Vincent Young

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. Rao K, Young V. Probiotics for Prevention of Clostridium difficile Infection in Hospitalized Patients: Is the Jury Still Out?. Gastroenterology. 2017;152:1817-1819 pubmed publisher
  2. Young V. The intestinal microbiota in health and disease. Curr Opin Gastroenterol. 2012;28:63-9 pubmed publisher
    ..Understanding how the gut microbiome contributes to intestinal health should lead to novel preventive strategies and therapies for a variety of gastrointestinal conditions. ..
  3. Leslie J, Young V. The rest of the story: the microbiome and gastrointestinal infections. Curr Opin Microbiol. 2015;23:121-5 pubmed publisher
  4. Koenigsknecht M, Theriot C, Bergin I, Schumacher C, Schloss P, Young V. Dynamics and establishment of Clostridium difficile infection in the murine gastrointestinal tract. Infect Immun. 2015;83:934-41 pubmed publisher
    ..This study provides an integrated understanding of the timing and location of the events surrounding C. difficile colonization and identifies potential targets for the development of new therapeutic strategies. ..
  5. Rao K, Young V. Fecal microbiota transplantation for the management of Clostridium difficile infection. Infect Dis Clin North Am. 2015;29:109-22 pubmed publisher
    ..The use of FMT for recurrent CDI is characterized by a high response rate and short term safety is excellent, although the long-term effects of FMT are as yet unknown. ..
  6. Seekatz A, Theriot C, Molloy C, Wozniak K, Bergin I, Young V. Fecal Microbiota Transplantation Eliminates Clostridium difficile in a Murine Model of Relapsing Disease. Infect Immun. 2015;83:3838-46 pubmed publisher
    ..difficile, and the gut microbiota in these mice persisted at low diversity. These results suggest that full recovery of colonization resistance against C. difficile requires the restoration of a specific community structure. ..
  7. Seekatz A, Theriot C, Rao K, Chang Y, Freeman A, Kao J, et al. Restoration of short chain fatty acid and bile acid metabolism following fecal microbiota transplantation in patients with recurrent Clostridium difficile infection. Anaerobe. 2018;: pubmed publisher
    ..The longitudinal aspect of this study allowed us to characterize individualized patterns of recovery, revealing variability between and within patients following FMT. ..
  8. Seekatz A, Wolfrum E, DeWald C, Putler R, Vendrov K, Rao K, et al. Presence of multiple Clostridium difficile strains at primary infection is associated with development of recurrent disease. Anaerobe. 2018;: pubmed publisher
    ..Our results suggest that mixed C. difficile infection is more prevalent than previously demonstrated and potentially a marker of susceptibility to recurrence. ..
  9. Young V, Raffals L, Huse S, Vital M, Dai D, Schloss P, et al. Multiphasic analysis of the temporal development of the distal gut microbiota in patients following ileal pouch anal anastomosis. Microbiome. 2013;1:9 pubmed publisher

More Information

Publications14

  1. Leslie J, Young V. A whole new ball game: Stem cell-derived epithelia in the study of host-microbe interactions. Anaerobe. 2016;37:25-8 pubmed publisher
    ..Furthermore we highlight aspects of these techniques that warrant further development to facilitate the study of host-microbe interactions. ..
  2. Seekatz A, Rao K, Santhosh K, Young V. Dynamics of the fecal microbiome in patients with recurrent and nonrecurrent Clostridium difficile infection. Genome Med. 2016;8:47 pubmed publisher
    ..Our data demonstrate that specific microbiota-derived characteristics associate with disease severity and recurrence and that future studies could incorporate these characteristics into predictive models. ..
  3. Young V. Therapeutic manipulation of the microbiota: past, present, and considerations for the future. Clin Microbiol Infect. 2016;22:905-909 pubmed publisher
    ..A key conclusion that can be drawn is that understanding of the precise role of the microbiota in the pathogenesis of a specific disease is necessary prior to determining if microbiota manipulation represents a novel treatment therapy. ..
  4. Young V. The role of the microbiome in human health and disease: an introduction for clinicians. BMJ. 2017;356:j831 pubmed publisher
    ..With the explosion of studies relating the microbiome to health and disease, this review aims to provide a foundation for clinicians to follow this developing area of biomedical research. ..
  5. Young V. Old and new models for studying host-microbe interactions in health and disease: C. difficile as an example. Am J Physiol Gastrointest Liver Physiol. 2017;312:G623-G627 pubmed publisher