Guoqiang Yu

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Frequency-domain multiplexing system for in vivo diffuse light measurements of rapid cerebral hemodynamics
    Guoqiang Yu
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Appl Opt 42:2931-9. 2003
  2. ncbi request reprint Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy
    Guoqiang Yu
    Department of Physics and Astronomy, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 11:3543-52. 2005
  3. ncbi request reprint Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies
    Guoqiang Yu
    University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 10:024027. 2005
  4. ncbi request reprint Real-time in situ monitoring of human prostate photodynamic therapy with diffuse light
    Guoqiang Yu
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA
    Photochem Photobiol 82:1279-84. 2006
  5. pmc Direct measurement of tissue blood flow and metabolism with diffuse optics
    Rickson C Mesquita
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
    Philos Transact A Math Phys Eng Sci 369:4390-406. 2011
  6. pmc Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults
    Meeri N Kim
    Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104, USA
    Neurocrit Care 12:173-80. 2010
  7. ncbi request reprint Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation
    Turgut Durduran
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Opt Lett 29:1766-8. 2004
  8. pmc Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapy
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, B13 Anatomy and Chemistry, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
    Photochem Photobiol Sci 8:1683-93. 2009
  9. ncbi request reprint Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry
    Turgut Durduran
    Departments of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cereb Blood Flow Metab 24:518-25. 2004
  10. pmc Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury
    Chao Zhou
    University of Pennsylvania, Department of Physics, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 14:034015. 2009

Research Grants

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Frequency-domain multiplexing system for in vivo diffuse light measurements of rapid cerebral hemodynamics
    Guoqiang Yu
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Appl Opt 42:2931-9. 2003
    ..We evaluate the performance of the instrument with tissue phantoms, and then employ the system to measure in vivo cerebral blood oxygenation during forepaw stimulation of a rat's brain...
  2. ncbi request reprint Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy
    Guoqiang Yu
    Department of Physics and Astronomy, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 11:3543-52. 2005
    ..To monitor tumor blood flow noninvasively during photodynamic therapy (PDT) and to correlate flow responses with therapeutic efficacy...
  3. ncbi request reprint Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies
    Guoqiang Yu
    University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 10:024027. 2005
    ..The instrument thus provides a method for evaluation of microcirculation and muscle metabolism in patients with vascular diseases...
  4. ncbi request reprint Real-time in situ monitoring of human prostate photodynamic therapy with diffuse light
    Guoqiang Yu
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA
    Photochem Photobiol 82:1279-84. 2006
    ....
  5. pmc Direct measurement of tissue blood flow and metabolism with diffuse optics
    Rickson C Mesquita
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
    Philos Transact A Math Phys Eng Sci 369:4390-406. 2011
    ....
  6. pmc Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults
    Meeri N Kim
    Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104, USA
    Neurocrit Care 12:173-80. 2010
    ....
  7. ncbi request reprint Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation
    Turgut Durduran
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Opt Lett 29:1766-8. 2004
    ..The feasibility for noninvasive optical measurement of blood flow through the skull of an adult brain is thus demonstrated, and the clinical potential of this hybrid, all-optical noninvasive, methodology can now be explored...
  8. pmc Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapy
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, B13 Anatomy and Chemistry, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
    Photochem Photobiol Sci 8:1683-93. 2009
    ..This research suggests that the benefits of low-fluence-rate PDT are mediated in part by a reduction in intratumor heterogeneity in hypoxic, vascular and cytotoxic responses...
  9. ncbi request reprint Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry
    Turgut Durduran
    Departments of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cereb Blood Flow Metab 24:518-25. 2004
    ....
  10. pmc Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury
    Chao Zhou
    University of Pennsylvania, Department of Physics, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 14:034015. 2009
    ..In total, the investigation corraborates potential of the optical methods for bedside monitoring of pediatric and adult human patients in the neurointensive care unit...
  11. ncbi request reprint Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy
    Chao Zhou
    University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 12:051903. 2007
    ..The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms...
  12. pmc Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients
    Turgut Durduran
    Departments of Radiology, University of Pennsylvania, PA, USA
    Opt Express 17:3884-902. 2009
    ..Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere...
  13. pmc Acute functional recovery of cerebral blood flow after forebrain ischemia in rat
    Chao Zhou
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Cereb Blood Flow Metab 28:1275-84. 2008
    ..4+/-0.2 secs before ischemia to 3.6+/-0.1 secs at 20 mins into reperfusion (P<0.001); the delay was reduced gradually to 2.9+/-0.2 secs after 3 h, which was still significantly greater than that observed before the insult (P=0.04)...
  14. pmc Increasing damage to tumor blood vessels during motexafin lutetium-PDT through use of low fluence rate
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania 19104, USA
    Radiat Res 174:331-40. 2010
    ..Further study of low fluence rate as a means to improve responses to PDT under conditions designed to predominantly damage vasculature is warranted...
  15. pmc Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound
    Erin M Buckley
    Department of Physics and Astronomy, University of Pennsylvania, 209 S 33rd St, Philadelphia, PA 19104, USA
    Opt Express 17:12571-81. 2009
    ....
  16. ncbi request reprint Diffuse optical measurement of blood flow in breast tumors
    Turgut Durduran
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Opt Lett 30:2915-7. 2005
    ..Increased blood flow was observed in tumor regions relative to healthy tissue, and control subjects did not exhibit significant blood flow heterogeneity. The measurements introduce a new optical contrast for diffuse optical mammography...
  17. ncbi request reprint Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study
    Ulas Sunar
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6396, USA
    J Biomed Opt 11:064021. 2006
    ..0+/-8.1) [microM] at the end of the fourth week of therapy. These preliminary results suggest daily diffuse-optics-based therapy monitoring is feasible during the first two weeks and may have clinical promise...
  18. pmc Diffuse optical characterization of an exercising patient group with peripheral artery disease
    Rickson C Mesquita
    University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, PA 19104, USA
    J Biomed Opt 18:57007. 2013
    ..041), even after adjustment for ankle brachial index. This suggests a physiologic connection between rBF and oxygenation that can be measured using diffuse optics, and potentially employed as an evaluative tool in further studies...
  19. pmc Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects
    Turgut Durduran
    ICFO Institut de Ciencies Fotoniques, Av Canal Olimpic s n, Castelldefels 08860, Spain
    J Biomed Opt 15:037004. 2010
    ..7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population...
  20. pmc Tumor vascular microenvironment determines responsiveness to photodynamic therapy
    Amanda L Maas
    Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 72:2079-88. 2012
    ..The vascular basement membrane is thus identified to be a determinant of therapeutic outcome in PDT of tumors...
  21. pmc Transabdominal near infrared oximetry of hypoxic stress in fetal sheep brain in utero
    Regine Choe
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 100:12950-4. 2003
    ..Fetal hypoxia was detected. Good agreement was found between fetal blood saturation determined by the transabdominal NIR method and arterial and venous fetal blood saturation quantified from fetal blood samples by using a hemoximeter...
  22. ncbi request reprint Surface property and in vitro biodegradation of microspheres fabricated by poly(epsilon-caprolactone-b-ethylene oxide) diblock copolymers
    Guoqiang Yu
    CAS Key Laboratory of Engineering Plastics, Joint Laboratory of Polymer Sciences and Materials, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China
    J Biomed Mater Res A 84:926-39. 2008
    ..These microspheres with controllable surface morphology and amino functional groups are expected to be promising alternatives for the further biomimetic modification to promote cell growth on materials...

Research Grants2

  1. Assessment of Muscle Vascular Disease with Diffuse Light
    Guoqiang Yu; Fiscal Year: 2007
    ..The proposed, noninvasive, portable, and inexpensive optical technology may fill in this gap by providing multiple hemodynamic information and by enabling continuous measurements at the bed-side and in ambulatory care. ..
  2. Assessment of Muscle Vascular Disease with Diffuse Light
    Guoqiang Yu; Fiscal Year: 2007
    ..The proposed, non- invasive, portable, and inexpensive optical technology may fill in this gap by providing multiple hemodynamic information and by enabling continuous measurements at the bed-side and in.ambulatory care. ..