Chang-En Yu

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association
    Chang En Yu
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Genomics 89:655-65. 2007
  2. ncbi request reprint ADLAPH: A molecular haplotyping method based on allele-discriminating long-range PCR
    Chang En Yu
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Genomics 84:600-12. 2004
  3. ncbi request reprint Accounting for linkage disequilibrium among markers in linkage analysis: impact of haplotype frequency estimation and molecular haplotypes for a gene in a candidate region for Alzheimer's disease
    Weiva Sieh
    Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    Hum Hered 63:26-34. 2007
  4. pmc Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 13:255-66. 2008
  5. ncbi request reprint Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia
    Purnima Desai Sundar
    Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA 98195, USA
    Hum Mol Genet 16:295-306. 2007
  6. ncbi request reprint Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large Veterans Affairs Cooperative Study sample
    A D Skol
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA
    Am J Med Genet B Neuropsychiatr Genet 118:8-15. 2003
  7. ncbi request reprint Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C-->T (Arg493X) mutation: an international initiative
    Rosa Rademakers
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Lancet Neurol 6:857-68. 2007
  8. pmc Presence of large deletions in kindreds with autism
    Chang En Yu
    Geriatrics Research Education and Clinical Center, Puget Sound Veterans Affairs Medical Center, University of Washington, Seattle 98108, USA
    Am J Hum Genet 71:100-15. 2002
  9. ncbi request reprint Heterozygous parkin point mutations are as common in control subjects as in Parkinson's patients
    Denise M Kay
    Wadsworth Center, New York State Department of Health, Albany, NY 12201 2002, USA
    Ann Neurol 61:47-54. 2007
  10. ncbi request reprint Mapping autism risk loci using genetic linkage and chromosomal rearrangements
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Nat Genet 39:319-28. 2007

Research Grants

Detail Information

Publications11

  1. pmc Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association
    Chang En Yu
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Genomics 89:655-65. 2007
    ..These observations diminish the possibility that loci in the TOMM40 gene may have a major effect on the risk for LOAD in Caucasians...
  2. ncbi request reprint ADLAPH: A molecular haplotyping method based on allele-discriminating long-range PCR
    Chang En Yu
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Genomics 84:600-12. 2004
    ..We demonstrate the feasibility of this molecular haplotyping procedure by generating apolipoprotein E (APOE) haplotypes from 100 unrelated subjects...
  3. ncbi request reprint Accounting for linkage disequilibrium among markers in linkage analysis: impact of haplotype frequency estimation and molecular haplotypes for a gene in a candidate region for Alzheimer's disease
    Weiva Sieh
    Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    Hum Hered 63:26-34. 2007
    ..We evaluated the effects of different methods of haplotype frequency estimation, and the use of marker phase information, on linkage analysis of a multi-SNP cluster in a candidate region for Alzheimer's disease (AD)...
  4. pmc Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 13:255-66. 2008
    ..Further investigation of the genetic influence of these loci on apoE expression levels in the central nervous system is likely to provide new insight into apoE regulation as well as AD pathogenesis...
  5. ncbi request reprint Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia
    Purnima Desai Sundar
    Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA 98195, USA
    Hum Mol Genet 16:295-306. 2007
    ..Others have shown that SNP6 is also associated with risk for progressive supranuclear palsy. These two independent cis-acting sites presumably influence risk for Guam neuro-degenerative disorders by regulating MAPT expression...
  6. ncbi request reprint Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large Veterans Affairs Cooperative Study sample
    A D Skol
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA
    Am J Med Genet B Neuropsychiatr Genet 118:8-15. 2003
    ..The 8 and 13 repeat alleles were previously identified to be positively associated with schizophrenia by Wei and Hemmings [2000: Nat Genet 25:376-377] and Sklar et al. [2001: Nat Genet 28:126-128], respectively...
  7. ncbi request reprint Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C-->T (Arg493X) mutation: an international initiative
    Rosa Rademakers
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Lancet Neurol 6:857-68. 2007
    ..The most common mutation in GRN is Arg493X. We aimed to establish the contribution of this mutation to FTLD and related disorders...
  8. pmc Presence of large deletions in kindreds with autism
    Chang En Yu
    Geriatrics Research Education and Clinical Center, Puget Sound Veterans Affairs Medical Center, University of Washington, Seattle 98108, USA
    Am J Hum Genet 71:100-15. 2002
    ..An alternative hypothesis is that autism-susceptibility alleles elsewhere cause the deletions detected here, possibly by inducing errors during meiosis...
  9. ncbi request reprint Heterozygous parkin point mutations are as common in control subjects as in Parkinson's patients
    Denise M Kay
    Wadsworth Center, New York State Department of Health, Albany, NY 12201 2002, USA
    Ann Neurol 61:47-54. 2007
    ..We present a comprehensive sequence analysis of parkin in control subjects...
  10. ncbi request reprint Mapping autism risk loci using genetic linkage and chromosomal rearrangements
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Nat Genet 39:319-28. 2007
    ..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...
  11. pmc TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis
    Vivianna M Van Deerlin
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Lancet Neurol 7:409-16. 2008
    ..Our aim was to investigate whether TARDBP is a candidate disease gene for familial ALS that is not associated with mutations in superoxide dismutase 1 (SOD1)...

Research Grants1

  1. APOE Gene-Based Haplotype Study in Alzeheimer's Disease
    Chang En Yu; Fiscal Year: 2005
    ..2. Analyze the association between APOE haplotypes and AD. 3. Establish association between APOE expression level and haplotypes. 4. Identify critical SNPs from candidate haplotypes that affect APOE expression. ..