Research Topics
Species | ELIZABETH ANN YOUNGSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Saliva cortisol in posttraumatic stress disorder: a community epidemiologic studyElizabeth A Young
Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan, USA
Biol Psychiatry 56:205-9. 2004..To address this question, we collected saliva cortisol at home in a subsample of a longitudinal epidemiologic sample...- Cortisol pulsatility and its role in stress regulation and healthElizabeth A Young
Department of Psychiatry, The University of Michigan, USA
Front Neuroendocrinol 25:69-76. 2004..In this review we propose some novel ideas relating to the importance of pulsatility both for the design of human stress-response studies and for their interpretation as well as implications for our understanding of disease... - The role of mineralocorticoid receptors in hypothalamic-pituitary-adrenal axis regulation in humansE A Young
Mental Health Research Institute, University of Michigan, Ann Arbor 48109, USA
J Clin Endocrinol Metab 83:3339-45. 1998..These data suggest that MR appear to play a clear role in HPA axis regulation during the time of the circadian peak as well as the trough. Furthermore, MR blockade may affect the sensitivity of the adrenal to ACTH... - Saliva cortisol and response to dexamethasone in children of depressed parentsElizabeth A Young
Department of Psychiatry, Mental Health Research Institute, University of Michigan, School of Medicine, Ann Arbor, Michigan 48109 0720, USA
Biol Psychiatry 60:831-6. 2006..However, depression in a parent might also act as a stressor leading to increased activation of neuroendocrine stress circuits. To address this question we examined saliva cortisol in children whose parents have a history of MDD... - HPA axis activation in major depression and response to fluoxetine: a pilot studyElizabeth A Young
Department of Psychiatry, The Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0729, USA
Psychoneuroendocrinology 29:1198-204. 2004..This may reflect the greater severity of subjects with HPA axis dysregulation or the need to normalize the HPA axis with medications for optimal response... - Sex differences in the ACTH response to 24H metyrapone in depressionElizabeth A Young
Department of Psychiatry, The University of Michigan, MI 48109 0720, USA
Brain Res 1126:148-55. 2006..These data support an increased evening CRH drive in depressed women, but overall decreased CRH drive in depressed men... - Puberty, ovarian steroids, and stressElizabeth A Young
Department of Psychiatry and Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
Ann N Y Acad Sci 1021:124-33. 2004..The onset of these reproductive hormonal changes modulating stress systems at puberty may sensitize girls to stressful life events, which become more frequent at the transition to puberty and young adulthood... - Disordered adrenocorticotropin secretion in women with major depressionElizabeth A Young
Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
J Clin Endocrinol Metab 91:1924-8. 2006..Major depression is accompanied by activation of the hypothalamic pituitary axis and evidence of abnormalities in circadian and ultradian hormone rhythms. In addition, diminished negative feedback of cortisol on ACTH has been found... - Suicide and the hypothalamic-pituitary-adrenal axisElizabeth A Young
Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USA
Lancet 366:959-61. 2005 
Sex differences in ACTH pulsatility following metyrapone blockade in patients with major depressionElizabeth A Young
Department of Psychiatry, The University of Michigan, Ann Arbor, MI 48109, USA
Psychoneuroendocrinology 32:503-7. 2007..These data suggest that pulsatility and mean ACTH levels are examining different aspects of HPA axis function, and that the types of HPA axis dysregulation in depression may differ between men and women...- Influences of hormone-based contraception on depressive symptoms in premenopausal women with major depressionElizabeth A Young
Department of Psychiatry and Molecular and Behavioral Neurosciences Institute, University of Michigan, MBNI, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, and Massachusetts General Hospital, Boston 02114, USA
Psychoneuroendocrinology 32:843-53. 2007.... - Sex differences in response to citalopram: a STAR*D reportElizabeth A Young
Department of Psychiatry and Molecular and Behavioral Neurosciences Institute, University of Michigan, Ann Arbor, MI 48109 5765, USA
J Psychiatr Res 43:503-11. 2009..The purpose of this report was to determine whether men and women differ in their responses to treatment with the SSRI citalopram using a large sample of real world patients from primary and psychiatric specialty care settings... - Anxiety and cardiovascular reactivity in the Tecumseh populationE A Young
Department of Psychiatry, Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor 48109, USA
J Hypertens 16:1727-33. 1998..The studies reported here were undertaken to examine the relationship between trait anxiety and cardiovascular stress reactivity in a community-based sample (Tecumseh)... - Effect of ruminations on the saliva cortisol response to a social stressorE A Young
Mental Health Research Institute, Ann Arbor, MI 48109, USA
Psychoneuroendocrinology 26:319-29. 2001..Finally, a modified version of the TSST in which the subjects were allowed a longer preparatory period resulted in a markedly diminished saliva cortisol response to the TSST... - Twenty-four-hour ACTH and cortisol pulsatility in depressed womenE A Young
Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor 48109 0729, USA
Neuropsychopharmacology 25:267-76. 2001..These data suggest that the pulsatile and circadian components of the HPA axis are normal in premenopausal depressed women and that only 24% of depressed women demonstrate hypercortisolemia... - Effects of estrogen antagonists and agonists on the ACTH response to restraint stress in female ratsE A Young
Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 0729, USA
Neuropsychopharmacology 25:881-91. 2001..These data suggest that in the physiological range estradiol is an important inhibitory factor in the hypothalamic-pituitary-adrenal stress response of females... - The hypothalamic-pituitary-gonadal axis in mood disordersElizabeth A Young
Department of Psychiatry and MHRI, University of Michigan, Ann Arbor, MI, USA
Endocrinol Metab Clin North Am 31:63-78. 2002.... - Cortisol and catecholamines in posttraumatic stress disorder: an epidemiologic community studyElizabeth A Young
Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, 48109 0720, USA
Arch Gen Psychiatry 61:394-401. 2004..Prior research has connected posttraumatic stress disorder (PTSD) to increased levels of catecholamines. However, studies of cortisol levels have produced mixed results... 
Perspective: sex matters: gonadal steroids and the brainElizabeth A Young
Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA
Neuropsychopharmacology 34:537-8. 2009..This body of work challenges all of neuropsychopharmacology to consider the importance of sex and gonadal steroids in future studies...- Mineralocorticoid receptor function in major depressionElizabeth A Young
Mental Health Research Institute and Department of Psychiatry, University of Michigan, 205 Zina Pitcher Pl, Ann Arbor, MI 48109 0720, USA
Arch Gen Psychiatry 60:24-8. 2003.... - Interaction of brain noradrenergic system and the hypothalamic-pituitary-adrenal (HPA) axis in manElizabeth A Young
Department of Psychiatry, University of Michigan, Ann Arbor, 48109 0720, USA
Psychoneuroendocrinology 30:807-14. 2005..This relationship is less well characterized in humans and little is known about the influence of psychiatric disorders, which disturb one of these systems, on this relationship... - Dysregulation of endogenous opioid emotion regulation circuitry in major depression in womenSusan E Kennedy
Department of Psychiatry, University of Michigan, Ann Arbor 48109-0720, USA
Arch Gen Psychiatry 63:1199-208. 2006..These data demonstrate that endogenous opioid neurotransmission on mu-opioid receptors, a system implicated in stress responses and emotional regulation, is altered in patients diagnosed with MDD... - What predicts attrition in second step medication treatments for depression?: a STAR*D ReportDiane Warden
Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9119, USA
Int J Neuropsychopharmacol 12:459-73. 2009..Focus on patients with attrition risk factors for medication augmentation or switch strategies may enhance retention and improve outcomes... - Effect of comorbid anxiety disorders on the hypothalamic-pituitary-adrenal axis response to a social stressor in major depressionElizabeth A Young
Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109-0720, USA
Biol Psychiatry 56:113-20. 2004..All patient groups showed similar levels of TSST-induced anxiety. CONCLUSIONS: Comorbid anxiety disorders might play a role in the increased activation of the HPA axis observed in patients with major depression... - Salivary cortisol and posttraumatic stress disorder in a low-income community sample of womenElizabeth A Young
Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan, USA
Biol Psychiatry 55:621-6. 2004..CONCLUSIONS: While recent trauma exposure can increase saliva cortisol, neither recent nor past PTSD affected saliva cortisol in our community sample of women. Our data do not support saliva cortisol changes associated with PTSD... - Clinical predictors of suicide in primary major depressive disorderWilliam Coryell
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
J Clin Psychiatry 66:412-7. 2005..The following analysis takes advantage of a large cohort of depressed patients given detailed, structured interviews 2 decades ago... - Cognitive modulation of the endocrine stress response to a pharmacological challenge in normal and panic disorder subjectsJames L Abelson
Department of Psychiatry and Mental Health Research Institute, Trauma, Stress and Anxiety Research Group, University of Michigan, Ann Arbor 48109 0118, USA
Arch Gen Psychiatry 62:668-75. 2005..Scientific study of how such factors moderate human HPA axis activity has been limited. Their relevance to HPA axis disturbances in psychiatric patients is largely unexplored... - A task to manipulate attentional load, set-shifting, and inhibitory control: convergent validity and test-retest reliability of the Parametric Go/No-Go TestScott A Langenecker
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
J Clin Exp Neuropsychol 29:842-53. 2007..Learning effects were significantly less than those for the Trail Making Test. The present results provide solid initial support for the validity and reliability of the PGNG... - Sex differences in depression symptoms in treatment-seeking adults: confirmatory analyses from the Sequenced Treatment Alternatives to Relieve Depression studySheila M Marcus
Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI 48105, USA
Compr Psychiatry 49:238-46. 2008..This article examines sex differences in terms of illness attributes in a cohort of 2541 outpatients from across the United States who enrolled in the Sequenced Treatment Alternatives to Relieve Depression study... - Effects of perceived control and cognitive coping on endocrine stress responses to pharmacological activationJames L Abelson
Department of Psychiatry, Trauma, Stress and Anxiety Research Group, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA
Biol Psychiatry 64:701-7. 2008..This study attempted to identify the core factors that modulate HPA axis activity in this model... - The pattern of growth hormone secretion during the menstrual cycle in normal and depressed womenJosephine Z Kasa-Vubu
Department of Pediatrics, Division of Pediatric Endocrinology, University of Michigan, Ann Arbor, Michigan 48019 0718, USA
Clin Endocrinol (Oxf) 62:656-60. 2005..The aim of this study was to investigate changes of growth hormone (GH) secretion during the menstrual cycle in normal and depressed women... - Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmissionJon Kar Zubieta
Department of Psychiatry and Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
Arch Gen Psychiatry 60:1145-53. 2003..The mu-opioid neurotransmitter system is distributed in, and thought to regulate the function of, brain regions centrally implicated in affective processing... - Gender-specific disruptions in emotion processing in younger adults with depressionSara L Wright
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan 48105, USA
Depress Anxiety 26:182-9. 2009..This study sought to explore how gender and depression status relate to emotion processing... - Association of daily stressors and salivary cortisol in spinal cord injuryClaire Z Kalpakjian
Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48109, USA
Rehabil Psychol 54:288-98. 2009..Examine the diurnal variation of salivary cortisol in adults with spinal cord injury (SCI) and the effect of stressors on cortisol and mood... - Cognitive modulation of endocrine responses to CRH stimulation in healthy subjectsJames L Abelson
University of Michigan Department of Psychiatry, Trauma, Stress and Anxiety Research Group, Molecular and Behavioral Neuroscience Institute, United States
Psychoneuroendocrinology 35:451-9. 2010.... - Frontal and limbic activation during inhibitory control predicts treatment response in major depressive disorderScott A Langenecker
Department of Psychiatry, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
Biol Psychiatry 62:1272-80. 2007..Inhibitory control is addressed specifically by using a task devoid of affectively-laden stimuli, to disentangle the effects of altered affect and altered inhibitory processes in MDD... - SSRI response in depression may be influenced by SNPs in HTR1B and HTR1ASandra M Villafuerte
Molecular and Behavioral Neuroscience Institute, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
Psychiatr Genet 19:281-91. 2009..Variations in gene expression in these genes may thus affect SSRI response... - The sensitivity and psychometric properties of a brief computer-based cognitive screening battery in a depression clinicScott A Langenecker
Department of Psychiatry, University of Michigan Medical Center, C480 Med Inn Building, 1500 East Medical Center, Ann Arbor, MI 48109, USA
Psychiatry Res 152:143-54. 2007..Developing valid and reliable measures of cognitive signs in mood disorders creates excellent opportunities for tracking cognitive status prior to initiation of treatment, and allows for reliable retest following treatment... - Modeling cortisol rhythms in a population-based studyNalini Ranjit
Department of Epidemiology, Center for Social Epidemiology and Population Health, School of Public Health, University of Michigan, Ann Arbor, MI 48104, USA
Psychoneuroendocrinology 30:615-24. 2005..Sharp inflection points for the diurnal profile of cortisol were noted at 30 and 75 min past awakening. Obese women showed a slight tendency to have a less sharply rising and declining response to awakening than non-obese women... - Material hardship alters the diurnal rhythm of salivary cortisolNalini Ranjit
Center for Social Epidemiology and Population Health, Department of Epidemiology, School of Public Health, University of Michigan, MI, USA
Int J Epidemiol 34:1138-43. 2005..As there is some evidence that both acute and chronic stress raise cortisol levels, and material hardship is a stressor, we examined the relationship of chronic material hardship with salivary cortisol levels over the day... - Gender differences in depression: findings from the STAR*D studySheila M Marcus
Department of Psychiatry, University of Michigan Medical School, 2101 Commonwealth Blvd Suite B, Ann Arbor, MI 48105, USA
J Affect Disord 87:141-50. 2005..The STAR*D (Sequenced Treatment Alternatives to Relieve Depression) multicenter trial provides a unique opportunity to explore gender differences in outpatients with nonpsychotic MDD... - The health of poor women under welfare reformGeorge A Kaplan
Center for Social Epidemiology and Population Health, 1214 S University Ave, Ann Arbor, MI 48104, USA
Am J Public Health 95:1252-8. 2005..We compared the health of single mothers affected by welfare reform with the health of a nationally representative sample of women to document the prevalence of poor health as single mothers experience the effects of welfare reform... - Anxious and depressive disorders and their comorbidity: effect on central nervous system noradrenergic functionOliver G Cameron
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan, USA
Biol Psychiatry 56:875-83. 2004.... - What happened to lithium? Antidepressant augmentation in clinical settingsMarcia Valenstein
Health Services Research and Development, VA Medical Center, P O Box 130170, Ann Arbor, MI 48113 0170, USA
Am J Psychiatry 163:1219-25. 2006..Antidepressant augmentation is recommended when patients do not respond to antidepressant monotherapy. However, little is know about antidepressant augmentation in clinical settings and whether these practices reflect the research evidence... - HPA axis activity in patients with panic disorder: review and synthesis of four studiesJames L Abelson
Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, Trauma, Stress and Anxiety Research Group, University of Michigan, Ann Arbor, Michigan 48109 0118, USA
Depress Anxiety 24:66-76. 2007..Most of the published panic/HPA literature is consistent with the hypothesis that HPA axis dysregulation in panic is due to hypersensitivity to contextual cues. This hypothesis requires experimental testing... - Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndromeLeslie J Crofford
Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA
Brain Behav Immun 18:314-25. 2004..The abnormalities in FMS patients are consistent with loss of HPA axis resiliency... - Acute effects of electroconvulsive therapy on lymphocyte natural killer cell activity in patients with major depressionZiad Kronfol
Department of Psychiatry, University of Michigan Health System, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0722, USA
J Affect Disord 71:211-5. 2002..The effects of biological treatment of depression on the immune system have not been systematically investigated. The present study addresses the acute effects of electroconvulsive therapy (ECT) on NKCA... - Does cortisol mediate endotoxin-induced inhibition of pulsatile luteinizing hormone and gonadotropin-releasing hormone secretion?Nathalie Debus
Reproductive Sciences Program, University of Michigan, Ann Arbor 48109 0404, USA
Endocrinology 143:3748-58. 2002.... - Does the type II glucocorticoid receptor mediate cortisol-induced suppression in pituitary responsiveness to gonadotropin-releasing hormone?Kellie M Breen
Reproductive Sciences Program, University of Michigan, 300 North Ingalls Building, Room 1101 SW, Ann Arbor, Michigan 48109 0404, USA
Endocrinology 145:2739-46. 2004..Together, these observations imply that the type II GR mediates cortisol-induced suppression of pituitary responsiveness to GnRH...
Research Grants
- DST and Suicide PredictionElizabeth Young; Fiscal Year: 2003....
- HPA Axis in Depression and AnxietyElizabeth Young; Fiscal Year: 2005....
- BIOLOGY OF COMORBID DEPRESSION AND ANXIETYElizabeth Young; Fiscal Year: 2001..The results of these studies will provide data on whether the biology of these disorders support the nosological distinction between panic disorder, pure major depression and major depression with co-morbid panic disorder. ..