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Genomes and Genes | Samuel A YousemSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Idiopathic bronchiolocentric interstitial pneumoniaSamuel A Yousem
Department of Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, Pennsylvania 15213, USA
Mod Pathol 15:1148-53. 2002....
The histopathology of lung allograft dysfunction associated with the development of donor-specific HLA alloantibodiesSamuel A Yousem
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213 2582, USA
Am J Surg Pathol 36:987-92. 2012....- Comparative mutational analysis of pulmonary scar epithelium, bronchioloalveolar carcinomas, and invasive well-differentiated pulmonary adenocarcinomas: a molecular approach to diagnostically challenging casesHina A Sheikh
Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Am J Surg Pathol 29:1267-73. 2005..These molecular differences may serve as an adjunct to histology in challenging glandular lesions of the lung... - Micropapillary lung adenocarcinoma: EGFR, K-ras, and BRAF mutational profileRosane De Oliveira Duarte Achcar
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
Am J Clin Pathol 131:694-700. 2009..We conclude that K-ras, EGFR, and BRAF mutations are disproportionately seen in adenocarcinomas of lung with a dominant micropapillary growth pattern compared with conventional adenocarcinoma in our institutional experience... - Increased levels of tumor-infiltrating lymphocytes are associated with improved recurrence-free survival in stage 1A non-small-cell lung cancerZachary D Horne
Division of Thoracic Surgery, Heart, Lung, and Esophageal Surgery Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15232, USA
J Surg Res 171:1-5. 2011..We compared the outcomes of stage 1A NSCLC with and without tumor infiltrating lymphocytes to evaluate the effects of TILs on recurrence and survival patterns... - Mammalian mastermind like 2 11q21 gene rearrangement in bronchopulmonary mucoepidermoid carcinomaRosane de Oliveira Duarte Achcar
Department of Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, PA 15213, USA
Hum Pathol 40:854-60. 2009.... - Initial experience with a novel pre-sign-out quality assurance tool for review of random surgical pathology diagnoses in a subspecialty-based university practiceScott R Owens
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Am J Surg Pathol 34:1319-23. 2010..The tool is a useful quality assurance instrument and its prospective nature allows for the potential prevention of some serious errors... - Significance of EGFR protein expression and gene amplification in non-small cell lung carcinomaSanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
Am J Clin Pathol 125:860-5. 2006..EGFR protein expression was uncoupled from gene amplification in most cases, although good correlation occurred in a subset of SCCs... - A randomized trial of inhaled cyclosporine in lung-transplant recipientsAldo T Iacono
Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, USA
N Engl J Med 354:141-50. 2006..Topical delivery of cyclosporine in addition to conventional systemic immunosuppression might help prevent acute and chronic rejection events... - Gross cystic disease fluid protein-(GCDFP-15): expression in primary lung adenocarcinomaJoan M Striebel
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
Am J Surg Pathol 32:426-32. 2008..This report details the first 11 cases of pulmonary adenocarcinoma to express GCDFP-15 and their distinctive morphology with frequent mucin production and coexpression of thyroid transcription factor-1 and synaptophysin... - Adenosquamous carcinoma of the lung: a microdissection study of KRAS and EGFR mutational and amplification status in a western patient populationNaobumi Tochigi
Dept of Pathology, UPMC Presbyterian Shadyside, Pittsburgh, PA 15213 2582, USA
Am J Clin Pathol 135:783-9. 2011..EGFR mutations occur in adenosquamous carcinoma in the same percentages as in conventional adenocarcinoma in the Western population. KRAS mutations are less common... - Microsatellite instability is uncommon in lymphoepithelioma-like carcinoma of the lungSanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
Am J Clin Pathol 127:282-6. 2007..55). MSI is very uncommon in LELC, indicating that MSI is not an important event in carcinogenesis for this tumor subtype. The presence of LOH suggests a probable role of tumor suppressor genes in LELC carcinogenesis... - Anti-human leukocyte antigen antibodies, vascular C4d deposition and increased soluble c4d in broncho-alveolar lavage of lung allograftsAlin L Girnita
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Transplantation 86:342-7. 2008..A simultaneous determination of vascular C4d with soluble C4d in broncho-alveolar lavage fluid (BAL) and circulating anti-human leukocyte antigen (HLA) antibodies (HLA-Ab) has not been reported in lung transplantation... - Genetic profile of cumulative mutational damage associated with early pulmonary adenocarcinoma: bronchioloalveolar carcinoma vs. stage I invasive adenocarcinomaEizaburo Sasatomi
Departments of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Am J Surg Pathol 28:1280-8. 2004..LOH of 1p, 3p, 7q, and 18q was associated with invasive properties of pulmonary AD and may be useful in identifying invasive adenocarcinoma when conventional histomorphological tools are not helpful... 
Inhibition and role of let-7d in idiopathic pulmonary fibrosisKusum V Pandit
University of Pittsburgh Medical Center, NW 628 MUH, 3459 5th Avenue, Pittsburgh, PA 15261, USA
Am J Respir Crit Care Med 182:220-9. 2010..Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and usually lethal fibrotic lung disease characterized by profound changes in epithelial cell phenotype and fibroblast proliferation...- Clonal selection of adenocarcinoma of the lung as determined by loss of heterozygositySanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, 200 Lothrop Street, PUH A610 2, Pittsburgh, PA 15213, USA
Exp Mol Pathol 78:135-9. 2005..A trend towards lower overall FAL in advanced stage tumors and in their metastases suggests that clonal selection may play a role in lung adenocarcinoma progression... - Small-cell neuroendocrine carcinoma displays unique profiles of tumor-suppressor gene loss in relationship to the primary site of formationSanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, PA 15213, USA
Hum Pathol 33:927-32. 2002..These attributes can be effectively used for primary localization of metastatic SCNC, thereby assisting in the diagnosis and classification of this neoplasm... - The pulmonary histopathologic manifestations of the anti-Jo-1 tRNA synthetase syndromeSamuel A Yousem
Department of Pathology, UPMC Presbyterian Shadyside, Pittsburgh, PA 15213 2582, USA
Mod Pathol 23:874-80. 2010.... - Impact of angiolymphatic and pleural invasion on surgical outcomes for stage I non-small cell lung cancerMatthew J Schuchert
Division of Thoracic and Foregut Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Ann Thorac Surg 91:1059-65; discussion 1065. 2011..In the current study, we analyze the impact of pathologic variables (angiolymphatic invasion, visceral pleural invasion, and tumor inflammation) upon survival outcomes after segmentectomy or lobectomy for stage I non-small cell lung cancer... - Patterns of allelic loss of synchronous adenocarcinomas of the lungSanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
Am J Surg Pathol 29:897-902. 2005..Our study showed that discordant and concordant genotypic profiles exist in morphologically similar synchronous ADC of the lung... - Widespread molecular alterations present in stage I non-small cell lung carcinoma fail to predict tumor recurrenceFabien K Baksh
Department of Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, Pennsylvania 15213, USA
Mod Pathol 16:28-34. 2003..The approach of investigating a panel of genes for alterations can be applied to any given tumor type, and provides information on patterns of mutations/LOH that can help us better understand the molecular biology of tumorigenesis... - Recurrent sarcoidosis in lung transplant allografts: granulomas are of recipient originDiana N Ionescu
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Diagn Mol Pathol 14:140-5. 2005..The origin of the histiocytes composing the noncaseating granulomas in the allograft lung in patients with recurrent sarcoidosis (RS) was analyzed using DNA identity testing in 4 cases... - Impact of mold infections in explanted lungs on outcomes of lung transplantationAniket Vadnerkar
Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15251, USA
Transplantation 89:253-60. 2010..Little is known about the incidence or significance of mold infections in the explanted lungs of lung transplant recipients... - Peripheral squamous cell carcinoma of lung: patterns of growth with particular focus on airspace fillingSamuel A Yousem
Department of Pathology, University of Pittsburgh Medical Center, PA 15213 2582, USA
Hum Pathol 40:861-7. 2009..Nonetheless, such a growth pattern was common and should be studied further in larger series to determine if an airspace filling growth pattern in squamous carcinoma is clinically important... - Recommendations for the supervision of pathology assistants: association of directors of anatomic and surgical pathologySamuel A Yousem
University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Hum Pathol 37:253-5. 2006 - Comparison of accumulated allele loss between primary tumor and lymph node metastasis in stage II non-small cell lung carcinoma: implications for the timing of lymph node metastasis and prognostic valueEizaburo Sasatomi
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
Cancer Res 62:2681-9. 2002..552). A composite mutational profile for each patient based on the allelotyping of the primary tumor and lymph node deposits may make a significant contribution to a more accurate prognosis of stage II NSCLC... - Molecular pathogenesis of pulmonary carcinosarcoma as determined by microdissection-based allelotypingSanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, Pennsylvania, USA
Am J Surg Pathol 26:510-6. 2002..The data support the efficacy of microdissection-based allelic fingerprinting to delineate the relationship between different morphologic components of a single neoplasm... - Pulmonary meningothelial-like nodules: a genotypic comparison with meningiomasDiana N Ionescu
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Room A610, 200 Lothrop St, Pittsburgh, PA 15213, USA
Am J Surg Pathol 28:207-14. 2004..Minute pulmonary meningothelial-like nodules (MPMNs) are incidental interstitial pulmonary nodules. They share histologic, ultrastructural, and immunohistochemical features with meningiomas (MGs)... - Comparison of mutational changes in involved N1 lymph nodes with those in primary tumors in stage II non-small cell lung cancer: a pilot studyHiran C Fernando
Division of Thoracic and Foregut Surgery, University of Pittsburgh Medical Center Health System, UPMC Presbyterian, PA 15213, USA
J Thorac Cardiovasc Surg 127:87-91. 2004..This study compared mutational changes in involved lymph nodes and primary tumors from patients with stage II non-small cell lung cancer to determine whether risk factors for recurrence could be identified... - Asthmatic granulomatosis: a novel disease with asthmatic and granulomatous featuresSally E Wenzel
University of Pittsburgh Asthma Institute at University of Pittsburgh Medical Center University of Pittsburgh School of Medicine, Pulmonary Allergy and Critical Care Medicine Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Am J Respir Crit Care Med 186:501-7. 2012..Although it is increasingly recognized as consisting of numerous heterogenous phenotypes, their immunopathology, particularly in the distal airways and interstitium, remains poorly described... - Nonspecific interstitial pneumonia: a study of 6 patients with progressive diseaseFrank Schneider
Department of Pathology and Pulmonary Medicine, University of Pittsburgh Medical Center Presbyterian, Pittsburgh, PA, USA
Am J Surg Pathol 36:89-93. 2012..The potential pathophysiologic explanation for such a change is discussed... - Bronchioloalveolar carcinoma: a review of current concepts and evolving issuesSamuel A Yousem
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Arch Pathol Lab Med 131:1027-32. 2007..Both pathologic and clinical aspects of this carcinoma are the subject of considerable interest... - The surgical pathology of pulmonary infarcts: diagnostic confusion with granulomatous disease, vasculitis, and neoplasiaSamuel A Yousem
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
Mod Pathol 22:679-85. 2009.... - Respiratory bronchiolitis-associated interstitial lung disease with fibrosis is a lesion distinct from fibrotic nonspecific interstitial pneumonia: a proposalSamuel A Yousem
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
Mod Pathol 19:1474-9. 2006..The morphology of this process raises the differential diagnosis with the fibrotic form of nonspecific interstitial pneumonia and highlights the role of cigarette smoking as a potential cause of fibrotic lung disease... - Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary diseaseZhi Hua Chen
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
PLoS ONE 3:e3316. 2008..Autophagy is a degradative process involving lysosomal turnover of cellular components, though its role in human diseases remains unclear... - Numerical fidelity of endoscopic biopsy fragments in the processing sequence of a university surgical pathology laboratoryScott R Owens
Department of Pathology, University of Pittsburgh Medical Center, Presbyterian Campus, Pennsylvania 15213 2582, USA
Arch Pathol Lab Med 135:1561-4. 2011..Conservation and effective utilization of small biopsy tissue is therefore crucial in the pathology laboratory... - The histopathology of BRAF-V600E-mutated lung adenocarcinomaSamuel A Yousem
Department of Pathology, Presbyterian Campus, UPMC Presbyterian Shadyside, Pittsburgh, PA 15213, USA
Am J Surg Pathol 32:1317-21. 2008..Adenocarcinomas with this clinicopathologic phenotype may be worthwhile investigating for BRAF-V600E mutation as more genetically oriented drug therapies emerge... - Significance of a solitary perivascular mononuclear infiltrate in lung allograft recipients with mild acute cellular rejectionDong-Won Kim
Department of Pathology and Pulmonary Medicine, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
J Heart Lung Transplant 24:152-5. 2005..Solitary mononuclear infiltrates showed persistence or progression without therapy and therefore need to be treated as, not segregated from, the "usual" forms of mild acute allograft rejection... - A combination of molecular markers accurately detects lymph node metastasis in non-small cell lung cancer patientsLiqiang Xi
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Clin Cancer Res 12:2484-91. 2006..The combination of these genes identified 32 of 462 (7%) lymph nodes from 20 of 68 (29%) patients as potentially positive for occult metastasis. Long-term follow-up will determine the clinical relevance of these findings... - Recommendations for the supervision of pathology assistantsSamuel A Yousem
Department of Pathology, Presbyterian University Hospital--A610, Pittsburgh, PA 15213-2582, USA
Am J Surg Pathol 30:537-8. 2006 - Role of molecular studies in the diagnosis of lung adenocarcinomaSamuel A Yousem
Department of Pathology, University of Pittsburgh Medical Center Presbyterian Campus, Pittsburgh, PA 15213 2582, USA
Mod Pathol 25:S11-7. 2012..Interestingly, these molecular changes have correlated with distinct, although not unique, demographics, histopathologies, and response to pharmacological agents... - Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosisKazuhisa Konishi
Division of Pulmonary, Allergy and Critical Care Medicine, Dorothy P and Richard P Simmons Center for Interstitial Lung Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Respir Crit Care Med 180:167-75. 2009..The molecular mechanisms underlying acute exacerbations of idiopathic pulmonary fibrosis (IPF) are poorly understood. We studied the global gene expression signature of acute exacerbations of IPF... - Pulmonary lymphohistiocytic reactions temporally related to etanercept therapySamuel A Yousem
The Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213 2582, USA
Mod Pathol 18:651-5. 2005..The association with etanercept therapy and granulomatous reactions is discussed along with the differential diagnosis... - The development and testing of a laboratory information system-driven tool for pre-sign-out quality assurance of random surgical pathology reportsScott R Owens
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Am J Clin Pathol 133:836-41. 2010..There has been no significant delay in case turnaround time since implementation. Further assessment of the tool's function after full departmental application is underway... - Histopathology of aspiration pneumonia not associated with food or other particulate matter: a clinicopathologic study of 10 cases diagnosed on biopsySamuel A Yousem
Department of Pathology, University of Pittsburgh Medical Center, PA 15213 2582, USA
Am J Surg Pathol 35:426-31. 2011.... - HLA-specific antibodies are risk factors for lymphocytic bronchiolitis and chronic lung allograft dysfunctionAlin L Girnita
Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
Am J Transplant 5:131-8. 2005.... - HLA-specific antibodies are associated with high-grade and persistent-recurrent lung allograft acute rejectionAlin L Girnita
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
J Heart Lung Transplant 23:1135-41. 2004..These lung-transplanted patients may benefit from an altered strategy of immunosuppression... - Pulmonary intestinal-type adenocarcinoma does not show enteric differentiation by immunohistochemical studySamuel A Yousem
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2582, USA
Mod Pathol 18:816-21. 2005..Stains for a variety of epithelial mucins (MUC1, MUC2, MUC5AC) also support this observation. The differential diagnosis with other pulmonary adenocarcinomas, especially those with mucinous differentiation, is discussed... - Loss of heterozygosity patterns of sclerosing hemangioma of the lung and bronchioloalveolar carcinoma indicate a similar molecular pathogenesisSanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
Arch Pathol Lab Med 128:880-4. 2004..Most cases of SH are benign, but they can metastasize to the regional lymph nodes... - Histologic classification of idiopathic chronic interstitial pneumoniasSanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, Pennsylvania, USA
Am J Respir Cell Mol Biol 29:S5-9. 2003 - In vivo expression of p53 and Bcl-2 and their role in programmed cell death in premalignant and malignant lung lesionsPatrick P Koty
Department of Environmental and Occupational Health, University of Pittsburgh, 260 Kappa Drive, Pittsburgh, PA 15238, USA
Lung Cancer 35:155-63. 2002..The ensuing increase in apoptosis appears to be relatively independent of mutant or wild-type p53 expression, but does not occur in cells expressing bcl-2... - Epstein-Barr virus infection is not associated with fibroadenomas of the breast in immunosuppressed patients after organ transplantationSean K Lau
Department of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
Mod Pathol 16:1242-7. 2003..The findings of the present study argue against a significant relationship between Epstein-Barr virus and fibroadenomas of the breast in the setting of transplant-associated immunosuppression... - Intrathymic inoculation of donor bone marrow induces long-term acceptance of lung allograftsSen Li
Division of Cardiothoracic Surgery, University of Miami School of Medicine, Miami, Florida 33136, USA
Ann Thorac Surg 75:257-63; discussion 263. 2003..This simple approach of tolerance induction may have clinical application... - Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejectionSusan Stewart
Papworth Everard Pathology Department, Papworth Hospital, Cambridge, UK
J Heart Lung Transplant 26:1229-42. 2007..This consensus revision of the working formulation was approved by the ISHLT board of directors in April 2007... - Recommendations for the supervision of pathology assistantsSamuel A Yousem
Am J Clin Pathol 125:171-2. 2006