materials...
Research Grants
- Assessment of Muscle Vascular Disease with Diffuse LightGuoqiang Yu; Fiscal Year: 2007..The proposed, noninvasive, portable, and inexpensive optical technology may fill in this gap by providing multiple hemodynamic information and by enabling continuous measurements at the bed-side and in ambulatory care. ..
- Assessment of Muscle Vascular Disease with Diffuse LightGuoqiang Yu; Fiscal Year: 2007..The proposed, non- invasive, portable, and inexpensive optical technology may fill in this gap by providing multiple hemodynamic information and by enabling continuous measurements at the bed-side and in.ambulatory care. ..