William L Young

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Anesthesia for endovascular neurosurgery and interventional neuroradiology
    Chanhung Z Lee
    Department of Anesthesia and Perioperative Care, University of California San Francisco, CA 94110, USA
    Anesthesiol Clin 30:127-47. 2012
  2. pmc Brain-derived neurotrophic factor Val66Met polymorphism predicts worse functional outcome after surgery in patients with unruptured brain arteriovenous malformation
    Erick M Westbroek
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
    Stroke 43:2255-7. 2012
  3. ncbi request reprint Anesthesia for endovascular neurosurgery and interventional neuroradiology
    William L Young
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, 1001 Potrero Avenue, Room 3C 38, San Francisco, CA 94110, USA
    Anesthesiol Clin 25:391-412, vii. 2007
  4. ncbi request reprint Gene microarray analysis of human brain arteriovenous malformations
    Tomoki Hashimoto
    Department of Anesthesia and Perioperative Care, and Center for Cerebrovascular Research, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Neurosurgery 54:410-23; discussion 423-5. 2004
  5. ncbi request reprint Are there genetic influences on sporadic brain arteriovenous malformations?
    William L Young
    Department of Anesthesia, Center for Cerebrovascular Research, Neurological Surgery, and Neurology, University of California San Franscisco, 1001 Potrero Ave, Box 1371 San Francisco, CA 94110, USA
    Stroke 35:2740-5. 2004
  6. pmc Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Cerebrovasc Dis 27:176-82. 2009
  7. ncbi request reprint Anesthetic management of deep hypothermic circulatory arrest for cerebral aneurysm clipping
    William L Young
    Department of Anesthesia and Perioperative Care, and the Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California 94110, USA
    Anesthesiology 96:497-503. 2002
  8. pmc Soluble endoglin modulates aberrant cerebral vascular remodeling
    Yongmei Chen
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California San Francisco, San Francisco, CA, USA
    Ann Neurol 66:19-27. 2009
  9. pmc Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation
    Qi Hao
    University of California, San Francisco, Department of Anesthesia and Perioperative Care, 1001 Potrero Ave, Rm 3C 38, San Francisco, CA 94110, USA
    Am J Physiol Heart Circ Physiol 295:H2250-6. 2008
  10. pmc Angiopoietin-like 4 (ANGPTL4) gene polymorphisms and risk of brain arteriovenous malformations
    Bahar Mikhak
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, 94110, USA
    Cerebrovasc Dis 31:338-45. 2011

Collaborators

Detail Information

Publications115 found, 100 shown here

  1. doi request reprint Anesthesia for endovascular neurosurgery and interventional neuroradiology
    Chanhung Z Lee
    Department of Anesthesia and Perioperative Care, University of California San Francisco, CA 94110, USA
    Anesthesiol Clin 30:127-47. 2012
    ..Planning the anesthetic and perioperative management is predicated on understanding the goals of the therapeutic intervention and anticipating potential problems...
  2. pmc Brain-derived neurotrophic factor Val66Met polymorphism predicts worse functional outcome after surgery in patients with unruptured brain arteriovenous malformation
    Erick M Westbroek
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
    Stroke 43:2255-7. 2012
    ..We hypothesized that the Met allele is associated with worsening of functional outcome after brain arteriovenous malformation resection...
  3. ncbi request reprint Anesthesia for endovascular neurosurgery and interventional neuroradiology
    William L Young
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, 1001 Potrero Avenue, Room 3C 38, San Francisco, CA 94110, USA
    Anesthesiol Clin 25:391-412, vii. 2007
    ..Planning anesthetic and perioperative management is predicated on understanding the goals of the therapeutic intervention and anticipating potential problems...
  4. ncbi request reprint Gene microarray analysis of human brain arteriovenous malformations
    Tomoki Hashimoto
    Department of Anesthesia and Perioperative Care, and Center for Cerebrovascular Research, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Neurosurgery 54:410-23; discussion 423-5. 2004
    ..Human brain arteriovenous malformations (BAVMs) display abnormal expression of various angiogenesis-related genes and their products. We examined gene expression patterns in BAVMs by the gene microarray technique...
  5. ncbi request reprint Are there genetic influences on sporadic brain arteriovenous malformations?
    William L Young
    Department of Anesthesia, Center for Cerebrovascular Research, Neurological Surgery, and Neurology, University of California San Franscisco, 1001 Potrero Ave, Box 1371 San Francisco, CA 94110, USA
    Stroke 35:2740-5. 2004
    ..Moreover, single-nucleotide polymorphisms identification would provide targets for risk stratification for planning clinical trials and eventually guiding management...
  6. pmc Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Cerebrovasc Dis 27:176-82. 2009
    ..The aim of this study was to investigate associations between single nucleotide polymorphisms (SNPs) in IL-1beta and intracranial hemorrhage (ICH) in the natural course of brain arteriovenous malformation (BAVM) patients...
  7. ncbi request reprint Anesthetic management of deep hypothermic circulatory arrest for cerebral aneurysm clipping
    William L Young
    Department of Anesthesia and Perioperative Care, and the Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California 94110, USA
    Anesthesiology 96:497-503. 2002
  8. pmc Soluble endoglin modulates aberrant cerebral vascular remodeling
    Yongmei Chen
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California San Francisco, San Francisco, CA, USA
    Ann Neurol 66:19-27. 2009
    ....
  9. pmc Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation
    Qi Hao
    University of California, San Francisco, Department of Anesthesia and Perioperative Care, 1001 Potrero Ave, Rm 3C 38, San Francisco, CA 94110, USA
    Am J Physiol Heart Circ Physiol 295:H2250-6. 2008
    ....
  10. pmc Angiopoietin-like 4 (ANGPTL4) gene polymorphisms and risk of brain arteriovenous malformations
    Bahar Mikhak
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, 94110, USA
    Cerebrovasc Dis 31:338-45. 2011
    ..We investigated whether common single nucleotide polymorphisms (SNPs) in ANGPTL4 were associated with risk of BAVM or ICH...
  11. pmc Postischemic IGF-1 gene transfer promotes neurovascular regeneration after experimental stroke
    Wei Zhu
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California San Francisco, San Francisco, California, USA
    J Cereb Blood Flow Metab 29:1528-37. 2009
    ..These data show that postischemic treatment of IGF-1 effectively promoted neural and vascular regeneration in the chronic stage of cerebral infarction...
  12. pmc Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9
    Peng Gao
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, California 94110, USA
    J Cereb Blood Flow Metab 29:1482-90. 2009
    ..Our findings suggest that mild nonischemic VH results in a pro-angiogenic stage in the brain by upregulating HIF-1 and its downstream targets, VEGF and SDF-1alpha, increasing leukocyte infiltration and MMP-9 activity...
  13. pmc Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro
    Yongfeng Fan
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA 94110, USA
    J Cereb Blood Flow Metab 28:90-8. 2008
    ..05). These results suggest that IL-6 plays a crucial role in the biologic behavior of blood-derived EPCs, which may help clarify the mechanism of IL-6 inflammatory-related diseases...
  14. pmc Endothelial progenitor cell transplantation improves long-term stroke outcome in mice
    Yongfeng Fan
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA
    Ann Neurol 67:488-97. 2010
    ..However, the cause of EPC migration and the function of EPCs after ischemia are unclear. In this study, we demonstrated the effects of EPCs on ischemic brain injury in a mouse model of transient middle cerebral artery occlusion (tMCAO)...
  15. ncbi request reprint Estimation of fusiform intracranial aneurysm growth by serial magnetic resonance imaging
    Bradley P Dispensa
    Department of Anesthesia and Perioperative Care and Center for Cerebrovascular Research, University of California San Francisco, San Francisco, California 94110, USA
    J Magn Reson Imaging 26:177-83. 2007
    ..Intracranial aneurysm (IA) growth is associated with increased morbidity. We sought to establish a quantitative computational method based on contrast-enhanced MR angiography (CE-MRA) for estimating aneurysmal volume changes over time...
  16. ncbi request reprint Interleukin-6 upregulates expression of KDR and stimulates proliferation of human cerebrovascular smooth muscle cells
    Jianhua S Yao
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, CA 94110, USA
    J Cereb Blood Flow Metab 27:510-20. 2007
    ..A novel role of IL-6 during HCSMC proliferation is upregulating KDR expression and phosphorylation. The results may contribute to the angiogenic phenotype of human brain vascular diseases, such as brain AVM...
  17. ncbi request reprint Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatment
    Achal S Achrol
    Center for Cerebrovascular Research and Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94110, USA
    Neurosurgery 61:731-9; discussion 740. 2007
    ..We hypothesized that the risk of posttreatment ICH would also be greater in patients with brain arteriovenous malformations with these genotypes...
  18. ncbi request reprint Tumor necrosis factor-alpha-238G>A promoter polymorphism is associated with increased risk of new hemorrhage in the natural course of patients with brain arteriovenous malformations
    Achal S Achrol
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, California, USA
    Stroke 37:231-4. 2006
    ....
  19. ncbi request reprint Racial/Ethnic differences in longitudinal risk of intracranial hemorrhage in brain arteriovenous malformation patients
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94115, USA
    Stroke 38:2430-7. 2007
    ..We evaluated whether race/ethnicity was a risk factor for ICH in the natural course in a large, multiethnic cohort of patients with brain arteriovenous malformation followed longitudinally...
  20. pmc Contribution of bone marrow-derived cells associated with brain angiogenesis is primarily through leukocytes and macrophages
    Qi Hao
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA
    Arterioscler Thromb Vasc Biol 28:2151-7. 2008
    ..We investigated the role of bone marrow-derived cells (BMDCs) in an angiogenic focus, induced by VEGF stimulation...
  21. pmc Insulin growth factor-1 gene transfer enhances neurovascular remodeling and improves long-term stroke outcome in mice
    Wei Zhu
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California San Francisco, San Francisco, CA 94110, USA
    Stroke 39:1254-61. 2008
    ..The aim of this study is to examine whether IGF-1 overexpression through adeno-associated virus (AAV) -mediated gene transfer enhances neurovascular remodeling and improves functional outcome in a mouse model of focal cerebral ischemia...
  22. pmc Del-1 gene transfer induces cerebral angiogenesis in mice
    Yongfeng Fan
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, 1001 Potrero Avenue, Room 3C 38, San Francisco, CA 94110, USA
    Brain Res 1219:1-7. 2008
    ..Our data suggest that Del-1 may participate in modulating cerebral angiogenesis, and that gene transfer of Del-1 may provide a novel and potent means for stimulating cerebral angiogenesis...
  23. pmc Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis
    Hua Su
    Center of Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
    Am J Pathol 176:1018-27. 2010
    ..These three lines of evidence from human studies and a mouse model suggest that reduced expression of integrin beta8 may be involved in the pathogenesis of sporadic BAVMs...
  24. ncbi request reprint MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations
    Yongmei Chen
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Front Biosci 11:3121-8. 2006
    ..MPO co-localized with majority of MMP-9 signal by immunohistochemistry. Our data suggest that inflammation is a prominent feature of BAVM lesional phenotype, and neutrophils appear to be a major source of MMP-9 in these lesions...
  25. pmc Evidence of inflammatory cell involvement in brain arteriovenous malformations
    Yongmei Chen
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 62:1340-9; discussion 1349-50. 2008
    ..In this study, we characterized the presence of inflammatory cells in AVM lesional tissue specimens...
  26. pmc Population stratification in a case-control study of brain arteriovenous malformation in Latinos
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California 94110, USA
    Neuroepidemiology 31:224-8. 2008
    ..The purpose of this pilot study was to determine the presence and effect of population stratification in a case-control study of brain arteriovenous malformation (BAVM)...
  27. ncbi request reprint Interleukin-6 involvement in brain arteriovenous malformations
    Yongmei Chen
    Center for Cerebrovascular Research, University of California at San Francisco, 1001 Potrero Avenue, San Francisco, CA, USA
    Ann Neurol 59:72-80. 2006
    ....
  28. ncbi request reprint Adrenoceptor polymorphisms and the risk of cardiac injury and dysfunction after subarachnoid hemorrhage
    Jonathan G Zaroff
    Department of Medicine, University of California, San Francisco, USA
    Stroke 37:1680-5. 2006
    ..We hypothesized that adrenoceptor polymorphisms resulting in greater catecholamine sensitivity would be associated with an increased risk of cardiac injury...
  29. pmc Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhage
    Nerissa U Ko
    Department of Neurology, University of California, San Francisco, USA
    Stroke 39:1103-8. 2008
    ..Decreased availability of nitric oxide (NO) may be crucial in its pathogenesis. We hypothesized that endothelial NO synthase (eNOS) polymorphisms may determine susceptibility to vasospasm in SAH patients...
  30. ncbi request reprint Neutrophil depletion decreases VEGF-induced focal angiogenesis in the mature mouse brain
    Qi Hao
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, CA 94110, USA
    J Cereb Blood Flow Metab 27:1853-60. 2007
    ..In addition, brain MMP-9 activity was attenuated after neutrophil depletion, suggesting that neutrophil is an important source of MMP-9...
  31. pmc Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain
    Wanqiu Chen
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, CA 94110, USA
    Arterioscler Thromb Vasc Biol 33:305-10. 2013
    ..We tested the hypothesis that vascular endothelial growth factor impairs vascular integrity in the Alk1-deficient brain through reduction of mural cell coverage...
  32. pmc Feasibility of minocycline and doxycycline use as potential vasculostatic therapy for brain vascular malformations: pilot study of adverse events and tolerance
    Tim Frenzel
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Cerebrovasc Dis 25:157-63. 2008
    ..Tetracyclines may be useful in preventing pathological vascular remodeling, thus decreasing the risk of spontaneous hemorrhage from brain vascular malformations...
  33. ncbi request reprint Polymorphisms in transforming growth factor-beta-related genes ALK1 and ENG are associated with sporadic brain arteriovenous malformations
    Ludmila Pawlikowska
    Cardiovascular Research Institute, University of California, San Francisco, CA 94110, USA
    Stroke 36:2278-80. 2005
    ..We investigated whether polymorphisms in these genes are also associated with sporadic BAVM...
  34. pmc Phase-contrast magnetic resonance imaging measurements in intracranial aneurysms in vivo of flow patterns, velocity fields, and wall shear stress: comparison with computational fluid dynamics
    Loic Boussel
    Radiology Service, VA Medical Center, San Francisco, California 94121, USA
    Magn Reson Med 61:409-17. 2009
    ..These results indicate that 7D-MRV can be used in vivo to measure velocity flow fields and for estimating MSS and WSS. Currently, however, this method cannot accurately quantify the latter two parameters...
  35. pmc Evaluating performance of the spetzler-martin supplemented model in selecting patients with brain arteriovenous malformation for surgery
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA
    Stroke 43:2497-9. 2012
    ....
  36. ncbi request reprint Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice
    Fanxia Shen
    University of California, San Francisco, Department of Anesthesia and Perioperative Care, 1001 Potrero Ave, San Francisco, CA 94110, USA
    Stroke 37:2601-6. 2006
    ..We investigated the use of a hypoxia-responsive element to control VEGF expression given for neuroprotection...
  37. pmc AAV-mediated netrin-1 overexpression increases peri-infarct blood vessel density and improves motor function recovery after experimental stroke
    Hui Sun
    Department of Neurological Surgery, San Francisco, CA, USA
    Neurobiol Dis 44:73-83. 2011
    ..However, it had little effect on post-stroke spatial learning and memory. Our results suggest that AAV mediated netrin-1 overexpression improves peri-infarct vascular density and post stroke motor function...
  38. doi request reprint Numerical simulations of flow in cerebral aneurysms: comparison of CFD results and in vivo MRI measurements
    Vitaliy L Rayz
    Radiology Service, VA Medical Center San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Biomech Eng 130:051011. 2008
    ..The results demonstrate the clinical relevance of computational models and suggest that realistic patient-specific flow conditions are required for numerical simulations of the flow in aneurysmal blood vessels...
  39. pmc Attenuation of brain response to vascular endothelial growth factor-mediated angiogenesis and neurogenesis in aged mice
    Peng Gao
    Department of Anesthesia and Perioperative Care, University of California, Center for Cerebrovascular Research, San Francisco, Calif 94110, USA
    Stroke 40:3596-600. 2009
    ..Alterations of neuroangiogenic response play important roles in the development of aging-related neurodisorders and affect gene-based therapies. We tested brain response to vascular endothelial growth factor (VEGF) in aged mice...
  40. ncbi request reprint Cardiovascular predictors of in-patient mortality after subarachnoid hemorrhage
    Sirisha Yarlagadda
    Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0124, USA
    Neurocrit Care 5:102-7. 2006
    ..The objective of this study was to test the hypothesis that cardiovascular abnormalities are independently related to in-patient mortality after SAH...
  41. ncbi request reprint Interleukin-6 triggers human cerebral endothelial cells proliferation and migration: the role for KDR and MMP-9
    Jianhua S Yao
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Biochem Biophys Res Commun 342:1396-404. 2006
    ..We conclude that IL-6 triggers VEGF-induced angiogenic activity through increasing VEGF release, up-regulates KDR expression and phosphorylation through activating ERK1/2 signaling, and stimulates MMP-9 overexpression...
  42. pmc Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse
    Eun Jung Choi
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, CA 94110, USA
    Cerebrovasc Dis 33:540-7. 2012
    ..We hypothesized that Eng deletion plus VEGF stimulation would induce a similar degree of cerebrovascular dysplasia as the Alk1-deleted brain...
  43. pmc Endoglin deficiency in bone marrow is sufficient to cause cerebrovascular dysplasia in the adult mouse after vascular endothelial growth factor stimulation
    Eun Jung Choi
    UCSF, Department of Anesthesia and Perioperative Care, San Francisco, CA 94110, USA
    Stroke 44:795-8. 2013
    ..We hypothesized that Eng(+/-) BMDCs cause cerebrovascular dysplasia in the adult mouse after VEGF stimulation...
  44. ncbi request reprint Effect of presenting hemorrhage on outcome after microsurgical resection of brain arteriovenous malformations
    Michael T Lawton
    Department of Neurological Surgery, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 56:485-93; discussion 485-93. 2005
    ..We hypothesized that patients with unruptured arteriovenous malformations (AVMs) at presentation have an increased risk of deterioration compared with patients with ruptured AVMs...
  45. pmc Ten-year detection rate of brain arteriovenous malformations in a large, multiethnic, defined population
    Rodney A Gabriel
    UCSF Department of Anesthesia and Perioperative Care, 1001 Potrero Ave, Room 3C 38, San Francisco, CA 94110, USA
    Stroke 41:21-6. 2010
    ....
  46. pmc Evidence of endothelial progenitor cells in the human brain and spinal cord arteriovenous malformations
    Peng Gao
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 67:1029-35. 2010
    ..Endothelial progenitor cells (EPCs) can be recruited by stromal cell-derived factor-1 (SDF-1), and participate in vascular remodeling in both physiological and pathological settings...
  47. pmc Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic development
    Helen Kim
    Center for Cerebrovascular Research, University of California, San Francisco, Calif, USA
    Stroke 40:S95-7. 2009
    ....
  48. ncbi request reprint Minocycline exerts multiple inhibitory effects on vascular endothelial growth factor-induced smooth muscle cell migration: the role of ERK1/2, PI3K, and matrix metalloproteinases
    Jianhua S Yao
    The Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco 94110, USA
    Circ Res 95:364-71. 2004
    ....
  49. ncbi request reprint Apolipoprotein E epsilon 2 is associated with new hemorrhage risk in brain arteriovenous malformations
    Ludmila Pawlikowska
    The Cardiovascular Research Institute, University of California, San Francisco 94110, USA
    Neurosurgery 58:838-43; discussion 838-43. 2006
    ..Identification of genetic variants associated with increased new ICH risk would facilitate risk stratification and guide therapeutic intervention...
  50. ncbi request reprint Long-term hemorrhage risk in children versus adults with brain arteriovenous malformations
    Heather J Fullerton
    Department of Neurology, University of California, San Francisco, CA 94143 0137, USA
    Stroke 36:2099-104. 2005
    ..Children with brain arteriovenous malformations (BAVMs) are said to be at higher risk for intracranial hemorrhage (ICH) than adults. Although this notion affects treatment decisions, the evidence to support this claim is limited...
  51. pmc EPHB4 gene polymorphisms and risk of intracranial hemorrhage in patients with brain arteriovenous malformations
    Shantel Weinsheimer
    Center for Cerebrovascular Research, University of California, San Francisco, Calif 94110, USA
    Circ Cardiovasc Genet 2:476-82. 2009
    ..We investigated the association of single-nucleotide polymorphisms (SNPs) and haplotypes in EPHB4 with risk of ICH at clinical presentation in patients with BAVM...
  52. ncbi request reprint Matrix metalloproteinase-9 inhibition attenuates vascular endothelial growth factor-induced intracerebral hemorrhage
    Chanhung Z Lee
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, CA 94110, USA
    Stroke 38:2563-8. 2007
    ..We hypothesized that increased MMP-9 was associated with ICH induced by vascular endothelial growth factor hyperstimulation and that this effect could be attenuated by nonspecific MMP inhibition...
  53. ncbi request reprint Estimating the hemodynamic impact of interventional treatments of aneurysms: numerical simulation with experimental validation: technical case report
    Gabriel Acevedo-Bolton
    Department of Radiology, Veterans Affairs Medical Center San Francisco, San Francisco, California 94121, USA
    Neurosurgery 59:E429-30; author reply E429-30. 2006
    ....
  54. pmc Upregulation of EMMPRIN after permanent focal cerebral ischemia
    Wei Zhu
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA
    Neurochem Int 52:1086-91. 2008
    ..The spatial and temporal association between increased EMMPRIN expression and elevated MMP-9 levels suggest that EMMPRIN may modulate MMP-9 activity, and participate in neurovascular remodeling after ischemic stroke...
  55. pmc Overexpression of netrin-1 induces neovascularization in the adult mouse brain
    Yongfeng Fan
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94110, USA
    J Cereb Blood Flow Metab 28:1543-51. 2008
    ..Our findings suggest that netrin-1 plays an important role in promoting blood vessel formation in the adult rodent central nervous system, and could have broad implication in cerebrovascular development and remodeling...
  56. ncbi request reprint Polymorphisms in genes involved in inflammatory and angiogenic pathways and the risk of hemorrhagic presentation of brain arteriovenous malformations
    Ludmila Pawlikowska
    Cardiovascular Research Institute, University of California, San Francisco, Calif 94110, USA
    Stroke 35:2294-300. 2004
    ..Identification of genetic polymorphisms associated with ICH would facilitate risk stratification in BAVM patients...
  57. ncbi request reprint Expression of hypoxia-inducible factor-1 and vascular endothelial growth factor in response to venous hypertension
    Yiqian Zhu
    Center for Cerebrovascular Research, and Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0112, USA
    Neurosurgery 59:687-96; discussion 687-96. 2006
    ..Our aim was to study the effect of nonischemic venous hypertension on the elaboration of the angiogenic signal, hypoxia-inducible factor-1 (HIF-1), and its downstream signal, vascular endothelial growth factor (VEGF)...
  58. pmc Coexpression of angiopoietin-1 with VEGF increases the structural integrity of the blood-brain barrier and reduces atrophy volume
    Fanxia Shen
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, California 94110, USA
    J Cereb Blood Flow Metab 31:2343-51. 2011
    ..85). Thus, coexpression of ANG1 with VEGF improved BBB integrity and resulted in better neuroprotection compared with VEGF expression alone...
  59. pmc Bone marrow-derived cells contribute to vascular endothelial growth factor-induced angiogenesis in the adult mouse brain by supplying matrix metalloproteinase-9
    Qi Hao
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Stroke 42:453-8. 2011
    ..The angiogenic response to vascular endothelial growth factor (VEGF) stimulation is reduced in matrix metalloproteinase-9 (MMP-9) knockout mice. We hypothesized that BMDCs contribute to VEGF-induced angiogenesis by supplying MMP-9...
  60. ncbi request reprint The effects of diffuseness and deep perforating artery supply on outcomes after microsurgical resection of brain arteriovenous malformations
    Rose Du
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 60:638-46; discussion 646-8. 2007
    ..Deep perforating arteries often contribute to the ragged border of these diffuse AVMs. We hypothesized that diffuseness and deep perforator supply increase the difficulties and risks associated with microsurgical AVM resection...
  61. pmc Comparison of 2 approaches for determining the natural history risk of brain arteriovenous malformation rupture
    Helen Kim
    Department of Anesthesia and Perioperative Care, School of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA
    Am J Epidemiol 171:1317-22. 2010
    ..The data also suggest a biologic change around age 10 years influencing ICH rate...
  62. ncbi request reprint Angiopoietin-2 facilitates vascular endothelial growth factor-induced angiogenesis in the mature mouse brain
    Yiqian Zhu
    Center for Cerebrovascular Research, Department of Anesthesia, University of California, San Francisco, CA, USA
    Stroke 36:1533-7. 2005
    ..However, the function of angiopoietin-2 (Ang-2) in cerebral angiogenesis has not been clarified. The goal of this study was to identify the combined effects of VEGF and Ang-2 on cerebral angiogenesis and the blood-brain barrier (BBB)...
  63. ncbi request reprint Recombinant adeno-associated viral vector encoding human VEGF165 induces neomicrovessel formation in the adult mouse brain
    Fanxia Shen
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Front Biosci 11:3190-8. 2006
    ..Our data underline the importance of angiogenesis in the brain tissue and indicate that VEGF gene transfer might present a valuable approach to treat brain ischemic disorders...
  64. pmc Temporal stability of dysmorphic fusiform aneurysms of the intracranial internal carotid artery
    Loic Boussel
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    J Vasc Interv Radiol 22:1007-11. 2011
    ....
  65. doi request reprint An admission bioclinical score to predict 1-year outcomes in patients undergoing aneurysm coiling
    Vincent Degos
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Stroke 43:1253-9. 2012
    ..Our goal was to develop, compare, and validate a predictive score for 1-year outcomes in patients with coiled subarachnoid hemorrhage...
  66. pmc Comparison of doxycycline and minocycline in the inhibition of VEGF-induced smooth muscle cell migration
    Jianhua S Yao
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Neurochem Int 50:524-30. 2007
    ....
  67. doi request reprint Radiation arteriopathy in the transgenic arteriovenous fistula model
    Michael T Lawton
    Department of Neurological Surgery, Center for Cerebrovascular Research, University of California at San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 62:1129-38; discussion 138-9. 2008
    ....
  68. ncbi request reprint Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations
    Tomoki Hashimoto
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94110, USA
    Stroke 34:925-31. 2003
    ..In this study we examined the expression of MMPs and tissue inhibitors of metalloproteinases (TIMPs) in brain arteriovenous malformations (BAVMs)...
  69. ncbi request reprint Doxycycline suppresses cerebral matrix metalloproteinase-9 and angiogenesis induced by focal hyperstimulation of vascular endothelial growth factor in a mouse model
    Chanhung Z Lee
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA
    Stroke 35:1715-9. 2004
    ....
  70. ncbi request reprint Increased cerebral blood flow after brain arteriovenous malformation resection is substantially independent of changes in cardiac output
    Tomoki Hashimoto
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94110, USA
    J Neurosurg Anesthesiol 14:204-8. 2002
    ..The change in CBFGLOBAL was not correlated with changes in CO (r =.154, P =.517). BAVM resection resulted in global increases in CBF that was not substantially related to changes in CO or other systemic parameters...
  71. pmc Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain
    Yiqian Zhu
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA
    J Neuropathol Exp Neurol 68:626-32. 2009
    ..These data suggest that restoring HoxA5 can attenuate experimental brain hemangioma development...
  72. pmc A supplementary grading scale for selecting patients with brain arteriovenous malformations for surgery
    Michael T Lawton
    Department of Neurological Surgery, and Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 66:702-13; discussion 713. 2010
    ..Patient age, hemorrhagic presentation, nidal diffuseness, and deep perforating artery supply are important factors when selecting patients with brain arteriovenous malformations (AVMs) for surgery...
  73. ncbi request reprint Retroviral delivery of homeobox D3 gene induces cerebral angiogenesis in mice
    Yongmei Chen
    Department of Anesthesia and Perioperative Care, The Center for Cerebrovascular Research, University of California, San Francisco, California 94410, USA
    J Cereb Blood Flow Metab 24:1280-7. 2004
    ..The data suggest that HOXD3 may play an important role in regulating cerebral angiogenesis, and that gene transfer of HOXD3 may provide a novel and potent means to stimulate angiogenesis...
  74. ncbi request reprint Vascular endothelial growth factor induces abnormal microvasculature in the endoglin heterozygous mouse brain
    Bin Xu
    Department of Anesthesia and Perioperative Care, UC San Francisco, California 94110, USA
    J Cereb Blood Flow Metab 24:237-44. 2004
    ..These observations are relevant to our general understanding of the maintenance of vascular integrity...
  75. doi request reprint Numerical simulation of pre- and postsurgical flow in a giant basilar aneurysm
    Vitaliy L Rayz
    Radiology Service, VA Medical Center San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Biomech Eng 130:021004. 2008
    ..The study demonstrates that computational models may provide hypotheses to test in future studies, and might offer guidance for the interventional treatment of cerebral aneurysms...
  76. ncbi request reprint Dose-response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulation
    Chanhung Z Lee
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, 94110, USA
    J Cereb Blood Flow Metab 26:1157-64. 2006
    ..This study provided the evidence that the tetracyclines inhibit stimulated cerebral MMP-9 at multiple levels and are effective at very low doses, offering great potential for therapeutic use...
  77. ncbi request reprint Coexpression of angiogenic factors in brain arteriovenous malformations
    Tomoki Hashimoto
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California 94110, USA
    Neurosurgery 56:1058-65; discussion 1058-65. 2005
    ..Therefore, we hypothesized that there are close correlations among key angiogenic factors in BAVMs and that levels of key angiogenic factors are associated with BAVM clinical characteristics that are linked with vascular instability...
  78. pmc Pharmacologically induced thoracic and abdominal aortic aneurysms in mice
    Yasuhisa Kanematsu
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
    Hypertension 55:1267-74. 2010
    ..The aneurysm formation in this model depended on hypertension but not on direct effects of angiotensin II to the vascular wall...
  79. pmc Elastase-induced intracranial aneurysms in hypertensive mice
    Yoshitsugu Nuki
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, 1001 Potrero Ave, No 3C 38, San Francisco, CA 94110, USA
    Hypertension 54:1337-44. 2009
    ..The intracranial aneurysm formation in this model appeared to depend on MMP activation...
  80. pmc Critical roles of macrophages in the formation of intracranial aneurysm
    Yasuhisa Kanematsu
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
    Stroke 42:173-8. 2011
    ..Using a mouse model of intracranial aneurysms, we tested whether macrophages play critical roles in the formation of intracranial aneurysms...
  81. pmc Roles of macrophages in flow-induced outward vascular remodeling
    Yoshitsugu Nuki
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94110, USA
    J Cereb Blood Flow Metab 29:495-503. 2009
    ..05). These data show critical roles of macrophages in flow-induced outward vascular remodeling. Inflammatory cell infiltration and their subsequent release of cytokines may be key processes for flow-induced outward vascular remodeling...
  82. ncbi request reprint Characteristics of brain arteriovenous malformations with coexisting aneurysms: a comparison of two referral centers
    Alexander X Halim
    Departments of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Stroke 33:675-9. 2002
    ..We studied the association between coexisting aneurysms and initial presentation with intracranial hemorrhage (ICH) in patients with BAVM evaluated at two tertiary-care centers...
  83. ncbi request reprint Angiogenesis in the brain during development: the effects of vascular endothelial growth factor and angiopoietin-2 in an animal model
    G Edward Vates
    Department of Neurology, Center for Cerebrovascular Research, University of California, San Francisco, California, USA
    J Neurosurg 103:136-45. 2005
    ..The goal of this study was to examine the roles of vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2) in the formation of blood vessels in the brain in a developmental animal model not routinely used for such a study...
  84. ncbi request reprint Induction of focal angiogenesis through adenoviral vector mediated vascular endothelial cell growth factor gene transfer in the mature mouse brain
    Guo Yuan Yang
    Departments of Anesthesia and Neurosurgery, The Center for Cerebrovascular Research, University of California, San Francisco, California, USA
    Angiogenesis 6:151-8. 2003
    ..This novel method of inducing in vivo brain focal angiogenesis provides an opportunity to study the molecular mechanisms independent of the confounding effects of upstream inciting stimuli such as ischemia or tumor...
  85. pmc A mouse model of intracranial aneurysm: technical considerations
    Yoshiteru Tada
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, 1001, Potrero Avenue, No 3C 38, San Francisco, CA 94110, USA
    Acta Neurochir Suppl 111:31-5. 2011
    ....
  86. ncbi request reprint The transgenic arteriovenous fistula in the rat: an experimental model of gene therapy for brain arteriovenous malformations
    Michael T Lawton
    Department of Neurological Surgery, Center for Cerebrovascular Research, University of California, San Francisco, 94143 0012, USA
    Neurosurgery 54:1463-71; discussion 1471. 2004
    ....
  87. pmc Roles of matrix metalloproteinases in flow-induced outward vascular remodeling
    Ryo Ota
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94110, USA
    J Cereb Blood Flow Metab 29:1547-58. 2009
    ..These data revealed that MMPs, especially MMP-9, are critical in flow-induced outward vascular remodeling...
  88. ncbi request reprint Relationship of nidal vessel radius and wall thickness to brain arteriovenous malformation hemorrhage
    Christopher M Quick
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco 94110, USA
    Neurol Res 24:495-500. 2002
    ..Because BAVM vessels from patients presenting with hemorrhage had thicker vessel walls, the search for structural properties predisposing BAVM rupture should be expanded beyond the morphological properties analyzed here...
  89. ncbi request reprint Interventional neuroradiology--anesthetic considerations
    Tomoki Hashimoto
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco General Hospital, 1001 Potrero Avenue, Room 3C 38, San Francisco, CA 94110, USA
    Anesthesiol Clin North America 20:347-59, vi. 2002
    ..This article provides a brief overview of special considerations in conducting general anesthesia, sedation, and cerebral hemodynamic monitoring for patients undergoing interventional neuroradiologic procedures...
  90. pmc Suppression of MMP-9 by doxycycline in brain arteriovenous malformations
    Tomoki Hashimoto
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, San Francisco, California, USA
    BMC Neurol 5:1. 2005
    ..The primary aim of this study is to demonstrate the feasibility of utilizing doxycycline to suppress matrix metalloproteinase-9 (MMP-9) in brain arteriovenous malformations (AVMs)...
  91. pmc Intracranial aneurysms: links among inflammation, hemodynamics and vascular remodeling
    Tomoki Hashimoto
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, 1001 Potrero Avenue, Room 3C 38, 94110, USA
    Neurol Res 28:372-80. 2006
    ..Such an approach would aim to stabilize these vascular lesions and prevent future expansion or rupture...
  92. pmc Radiosurgery facilitates resection of brain arteriovenous malformations and reduces surgical morbidity
    Rene O Sanchez-Mejia
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 02114, USA
    Neurosurgery 64:231-8; discussion 238-40. 2009
    ..To better characterize these effects, we compared results of microsurgical resection of radiated (RS) and nonradiated (RS) AVMs to demonstrate that previous radiosurgery facilitates surgery and decreases operative morbidity...
  93. pmc Angiopoietin-2: modulator of vascular permeability in acute lung injury?
    Tomoki Hashimoto
    Department of Anesthesia, University of California San Francisco, San Francisco, California, USA
    PLoS Med 3:e113. 2006
  94. ncbi request reprint Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage
    Wade S Smith
    Department of Neurology, University of California, San Francisco, Calif 94134 0114, USA
    Stroke 35:2518-22. 2004
    ..Papaverine is used to vasodilate cerebral arteries undergoing vasospasm from subarachnoid hemorrhage. However, papaverine inhibits cellular respiration in vitro and could cause neurotoxicity in humans...
  95. ncbi request reprint Neurosurgery at the crossroads: integrated multidisciplinary management of 449 patients with brain arteriovenous malformations
    Rose Du
    Department of Neurological Surgery, University of California, San Francisco, USA
    Clin Neurosurg 52:177-91. 2005
  96. ncbi request reprint Giant infiltrative cavernous malformation: clinical presentation, intervention, and genetic analysis: case report
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 55:979-80. 2004
    ..We present the case of a young boy with a complex cavernous malformation that evolved during the course of a decade to encompass the majority of his right cerebral hemisphere...
  97. ncbi request reprint Adaptation of cerebral circulation to brain arteriovenous malformations increases feeding artery pressure and decreases regional hypotension
    Christopher M Quick
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, 1001 Potrero Avenue, Rm 3C 38, San Francisco, CA 94110, USA
    Neurosurgery 50:167-73; discussion 173-5. 2002
    ..To determine how the adaptation of extranidal cerebral vessels affects feeding artery pressure, draining vein pressure, and regional hypotension due to the presence of brain arteriovenous malformations (BAVMs)...
  98. doi request reprint Risk factors for hemorrhagic presentation in patients with dural arteriovenous fistulae
    Vineeta Singh
    Department of Neurology, University of California at San Francisco, San Francisco, CA 94143, USA
    Neurosurgery 62:628-35; discussion 628-35. 2008
    ..The aim of this study was to investigate the independent effects of specific demographic and clinical variables on hemorrhagic presentation in patients with DAVFs...
  99. ncbi request reprint Sylvian fissure arteriovenous malformations: an application of the Sugita classification to 28 surgical patients
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 61:29-36; discussion 36-8. 2007
    ..This classification scheme is simple and appealing, but is rarely applied. We applied the Sugita classification to a consecutive, single-surgeon experience with 28 patients to better characterize the Sugita subtypes...
  100. ncbi request reprint Participation of PI3K and ERK1/2 pathways are required for human brain vascular smooth muscle cell migration
    Guo Yuan Yang
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, 1001 Potrero Avenue, 3C 38, San Francisco, CA 94110, USA
    Neurochem Int 44:441-6. 2004
    ..We provide the first evidence that activation of PI3K or ERK1/2 pathways are a crucial event in VEGF(165) mediated signal transduction leading to HBVSMC migration...
  101. doi request reprint Anesthetic concerns in patients with known cerebrovascular insufficiency
    Anna V Logvinova
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Anesthesiol Clin 28:1-12. 2010
    ..Planning the anesthetic and perioperative management is predicated on understanding the goals of the therapeutic intervention and anticipating potential problems...