ELIZABETH ANN YOUNG

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Saliva cortisol in posttraumatic stress disorder: a community epidemiologic study
    Elizabeth A Young
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan, USA
    Biol Psychiatry 56:205-9. 2004
  2. ncbi request reprint Cortisol pulsatility and its role in stress regulation and health
    Elizabeth A Young
    Department of Psychiatry, The University of Michigan, USA
    Front Neuroendocrinol 25:69-76. 2004
  3. ncbi request reprint The role of mineralocorticoid receptors in hypothalamic-pituitary-adrenal axis regulation in humans
    E A Young
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109, USA
    J Clin Endocrinol Metab 83:3339-45. 1998
  4. ncbi request reprint Saliva cortisol and response to dexamethasone in children of depressed parents
    Elizabeth A Young
    Department of Psychiatry, Mental Health Research Institute, University of Michigan, School of Medicine, Ann Arbor, Michigan 48109 0720, USA
    Biol Psychiatry 60:831-6. 2006
  5. ncbi request reprint HPA axis activation in major depression and response to fluoxetine: a pilot study
    Elizabeth A Young
    Department of Psychiatry, The Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0729, USA
    Psychoneuroendocrinology 29:1198-204. 2004
  6. ncbi request reprint Sex differences in the ACTH response to 24H metyrapone in depression
    Elizabeth A Young
    Department of Psychiatry, The University of Michigan, MI 48109 0720, USA
    Brain Res 1126:148-55. 2006
  7. ncbi request reprint Puberty, ovarian steroids, and stress
    Elizabeth A Young
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Ann N Y Acad Sci 1021:124-33. 2004
  8. ncbi request reprint Disordered adrenocorticotropin secretion in women with major depression
    Elizabeth A Young
    Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    J Clin Endocrinol Metab 91:1924-8. 2006
  9. ncbi request reprint Suicide and the hypothalamic-pituitary-adrenal axis
    Elizabeth A Young
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Lancet 366:959-61. 2005
  10. pmc Sex differences in ACTH pulsatility following metyrapone blockade in patients with major depression
    Elizabeth A Young
    Department of Psychiatry, The University of Michigan, Ann Arbor, MI 48109, USA
    Psychoneuroendocrinology 32:503-7. 2007

Research Grants

  1. DST and Suicide Prediction
    Elizabeth Young; Fiscal Year: 2003
  2. HPA Axis in Depression and Anxiety
    Elizabeth Young; Fiscal Year: 2005
  3. BIOLOGY OF COMORBID DEPRESSION AND ANXIETY
    Elizabeth Young; Fiscal Year: 2001

Detail Information

Publications49

  1. ncbi request reprint Saliva cortisol in posttraumatic stress disorder: a community epidemiologic study
    Elizabeth A Young
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan, USA
    Biol Psychiatry 56:205-9. 2004
    ..To address this question, we collected saliva cortisol at home in a subsample of a longitudinal epidemiologic sample...
  2. ncbi request reprint Cortisol pulsatility and its role in stress regulation and health
    Elizabeth A Young
    Department of Psychiatry, The University of Michigan, USA
    Front Neuroendocrinol 25:69-76. 2004
    ..In this review we propose some novel ideas relating to the importance of pulsatility both for the design of human stress-response studies and for their interpretation as well as implications for our understanding of disease...
  3. ncbi request reprint The role of mineralocorticoid receptors in hypothalamic-pituitary-adrenal axis regulation in humans
    E A Young
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109, USA
    J Clin Endocrinol Metab 83:3339-45. 1998
    ..These data suggest that MR appear to play a clear role in HPA axis regulation during the time of the circadian peak as well as the trough. Furthermore, MR blockade may affect the sensitivity of the adrenal to ACTH...
  4. ncbi request reprint Saliva cortisol and response to dexamethasone in children of depressed parents
    Elizabeth A Young
    Department of Psychiatry, Mental Health Research Institute, University of Michigan, School of Medicine, Ann Arbor, Michigan 48109 0720, USA
    Biol Psychiatry 60:831-6. 2006
    ..However, depression in a parent might also act as a stressor leading to increased activation of neuroendocrine stress circuits. To address this question we examined saliva cortisol in children whose parents have a history of MDD...
  5. ncbi request reprint HPA axis activation in major depression and response to fluoxetine: a pilot study
    Elizabeth A Young
    Department of Psychiatry, The Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0729, USA
    Psychoneuroendocrinology 29:1198-204. 2004
    ..This may reflect the greater severity of subjects with HPA axis dysregulation or the need to normalize the HPA axis with medications for optimal response...
  6. ncbi request reprint Sex differences in the ACTH response to 24H metyrapone in depression
    Elizabeth A Young
    Department of Psychiatry, The University of Michigan, MI 48109 0720, USA
    Brain Res 1126:148-55. 2006
    ..These data support an increased evening CRH drive in depressed women, but overall decreased CRH drive in depressed men...
  7. ncbi request reprint Puberty, ovarian steroids, and stress
    Elizabeth A Young
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Ann N Y Acad Sci 1021:124-33. 2004
    ..The onset of these reproductive hormonal changes modulating stress systems at puberty may sensitize girls to stressful life events, which become more frequent at the transition to puberty and young adulthood...
  8. ncbi request reprint Disordered adrenocorticotropin secretion in women with major depression
    Elizabeth A Young
    Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    J Clin Endocrinol Metab 91:1924-8. 2006
    ..Major depression is accompanied by activation of the hypothalamic pituitary axis and evidence of abnormalities in circadian and ultradian hormone rhythms. In addition, diminished negative feedback of cortisol on ACTH has been found...
  9. ncbi request reprint Suicide and the hypothalamic-pituitary-adrenal axis
    Elizabeth A Young
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Lancet 366:959-61. 2005
  10. pmc Sex differences in ACTH pulsatility following metyrapone blockade in patients with major depression
    Elizabeth A Young
    Department of Psychiatry, The University of Michigan, Ann Arbor, MI 48109, USA
    Psychoneuroendocrinology 32:503-7. 2007
    ..These data suggest that pulsatility and mean ACTH levels are examining different aspects of HPA axis function, and that the types of HPA axis dysregulation in depression may differ between men and women...
  11. pmc Influences of hormone-based contraception on depressive symptoms in premenopausal women with major depression
    Elizabeth A Young
    Department of Psychiatry and Molecular and Behavioral Neurosciences Institute, University of Michigan, MBNI, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, and Massachusetts General Hospital, Boston 02114, USA
    Psychoneuroendocrinology 32:843-53. 2007
    ....
  12. pmc Sex differences in response to citalopram: a STAR*D report
    Elizabeth A Young
    Department of Psychiatry and Molecular and Behavioral Neurosciences Institute, University of Michigan, Ann Arbor, MI 48109 5765, USA
    J Psychiatr Res 43:503-11. 2009
    ..The purpose of this report was to determine whether men and women differ in their responses to treatment with the SSRI citalopram using a large sample of real world patients from primary and psychiatric specialty care settings...
  13. ncbi request reprint Anxiety and cardiovascular reactivity in the Tecumseh population
    E A Young
    Department of Psychiatry, Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor 48109, USA
    J Hypertens 16:1727-33. 1998
    ..The studies reported here were undertaken to examine the relationship between trait anxiety and cardiovascular stress reactivity in a community-based sample (Tecumseh)...
  14. ncbi request reprint Effect of ruminations on the saliva cortisol response to a social stressor
    E A Young
    Mental Health Research Institute, Ann Arbor, MI 48109, USA
    Psychoneuroendocrinology 26:319-29. 2001
    ..Finally, a modified version of the TSST in which the subjects were allowed a longer preparatory period resulted in a markedly diminished saliva cortisol response to the TSST...
  15. ncbi request reprint Twenty-four-hour ACTH and cortisol pulsatility in depressed women
    E A Young
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor 48109 0729, USA
    Neuropsychopharmacology 25:267-76. 2001
    ..These data suggest that the pulsatile and circadian components of the HPA axis are normal in premenopausal depressed women and that only 24% of depressed women demonstrate hypercortisolemia...
  16. ncbi request reprint Effects of estrogen antagonists and agonists on the ACTH response to restraint stress in female rats
    E A Young
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 0729, USA
    Neuropsychopharmacology 25:881-91. 2001
    ..These data suggest that in the physiological range estradiol is an important inhibitory factor in the hypothalamic-pituitary-adrenal stress response of females...
  17. ncbi request reprint The hypothalamic-pituitary-gonadal axis in mood disorders
    Elizabeth A Young
    Department of Psychiatry and MHRI, University of Michigan, Ann Arbor, MI, USA
    Endocrinol Metab Clin North Am 31:63-78. 2002
    ....
  18. ncbi request reprint Cortisol and catecholamines in posttraumatic stress disorder: an epidemiologic community study
    Elizabeth A Young
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, 48109 0720, USA
    Arch Gen Psychiatry 61:394-401. 2004
    ..Prior research has connected posttraumatic stress disorder (PTSD) to increased levels of catecholamines. However, studies of cortisol levels have produced mixed results...
  19. doi request reprint Perspective: sex matters: gonadal steroids and the brain
    Elizabeth A Young
    Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Neuropsychopharmacology 34:537-8. 2009
    ..This body of work challenges all of neuropsychopharmacology to consider the importance of sex and gonadal steroids in future studies...
  20. ncbi request reprint Mineralocorticoid receptor function in major depression
    Elizabeth A Young
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, 205 Zina Pitcher Pl, Ann Arbor, MI 48109 0720, USA
    Arch Gen Psychiatry 60:24-8. 2003
    ....
  21. ncbi request reprint Interaction of brain noradrenergic system and the hypothalamic-pituitary-adrenal (HPA) axis in man
    Elizabeth A Young
    Department of Psychiatry, University of Michigan, Ann Arbor, 48109 0720, USA
    Psychoneuroendocrinology 30:807-14. 2005
    ..This relationship is less well characterized in humans and little is known about the influence of psychiatric disorders, which disturb one of these systems, on this relationship...
  22. ncbi request reprint Dysregulation of endogenous opioid emotion regulation circuitry in major depression in women
    Susan E Kennedy
    Department of Psychiatry, University of Michigan, Ann Arbor 48109 0720, USA
    Arch Gen Psychiatry 63:1199-208. 2006
    ..Endogenous opioid neurotransmission activating mu-opioid receptors is involved in stress and emotion regulatory processes and has been further implicated in MDD...
  23. doi request reprint What predicts attrition in second step medication treatments for depression?: a STAR*D Report
    Diane Warden
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9119, USA
    Int J Neuropsychopharmacol 12:459-73. 2009
    ..Focus on patients with attrition risk factors for medication augmentation or switch strategies may enhance retention and improve outcomes...
  24. ncbi request reprint Effect of comorbid anxiety disorders on the hypothalamic-pituitary-adrenal axis response to a social stressor in major depression
    Elizabeth A Young
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    Biol Psychiatry 56:113-20. 2004
    ..This study examined the influence of anxiety comorbidity on the hypothalamic-pituitary-adrenal (HPA) axis response to stress in patients with MDD...
  25. ncbi request reprint Salivary cortisol and posttraumatic stress disorder in a low-income community sample of women
    Elizabeth A Young
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan, USA
    Biol Psychiatry 55:621-6. 2004
    ..Studies with women with posttraumatic stress disorder (PTSD) have focused on childhood sexual abuse and holocaust survivors, both of whom experienced trauma during development, which could be different than adult trauma exposure...
  26. ncbi request reprint Clinical predictors of suicide in primary major depressive disorder
    William Coryell
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Clin Psychiatry 66:412-7. 2005
    ..The following analysis takes advantage of a large cohort of depressed patients given detailed, structured interviews 2 decades ago...
  27. ncbi request reprint Cognitive modulation of the endocrine stress response to a pharmacological challenge in normal and panic disorder subjects
    James L Abelson
    Department of Psychiatry and Mental Health Research Institute, Trauma, Stress and Anxiety Research Group, University of Michigan, Ann Arbor 48109 0118, USA
    Arch Gen Psychiatry 62:668-75. 2005
    ..Scientific study of how such factors moderate human HPA axis activity has been limited. Their relevance to HPA axis disturbances in psychiatric patients is largely unexplored...
  28. ncbi request reprint A task to manipulate attentional load, set-shifting, and inhibitory control: convergent validity and test-retest reliability of the Parametric Go/No-Go Test
    Scott A Langenecker
    Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Clin Exp Neuropsychol 29:842-53. 2007
    ..Learning effects were significantly less than those for the Trail Making Test. The present results provide solid initial support for the validity and reliability of the PGNG...
  29. pmc Sex differences in depression symptoms in treatment-seeking adults: confirmatory analyses from the Sequenced Treatment Alternatives to Relieve Depression study
    Sheila M Marcus
    Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    Compr Psychiatry 49:238-46. 2008
    ..This article examines sex differences in terms of illness attributes in a cohort of 2541 outpatients from across the United States who enrolled in the Sequenced Treatment Alternatives to Relieve Depression study...
  30. pmc Effects of perceived control and cognitive coping on endocrine stress responses to pharmacological activation
    James L Abelson
    Department of Psychiatry, Trauma, Stress and Anxiety Research Group, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA
    Biol Psychiatry 64:701-7. 2008
    ..This study attempted to identify the core factors that modulate HPA axis activity in this model...
  31. ncbi request reprint The pattern of growth hormone secretion during the menstrual cycle in normal and depressed women
    Josephine Z Kasa-Vubu
    Department of Pediatrics, Division of Pediatric Endocrinology, University of Michigan, Ann Arbor, Michigan 48019 0718, USA
    Clin Endocrinol (Oxf) 62:656-60. 2005
    ..The aim of this study was to investigate changes of growth hormone (GH) secretion during the menstrual cycle in normal and depressed women...
  32. ncbi request reprint Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmission
    Jon Kar Zubieta
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Arch Gen Psychiatry 60:1145-53. 2003
    ..The mu-opioid neurotransmitter system is distributed in, and thought to regulate the function of, brain regions centrally implicated in affective processing...
  33. pmc Gender-specific disruptions in emotion processing in younger adults with depression
    Sara L Wright
    Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan 48105, USA
    Depress Anxiety 26:182-9. 2009
    ..This study sought to explore how gender and depression status relate to emotion processing...
  34. pmc Association of daily stressors and salivary cortisol in spinal cord injury
    Claire Z Kalpakjian
    Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48109, USA
    Rehabil Psychol 54:288-98. 2009
    ..Examine the diurnal variation of salivary cortisol in adults with spinal cord injury (SCI) and the effect of stressors on cortisol and mood...
  35. pmc Cognitive modulation of endocrine responses to CRH stimulation in healthy subjects
    James L Abelson
    University of Michigan Department of Psychiatry, Trauma, Stress and Anxiety Research Group, Molecular and Behavioral Neuroscience Institute, United States
    Psychoneuroendocrinology 35:451-9. 2010
    ....
  36. pmc Frontal and limbic activation during inhibitory control predicts treatment response in major depressive disorder
    Scott A Langenecker
    Department of Psychiatry, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Biol Psychiatry 62:1272-80. 2007
    ..Inhibitory control is addressed specifically by using a task devoid of affectively-laden stimuli, to disentangle the effects of altered affect and altered inhibitory processes in MDD...
  37. pmc SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A
    Sandra M Villafuerte
    Molecular and Behavioral Neuroscience Institute, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Psychiatr Genet 19:281-91. 2009
    ..Variations in gene expression in these genes may thus affect SSRI response...
  38. ncbi request reprint The sensitivity and psychometric properties of a brief computer-based cognitive screening battery in a depression clinic
    Scott A Langenecker
    Department of Psychiatry, University of Michigan Medical Center, C480 Med Inn Building, 1500 East Medical Center, Ann Arbor, MI 48109, USA
    Psychiatry Res 152:143-54. 2007
    ..Developing valid and reliable measures of cognitive signs in mood disorders creates excellent opportunities for tracking cognitive status prior to initiation of treatment, and allows for reliable retest following treatment...
  39. ncbi request reprint Modeling cortisol rhythms in a population-based study
    Nalini Ranjit
    Department of Epidemiology, Center for Social Epidemiology and Population Health, School of Public Health, University of Michigan, Ann Arbor, MI 48104, USA
    Psychoneuroendocrinology 30:615-24. 2005
    ..Sharp inflection points for the diurnal profile of cortisol were noted at 30 and 75 min past awakening. Obese women showed a slight tendency to have a less sharply rising and declining response to awakening than non-obese women...
  40. ncbi request reprint Material hardship alters the diurnal rhythm of salivary cortisol
    Nalini Ranjit
    Center for Social Epidemiology and Population Health, Department of Epidemiology, School of Public Health, University of Michigan, MI, USA
    Int J Epidemiol 34:1138-43. 2005
    ..As there is some evidence that both acute and chronic stress raise cortisol levels, and material hardship is a stressor, we examined the relationship of chronic material hardship with salivary cortisol levels over the day...
  41. ncbi request reprint Gender differences in depression: findings from the STAR*D study
    Sheila M Marcus
    Department of Psychiatry, University of Michigan Medical School, 2101 Commonwealth Blvd Suite B, Ann Arbor, MI 48105, USA
    J Affect Disord 87:141-50. 2005
    ..The STAR*D (Sequenced Treatment Alternatives to Relieve Depression) multicenter trial provides a unique opportunity to explore gender differences in outpatients with nonpsychotic MDD...
  42. pmc The health of poor women under welfare reform
    George A Kaplan
    Center for Social Epidemiology and Population Health, 1214 S University Ave, Ann Arbor, MI 48104, USA
    Am J Public Health 95:1252-8. 2005
    ..We compared the health of single mothers affected by welfare reform with the health of a nationally representative sample of women to document the prevalence of poor health as single mothers experience the effects of welfare reform...
  43. ncbi request reprint Anxious and depressive disorders and their comorbidity: effect on central nervous system noradrenergic function
    Oliver G Cameron
    Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Biol Psychiatry 56:875-83. 2004
    ....
  44. ncbi request reprint What happened to lithium? Antidepressant augmentation in clinical settings
    Marcia Valenstein
    Health Services Research and Development, VA Medical Center, P O Box 130170, Ann Arbor, MI 48113 0170, USA
    Am J Psychiatry 163:1219-25. 2006
    ..Antidepressant augmentation is recommended when patients do not respond to antidepressant monotherapy. However, little is know about antidepressant augmentation in clinical settings and whether these practices reflect the research evidence...
  45. ncbi request reprint HPA axis activity in patients with panic disorder: review and synthesis of four studies
    James L Abelson
    Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, Trauma, Stress and Anxiety Research Group, University of Michigan, Ann Arbor, Michigan 48109 0118, USA
    Depress Anxiety 24:66-76. 2007
    ..Most of the published panic/HPA literature is consistent with the hypothesis that HPA axis dysregulation in panic is due to hypersensitivity to contextual cues. This hypothesis requires experimental testing...
  46. ncbi request reprint Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndrome
    Leslie J Crofford
    Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Brain Behav Immun 18:314-25. 2004
    ..The abnormalities in FMS patients are consistent with loss of HPA axis resiliency...
  47. ncbi request reprint Acute effects of electroconvulsive therapy on lymphocyte natural killer cell activity in patients with major depression
    Ziad Kronfol
    Department of Psychiatry, University of Michigan Health System, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0722, USA
    J Affect Disord 71:211-5. 2002
    ..The effects of biological treatment of depression on the immune system have not been systematically investigated. The present study addresses the acute effects of electroconvulsive therapy (ECT) on NKCA...
  48. ncbi request reprint Does cortisol mediate endotoxin-induced inhibition of pulsatile luteinizing hormone and gonadotropin-releasing hormone secretion?
    Nathalie Debus
    Reproductive Sciences Program, University of Michigan, Ann Arbor 48109 0404, USA
    Endocrinology 143:3748-58. 2002
    ....
  49. ncbi request reprint Does the type II glucocorticoid receptor mediate cortisol-induced suppression in pituitary responsiveness to gonadotropin-releasing hormone?
    Kellie M Breen
    Reproductive Sciences Program, University of Michigan, 300 North Ingalls Building, Room 1101 SW, Ann Arbor, Michigan 48109 0404, USA
    Endocrinology 145:2739-46. 2004
    ..Together, these observations imply that the type II GR mediates cortisol-induced suppression of pituitary responsiveness to GnRH...

Research Grants16

  1. DST and Suicide Prediction
    Elizabeth Young; Fiscal Year: 2003
    ....
  2. HPA Axis in Depression and Anxiety
    Elizabeth Young; Fiscal Year: 2005
    ....
  3. BIOLOGY OF COMORBID DEPRESSION AND ANXIETY
    Elizabeth Young; Fiscal Year: 2001
    ..The results of these studies will provide data on whether the biology of these disorders support the nosological distinction between panic disorder, pure major depression and major depression with co-morbid panic disorder. ..