S E Young

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. ncbi request reprint Genetic and environmental vulnerabilities underlying adolescent substance use and problem use: general or specific?
    Susan E Young
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80303, USA
    Behav Genet 36:603-15. 2006
  2. ncbi request reprint Sibling-based association analyses of the serotonin transporter polymorphism and internalizing behavior problems in children
    Susan E Young
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA
    J Child Psychol Psychiatry 44:961-7. 2003
  3. pmc Behavioral disinhibition: liability for externalizing spectrum disorders and its genetic and environmental relation to response inhibition across adolescence
    Susan E Young
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Abnorm Psychol 118:117-30. 2009
  4. ncbi request reprint Substance use, abuse and dependence in adolescence: prevalence, symptom profiles and correlates
    S E Young
    Institute for Behavioral Genetics, University of Colorado, Campus Box 447, Boulder, CO 80309, USA
    Drug Alcohol Depend 68:309-22. 2002
  5. ncbi request reprint Dopamine transporter polymorphism associated with externalizing behavior problems in children
    Susan E Young
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Am J Med Genet 114:144-9. 2002
  6. ncbi request reprint Genetic and environmental influences on behavioral disinhibition
    S E Young
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Am J Med Genet 96:684-95. 2000
  7. ncbi request reprint Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: failure to confirm in adolescent patients
    Susan E Young
    Institute for Behavioral Genetics, UCB 447, University of Colorado, Boulder, CO 80301, USA
    Am J Psychiatry 163:1019-25. 2006
  8. ncbi request reprint The familial aggregation of depressive symptoms, antisocial behavior, and alcohol abuse
    M C Stallings
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Am J Med Genet 74:183-91. 1997
  9. pmc Developmental epidemiology of drug use and abuse in adolescence and young adulthood: Evidence of generalized risk
    R H C Palmer
    Institute for Behavioral Genetics, UCB 447 Boulder, CO 80309 0447, USA
    Drug Alcohol Depend 102:78-87. 2009
  10. ncbi request reprint Relationships between personality and preferred substance and motivations for use among adolescent substance abusers
    Justin B Adams
    Department of Psychology, University of Colorado, Boulder, Colorado 80309 0447, USA
    Am J Drug Alcohol Abuse 29:691-712. 2003

Research Grants

Detail Information

Publications39

  1. ncbi request reprint Genetic and environmental vulnerabilities underlying adolescent substance use and problem use: general or specific?
    Susan E Young
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80303, USA
    Behav Genet 36:603-15. 2006
    ..Our results suggest that tobacco, alcohol, and marijuana problem use are mediated by common genetic influences, but shared environmental influences may be more substance-specific for problem use...
  2. ncbi request reprint Sibling-based association analyses of the serotonin transporter polymorphism and internalizing behavior problems in children
    Susan E Young
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA
    J Child Psychol Psychiatry 44:961-7. 2003
    ..However, the specific genetic mechanisms responsible for this risk have not yet been identified...
  3. pmc Behavioral disinhibition: liability for externalizing spectrum disorders and its genetic and environmental relation to response inhibition across adolescence
    Susan E Young
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Abnorm Psychol 118:117-30. 2009
    ..These results highlight the dynamic nature of behavioral disinhibition across adolescence and suggest that response inhibition may be an important mechanism underlying vulnerability to disinhibitory psychopathology...
  4. ncbi request reprint Substance use, abuse and dependence in adolescence: prevalence, symptom profiles and correlates
    S E Young
    Institute for Behavioral Genetics, University of Colorado, Campus Box 447, Boulder, CO 80309, USA
    Drug Alcohol Depend 68:309-22. 2002
    ..A comparison of abuse and dependence symptom profiles shows some interesting variability across substances, and suggests that manifestations of a subset of symptoms are gender specific...
  5. ncbi request reprint Dopamine transporter polymorphism associated with externalizing behavior problems in children
    Susan E Young
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Am J Med Genet 114:144-9. 2002
    ..001) and 7 years (P=0.02). Although the effect size was negligible at age 9 (P=0.92), a formal test of the developmental decrease in effect across the three ages was non-significant (P=0.70)...
  6. ncbi request reprint Genetic and environmental influences on behavioral disinhibition
    S E Young
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Am J Med Genet 96:684-95. 2000
    ..These results suggest that a variety of adolescent problem behaviors may share a common underlying genetic risk...
  7. ncbi request reprint Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: failure to confirm in adolescent patients
    Susan E Young
    Institute for Behavioral Genetics, UCB 447, University of Colorado, Boulder, CO 80301, USA
    Am J Psychiatry 163:1019-25. 2006
    ....
  8. ncbi request reprint The familial aggregation of depressive symptoms, antisocial behavior, and alcohol abuse
    M C Stallings
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Am J Med Genet 74:183-91. 1997
    ..More important, correlations among the transmissible family factors for these psychiatric syndromes ranged from .58 to .73, suggesting substantial overlap among the underlying familial antecedents for these disorders...
  9. pmc Developmental epidemiology of drug use and abuse in adolescence and young adulthood: Evidence of generalized risk
    R H C Palmer
    Institute for Behavioral Genetics, UCB 447 Boulder, CO 80309 0447, USA
    Drug Alcohol Depend 102:78-87. 2009
    ..Our data also confirm either a generalized risk or correlated risk factors for early onset substance use and subsequent development of SUDs...
  10. ncbi request reprint Relationships between personality and preferred substance and motivations for use among adolescent substance abusers
    Justin B Adams
    Department of Psychology, University of Colorado, Boulder, Colorado 80309 0447, USA
    Am J Drug Alcohol Abuse 29:691-712. 2003
    ....
  11. ncbi request reprint Contributions of genes and environments to stability and change in externalizing and internalizing problems during elementary and middle school
    Brett C Haberstick
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Behav Genet 35:381-96. 2005
    ..Clinical implications of these findings are discussed...
  12. pmc Common genetic and environmental influences on major depressive disorder and conduct disorder
    Anjali Subbarao
    Department of Psychology, University of Colorado, Boulder, CO, USA
    J Abnorm Child Psychol 36:433-44. 2008
    ..Our results suggest that some genetic factors will increase an individual's vulnerability to both MDD and CD in adolescence...
  13. ncbi request reprint Heritability and the comorbidity of attention deficit hyperactivity disorder with behavioral disorders and executive function deficits: a preliminary investigation
    F L Coolidge
    Department of Psychology, University of Colorado, Colorado Springs 80933 7150, USA
    Dev Neuropsychol 17:273-87. 2000
    ..The residual genetic variance provides preliminary support for additional genetic influences underlying CD, ODD, and EF that are independent of ADHD...
  14. ncbi request reprint Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine
    Marissa A Ehringer
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Am J Med Genet B Neuropsychiatr Genet 144:596-604. 2007
    ..This study provides the first evidence for association between the CHRNB2 gene and nicotine- and alcohol-related phenotypes, and suggests that polymorphisms in CHRNB2 may be important in mediating early responses to nicotine and alcohol...
  15. ncbi request reprint The human protein kinase C gamma gene (PRKCG) as a susceptibility locus for behavioral disinhibition
    Isabel R Schlaepfer
    Institute for Behavioral Genetics, University of Colorado, Boulder, USA, and Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Addict Biol 12:200-9. 2007
    ..This study provides the first exploration of the PRKCG gene and its association with behavioral disinhibition and warrants further study in other larger population samples...
  16. pmc Between- and within-family association test of the dopamine receptor D2 TaqIA polymorphism and alcohol abuse and dependence in a general population sample of adults
    Brett C Haberstick
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309 0447, USA
    J Stud Alcohol Drugs 68:362-70. 2007
    ..The mixed results of association between the DRD2 TaqIA polymorphism and alcohol-use disorders may be the result of differences in sample size, phenotype definition, heterogeneity of the samples, and genetic admixture...
  17. ncbi request reprint Delinquent peer affiliation and conduct problems: A twin study
    Tanya M M Button
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    J Abnorm Psychol 116:554-64. 2007
    ..The magnitude of the genetic variance of conduct problems was contextually dependent on levels of delinquent peer affiliation and was greater at higher levels of delinquent peer affiliation...
  18. ncbi request reprint Greater attention problems during childhood predict poorer executive functioning in late adolescence
    Naomi P Friedman
    Institute for Behavioral Genetics, 447 UCB, University of Colorado, Boulder, CO 80309, USA
    Psychol Sci 18:893-900. 2007
    ..These results support the hypothesis that attention problems primarily reflect difficulties with response inhibition...
  19. pmc Item response theory analysis of DSM-IV cannabis abuse and dependence criteria in adolescents
    Christie A Hartman
    School of Medicine at the University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    J Am Acad Child Adolesc Psychiatry 47:165-73. 2008
    ..different levels of severity of substance involvement, to what degree do each of the 11 abuse and dependence criteria assess adolescent cannabis problems, and do the DSM-IV items function similarly across different adolescent populations?..
  20. doi request reprint Case-control and within-family tests for an association between conduct disorder and DAT1
    R Jay Schulz-Heik
    Institute for Behavioral Genetics, Department of Psychology, University of Colorado, Boulder 80309, USA
    Psychiatr Genet 18:17-24. 2008
    ..Evidence suggests that a variable number tandem repeat polymorphism of the dopamine transporter (DAT1) gene may be associated with externalizing behavior in children...
  21. pmc Association of candidate genes with antisocial drug dependence in adolescents
    Robin P Corley
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
    Drug Alcohol Depend 96:90-8. 2008
    ..The custom-designed SNP chip served as an effective and flexible platform for rapid interrogation of a large number of plausible candidate genes...
  22. pmc Individual differences in executive functions are almost entirely genetic in origin
    Naomi P Friedman
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Exp Psychol Gen 137:201-25. 2008
    ....
  23. ncbi request reprint Childhood maltreatment, subsequent antisocial behavior, and the role of monoamine oxidase A genotype
    David Huizinga
    Institute of Behavioral Science, University of Colorado, Boulder, 80303, USA
    Biol Psychiatry 60:677-83. 2006
    ..Despite wide interest in this hypothesis, results remain mixed from the few attempts at replication...
  24. pmc Subjective effects to marijuana associated with marijuana use in community and clinical subjects
    Joanna S Zeiger
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, United States
    Drug Alcohol Depend 109:161-6. 2010
    ..e. subjective effects). We have examined subjective effects in adolescent, young adult community, and clinical populations to determine how patterns of use may be predicted by an individual's subjective experiences with the drug...
  25. ncbi request reprint A genome-wide search for quantitative trait loci influencing substance dependence vulnerability in adolescence
    Michael C Stallings
    Institute for Behavioral Genetics, University of Colorado, Campus Box 447, Boulder, CO 80309 0447, USA
    Drug Alcohol Depend 70:295-307. 2003
    ..2. Multipoint mapping corroborated two locations and provided preliminary evidence for linkage to regions on chromosome 3q24-25 (near markers D3S1279 and D3S1614) and chromosome 9q34 (near markers D9S1826 and D9S1838)...
  26. ncbi request reprint Genetic and environmental influences on substance initiation, use, and problem use in adolescents
    Soo Hyun Rhee
    Department of Psychology and the Institute for Behavioral Genetics, University of Colorado at Boulder, 90309, USA
    Arch Gen Psychiatry 60:1256-64. 2003
    ..We conducted a sibling/twin/adoption study of substance initiation, use, and problem use, estimating the relative contribution of genetic and environmental influences on these phenotypes in adolescents...
  27. ncbi request reprint Investigating the genetic and environmental structure of Cloninger's personality dimensions in adolescence
    Noa Heiman
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    Twin Res 7:462-70. 2004
    ..We found moderate heritability estimates for NS, HA and RD ranging from .28 to .36--with no evidence for sex-limitation in those influences...
  28. ncbi request reprint Genetic and environmental influences on conduct disorder: symptom, domain and full-scale analyses
    Heather L Gelhorn
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
    J Child Psychol Psychiatry 46:580-91. 2005
    ....
  29. ncbi request reprint A genome-wide search for quantitative trait Loci that influence antisocial drug dependence in adolescence
    Michael C Stallings
    Institute for Behavioral Genetics and Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, 80309 0444, USA
    Arch Gen Psychiatry 62:1042-51. 2005
    ..Previously we reported 2 chromosomal regions (3q24-3q25 and 9q34) likely to contain genes that influence substance dependence vulnerability (DV) in adolescence...
  30. ncbi request reprint Comorbidity between alcohol dependence and illicit drug dependence in adolescents with antisocial behavior and matched controls
    Soo Hyun Rhee
    Institute for Behavioral Genetics, Campus Box 447, University of Colorado, Boulder, CO 80309, USA
    Drug Alcohol Depend 84:85-92. 2006
    ..Discrepancies in results may reflect different analytical approaches or differences in the samples. Here, we examine the causes of comorbidity between alcohol dependence and illicit drug dependence in adolescents...
  31. ncbi request reprint Not all executive functions are related to intelligence
    Naomi P Friedman
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309, USA
    Psychol Sci 17:172-9. 2006
    ....
  32. ncbi request reprint Examination of the causes of covariation between conduct disorder symptoms and vulnerability to drug dependence
    Tanya M M Button
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309 0447, USA
    Twin Res Hum Genet 9:38-45. 2006
    ..Therefore, there appears to be pleiotropic genetic influence on CD symptoms and dependence vulnerability...
  33. ncbi request reprint Genes and developmental stabiltiy of aggressive behavior problems at home and school in a community sample of twins aged 7-12
    Brett C Haberstick
    Institute of Behavioral Genetics, University of Colorado at Boulder, Campus Box 447, Boulder, Colorado 80309 0447, USA
    Behav Genet 36:809-19. 2006
    ..Developmentally stable levels of aggressive behavior result from genetic influences common to all ages and individual environmental influences whose effects persist across ages...
  34. ncbi request reprint The role of conduct disorder in explaining the comorbidity between alcohol and illicit drug dependence in adolescence
    Tanya M M Button
    Institute for Behavioral Genetics, Campus Box 447, University of Colorado, Boulder, CO 80309, USA
    Drug Alcohol Depend 87:46-53. 2007
    ..This paper describes the result of an investigation of the extent to which comorbid alcohol and illicit drug dependence in adolescents are explained by etiological factors in common with conduct disorder...
  35. pmc Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents
    Christian J Hopfer
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Med Genet B Neuropsychiatr Genet 141:895-901. 2006
    ..Our findings provide evidence suggesting that a common CNR1 haplotype is associated with developing fewer cannabis dependence symptoms among adolescents who have experimented with cannabis...
  36. pmc A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9
    Christian J Hopfer
    Division of Substance Dependence, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Drug Alcohol Depend 89:34-41. 2007
    ..Genetic risk factors account for part of the variation in the development of cannabis dependence symptoms; however, no linkage studies have been performed for cannabis dependence symptoms. This study aimed to identify such loci...
  37. ncbi request reprint Test of association between TaqIA A1 allele and alcohol use disorder phenotypes in a sample of adolescent patients with serious substance and behavioral problems
    Joseph T Sakai
    Department of Psychiatry, Division of Substance Dependence, University of Colorado School of Medicine, Denver, CO 80262, USA
    Drug Alcohol Depend 88:130-7. 2007
    ....
  38. ncbi request reprint The heritability of gender identity disorder in a child and adolescent twin sample
    Frederick L Coolidge
    Psychology Department, University of Colorado at Colorado Springs, 80933 7150, USA
    Behav Genet 32:251-7. 2002
    ..05). Overall, the results support the hypothesis that there is a strong heritable component to GID. The findings may also imply that gender identity may be much less a matter of choice and much more a matter of biology...
  39. ncbi request reprint Case-control and within-family tests for an association between conduct disorder and 5HTTLPR
    Joseph T Sakai
    Division of Substance Dependence, Department of Psychiatry, University of Colorado School of Medicine, Denver, CO, USA
    Am J Med Genet B Neuropsychiatr Genet 141:825-32. 2006
    ..61; P = 0.20). These data suggest that the s-allele may confer some risk for aggressive behavior or may be in linkage disequilibrium with such an allele...

Research Grants1

  1. Executive Function: Links to Drug Use & Psychopathology
    Susan Young; Fiscal Year: 2006
    ..Our final aim is to determine the extent to which the covariation between ECF deficits and comorbid psychopathology is due to genetic and/or environmental factors. ..