Stephen Young

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Nuclear lamins and neurobiology
    Stephen G Young
    Department of Medicine, University of California, Los Angeles, California, USA Department of Human Genetics, University of California, Los Angeles, California, USA Molecular Biology Institute, University of California, Los Angeles, California, USA
    Mol Cell Biol 34:2776-85. 2014
  2. pmc Localization of lipoprotein lipase and GPIHBP1 in mouse pancreas: effects of diet and leptin deficiency
    Rakel Nyrén
    Department of Medical Biosciences Physiological Chemistry, Umea University, Umea, Sweden
    BMC Physiol 12:14. 2012
  3. pmc Biochemistry and pathophysiology of intravascular and intracellular lipolysis
    Stephen G Young
    Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Genes Dev 27:459-84. 2013
  4. pmc Understanding the roles of nuclear A- and B-type lamins in brain development
    Stephen G Young
    Department of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 287:16103-10. 2012
  5. pmc Biventricular adaptation to volume overload in mice with aortic regurgitation
    Christopher J Berry
    University of Iowa Carver College of Medicine, Iowa City, USA
    J Cardiovasc Magn Reson 11:27. 2009
  6. ncbi request reprint Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis
    Stephen G Young
    Division of Cardiology, Department of Internal Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 46:2531-58. 2005
  7. pmc GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons
    Stephen G Young
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Curr Opin Lipidol 18:389-96. 2007
  8. pmc GPIHBP1, an endothelial cell transporter for lipoprotein lipase
    Stephen G Young
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 52:1869-84. 2011
  9. pmc Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice
    Michael M Weinstein
    695 Charles E Young Dr S, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 32:230-5. 2012
  10. ncbi request reprint Prelamin A farnesylation and progeroid syndromes
    Stephen G Young
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 281:39741-5. 2006

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Nuclear lamins and neurobiology
    Stephen G Young
    Department of Medicine, University of California, Los Angeles, California, USA Department of Human Genetics, University of California, Los Angeles, California, USA Molecular Biology Institute, University of California, Los Angeles, California, USA
    Mol Cell Biol 34:2776-85. 2014
    ..In this review, we summarize recent progress in elucidating links between nuclear lamins and neurobiology. ..
  2. pmc Localization of lipoprotein lipase and GPIHBP1 in mouse pancreas: effects of diet and leptin deficiency
    Rakel Nyrén
    Department of Medical Biosciences Physiological Chemistry, Umea University, Umea, Sweden
    BMC Physiol 12:14. 2012
    ..The distribution of LPL and GPIHBP1 was compared to insulin, glucagon and CD31. Heparin injections were used to discriminate between intracellular and extracellular LPL...
  3. pmc Biochemistry and pathophysiology of intravascular and intracellular lipolysis
    Stephen G Young
    Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Genes Dev 27:459-84. 2013
    ..This review summarizes current views of lipolysis and highlights the relevance of this process to human disease...
  4. pmc Understanding the roles of nuclear A- and B-type lamins in brain development
    Stephen G Young
    Department of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 287:16103-10. 2012
    ..The relevance of lamins A and C in the brain remains unclear, but it is intriguing that prelamin A expression in the brain is low and is regulated by miR-9, a brain-specific microRNA...
  5. pmc Biventricular adaptation to volume overload in mice with aortic regurgitation
    Christopher J Berry
    University of Iowa Carver College of Medicine, Iowa City, USA
    J Cardiovasc Magn Reson 11:27. 2009
    ..The purpose of this study was to ascertain the prevalence of aortic regurgitation in hypercholesterolemic mice and to determine its impact on the left and right ventricles...
  6. ncbi request reprint Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis
    Stephen G Young
    Division of Cardiology, Department of Internal Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 46:2531-58. 2005
    ....
  7. pmc GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons
    Stephen G Young
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Curr Opin Lipidol 18:389-96. 2007
    ..To summarize recent data indicating that glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) plays a key role in the lipolytic processing of chylomicrons...
  8. pmc GPIHBP1, an endothelial cell transporter for lipoprotein lipase
    Stephen G Young
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 52:1869-84. 2011
    ..We also discuss the human genetics of LPL transport, focusing on cases of chylomicronemia caused by GPIHBP1 mutations that abolish GPIHBP1's ability to bind LPL, and LPL mutations that prevent LPL binding to GPIHBP1...
  9. pmc Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice
    Michael M Weinstein
    695 Charles E Young Dr S, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 32:230-5. 2012
    ..We also asked whether perturbations in adipose tissue composition and gene expression, if they occur, would be accompanied by reciprocal metabolic changes in the liver...
  10. ncbi request reprint Prelamin A farnesylation and progeroid syndromes
    Stephen G Young
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 281:39741-5. 2006
    ..Also, administering an FTI to mouse models of HGPS and RD ameliorates the phenotypes of progeria. These studies have prompted interest in testing the efficacy of FTIs in children with HGPS...
  11. pmc Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect
    Martin O Bergo
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141 9100, USA
    Proc Natl Acad Sci U S A 99:13049-54. 2002
    ..Muscle weakness in Zmpste24(-/-) mice can be reasonably ascribed to defective processing of prelamin A, but the brittle bone phenotype suggests a broader role for Zmpste24 in mammalian biology...
  12. pmc Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated
    Shao H Yang
    Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California, USA
    J Clin Invest 118:3291-300. 2008
    ....
  13. doi request reprint Eliminating the synthesis of mature lamin A reduces disease phenotypes in mice carrying a Hutchinson-Gilford progeria syndrome allele
    Shao H Yang
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 283:7094-9. 2008
    ..These studies suggest that compositional changes in the nuclear lamina can influence both the steady-state levels of progerin and the severity of progeria-like disease phenotypes...
  14. pmc Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 50:126-34. 2009
    ..The steady-state levels of progerin, relative to lamin C, were lower in Lmna(ggHG/+) mice than in Lmna(HG/+) mice, providing a potential explanation for the milder disease in Lmna(ggHG/+) mice...
  15. pmc Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice
    Michael M Weinstein
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 283:34511-8. 2008
    ..The differences in LPL release after intravenous heparin and Intralipid strongly suggest that GPIHBP1 represents an important binding site for LPL in vivo...
  16. pmc The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons
    Peter Gin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 283:29554-62. 2008
    ..These studies indicate that the acidic domain of GPIHBP1 is important and that electrostatic interactions play a key role in ligand binding...
  17. pmc Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation
    Shao H Yang
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 102:10291-6. 2005
    ..0001 by chi2 statistic). These studies suggest a possible treatment strategy for HGPS...
  18. pmc Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria
    Shao H Yang
    Department of Medicine, University of California, Los Angeles, Los Angeles, CA
    J Lipid Res 51:400-5. 2010
    ..The failure of the FTI to ameliorate disease in Lmna(nHG/+) mice supports the idea that the beneficial effects of an FTI in Lmna(HG/+) mice are due to the effect of drug on the farnesylation of progerin...
  19. pmc Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes
    Julia I Toth
    Department of Medicine and Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 102:12873-8. 2005
    ..0003 and P < 0.0001). These findings establish a paradigm for ameliorating the most obvious cellular pathology in lamin-related progeroid syndromes and suggest a potential strategy for treating these diseases...
  20. pmc Laminopathies and the long strange trip from basic cell biology to therapy
    Howard J Worman
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    J Clin Invest 119:1825-36. 2009
    ..Here, we review the laminopathies and the long strange trip from basic cell biology to therapeutic approaches for these diseases...
  21. pmc Factors affecting the prevalence of strongly and weakly carcinogenic and lower-risk human papillomaviruses in anal specimens in a cohort of men who have sex with men (MSM)
    Dorothy J Wiley
    School of Nursing, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e79492. 2013
    ..HPVs rarely associated with malignancy are classified as lower-risk HPVs (lrHPVs)...
  22. pmc Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity
    Laurent Vergnes
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 47:745-54. 2006
    ..Thus, Agpat6 plays a unique role in determining triglyceride content and composition in adipose tissue and liver that cannot be compensated by other members of the Agpat family...
  23. ncbi request reprint N-myristoyltransferase 1 is essential in early mouse development
    Shao H Yang
    Department of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 280:18990-5. 2005
    ..We conclude that Nmt1 is not essential for the viability of mammalian cells but is required for development, likely because it is the principal N-myristoyltransferase in early embryogenesis...
  24. pmc Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases
    David Michaelson
    Department of Medicine, Cell Biology, and Pharmacology, New York University School of Medicine, NY 10016, USA
    Mol Biol Cell 16:1606-16. 2005
    ..These results suggest that postprenylation CAAX processing is required for proper localization of farnesylated Ras but not geranygeranylated Rho proteins...
  25. ncbi request reprint Protein farnesyltransferase inhibitors and progeria
    Margarita Meta
    Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Trends Mol Med 12:480-7. 2006
    ..In addition, recent data showing that FTIs ameliorate disease phenotypes in a pair of mouse models of progeria are discussed...
  26. ncbi request reprint Lamins A and C but not lamin B1 regulate nuclear mechanics
    Jan Lammerding
    Cardiovascular Division, Department of Medicine, and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    J Biol Chem 281:25768-80. 2006
    ..Our study indicates that lamins A and C are important contributors to the mechanical stiffness of nuclei, whereas lamin B1 contributes to nuclear integrity but not stiffness...
  27. pmc Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution
    Peter Gin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Biochim Biophys Acta 1771:1464-8. 2007
    ....
  28. pmc Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation
    Shao H Yang
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Biochim Biophys Acta 1781:36-9. 2008
    ..Treatment with the FTI also improved body weight curves and reduced the number of spontaneous rib fractures. This study provides further evidence for a beneficial effect of an FTI in HGPS...
  29. ncbi request reprint Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver
    Anne Beigneux
    Gladstone Institute of Cardiovascular Disease and the Cardiovascular Research Institute, University of California, San Francisco, California 94141 9100, USA
    J Biol Chem 277:38358-63. 2002
    ..We conclude that prenylcysteine lyase does play a physiologic role in cleaving prenylcysteines in mammals, but the absence of this activity does not lead to major pathologic consequences...
  30. pmc GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 12:42-52. 2010
    ..Our experiments define the function of GPIHBP1 in triglyceride metabolism and provide a mechanism for the transport of LPL into capillaries...
  31. ncbi request reprint Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes
    Casey L Moulson
    Department of Internal Medicine, Renal Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Hum Mutat 28:882-9. 2007
    ..Thus, farnesyltransferase inhibitors may prove to be useful even when progerin expression levels are higher than those in typical HGPS patients...
  32. pmc Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 284:30240-7. 2009
    ..In this assay, wild-type soluble GPIHBP1 bound LPL avidly, but the cysteine mutants did not. Thus, our studies suggest that a structurally intact Ly6 domain (in addition to the acidic domain) is essential for LPL binding...
  33. pmc Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice
    Catherine Coffinier
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    J Biol Chem 285:20818-26. 2010
    ..We conclude that prelamin A processing is dispensable in mice and that direct synthesis of mature lamin A has little if any effect on the targeting of lamin A to the nuclear rim in mouse tissues...
  34. pmc The posttranslational processing of prelamin A and disease
    Brandon S J Davies
    Department of Medicine, University of California, Los Angeles, California 90095, USA
    Annu Rev Genomics Hum Genet 10:153-74. 2009
    ..In this review, we discuss the posttranslational modifications of prelamin A and their relevance to the pathogenesis and treatment of progeroid syndromes...
  35. ncbi request reprint Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury
    Johan Björkegren
    Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, University of California, San Francisco 94110, USA
    J Biol Chem 277:5476-83. 2002
    ..Our results suggest that blocking lipoprotein secretion in the liver may increase the susceptibility of the liver to certain toxic challenges...
  36. pmc HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells
    Catherine Coffinier
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:13432-7. 2007
    ..6 microM; tipranavir, 1.2 +/- 0.4 microM). We conclude that the HIV-PIs inhibit ZMPSTE24, leading to an accumulation of farnesyl-prelamin A. The inhibition of ZMPSTE24 by HIV-PIs could play a role in the side effects of these drugs...
  37. pmc Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists
    Elena Scotti
    Howard Hughes Medical Institute, UCLA School of Medicine, Box 951662, Los Angeles, CA 90095 1662, USA
    Mol Cell Biol 31:1885-93. 2011
    ..These results demonstrate that the LXR-Idol pathway is an important contributor to feedback inhibition of the LDLR by sterols and a biological determinant of cellular LDL uptake...
  38. pmc An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 19:2682-94. 2010
    ..The latter finding is potentially relevant to the long-term use of protein farnesyltransferase inhibitors, which lead to an accumulation of non-farnesylated prelamin A...
  39. pmc Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency
    Catherine Coffinier
    Departments of Medicine and Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:5076-81. 2010
    ..These studies establish an essential function for lamin B2 in neuronal migration and brain development...
  40. pmc Chylomicronemia elicits atherosclerosis in mice--brief report
    Michael M Weinstein
    Departments of Medicine, University of California, Los Angeles, USA
    Arterioscler Thromb Vasc Biol 30:20-3. 2010
    ..In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficient mice (Gpihbp1(-/-)), which manifest severe chylomicronemia as a result of defective lipolysis...
  41. pmc Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 49:1312-21. 2008
    ..These studies demonstrate that N-glycosylation of GPIHBP1 is important for the trafficking of GPIHBP1 to the cell surface...
  42. pmc Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides
    Loren G Fong
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 18:2462-71. 2009
    ..Thus, different ASOs can be used to increase or decrease 'HGPS splicing'. ASOs represent a new and powerful tool for recreating HGPS pathophysiology in wild-type cells...
  43. pmc The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Mol Endocrinol 22:2496-504. 2008
    ..We conclude that GPIHBP1 is regulated by dietary factors and by PPARgamma...
  44. pmc GPIHBP1 and lipolysis: an update
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Curr Opin Lipidol 20:211-6. 2009
    ..This review will provide an update on the structure of GPIHBP1, a 28-kDa glycosylphosphatidylinositol-anchored glycoprotein, and its role in the lipolytic processing of triglyceride-rich lipoproteins...
  45. pmc Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 29:956-62. 2009
    ..Because GPIHBP1 deficiency causes chylomicronemia in mice, we sought to determine whether some cases of chylomicronemia in humans could be attributable to defective GPIHBP1 proteins...
  46. pmc GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 50:S57-62. 2009
    ..Here, we review recent progress in understanding GPIHBP1 and discuss its role in lipolysis...
  47. pmc A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells
    Catherine Coffinier
    Department of Medicine and Human Genetics, David Geffen School of Medicine, University of California Los Angeles, 695 Charles E Young Drive South, Los Angeles, CA 90095, USA
    J Biol Chem 283:9797-804. 2008
    ..Ritonavir, like lopinavir, inhibits ZMPSTE24 and leads to an accumulation of prelamin A...
  48. pmc Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons
    Anne P Beigneux
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, and Children s Hospital Oakland Research Institute 94609, USA
    Cell Metab 5:279-91. 2007
    ..Expression of GPIHBP1 in cultured cells confers the ability to bind both LpL and chylomicrons. These studies strongly suggest that GPIHBP1 is an important platform for the LpL-mediated processing of chylomicrons in capillaries...
  49. pmc Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium
    Anne P Beigneux
    Division of Cardiology, Department of Internal Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 47:734-44. 2006
    ..Thus, we identified a novel glycerolipid acyltransferase of the ER, AGPAT6, which is crucial for the production of milk fat by the mammary gland...
  50. ncbi request reprint A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria
    Loren G Fong
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:1621-3. 2006
    ..The FTI-treated mice exhibited improved body weight, grip strength, bone integrity, and percent survival at 20 weeks of age. These results suggest that FTIs may have beneficial effects in humans with progeria...
  51. pmc Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice
    Loren G Fong
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:18111-6. 2004
    ..These data suggest that prelamin A is toxic and that reducing its levels by as little as 50% provides striking protection from disease...
  52. pmc Lamin B1 is required for mouse development and nuclear integrity
    Laurent Vergnes
    Veterans Affairs Greater Los Angeles Healthcare System, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
    Proc Natl Acad Sci U S A 101:10428-33. 2004
    ..These mutant mice and cell lines derived from them will be useful models for studying the role of the nuclear lamina in various cellular processes...
  53. pmc Prelamin A and lamin A appear to be dispensable in the nuclear lamina
    Loren G Fong
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    J Clin Invest 116:743-52. 2006
    ..These studies suggest a new therapeutic strategy for treating progeria and other lamin A diseases...
  54. ncbi request reprint Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency
    Yan Xie
    Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:4075-86. 2006
    ..These findings establish distinctive features for MTTP involvement in intestinal chylomicron assembly and secretion and suggest that hepatic lipogenesis undergoes compensatory induction in the face of defective intestinal TG secretion...
  55. doi request reprint 17. Serum free testosterone levels associated with anal human papillomavirus types 16/18 in a cohort of men who have sex with men
    Hilary Hsu
    UCLA School of Nursing, Los Angeles, CA, USA
    Sex Health 10:578. 2013
    ..The mechanisms underlying this association remain unclear and warrant further study. ..
  56. pmc Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation
    Martin O Bergo
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141 9100, USA
    Mol Cell Biol 22:171-81. 2002
    ..These studies support the idea that interference with postisoprenylation processing retards cell growth, limits Ras-induced transformation, and sensitizes tumor cells to a farnesyltransferase inhibitor...
  57. pmc Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2
    Seung Soon Im
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
    Mol Cell Biol 29:4864-72. 2009
    ..Our chromatin immunoprecipitation results support this hypothesis...
  58. pmc A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation
    Shao H Yang
    Department of Medicine, Division of Cardiology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA, and Department of Medicine, Wallenberg Laboratory, Sahlgrenska University Hospital, Goteborg, Sweden
    J Clin Invest 116:2115-21. 2006
    ..These studies suggest that FTIs could be useful for treating humans with HGPS...
  59. pmc Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice
    Michael M Weinstein
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA
    Arterioscler Thromb Vasc Biol 30:2106-13. 2010
    ..To determine whether plasma triglyceride levels in adult Glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1)-deficient (Gpihbp1(-/-)) mice would be sensitive to cholesterol intake...
  60. ncbi request reprint Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death
    Aaron E Cozen
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, USA
    Circulation 109:2129-35. 2004
    ..Human atherosclerotic lesions contain elevated levels of urokinase plasminogen activator (uPA), expressed predominantly by macrophages...
  61. ncbi request reprint CD1d function is regulated by microsomal triglyceride transfer protein
    Suzana Brozovic
    Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Med 10:535-9. 2004
    ..These studies indicate that the CD1d-regulating function of MTP in the endoplasmic reticulum is complementary to that of the saposins in endosomes in vivo...
  62. pmc Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes
    Roger Lee
    Department of Medicine, David Geffen School of Medicine, University of California, LA, Los Angeles, CA 90095, USA
    Hum Mol Genet 19:1603-17. 2010
    ..Like Fntb-deficient keratinocytes, Pggt1b-deficient keratinocytes did not proliferate in culture. Thus, both FTase and GGTase-I are required for the homeostasis of skin keratinocytes...
  63. pmc ATP-citrate lyase deficiency in the mouse
    Anne P Beigneux
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141, USA
    J Biol Chem 279:9557-64. 2004
    ..The Acly knockout allele is useful for identifying cell types with a high demand for acetyl-CoA synthesis...
  64. pmc Caution! Analyze transcripts from conditional knockout alleles
    Shao H Yang
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Transgenic Res 18:483-9. 2009
    ..With thousands of new conditional knockout alleles under construction within mouse mutagenesis consortiums, the protein farnesyltransferase allele holds an important lesson-to characterize knockout alleles at both the DNA and RNA levels...
  65. pmc Lowering plasma cholesterol levels halts progression of aortic valve disease in mice
    Jordan D Miller
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Circulation 119:2693-701. 2009
    ....
  66. ncbi request reprint Hematologic effects of inactivating the Ras processing enzyme Rce1
    Abigail L Aiyagari
    Department of Pediatrics, Gladstone Institute of Cardiovascular Disease, University of California, San Francisco UCSF, CA 94143, USA
    Blood 101:2250-2. 2003
    ..These data suggest that pharmacologic inhibitors of Rce1 will have minimal effects on normal hematopoietic cells...
  67. ncbi request reprint Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression
    Shrikant Anant
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 127:1139-49. 2004
    ..This study aimed to determine the role of the RNA binding protein apobec-1 in radioprotection of the intestine...
  68. pmc A novel approach to tag and identify geranylgeranylated proteins
    Lai N Chan
    Departments of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095 1489, USA
    Electrophoresis 30:3598-606. 2009
    ..The "GG-azide"-labeling approach provides a new tool for the detection and proteomic analysis of geranylgeranylated proteins, and it can readily be extended to other post-translational modifications...
  69. ncbi request reprint Calcific aortic valve stenosis in old hypercholesterolemic mice
    Robert M Weiss
    Department of Internal Medicine, Room E317 A GH, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    Circulation 114:2065-9. 2006
    ..We tested the hypothesis that calcification and aortic valve stenosis would develop in genetically hypercholesterolemic old mice...
  70. ncbi request reprint Absence of VLDL secretion does not affect alpha-tocopherol content in peripheral tissues
    Kaori Minehira-Castelli
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 94158, USA
    J Lipid Res 47:1733-8. 2006
    ..We conclude that the absence of VLDL secretion has little effect on the stores of alpha-tocopherol in peripheral tissues, at least in the mouse...
  71. pmc Incident hepatitis C virus infection in men who have sex with men: a prospective cohort analysis, 1984-2011
    Mallory D Witt
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Clin Infect Dis 57:77-84. 2013
    ..Prospective characterization of hepatitis C virus (HCV) transmission in both human immunodeficiency virus (HIV)-infected and -uninfected men who have sex with men (MSM) over the entire HIV epidemic has not been comprehensively conducted...
  72. pmc Lactation intensity and postpartum maternal glucose tolerance and insulin resistance in women with recent GDM: the SWIFT cohort
    Erica P Gunderson
    Division of Research, Kaiser Permanente Northern California, Oakland, California, USA
    Diabetes Care 35:50-6. 2012
    ....
  73. pmc Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi
    David Michaelson
    Department of Medicine, Cell Biology and Pharmacology, NYU School of Medicine, 10016, USA
    Mol Biol Cell 13:3294-302. 2002
    ..Thus, two separate signals, analogous to the dual-signal targeting mechanism of Ras proteins, cooperate to target heterotrimeric G proteins to the PM via the endomembrane...
  74. pmc Fructose impairs glucose-induced hepatic triglyceride synthesis
    Danshan Huang
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Lipids Health Dis 10:20. 2011
    ..These studies provide novel insight into the mechanisms involved in fructose-mediated hepatic hypertriglyceridemia and identify fructose-uptake as a new potential therapeutic target for lipid-associated diseases...
  75. ncbi request reprint High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins
    Matthias Schneider
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94158, USA
    J Lipid Res 46:769-78. 2005
    ..The increase in oxidized lipids specific to Lp[a] in high-level apo[a]-expressing mice suggests a mechanism by which increased circulating levels of Lp[a] could contribute to atherogenesis...
  76. pmc The small molecule phenamil induces osteoblast differentiation and mineralization
    Kye Won Park
    Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095 1662, USA
    Mol Cell Biol 29:3905-14. 2009
    ..The synergistic use of small molecules such as phenamil along with BMPs may provide new strategies for the promotion of bone healing...
  77. pmc Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells
    Peter Gin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 31:176-82. 2011
    ..To define the ability of GPIHBP1 to bind other lipase family members and other apolipoproteins (apos) and lipoproteins...
  78. ncbi request reprint Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling
    Akihiko Ishimura
    The 21st Century Center of Excellence Program, Akita University School of Medicine, Hondo 1 1 1, Akita, Japan
    Development 133:3919-28. 2006
    ..These results have revealed a novel role for Man1 in angiogenesis and provide the first evidence that vascular remodeling can be regulated at the INM through the interaction between Man1 and Smads...
  79. ncbi request reprint Behavioural alterations in male mice lacking the gene for D-aspartate oxidase
    Zachary M Weil
    Department of Psychology, Institute for Behavioral Medicine Research, Ohio State University, Columbus, 43210, USA
    Behav Brain Res 171:295-302. 2006
    ....
  80. ncbi request reprint Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER
    Wei Liao
    Mammalian Cell and Molecular Biology Laboratory, San Diego State University, San Diego, CA 92182 4614, USA
    J Lipid Res 44:978-85. 2003
    ..The rapid degradation of secretion-incompetent apoB in the ER may block the induction of proteins associated with unfolded protein and heat shock responses...
  81. ncbi request reprint Defining the importance of phosphatidylserine synthase 2 in mice
    Martin O Bergo
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141 9100, USA
    J Biol Chem 277:47701-8. 2002
    ..We conclude that Pss2 is responsible for the majority of serine exchange activity in in vitro assays, but a deficiency in this enzyme does not cause perturbations in phospholipid content or severe developmental abnormalities...
  82. pmc AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase
    Yan Qun Chen
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    J Biol Chem 283:10048-57. 2008
    ..Our data indicate that AGPAT6 is a microsomal GPAT, and we propose renaming this enzyme GPAT4...
  83. pmc Mouse models of the laminopathies
    Colin L Stewart
    Laboratory of Cancer and Developmental Biology, National Cancer Institute, Frederick, Maryland 21702, USA
    Exp Cell Res 313:2144-56. 2007
    ..These mouse lines are providing insights into the functions of the lamina and how changes to the lamina affect the mechanical integrity of the nucleus as well as signaling pathways that, when disrupted, may contribute to the disease...
  84. pmc The knockout mouse project
    Christopher P Austin
    National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 31 Center Drive, Bethesda, Maryland 20892, USA
    Nat Genet 36:921-4. 2004
    ..It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain...
  85. pmc Endoproteolytic processing of RhoA by Rce1 is required for the cleavage of RhoA by Yersinia enterocolitica outer protein T
    Florian Fueller
    Institute for Experimental and Clinical Pharmacology and Toxicology, Albert Ludwigs University of Freiburg, Albert Str 25, 79104 Freiburg, Germany
    Infect Immun 74:1712-7. 2006
    ..Our data demonstrate that Rce1-mediated removal of -aaX from isoprenylated Rho GTPases is required for the proteolytic activity of YopT in living cells, whereas carboxyl methylation by Icmt is not...
  86. pmc Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects
    Rineke Steenbergen
    Canadian Institutes for Health Research Group on the Molecular and Cell Biology of Lipids and Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Biol Chem 280:40032-40. 2005
    ..Moreover, elimination of PE production in mitochondria causes fragmented, misshapen mitochondria, an abnormality that likely contributes to the embryonic lethality...
  87. ncbi request reprint Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway
    Kazutoshi Takahashi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University and CREST, Japan Science and Technology Agency, Kyoto 606 8507, Japan
    J Biol Chem 280:32768-74. 2005
    ..Rheb also shares the same membrane-targeting pathway but because of the absence of palmitoylation is located on endomembranes...
  88. pmc Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf
    Martin O Bergo
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
    J Clin Invest 113:539-50. 2004
    ..These studies identify Icmt as a potential target for reducing the growth of K-Ras- and B-Raf-induced malignancies...
  89. ncbi request reprint Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function
    Annika W Svensson
    Wallenberg Laboratory, Department of Internal Medicine, Sahlgrenska University Hospital, Sweden
    Methods Enzymol 407:144-59. 2006
    ....
  90. ncbi request reprint Cell nuclei spin in the absence of lamin b1
    Julie Y Ji
    Cardiovascular Division, Brigham and Women s Hospital, Cambridge, Massachusetts 02139, USA
    J Biol Chem 282:20015-26. 2007
    ..These findings demonstrate that lamin B1 serves a fundamental role within the nuclear envelope: anchoring the nucleus to the cytoskeleton...
  91. pmc HIV-protease inhibitors block the enzymatic activity of purified Ste24p
    Sarah E Hudon
    Department of Chemistry and the Purdue Cancer Center, Purdue University, 560 Oval Drive, West Lafayette, IN 47907 2084, USA
    Biochem Biophys Res Commun 374:365-8. 2008
    ....
  92. pmc Assembly of lipoprotein particles containing apolipoprotein-B: structural model for the nascent lipoprotein particle
    Paul E Richardson
    Department of Biochemistry and Molecular Genetics, Atherosclerosis Research Unit, University of Alabama at Birmingham Medical Center, USA
    Biophys J 88:2789-800. 2005
    ....
  93. pmc Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice
    Kaori Minehira
    Gladstone Institute of Cardiovascular Disease, University of California San Francisco, CA 94158, USA
    J Lipid Res 49:2038-44. 2008
    ..Thus, blocking VLDL secretion causes hepatic steatosis without insulin resistance, and there is little effect on muscle triglyceride stores or adiposity...
  94. pmc Genetic analyses of the role of RCE1 in RAS membrane association and transformation
    Martin O Bergo
    Wallenberg Laboratory, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Methods Enzymol 438:367-89. 2008
    ..Here, we will review methods that have been used to define the physiologic importance of the endoproteolytic processing step of CAAX protein processing...
  95. pmc Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis
    Gengshu Wu
    Canadian Institutes of Health Research Group on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Canada
    J Biol Chem 283:1456-62. 2008
    ..Thus, Chka is an essential gene for early embryonic development, but adult mice do not require full expression of the gene for normal levels of phosphatidylcholine...
  96. ncbi request reprint Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion
    Hsiao D Lieu
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141 9100, USA
    Circulation 107:1315-21. 2003
    ..We hypothesized that both the hypercholesterolemia and the susceptibility to atherosclerosis could be eliminated by switching off hepatic lipoprotein production...
  97. pmc BayGenomics: a resource of insertional mutations in mouse embryonic stem cells
    Doug Stryke
    Department of Pharmaceutical Chemistry, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Nucleic Acids Res 31:278-81. 2003
    ..They can then obtain the mutant ES cell line for the purpose of generating knockout mice...
  98. ncbi request reprint Immunochemical evidence that human apoB differs when expressed in rodent versus human cells
    Xingyu Wang
    Lipoprotein and Atherosclerosis Research Group and the Department of Pathology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Lipid Res 44:547-53. 2003
    ..Therefore, human apoB expressed by rodent hepatocytes or hepatoma cells appears to adopt a different conformation or undergoes different posttranslational modification than apoB expressed in human hepatocytes or hepatoma cells...
  99. ncbi request reprint Phospholipid homeostasis in phosphatidylserine synthase-2-deficient mice
    Rineke Steenbergen
    Canadian Institutes for Health Research Group on the Molecular and Cell Biology of Lipids and Department of Medicine, University of Alberta, 328 HMRC, Edmonton, Alberta, Canada T6G 2S2
    Biochim Biophys Acta 1761:313-23. 2006
    ....
  100. pmc Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models
    Murielle M Veniant
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    Curr Drug Targets 9:174-89. 2008
    ..Defining the extent of atherosclerosis in these mice should provide new insights into the atherogenicity of large, triglyceride-rich lipoproteins...
  101. pmc A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells
    Ann M Winter-Vann
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 102:4336-41. 2005
    ..These findings provide a compelling rationale for development of Icmt inhibitors as another approach to anticancer drug development...

Research Grants31

  1. Postisoprenylation Processing and the Nuclear Lamina
    Stephen Young; Fiscal Year: 2006
    ..During the past few years, the laboratory of Dr. Stephen Young has generated knockout alleles [as well as some conditional ("floxed") alleles] for many of the genes involved ..
  2. GHIHBP1 and the Metabolism of Triglyceride-Rich Lipoproteins
    Stephen Young; Fiscal Year: 2007
    ..In Specific Aim 3, we will test the idea that GPIHBP1 binds directly to triglyceride-rich lipoproteins and/or to LPL, thereby facilitating lipolysis. ..
  3. CAAX Protein Processing and Cancer Therapy
    Stephen Young; Fiscal Year: 2007
    ..These studies should define the therapeutic potential of blocking the three different steps of CAAX protein processing. ..
  4. Hutchinson Gilford Progeria Syndrome and Atherosclerosis
    Stephen Young; Fiscal Year: 2007
    ..The PI's laboratory has extensive experience in analyzing atherogenesis in mice and is thrilled with the prospect of exploring mechanisms of atherosclerosis in HGPS. ..
  5. NHLBI Bay Area Functional Genomics Consortium
    Stephen Young; Fiscal Year: 2007
    ..A fourth objective is to generate a limited number of genetically modified mice, for the purpose of defining the relevance of specific genes to cardiopulmonary development and disease (Components 4-6). ..
  6. Postisoprenylation Processing and the Nuclear Lamina
    Stephen Young; Fiscal Year: 2007
    ..During the past few years, the laboratory of Dr. Stephen Young has generated knockout alleles [as well as some conditional ("floxed") alleles] for many of the genes involved ..
  7. GHIHBP1 and the Metabolism of Triglyceride-Rich Lipoproteins
    Stephen Young; Fiscal Year: 2009
    ..In Specific Aim 3, we will test the idea that GPIHBP1 binds directly to triglyceride-rich lipoproteins and/or to LPL, thereby facilitating lipolysis. ..
  8. Hutchinson Gilford Progeria Syndrome and Atherosclerosis
    Stephen Young; Fiscal Year: 2009
    ..The PI's laboratory has extensive experience in analyzing atherogenesis in mice and is thrilled with the prospect of exploring mechanisms of atherosclerosis in HGPS. ..
  9. CaaX Protein Processing and Human Disease
    Stephen Young; Fiscal Year: 2009
    ..Our studies will be focused on the physiologic importance of the B-type lamins in the developing brain and other tissues and the physiologic importance of the posttranslational processing of prelamin A. ..
  10. GHIHBP1 and the Metabolism of Triglyceride-Rich Lipoproteins
    Stephen G Young; Fiscal Year: 2010
    ..In Specific Aim 3, we will test the idea that GPIHBP1 binds directly to triglyceride-rich lipoproteins and/or to LPL, thereby facilitating lipolysis. ..
  11. Hutchinson Gilford Progeria Syndrome and Atherosclerosis
    Stephen Young; Fiscal Year: 2006
    ..The PI's laboratory has extensive experience in analyzing atherogenesis in mice and is thrilled with the prospect of exploring mechanisms of atherosclerosis in HGPS. ..
  12. CAAX Protein Processing and Cancer Therapy
    Stephen Young; Fiscal Year: 2006
    ..These studies should define the therapeutic potential of blocking the three different steps of CAAX protein processing. ..
  13. Postisoprenylation Processing and the Nuclear Lamina
    Stephen Young; Fiscal Year: 2005
    ..During the past few years, the laboratory of Dr. Stephen Young has generated knockout alleles [as well as some conditional ("floxed") alleles] for many of the genes involved ..
  14. METABOLISM OF SPONTANEOUSLY DAMAGED PROTEINS IN AGING
    Stephen Young; Fiscal Year: 1999
    ..Finally, we propose to ask whether the expression of the repair methyltransferase in the extracellular compartment would limit the accumulation of spontaneous damage to extracellular proteins. ..
  15. METABOLISM OF SPONTANEOUSLY DAMAGED PROTEINS IN AGING
    Stephen Young; Fiscal Year: 2000
    ..Finally, we propose to ask whether the expression of the repair methyltransferase in the extracellular compartment would limit the accumulation of spontaneous damage to extracellular proteins. ..
  16. METABOLISM OF SPONTANEOUSLY DAMAGED PROTEINS IN AGING
    Stephen Young; Fiscal Year: 2001
    ..Finally, we propose to ask whether the expression of the repair methyltransferase in the extracellular compartment would limit the accumulation of spontaneous damage to extracellular proteins. ..
  17. METABOLISM OF SPONTANEOUSLY DAMAGED PROTEINS IN AGING
    Stephen Young; Fiscal Year: 2002
    ..Finally, we propose to ask whether the expression of the repair methyltransferase in the extracellular compartment would limit the accumulation of spontaneous damage to extracellular proteins. ..
  18. CAAX Protein Processing and Cancer Therapy
    Stephen Young; Fiscal Year: 2003
    ..These studies should define the therapeutic potential of blocking the three different steps of CAAX protein processing. ..
  19. THE NHLBI BAY AREA FUNCTIONAL GENOMICS COMSORTIUM
    Stephen Young; Fiscal Year: 2003
    ..The Consortium's resources will be distributed freely to any interested investigator and should provide a catalyst for many different NHLBI-funded research programs. ..
  20. Postisoprenylation Processing and the Nuclear Lamina
    Stephen Young; Fiscal Year: 2003
    ..During the past few years, the laboratory of Dr. Stephen Young has generated knockout alleles [as well as some conditional ("floxed") alleles] for many of the genes involved ..
  21. CAAX Protein Processing and Cancer Therapy
    Stephen Young; Fiscal Year: 2004
    ..These studies should define the therapeutic potential of blocking the three different steps of CAAX protein processing. ..
  22. Hutchinson Gilford Progeria Syndrome and Atherosclerosis
    Stephen Young; Fiscal Year: 2005
    ..The PI's laboratory has extensive experience in analyzing atherogenesis in mice and is thrilled with the prospect of exploring mechanisms of atherosclerosis in HGPS. ..
  23. CAAX Protein Processing and Cancer Therapy
    Stephen Young; Fiscal Year: 2005
    ..These studies should define the therapeutic potential of blocking the three different steps of CAAX protein processing. ..
  24. CAAX Processing Enzymes as Anticancer Targets
    Stephen Young; Fiscal Year: 2004
    ..Using these mice, we will define the impact of defective CAAX processing on the development, progression, and lethality of Ras-induced myeloproliferative disease. ..
  25. Postisoprenylation Processing and the Nuclear Lamina
    Stephen Young; Fiscal Year: 2004
    ..During the past few years, the laboratory of Dr. Stephen Young has generated knockout alleles [as well as some conditional ("floxed") alleles] for many of the genes involved ..
  26. CAAX Protein Processing and Cancer Therapy
    Stephen Young; Fiscal Year: 2004
    ..These studies should define the therapeutic potential of blocking the three different steps of CAAX protein processing. ..
  27. CaaX Protein Processing and Human Disease
    Stephen G Young; Fiscal Year: 2010
    ..Our studies will be focused on the physiologic importance of the B-type lamins in the developing brain and other tissues and the physiologic importance of the posttranslational processing of prelamin A. ..