Jack F Youngren

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Skeletal muscle content of membrane glycoprotein PC-1 in obesity. Relationship to muscle glucose transport
    J F Youngren
    Department of Medicine, Mount Zion Medical Center, University of California San Francisco 94120, USA
    Diabetes 45:1324-8. 1996
  2. ncbi request reprint Insulin receptor autophosphorylation in cultured myoblasts correlates to glucose disposal in Pima Indians
    J F Youngren
    Department of Medicine, Division of Diabetes and Endocrine Research, Mount Zion Medical Center, University of California, San Francisco, California, 94143 1616, USA
    Am J Physiol 276:E990-4. 1999
  3. ncbi request reprint Enhanced muscle insulin receptor autophosphorylation with short-term aerobic exercise training
    J F Youngren
    Division of Diabetes and Endocrine Research, Department of Medicine, Mount Zion Medical Center, University of California San Francisco, San Francisco, CA 94143, USA
    Am J Physiol Endocrinol Metab 280:E528-33. 2001
  4. ncbi request reprint Impaired insulin-receptor autophosphorylation is an early defect in fat-fed, insulin-resistant rats
    J F Youngren
    Division of Diabetes and Endocrine Research, Department of Medicine, Mount Zion Medical Center, University of California, San Francisco 94143 1616, USA
    J Appl Physiol (1985) 91:2240-7. 2001
  5. ncbi request reprint Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells
    Jack F Youngren
    Division of Diabetes and Endocrine Research, San Francisco Mt Zion Medical Center, University of California, San Francisco, CA 94143 1616, USA
    Breast Cancer Res Treat 94:37-46. 2005
  6. ncbi request reprint Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells
    Marianna Zavodovskaya
    Diabetes and Endocrine Research, University of California, San Francisco Mt Zion Medical Center, San Francisco, California, USA
    J Cell Biochem 103:624-35. 2008
  7. ncbi request reprint Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells
    Charles J Ryan
    Department of Medicine, University of California, San Francisco, California 94143, USA
    Prostate 68:1232-40. 2008
  8. ncbi request reprint Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia
    Betty A Maddux
    Department of Medicine and Diabetes Center, University of California, San Francisco 94143 1616, USA
    Am J Physiol Endocrinol Metab 290:E746-9. 2006
  9. ncbi request reprint Analysis of insulin-stimulated insulin receptor activation and glucose transport in cultured skeletal muscle cells from obese subjects
    Celia Pender
    Division of Diabetes and Endocrine Research, Department of Medicine, Mount Zion Medical Center, University of California San Francisco, Box 1616, San Francisco, CA 94143, USA
    Metabolism 54:598-603. 2005
  10. pmc Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle
    Umesh B Masharani
    Department of Medicine, Diabetes Center, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e19878. 2011

Research Grants

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Skeletal muscle content of membrane glycoprotein PC-1 in obesity. Relationship to muscle glucose transport
    J F Youngren
    Department of Medicine, Mount Zion Medical Center, University of California San Francisco 94120, USA
    Diabetes 45:1324-8. 1996
    ..These studies raise the possibility that increased expression of PC-1 and a decreased insulin receptor content in skeletal muscle may be involved in the insulin resistance of obesity...
  2. ncbi request reprint Insulin receptor autophosphorylation in cultured myoblasts correlates to glucose disposal in Pima Indians
    J F Youngren
    Department of Medicine, Division of Diabetes and Endocrine Research, Mount Zion Medical Center, University of California, San Francisco, California, 94143 1616, USA
    Am J Physiol 276:E990-4. 1999
    ....
  3. ncbi request reprint Enhanced muscle insulin receptor autophosphorylation with short-term aerobic exercise training
    J F Youngren
    Division of Diabetes and Endocrine Research, Department of Medicine, Mount Zion Medical Center, University of California San Francisco, San Francisco, CA 94143, USA
    Am J Physiol Endocrinol Metab 280:E528-33. 2001
    ....
  4. ncbi request reprint Impaired insulin-receptor autophosphorylation is an early defect in fat-fed, insulin-resistant rats
    J F Youngren
    Division of Diabetes and Endocrine Research, Department of Medicine, Mount Zion Medical Center, University of California, San Francisco 94143 1616, USA
    J Appl Physiol (1985) 91:2240-7. 2001
    ..These results demonstrate that high-fat feeding induces insulin resistance in muscle concomitant with a diminished IR signaling capacity, although the mechanism remains unknown...
  5. ncbi request reprint Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells
    Jack F Youngren
    Division of Diabetes and Endocrine Research, San Francisco Mt Zion Medical Center, University of California, San Francisco, CA 94143 1616, USA
    Breast Cancer Res Treat 94:37-46. 2005
    ..These studies indicate that the anti-breast cancer properties of NDGA are related to the inhibition of two important RTKs. Agents of this class may therefore provide new insights into potential therapies for this disease...
  6. ncbi request reprint Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells
    Marianna Zavodovskaya
    Diabetes and Endocrine Research, University of California, San Francisco Mt Zion Medical Center, San Francisco, California, USA
    J Cell Biochem 103:624-35. 2008
    ..These studies suggest that NDGA may have therapeutic benefits in HER2-positive, tamoxifen resistant, breast cancers in humans...
  7. ncbi request reprint Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells
    Charles J Ryan
    Department of Medicine, University of California, San Francisco, California 94143, USA
    Prostate 68:1232-40. 2008
    ..The current study evaluates the effect of NDGA on the androgen-stimulated growth of human prostate cancer cells...
  8. ncbi request reprint Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia
    Betty A Maddux
    Department of Medicine and Diabetes Center, University of California, San Francisco 94143 1616, USA
    Am J Physiol Endocrinol Metab 290:E746-9. 2006
    ....
  9. ncbi request reprint Analysis of insulin-stimulated insulin receptor activation and glucose transport in cultured skeletal muscle cells from obese subjects
    Celia Pender
    Division of Diabetes and Endocrine Research, Department of Medicine, Mount Zion Medical Center, University of California San Francisco, Box 1616, San Francisco, CA 94143, USA
    Metabolism 54:598-603. 2005
    ..These data therefore indicate that the insulin resistance associated with obesity is not maintained in cultured muscle cells and suggest that this insulin resistance is an acquired feature of obesity...
  10. pmc Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle
    Umesh B Masharani
    Department of Medicine, Diabetes Center, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e19878. 2011
    ..These stress kinases are activated through various mechanisms related to lipid oversupply locally in insulin target tissues and in various adipose depots...
  11. pmc Effects of controlled-release alpha lipoic acid in lean, nondiabetic patients with polycystic ovary syndrome
    Umesh Masharani
    Department of Medicine, University of California, San Francisco, Diabetes Center, San Francisco, California 94143, USA
    J Diabetes Sci Technol 4:359-64. 2010
    ..The purpose of this study was to determine whether a preparation of controlled-release alpha lipoic acid (CRLA) influences features of the polycystic ovary syndrome (PCOS)...
  12. pmc The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities
    Ira D Goldfine
    Department of Medicine and Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA
    Endocr Rev 29:62-75. 2008
    ..These data suggest therefore that PC-1 is a candidate protein that may play a role in human insulin resistance and T2D by its overexpression, its overactivity, or both...
  13. pmc Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells
    Gary E Meyer
    Department of Pediatrics, University of California, San Francisco, California 94143, USA
    J Cell Biochem 102:1529-41. 2007
    ..In addition, NDGA inhibits the growth of xenografted human neuroblastoma tumors in nude mice. These results indicate that NDGA may be useful in the treatment of neuroblastoma and may function in part via disruption of IGF-IR signaling...
  14. pmc Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs
    Joseph E Blecha
    Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132 4163, USA
    Bioorg Med Chem Lett 17:4026-9. 2007
    ..With increased specificity and potency, 7h may serve as a new lead in developing novel therapeutic agents for breast cancer...
  15. pmc Influence of gender on the relationship between insulin sensitivity, adiposity, and plasma lipids in lean nondiabetic subjects
    Umesh Masharani
    Division of Endocrinology and Metabolism, Department of Medicine, University of California San Francisco, San Francisco, CA 94115, USA
    Metabolism 58:1602-8. 2009
    ..These results both highlight sex differences in the associations between insulin resistance, regional adipose stores, and lipids values and emphasize the importance of adipose stores on the development of an individual's lipid profile...
  16. ncbi request reprint Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth
    Karissa L Gable
    Diabetes and Endocrine Research University of California, San Francisco Mt Zion Medical Center, Box 1616, San Francisco, CA 94143 1616, USA
    Mol Cancer Ther 5:1079-86. 2006
    ..p. injection thrice a week) reduced the growth rate of MCNeuA cells implanted into mice. These studies indicate that diaryl urea compounds are potential new agents to test in the treatment of breast and other IGF-I-sensitive cancers...
  17. ncbi request reprint Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators
    Ming Li
    University of California at San Francisco, Mount Zion Medical Center, San Francisco, California 94143, USA
    J Clin Endocrinol Metab 87:4088-93. 2002
    ..Moreover, the observation that TLK16998 and Merck L7 improved IR tyrosine phosphorylation in fibroblasts from patients with PCOS suggests that specific pharmacological therapies might be developed to treat the insulin resistance in PCOS...
  18. ncbi request reprint Regulation of insulin receptor function by a small molecule insulin receptor activator
    Celia Pender
    Mount Zion Medical Center, University of California, San Francisco 94143 1616, USA
    J Biol Chem 277:43565-71. 2002
    ..These studies suggest that these types of molecules could be developed to treat type 2 diabetes and other clinical conditions associated with insulin resistance...
  19. ncbi request reprint Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor
    Marc O Anderson
    Department of Pharmaceutical Chemistry, University of California, Box 2280, San Francisco, California 94143 2280, USA
    J Comb Chem 8:784-90. 2006
    ..Overall, eight compounds based on the 4-aminoquinaldine heteroaryl system were found to have moderate activity against IGF-1R with IC(50) values better than 40 microM...
  20. ncbi request reprint Expression of genes regulating malonyl-CoA in human skeletal muscle
    Celia Pender
    Department of Medicine, Diabetes and Endocrine Research, Mount Zion Medical Center, University of California, San Francisco, California 94143 1616, USA
    J Cell Biochem 99:860-7. 2006
    ..No other genes showed signs of increased mRNA content with obesity, suggesting that there may be selective transcriptional regulation of malonyl-CoA metabolism in human obesity...
  21. pmc Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity
    Umesh Masharani
    Department of Medicine, Diabetes Center, University of California San Francisco, 400 Parnassus Avenue, San Francisco, CA, 94143 1222, USA
    BMC Endocr Disord 12:31. 2012
    ..abstract:..
  22. doi request reprint A pilot dose-escalation study of the effects of nordihydroguareacetic acid on hormone and prostate specific antigen levels in patients with relapsed prostate cancer
    Charles J Ryan
    Department of Medicine and the corrected UCSF Comprehensive Cancer Center, University of California San Francisco, CA 94143, USA
    BJU Int 101:436-9. 2008
    ....
  23. ncbi request reprint Effective treatments for insulin resistance: trim the fat and douse the fire
    Joseph L Evans
    Medical Research Institute, San Francisco, CA 94107, USA
    Trends Endocrinol Metab 15:425-31. 2004
    ..One antioxidant that is safe and appears effective is alpha-lipoic acid. Thus, combinations of surgery, exercise training, insulin sensitizers and antioxidants will probably constitute future insulin resistance management...
  24. pmc Nordihydroguaiaretic acid inhibits transforming growth factor beta type 1 receptor activity and downstream signaling
    Fusheng Li
    Department of Medicine, University of California, San Francisco, California 94143, USA
    Eur J Pharmacol 616:31-7. 2009
    ....
  25. pmc Synthesis of aryl-heteroaryl ureas (AHUs) based on 4-aminoquinoline and their evaluation against the insulin-like growth factor receptor (IGF-1R)
    William Engen
    Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132, USA
    Bioorg Med Chem 18:5995-6005. 2010
    ....
  26. pmc Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T
    Xiaojuan Li
    Musculoskeletal Quantitative Imaging Research, Department of Radiology, University of California, San Francisco, CA 94107, USA
    Magn Reson Imaging 26:188-97. 2008
    ....
  27. ncbi request reprint Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance
    Hengjiang Dong
    Department of Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Diabetes 54:367-72. 2005
    ..These in vivo data support the concept, therefore, that PC-1 plays a role in insulin resistance and suggest that animals with overexpression of human PC-1 in liver may be interesting models to investigate this pathological process...
  28. ncbi request reprint Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling
    Anne Corbould
    Division of Women s Health, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol Endocrinol Metab 288:E1047-54. 2005
    ..These abnormalities differ from those reported in other insulin resistant states consistent with the hypothesis that PCOS is a genetically unique disorder conferring an increased risk for type 2 diabetes...
  29. ncbi request reprint Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:1884-8. 2002
    ..Prospectively, low plasma adiponectin concentration at baseline precedes a decrease in insulin sensitivity. Our data indicate that adiponectin plays an important role in regulation of insulin sensitivity in humans...
  30. ncbi request reprint Elevated plasma cell membrane glycoprotein levels and diminished insulin receptor autophosphorylation in obese, insulin-resistant rhesus monkeys
    Celia Pender
    Diabetes and Obesity Research Center, School of Medicine, Department of Physiology, University of Maryland at Baltimore, Baltimore, MD, USA
    Metabolism 51:465-70. 2002
    ..7 +/- 0.3; obese, 1.9 +/- 0.6; P <.05). We conclude that insulin resistance secondary to obesity in rhesus monkeys is associated with increased levels of PC-1 and decreased IR signaling capacity in skeletal muscle...

Research Grants1

  1. Carbonic Anhydrases in Obesity and Insulin Resistance
    JACK YOUNGREN; Fiscal Year: 2003
    ..These studies should provide important new data, therefore, on the CA family of enzymes, and their role in the insulin resistance. ..