Research Topics
Genomes and GenesSpecies | S E YoungSummaryAffiliation: University of Colorado Country: USA Publications
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Detail Information
Publications
Genetic and environmental vulnerabilities underlying adolescent substance use and problem use: general or specific?Susan E Young
Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80303, USA
Behav Genet 36:603-15. 2006..Our results suggest that tobacco, alcohol, and marijuana problem use are mediated by common genetic influences, but shared environmental influences may be more substance-specific for problem use...- Sibling-based association analyses of the serotonin transporter polymorphism and internalizing behavior problems in childrenSusan E Young
Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA
J Child Psychol Psychiatry 44:961-7. 2003..However, the specific genetic mechanisms responsible for this risk have not yet been identified... 
Behavioral disinhibition: liability for externalizing spectrum disorders and its genetic and environmental relation to response inhibition across adolescenceSusan E Young
Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309, USA
J Abnorm Psychol 118:117-30. 2009..These results highlight the dynamic nature of behavioral disinhibition across adolescence and suggest that response inhibition may be an important mechanism underlying vulnerability to disinhibitory psychopathology...- Substance use, abuse and dependence in adolescence: prevalence, symptom profiles and correlatesS E Young
Institute for Behavioral Genetics, University of Colorado, Campus Box 447, Boulder, CO 80309, USA
Drug Alcohol Depend 68:309-22. 2002..A comparison of abuse and dependence symptom profiles shows some interesting variability across substances, and suggests that manifestations of a subset of symptoms are gender specific... - Dopamine transporter polymorphism associated with externalizing behavior problems in childrenSusan E Young
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
Am J Med Genet 114:144-9. 2002..001) and 7 years (P=0.02). Although the effect size was negligible at age 9 (P=0.92), a formal test of the developmental decrease in effect across the three ages was non-significant (P=0.70)... - Genetic and environmental influences on behavioral disinhibitionS E Young
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
Am J Med Genet 96:684-95. 2000..These results suggest that a variety of adolescent problem behaviors may share a common underlying genetic risk... - Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: failure to confirm in adolescent patientsSusan E Young
Institute for Behavioral Genetics, UCB 447, University of Colorado, Boulder, CO 80301, USA
Am J Psychiatry 163:1019-25. 2006.... - The familial aggregation of depressive symptoms, antisocial behavior, and alcohol abuseM C Stallings
Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
Am J Med Genet 74:183-91. 1997..More important, correlations among the transmissible family factors for these psychiatric syndromes ranged from .58 to .73, suggesting substantial overlap among the underlying familial antecedents for these disorders... - Developmental epidemiology of drug use and abuse in adolescence and young adulthood: Evidence of generalized riskR H C Palmer
Institute for Behavioral Genetics, UCB 447 Boulder, CO 80309 0447, USA
Drug Alcohol Depend 102:78-87. 2009..Our data also confirm either a generalized risk or correlated risk factors for early onset substance use and subsequent development of SUDs... - Relationships between personality and preferred substance and motivations for use among adolescent substance abusersJustin B Adams
Department of Psychology, University of Colorado, Boulder, Colorado 80309-0447, USA
Am J Drug Alcohol Abuse 29:691-712. 2003.... - Contributions of genes and environments to stability and change in externalizing and internalizing problems during elementary and middle schoolBrett C Haberstick
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
Behav Genet 35:381-96. 2005..Clinical implications of these findings are discussed... - Common genetic and environmental influences on major depressive disorder and conduct disorderAnjali Subbarao
Department of Psychology, University of Colorado, Boulder, CO, USA
J Abnorm Child Psychol 36:433-44. 2008..Our results suggest that some genetic factors will increase an individual's vulnerability to both MDD and CD in adolescence... - Heritability and the comorbidity of attention deficit hyperactivity disorder with behavioral disorders and executive function deficits: a preliminary investigationF L Coolidge
Department of Psychology, University of Colorado, Colorado Springs 80933 7150, USA
Dev Neuropsychol 17:273-87. 2000..The residual genetic variance provides preliminary support for additional genetic influences underlying CD, ODD, and EF that are independent of ADHD... - Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotineMarissa A Ehringer
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
Am J Med Genet B Neuropsychiatr Genet 144:596-604. 2007..This study provides the first evidence for association between the CHRNB2 gene and nicotine- and alcohol-related phenotypes, and suggests that polymorphisms in CHRNB2 may be important in mediating early responses to nicotine and alcohol... - The human protein kinase C gamma gene (PRKCG) as a susceptibility locus for behavioral disinhibitionIsabel R Schlaepfer
Institute for Behavioral Genetics, University of Colorado, Boulder, USA, and Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
Addict Biol 12:200-9. 2007..This study provides the first exploration of the PRKCG gene and its association with behavioral disinhibition and warrants further study in other larger population samples... - Between- and within-family association test of the dopamine receptor D2 TaqIA polymorphism and alcohol abuse and dependence in a general population sample of adultsBrett C Haberstick
Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309 0447, USA
J Stud Alcohol Drugs 68:362-70. 2007..The mixed results of association between the DRD2 TaqIA polymorphism and alcohol-use disorders may be the result of differences in sample size, phenotype definition, heterogeneity of the samples, and genetic admixture... - Delinquent peer affiliation and conduct problems: A twin studyTanya M M Button
Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
J Abnorm Psychol 116:554-64. 2007..The magnitude of the genetic variance of conduct problems was contextually dependent on levels of delinquent peer affiliation and was greater at higher levels of delinquent peer affiliation... - Greater attention problems during childhood predict poorer executive functioning in late adolescenceNaomi P Friedman
Institute for Behavioral Genetics, 447 UCB, University of Colorado, Boulder, CO 80309, USA
Psychol Sci 18:893-900. 2007..These results support the hypothesis that attention problems primarily reflect difficulties with response inhibition... - Item response theory analysis of DSM-IV cannabis abuse and dependence criteria in adolescentsChristie A Hartman
School of Medicine at the University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
J Am Acad Child Adolesc Psychiatry 47:165-73. 2008..different levels of severity of substance involvement, to what degree do each of the 11 abuse and dependence criteria assess adolescent cannabis problems, and do the DSM-IV items function similarly across different adolescent populations?.. 
Case-control and within-family tests for an association between conduct disorder and DAT1R Jay Schulz-Heik
Institute for Behavioral Genetics, Department of Psychology, University of Colorado, Boulder 80309, USA
Psychiatr Genet 18:17-24. 2008..Evidence suggests that a variable number tandem repeat polymorphism of the dopamine transporter (DAT1) gene may be associated with externalizing behavior in children...- Association of candidate genes with antisocial drug dependence in adolescentsRobin P Corley
Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
Drug Alcohol Depend 96:90-8. 2008..The custom-designed SNP chip served as an effective and flexible platform for rapid interrogation of a large number of plausible candidate genes... - Individual differences in executive functions are almost entirely genetic in originNaomi P Friedman
Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309, USA
J Exp Psychol Gen 137:201-25. 2008.... - Childhood maltreatment, subsequent antisocial behavior, and the role of monoamine oxidase A genotypeDavid Huizinga
Institute of Behavioral Science, University of Colorado, Boulder, 80303, USA
Biol Psychiatry 60:677-83. 2006..Despite wide interest in this hypothesis, results remain mixed from the few attempts at replication... - Subjective effects to marijuana associated with marijuana use in community and clinical subjectsJoanna S Zeiger
Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, United States
Drug Alcohol Depend 109:161-6. 2010..e. subjective effects). We have examined subjective effects in adolescent, young adult community, and clinical populations to determine how patterns of use may be predicted by an individual's subjective experiences with the drug... - A genome-wide search for quantitative trait loci influencing substance dependence vulnerability in adolescenceMichael C Stallings
Institute for Behavioral Genetics, University of Colorado, Campus Box 447, Boulder, CO 80309 0447, USA
Drug Alcohol Depend 70:295-307. 2003..2. Multipoint mapping corroborated two locations and provided preliminary evidence for linkage to regions on chromosome 3q24-25 (near markers D3S1279 and D3S1614) and chromosome 9q34 (near markers D9S1826 and D9S1838)... - Genetic and environmental influences on substance initiation, use, and problem use in adolescentsSoo Hyun Rhee
Department of Psychology and the Institute for Behavioral Genetics, University of Colorado at Boulder, 90309, USA
Arch Gen Psychiatry 60:1256-64. 2003..We conducted a sibling/twin/adoption study of substance initiation, use, and problem use, estimating the relative contribution of genetic and environmental influences on these phenotypes in adolescents... - Investigating the genetic and environmental structure of Cloninger's personality dimensions in adolescenceNoa Heiman
Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado 80309, USA
Twin Res 7:462-70. 2004..We found moderate heritability estimates for NS, HA and RD ranging from .28 to .36--with no evidence for sex-limitation in those influences... - Genetic and environmental influences on conduct disorder: symptom, domain and full-scale analysesHeather L Gelhorn
Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
J Child Psychol Psychiatry 46:580-91. 2005.... - A genome-wide search for quantitative trait Loci that influence antisocial drug dependence in adolescenceMichael C Stallings
Institute for Behavioral Genetics and Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, 80309 0444, USA
Arch Gen Psychiatry 62:1042-51. 2005..Previously we reported 2 chromosomal regions (3q24-3q25 and 9q34) likely to contain genes that influence substance dependence vulnerability (DV) in adolescence... - Comorbidity between alcohol dependence and illicit drug dependence in adolescents with antisocial behavior and matched controlsSoo Hyun Rhee
Institute for Behavioral Genetics, Campus Box 447, University of Colorado, Boulder, CO 80309, USA
Drug Alcohol Depend 84:85-92. 2006..Discrepancies in results may reflect different analytical approaches or differences in the samples. Here, we examine the causes of comorbidity between alcohol dependence and illicit drug dependence in adolescents... - Not all executive functions are related to intelligenceNaomi P Friedman
Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309, USA
Psychol Sci 17:172-9. 2006.... - Examination of the causes of covariation between conduct disorder symptoms and vulnerability to drug dependenceTanya M M Button
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309 0447, USA
Twin Res Hum Genet 9:38-45. 2006..Therefore, there appears to be pleiotropic genetic influence on CD symptoms and dependence vulnerability... - Genes and developmental stabiltiy of aggressive behavior problems at home and school in a community sample of twins aged 7-12Brett C Haberstick
Institute of Behavioral Genetics, University of Colorado at Boulder, Campus Box 447, Boulder, Colorado 80309 0447, USA
Behav Genet 36:809-19. 2006..Developmentally stable levels of aggressive behavior result from genetic influences common to all ages and individual environmental influences whose effects persist across ages... - The role of conduct disorder in explaining the comorbidity between alcohol and illicit drug dependence in adolescenceTanya M M Button
Institute for Behavioral Genetics, Campus Box 447, University of Colorado, Boulder, CO 80309, USA
Drug Alcohol Depend 87:46-53. 2007..This paper describes the result of an investigation of the extent to which comorbid alcohol and illicit drug dependence in adolescents are explained by etiological factors in common with conduct disorder... - Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescentsChristian J Hopfer
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Med Genet B Neuropsychiatr Genet 141:895-901. 2006..Our findings provide evidence suggesting that a common CNR1 haplotype is associated with developing fewer cannabis dependence symptoms among adolescents who have experimented with cannabis... - A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9Christian J Hopfer
Division of Substance Dependence, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, CO 80262, USA
Drug Alcohol Depend 89:34-41. 2007..Genetic risk factors account for part of the variation in the development of cannabis dependence symptoms; however, no linkage studies have been performed for cannabis dependence symptoms. This study aimed to identify such loci... - Test of association between TaqIA A1 allele and alcohol use disorder phenotypes in a sample of adolescent patients with serious substance and behavioral problemsJoseph T Sakai
Department of Psychiatry, Division of Substance Dependence, University of Colorado School of Medicine, Denver, CO 80262, USA
Drug Alcohol Depend 88:130-7. 2007.... - The heritability of gender identity disorder in a child and adolescent twin sampleFrederick L Coolidge
Psychology Department, University of Colorado at Colorado Springs, 80933 7150, USA
Behav Genet 32:251-7. 2002..05). Overall, the results support the hypothesis that there is a strong heritable component to GID. The findings may also imply that gender identity may be much less a matter of choice and much more a matter of biology... - Case-control and within-family tests for an association between conduct disorder and 5HTTLPRJoseph T Sakai
Division of Substance Dependence, Department of Psychiatry, University of Colorado School of Medicine, Denver, CO, USA
Am J Med Genet B Neuropsychiatr Genet 141:825-32. 2006..61; P = 0.20). These data suggest that the s-allele may confer some risk for aggressive behavior or may be in linkage disequilibrium with such an allele...
Research Grants
- Executive Function: Links to Drug Use & PsychopathologySusan Young; Fiscal Year: 2006..Our final aim is to determine the extent to which the covariation between ECF deficits and comorbid psychopathology is due to genetic and/or environmental factors. ..