JOHN YOUNGER

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Complement activation in emergency department patients with severe sepsis
    John G Younger
    Department of Emergency Medicine, Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI, USA
    Acad Emerg Med 17:353-9. 2010
  2. ncbi request reprint Partial liquid ventilation protects lung during resuscitation from shock
    J G Younger
    Section of Emergency Medicine, University of Michigan, Ann Arbor 48109, USA
    J Appl Physiol (1985) 83:1666-70. 1997
  3. ncbi request reprint Murine complement interactions with Pseudomonas aeruginosa and their consequences during pneumonia
    John G Younger
    Department of Emergency Medicine, Division of Pulmonary and Critical Care Medicine, Univeristy of Michigan, Ann Arbor, MI 48109 0303
    Am J Respir Cell Mol Biol 29:432-8. 2003
  4. ncbi request reprint Systemic and lung physiological changes in rats after intravascular activation of complement
    J G Younger
    Department of Emergency Medicine, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Appl Physiol (1985) 90:2289-95. 2001
  5. ncbi request reprint Extracorporeal resuscitation of cardiac arrest
    J G Younger
    Extracorporeal Life Support Service, University of Michigan, Ann Arbor, USA
    Acad Emerg Med 6:700-7. 1999
  6. ncbi request reprint Detrimental effects of complement activation in hemorrhagic shock
    J G Younger
    Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan 48109 0303, USA
    J Appl Physiol (1985) 90:441-6. 2001
  7. ncbi request reprint The pattern of early lung parenchymal and air space injury following acute blood loss
    J G Younger
    Emergency Medicine Research Laboratories and the Section of Emergency Medicine, The University of Michigan, Ann Arbor 48109 0303, USA
    Acad Emerg Med 5:659-65. 1998
  8. doi request reprint Forecasting models of emergency department crowding
    Lisa M Schweigler
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Acad Emerg Med 16:301-8. 2009
  9. doi request reprint Real-time identification of serious infection in geriatric patients using clinical information system surveillance
    William J Meurer
    Department of Emergency Medicine, University of Michigan, Ann Arbor, 48109 5303, USA
    J Am Geriatr Soc 57:40-5. 2009
  10. pmc Acute respiratory infection with mouse adenovirus type 1
    Jason B Weinberg
    University of Michigan Health System, Division of Pediatric Infectious Diseases, Department of Pediatrics, Ann Arbor, 48109 0244, USA
    Virology 340:245-54. 2005

Research Grants

  1. LUNG INJURY, PERFLUOROCARBONS, AND HEMORRHAGIC SHOCK
    JOHN YOUNGER; Fiscal Year: 2003
  2. C5a in defense against murine Gram-negative pneumonia
    JOHN YOUNGER; Fiscal Year: 2007
  3. Biomechanics of Blood Stream Infections
    JOHN YOUNGER; Fiscal Year: 2009
  4. Biomechanics of Blood Stream Infections
    John G Younger; Fiscal Year: 2010

Collaborators

Detail Information

Publications26

  1. pmc Complement activation in emergency department patients with severe sepsis
    John G Younger
    Department of Emergency Medicine, Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI, USA
    Acad Emerg Med 17:353-9. 2010
    ..This study assessed the extent and mechanism of complement activation in community-acquired sepsis at presentation to the emergency department (ED) and following 24 hours of quantitative resuscitation...
  2. ncbi request reprint Partial liquid ventilation protects lung during resuscitation from shock
    J G Younger
    Section of Emergency Medicine, University of Michigan, Ann Arbor 48109, USA
    J Appl Physiol (1985) 83:1666-70. 1997
    ..045 +/- 0.045; 95% confidence interval for injury--PLV: -0.024, 0.1219). We conclude that PLV is associated with a decrease in pulmonary neutrophil accumulation and a trend toward decreased capillary leak after hemorrhagic shock...
  3. ncbi request reprint Murine complement interactions with Pseudomonas aeruginosa and their consequences during pneumonia
    John G Younger
    Department of Emergency Medicine, Division of Pulmonary and Critical Care Medicine, Univeristy of Michigan, Ann Arbor, MI 48109 0303
    Am J Respir Cell Mol Biol 29:432-8. 2003
    ..This interaction in vivo plays a central role in host survival beyond just recruitment and activation of phagocytes and may serve to limit the inflammatory response to and tissue injury resulting from bacterial infection...
  4. ncbi request reprint Systemic and lung physiological changes in rats after intravascular activation of complement
    J G Younger
    Department of Emergency Medicine, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Appl Physiol (1985) 90:2289-95. 2001
    ..These studies underscore the significant systemic abnormalities developing after systemic activation of complement...
  5. ncbi request reprint Extracorporeal resuscitation of cardiac arrest
    J G Younger
    Extracorporeal Life Support Service, University of Michigan, Ann Arbor, USA
    Acad Emerg Med 6:700-7. 1999
    ..The authors retrospectively reviewed their institution's seven-year experience with this intervention...
  6. ncbi request reprint Detrimental effects of complement activation in hemorrhagic shock
    J G Younger
    Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan 48109 0303, USA
    J Appl Physiol (1985) 90:441-6. 2001
    ..The lethality of CPNI during acute blood loss suggests that the anaphylatoxins are important in the pathophysiological events involved in hemorrhagic shock...
  7. ncbi request reprint The pattern of early lung parenchymal and air space injury following acute blood loss
    J G Younger
    Emergency Medicine Research Laboratories and the Section of Emergency Medicine, The University of Michigan, Ann Arbor 48109 0303, USA
    Acad Emerg Med 5:659-65. 1998
    ..Acute lung injury is a frequent clinical occurrence following blood loss and trauma. The nature of this injury remains poorly understood...
  8. doi request reprint Forecasting models of emergency department crowding
    Lisa M Schweigler
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Acad Emerg Med 16:301-8. 2009
    ..The authors investigated whether models using time series methods can generate accurate short-term forecasts of emergency department (ED) bed occupancy, using traditional historical averages models as comparison...
  9. doi request reprint Real-time identification of serious infection in geriatric patients using clinical information system surveillance
    William J Meurer
    Department of Emergency Medicine, University of Michigan, Ann Arbor, 48109 5303, USA
    J Am Geriatr Soc 57:40-5. 2009
    ..To develop and characterize an automated syndromic surveillance mechanism for early identification of older emergency department (ED) patients with possible life-threatening infection...
  10. pmc Acute respiratory infection with mouse adenovirus type 1
    Jason B Weinberg
    University of Michigan Health System, Division of Pediatric Infectious Diseases, Department of Pediatrics, Ann Arbor, 48109 0244, USA
    Virology 340:245-54. 2005
    ..MAV-1 infection of mice has the potential to serve as a model for inflammatory changes seen in human adenovirus respiratory disease...
  11. doi request reprint Accuracy of non-contact infrared thermometry versus rectal thermometry in young children evaluated in the emergency department for fever
    Ezio L Fortuna
    Children s Emergency Services, and Level E Nurse, Department of Emergency Medicine, Ann Arbor, MI, USA
    J Emerg Nurs 36:101-4. 2010
    ..We evaluated the accuracy of a non-contact infrared thermometer compared with a rectal thermometer...
  12. pmc Dynamics of intrapulmonary bacterial growth in a murine model of repeated microaspiration
    Itzhak Ben-David
    Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Am J Respir Cell Mol Biol 33:476-82. 2005
    ..When parallel experiments were performed in complement C3-deficient mice, no suppression of the second inoculum was noted, suggesting that early upregulation of antibacterial activity in the lung is a C3-mediated event...
  13. pmc Complement C5 and early oxygen kinetics during murine sepsis
    Gabriel Valencia
    Department of Emergency Medicine, University of Michigan, Room 7679 Kresge Research Building I, 200 Zina Pitcher Place, Ann Arbor, MI 48019, USA
    Acad Emerg Med 12:275-81. 2005
    ....
  14. pmc Segmental hemodynamics during partial liquid ventilation in isolated rat lungs
    Angela C Ko
    Department of Emergency Medicine, Room 7679 Kresge Research Building I, 200 Zina Pitcher Place, University of Michigan, 48109 0522, Ann Arbor, MI, USA
    Resuscitation 57:85-91. 2003
    ..These data support further investigation of this technique as an adjunct to cardiopulmonary resuscitation...
  15. ncbi request reprint In vitro and in silico analysis of annexin V binding to lymphocytes as a biomarker in emergency department sepsis studies
    Colin F Greineder
    Departments of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Acad Emerg Med 14:763-71. 2007
    ..Use of apoptosis as a biomarker in emergency department (ED) studies of sepsis is potentially difficult because of sample processing requirements and limited availability of a research cytometer with which to measure patient samples...
  16. doi request reprint Antibacterial properties of an iron-based hemostatic agent in vitro and in a rat wound model
    David O Bracho
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Acad Emerg Med 16:656-60. 2009
    ....
  17. ncbi request reprint Lipopolysaccharide O-antigen promotes persistent murine bacteremia
    Joanelle Z Lugo
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Shock 27:186-91. 2007
    ....
  18. pmc The Klebsiella pneumoniae O antigen contributes to bacteremia and lethality during murine pneumonia
    Sunita Shankar-Sinha
    Department of Emergency Medicine, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Infect Immun 72:1423-30. 2004
    ..These results suggest that during murine pneumonia caused by K. pneumoniae, O antigen contributes to lethality by increasing the propensity for bacteremia and not by significantly changing the early course of intrapulmonary infection...
  19. ncbi request reprint The role of complement C3 in intracerebral hemorrhage-induced brain injury
    Shuxu Yang
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109 0532, USA
    J Cereb Blood Flow Metab 26:1490-5. 2006
    ..These results suggest complement activation may affect heme metabolism and the inflammatory response after ICH suggesting that complement C3 is an important factor causing ICH-induced brain injury...
  20. ncbi request reprint Harmful and protective roles of neutrophils in sepsis
    Laszlo M Hoesel
    Department of Pathologycine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Shock 24:40-7. 2005
    ....
  21. pmc Contribution of the Klebsiella pneumoniae capsule to bacterial aggregate and biofilm microstructures
    Stephen P Dzul
    Department of Emergency Medicine, 4063 Biomedical Sciences Research Building, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Appl Environ Microbiol 77:1777-82. 2011
    ..pneumoniae, with capsule exerting influence at an interbacterial length scale and fluid dynamic forces affecting overall particle size...
  22. pmc Dynamics of human complement-mediated killing of Klebsiella pneumoniae
    Christina M Nypaver
    Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan 48109 3300, USA
    Am J Respir Cell Mol Biol 43:585-90. 2010
    ..The use of luminescent bacteria allowed for the development of a novel and powerful tool for assessing complement immunology for the purposes of mechanistic study and patient evaluation...
  23. pmc Generation of C5a by phagocytic cells
    Markus Huber-Lang
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
    Am J Pathol 161:1849-59. 2002
    ..These data indicate that phagocytic cells, especially lung macrophages, can generate C5a from C5. In the context of the lung, this may represent an important C5a-generating pathway that is independent of the plasma complement system...
  24. ncbi request reprint Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1072-81. 2003
    ..Experimental PE increased lung and systemic production of TxB(2). Inhibition at the COX-1/2 enzyme was equally as effective as inhibition of thromboxane synthase at reducing alveolar dead space and improving heart function after PE...
  25. ncbi request reprint Generation of C5a in the absence of C3: a new complement activation pathway
    Markus Huber-Lang
    Department of Traumatology, Hand and Reconstructive Surgery, University of Ulm Medical School, Steinhoevelstrasse 9, D 89075 Ulm, Germany
    Nat Med 12:682-7. 2006
    ..These data suggest that, in the genetic absence of C3, thrombin substitutes for the C3-dependent C5 convertase. This linkage between the complement and coagulation pathways may represent a new pathway of complement activation...

Research Grants9

  1. LUNG INJURY, PERFLUOROCARBONS, AND HEMORRHAGIC SHOCK
    JOHN YOUNGER; Fiscal Year: 2003
    ....
  2. C5a in defense against murine Gram-negative pneumonia
    JOHN YOUNGER; Fiscal Year: 2007
    ....
  3. Biomechanics of Blood Stream Infections
    JOHN YOUNGER; Fiscal Year: 2009
    ..Our research is being carried out to better understand how patients and bacteria interact and to look for new strategies for protecting and treating patients with serious bloodstream infections. ..
  4. Biomechanics of Blood Stream Infections
    John G Younger; Fiscal Year: 2010
    ..Our research is being carried out to better understand how patients and bacteria interact and to look for new strategies for protecting and treating patients with serious bloodstream infections. ..