Steven L Young

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Complexity in endometrial estradiol signaling
    Steven L Young
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, NC 27599 7570, USA
    Reprod Sci 14:627-8. 2007
  2. pmc Oestrogen and progesterone action on endometrium: a translational approach to understanding endometrial receptivity
    Steven L Young
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7570, United States Electronic address
    Reprod Biomed Online 27:497-505. 2013
  3. pmc Inter-laboratory validation of the measurement of follicle stimulating hormone (FSH) after various lengths of frozen storage
    Jessica Scriver
    School of Medicine, University of Virginia, Charlottesville, VA 22908 0712, USA
    Reprod Biol Endocrinol 8:145. 2010
  4. pmc 17Beta-estradiol suppresses TLR3-induced cytokine and chemokine production in endometrial epithelial cells
    Margaret J Lesmeister
    Department of Molecular Microbiology and Immunology, University of Missouri Columbia, School of Medicine, MO, USA
    Reprod Biol Endocrinol 3:74. 2005
  5. ncbi request reprint Progesterone function in human endometrium: clinical perspectives
    Steven L Young
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of North Carolina, Chapel Hill 27599 7570, North Carolina, USA
    Semin Reprod Med 28:5-16. 2010
  6. pmc Effects of variations in serum estradiol concentrations on secretory endometrial development and function in experimentally induced cycles in normal women
    Jeremy M Groll
    Division of Reproductive Endocrinology and Infertility, Wright Patterson AFB, Ohio 45433, USA
    Fertil Steril 92:2058-61. 2009
  7. pmc G protein-coupled estrogen receptor (GPER) expression in normal and abnormal endometrium
    Beth J Plante
    Department of Obstetrics and Gynecology, The University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Reprod Sci 19:684-93. 2012
  8. pmc Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation
    Suxia Bai
    Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Hum Reprod 14:107-16. 2008
  9. pmc Primate-specific melanoma antigen-A11 regulates isoform-specific human progesterone receptor-B transactivation
    Shifeng Su
    Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 287:34809-24. 2012
  10. pmc Endometrial development and function in experimentally induced luteal phase deficiency
    Rebecca S Usadi
    Carolinas Medical Center, Division of Reproductive Endocrinology and Infertility, Charlotte, North Carolina 28232 2861, USA
    J Clin Endocrinol Metab 93:4058-64. 2008

Research Grants

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Complexity in endometrial estradiol signaling
    Steven L Young
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, NC 27599 7570, USA
    Reprod Sci 14:627-8. 2007
  2. pmc Oestrogen and progesterone action on endometrium: a translational approach to understanding endometrial receptivity
    Steven L Young
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7570, United States Electronic address
    Reprod Biomed Online 27:497-505. 2013
    ....
  3. pmc Inter-laboratory validation of the measurement of follicle stimulating hormone (FSH) after various lengths of frozen storage
    Jessica Scriver
    School of Medicine, University of Virginia, Charlottesville, VA 22908 0712, USA
    Reprod Biol Endocrinol 8:145. 2010
    ..With increased frequency of research collaborations across institutions, it is essential that inter-laboratory validation is addressed...
  4. pmc 17Beta-estradiol suppresses TLR3-induced cytokine and chemokine production in endometrial epithelial cells
    Margaret J Lesmeister
    Department of Molecular Microbiology and Immunology, University of Missouri Columbia, School of Medicine, MO, USA
    Reprod Biol Endocrinol 3:74. 2005
    ..In this study, the effects of 17beta-estradiol (E2) and progesterone (P) on TLR3 expression and function in endometrial cell lines were investigated...
  5. ncbi request reprint Progesterone function in human endometrium: clinical perspectives
    Steven L Young
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of North Carolina, Chapel Hill 27599 7570, North Carolina, USA
    Semin Reprod Med 28:5-16. 2010
    ....
  6. pmc Effects of variations in serum estradiol concentrations on secretory endometrial development and function in experimentally induced cycles in normal women
    Jeremy M Groll
    Division of Reproductive Endocrinology and Infertility, Wright Patterson AFB, Ohio 45433, USA
    Fertil Steril 92:2058-61. 2009
    ..9 pg/mL and 17.5 ng/mL, 136.9 pg/mL and 21.2 pg/mL, and 23.8 ng/mL and 22.0 ng/mL, respectively, and there were no differences between groups in endometrial histology or expression of biomarkers of receptivity...
  7. pmc G protein-coupled estrogen receptor (GPER) expression in normal and abnormal endometrium
    Beth J Plante
    Department of Obstetrics and Gynecology, The University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Reprod Sci 19:684-93. 2012
    ..Together, these data suggest that normal endometrial GPER expression is cyclic and regulated by nuclear estrogen and progesterone receptors, while expression is dysregulated in endometriosis...
  8. pmc Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation
    Suxia Bai
    Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Hum Reprod 14:107-16. 2008
    ..The results suggest that MAGE-11 functions as a coregulator that increases AR transcriptional activity during the establishment of uterine receptivity in the human female...
  9. pmc Primate-specific melanoma antigen-A11 regulates isoform-specific human progesterone receptor-B transactivation
    Shifeng Su
    Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 287:34809-24. 2012
    ..We conclude that the coregulator function of MAGE-11 extends to isoform-specific regulation of PR-B during the cyclic development of the human endometrium...
  10. pmc Endometrial development and function in experimentally induced luteal phase deficiency
    Rebecca S Usadi
    Carolinas Medical Center, Division of Reproductive Endocrinology and Infertility, Charlotte, North Carolina 28232 2861, USA
    J Clin Endocrinol Metab 93:4058-64. 2008
    ..It is generally assumed that delayed endometrial development observed in luteal phase deficiency (LPD) is the result of abnormally low progesterone (P) levels. This hypothesis has never been tested by direct experiment...
  11. ncbi request reprint Regulated expression of heparin-binding EGF-like growth factor (HB-EGF) in the human endometrium: a potential paracrine role during implantation
    Bruce A Lessey
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Reprod Dev 62:446-55. 2002
    ..The stimulatory effect of the stromal-conditioned medium was blocked by antibodies that neutralize a known receptor for HB-EGF. These data suggest that uterine receptivity may be regulated in part by the stromal-derived HB-EGF...
  12. pmc Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women
    Bruce A Lessey
    Division of Reproductive Endocrinology and Infertility, University Medical Group, Department of Obstetrics and Gynecology, Greenville Hospital System, Greenville, SC, USA
    Reprod Biol Endocrinol 4:S9. 2006
    ..Such changes might be effectively treated by timely administration of the appropriate anti-estrogens to artificially block ER alpha and restore normal patterns of gene expression. Such treatments will require further clinical studies...
  13. pmc Cyclic regulation of transcription factor C/EBP beta in human endometrium
    Beth J Plante
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of North Carolina School of Medicine, CB 7570, Old Clinic Building, Chapel Hill, NC 27599, USA
    Reprod Biol Endocrinol 7:15. 2009
    ..Our objective is to characterize changes in C/EBP beta mRNA abundance and protein localization over the normal human menstrual cycle...
  14. pmc Proteomic analysis of the luteal endometrial secretome
    Jessica G Scotchie
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Reprod Sci 16:883-93. 2009
    ..This article describes the first application of proteomic analysis to endometrial secretions, allowing identification of novel endometrial proteins as well as those differentially secreted in prereceptive and receptive phases...
  15. pmc 17beta-Estradiol inhibits Ca2+-dependent homeostasis of airway surface liquid volume in human cystic fibrosis airway epithelia
    Ray D Coakley
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 118:4025-35. 2008
    ....
  16. ncbi request reprint In vivo and in vitro evidence suggest that HB-EGF regulates endometrial expression of human decay-accelerating factor
    Steven L Young
    Department of Obstetrics and Gynecology, University of Missouri, Columbia, Missouri 65212, USA
    J Clin Endocrinol Metab 87:1368-75. 2002
    ....
  17. ncbi request reprint Understanding endometriosis is the key to successful therapeutic management
    Kathy L Sharpe-Timms
    Department of Obstetrics and Gynecology, School of Medicine, University of Missouri Columbia, Columbia, Missouri 65212, USA
    Fertil Steril 81:1201-3. 2004
    ..Understanding endometriosis on a molecular, biochemical, and genetic level will lead to better methods for the diagnosis and therapeutic management of this enigmatic disease...
  18. pmc Expression of Toll-like receptors in human endometrial epithelial cells and cell lines
    Steven L Young
    Department of Obstetrics and Gynecology, School of Medicine, University of Missouri, Columbia, MO, USA
    Am J Reprod Immunol 52:67-73. 2004
    ..Are toll-like receptors (TLRs) expressed by human endometrium and endometrial cell lines?..
  19. pmc Human endometrial epithelial cells cyclically express Toll-like receptor 3 (TLR3) and exhibit TLR3-dependent responses to dsRNA
    Rebecca L Jorgenson
    Department of Molecular Microbiology and Immunology, University of Missouri Columbia, School of Medicine, Columbia, MO 65212, USA
    Hum Immunol 66:469-82. 2005
    ..Our findings suggest that TLR3 is involved in the immune responses of endometrial epithelial cells after exposure to dsRNA and has the potential to alter the cytokine milieu and influence the outcome and consequences of infection...
  20. pmc Epithelial invasion by Escherichia coli bearing Dr fimbriae is controlled by nitric oxide-regulated expression of CD55
    Li Fang
    Departments of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas 77555 1062, USA
    Infect Immun 72:2907-14. 2004
    ..The significance of NO-regulated receptor-ligand invasion is that it may represent a novel unrecognized phenomenon of epithelial defense against infection...
  21. ncbi request reprint Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells
    Gaurang S Daftary
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Mol Endocrinol 16:571-9. 2002
    ..beta3-Integrin expression was directly up-regulated by HOXA10 through a 41-bp 5'-regulatory element. Sex steroids regulate the expression of endometrial beta3-integrin through a pathway involving HOXA10...

Research Grants1

  1. Regulation of Human TLR3 & TLR9 Expression and Function
    Steven Young; Fiscal Year: 2004
    ..Thus, the proposed studies will contribute to an understanding of mechanisms regulating human endometrial cytokine expression, which could lead to the design of pharmacologic therapies for both infectious and reproductive disorders. ..