Greg Yothers

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Biomarker discovery for colon cancer using a 761 gene RT-PCR assay
    Kim M Clark-Langone
    Genomic Health, Inc, Redwood City, CA, USA
    BMC Genomics 8:279. 2007
  2. pmc Outcomes among black patients with stage II and III colon cancer receiving chemotherapy: an analysis of ACCENT adjuvant trials
    Greg Yothers
    National Surgical Adjuvant Breast and Bowel Project Biostatistical Center, One Sterling Plaza, 201 N Craig St, Pittsburgh, PA 15213, USA
    J Natl Cancer Inst 103:1498-506. 2011
  3. pmc Oxaliplatin as adjuvant therapy for colon cancer: updated results of NSABP C-07 trial, including survival and subset analyses
    Greg Yothers
    NSABP Biostatistical Center, One Sterling Plaza, 201 N Craig St, STE 350, Pittsburgh, PA 15213, USA
    J Clin Oncol 29:3768-74. 2011
  4. ncbi request reprint Quality of life in operable colon cancer patients receiving oral compared with intravenous chemotherapy: results from National Surgical Adjuvant Breast and Bowel Project Trial C-06
    Jacek A Kopec
    National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA, USA
    J Clin Oncol 25:424-30. 2007
  5. ncbi request reprint Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07
    J Philip Kuebler
    National Surgical Adjuvant Breast and Bowel Project Operations Office and Biostatistical Center, Pittsburgh, PA, USA
    J Clin Oncol 25:2198-204. 2007
  6. pmc Long-term survival results of surgery alone versus surgery plus 5-fluorouracil and leucovorin for stage II and stage III colon cancer: pooled analysis of NSABP C-01 through C-05. A baseline from which to compare modern adjuvant trials
    Neal W Wilkinson
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA
    Ann Surg Oncol 17:959-66. 2010
  7. ncbi request reprint Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project Protocol C-06
    Barry C Lembersky
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212, USA
    J Clin Oncol 24:2059-64. 2006
  8. ncbi request reprint Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemotherapy for node-positive breast cancer: results from NSABP B-28
    Eleftherios P Mamounas
    National Surgical Adjuvant Breast and Bowel Project, Operations Office and Biostatistical Center, Pittsburgh, PA, USA
    J Clin Oncol 23:3686-96. 2005
  9. ncbi request reprint Severe enteropathy among patients with stage II/III colon cancer treated on a randomized trial of bolus 5-fluorouracil/leucovorin plus or minus oxaliplatin: a prospective analysis
    J Philip Kuebler
    National Surgical Adjuvant Breast and Bowel Project NSABP, Pittsburgh, Pennsylvania 15212, USA
    Cancer 110:1945-50. 2007
  10. pmc Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03
    Mark S Roh
    National Surgical Adjuvant Breast and Bowel Project NSABP Operations Cente, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA
    J Clin Oncol 27:5124-30. 2009

Detail Information

Publications22

  1. pmc Biomarker discovery for colon cancer using a 761 gene RT-PCR assay
    Kim M Clark-Langone
    Genomic Health, Inc, Redwood City, CA, USA
    BMC Genomics 8:279. 2007
    ..This screening strategy remains attractive due to the inherent advantages of maintaining platform consistency from discovery through clinical application...
  2. pmc Outcomes among black patients with stage II and III colon cancer receiving chemotherapy: an analysis of ACCENT adjuvant trials
    Greg Yothers
    National Surgical Adjuvant Breast and Bowel Project Biostatistical Center, One Sterling Plaza, 201 N Craig St, Pittsburgh, PA 15213, USA
    J Natl Cancer Inst 103:1498-506. 2011
    ..We investigated whether disparities in survival and related endpoints would persist when patients were treated with identical therapies in controlled clinical trials...
  3. pmc Oxaliplatin as adjuvant therapy for colon cancer: updated results of NSABP C-07 trial, including survival and subset analyses
    Greg Yothers
    NSABP Biostatistical Center, One Sterling Plaza, 201 N Craig St, STE 350, Pittsburgh, PA 15213, USA
    J Clin Oncol 29:3768-74. 2011
    ..This analysis is the first publication of overall survival (OS) for the NSABP C-07 study. We updated DFS and examined both end points in clinically relevant patient subsets...
  4. ncbi request reprint Quality of life in operable colon cancer patients receiving oral compared with intravenous chemotherapy: results from National Surgical Adjuvant Breast and Bowel Project Trial C-06
    Jacek A Kopec
    National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA, USA
    J Clin Oncol 25:424-30. 2007
    ....
  5. ncbi request reprint Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07
    J Philip Kuebler
    National Surgical Adjuvant Breast and Bowel Project Operations Office and Biostatistical Center, Pittsburgh, PA, USA
    J Clin Oncol 25:2198-204. 2007
    ..This phase III clinical trial evaluated the impact on disease-free survival (DFS) of adding oxaliplatin to bolus weekly fluorouracil (FU) combined with leucovorin as surgical adjuvant therapy for stage II and III colon cancer...
  6. pmc Long-term survival results of surgery alone versus surgery plus 5-fluorouracil and leucovorin for stage II and stage III colon cancer: pooled analysis of NSABP C-01 through C-05. A baseline from which to compare modern adjuvant trials
    Neal W Wilkinson
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA
    Ann Surg Oncol 17:959-66. 2010
    ....
  7. ncbi request reprint Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project Protocol C-06
    Barry C Lembersky
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212, USA
    J Clin Oncol 24:2059-64. 2006
    ....
  8. ncbi request reprint Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemotherapy for node-positive breast cancer: results from NSABP B-28
    Eleftherios P Mamounas
    National Surgical Adjuvant Breast and Bowel Project, Operations Office and Biostatistical Center, Pittsburgh, PA, USA
    J Clin Oncol 23:3686-96. 2005
    ....
  9. ncbi request reprint Severe enteropathy among patients with stage II/III colon cancer treated on a randomized trial of bolus 5-fluorouracil/leucovorin plus or minus oxaliplatin: a prospective analysis
    J Philip Kuebler
    National Surgical Adjuvant Breast and Bowel Project NSABP, Pittsburgh, Pennsylvania 15212, USA
    Cancer 110:1945-50. 2007
    ..Cases of severe gastrointestinal toxicity were monitored prospectively during NSABP C-07, a randomized clinical trial of adjuvant therapy for patients with stage II/III colon cancer...
  10. pmc Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03
    Mark S Roh
    National Surgical Adjuvant Breast and Bowel Project NSABP Operations Cente, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA
    J Clin Oncol 27:5124-30. 2009
    ..The NSABP R-03 (National Surgical Adjuvant Breast and Bowel Project R-03) trial compared neoadjuvant versus adjuvant chemoradiotherapy in the treatment of locally advanced rectal carcinoma...
  11. pmc Relationship between tumor gene expression and recurrence in four independent studies of patients with stage II/III colon cancer treated with surgery alone or surgery plus adjuvant fluorouracil plus leucovorin
    MICHAEL J O'CONNELL
    National Surgical Adjuvant Breast and Bowel Project, University of Pittsburgh, Pittsburgh, PA 15212, USA
    J Clin Oncol 28:3937-44. 2010
    ....
  12. pmc Primary mFOLFOX6 plus bevacizumab without resection of the primary tumor for patients presenting with surgically unresectable metastatic colon cancer and an intact asymptomatic colon cancer: definitive analysis of NSABP trial C-10
    Laurence E McCahill
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA
    J Clin Oncol 30:3223-8. 2012
    ..Surgical resection of asymptomatic IPT is controversial...
  13. ncbi request reprint Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    Edward H Romond
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
    N Engl J Med 353:1673-84. 2005
    ..We present the combined results of two trials that compared adjuvant chemotherapy with or without concurrent trastuzumab in women with surgically removed HER2-positive breast cancer...
  14. pmc Defective mismatch repair and benefit from bevacizumab for colon cancer: findings from NSABP C-08
    Kay Pogue-Geile
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212, USA
    J Natl Cancer Inst 105:989-92. 2013
    ....
  15. pmc FOLFOX and FLOX regimens for the adjuvant treatment of resected stage II and III colon cancer
    Saima Sharif
    National Surgical Adjuvant Breast and Bowel Project Operations Office, Pittsburgh, Pennsylvania, USA
    Cancer Invest 26:956-63. 2008
    ..The benefit of oxaliplatin appears to be independent of the 5-FU/LV regimen used. This paper reviews the efficacy and toxicities of these two regimens and is meant to serve as a guide for clinical practice...
  16. pmc Seven-year follow-up assessment of cardiac function in NSABP B-31, a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel (ACP) with ACP plus trastuzumab as adjuvant therapy for patients with node-positive, human epidermal gr
    Edward H Romond
    National Surgical Adjuvant Breast and Bowel Project, East Commons Professional Building, Four Allegheny Center, 5th Floor, Pittsburgh, PA 15212, USA
    J Clin Oncol 30:3792-9. 2012
    ..Given the demonstrated efficacy of trastuzumab, ongoing assessment of cardiac safety and identification of risk factors for CD are important for optimal patient care...
  17. pmc Long-term neurotoxicity effects of oxaliplatin added to fluorouracil and leucovorin as adjuvant therapy for colon cancer: results from National Surgical Adjuvant Breast and Bowel Project trials C-07 and LTS-01
    Kelley M Kidwell
    National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, Pennsylvania 15213, USA
    Cancer 118:5614-22. 2012
    ....
  18. pmc Conditional survival and the choice of conditioning set for patients with colon cancer: an analysis of NSABP trials C-03 through C-07
    Beth A Zamboni
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Clin Oncol 28:2544-8. 2010
    ..We extend the concept of CS to condition on the set of patients alive, recurrence-free, and second primary cancer-free (disease-free survival [OS|DFS])...
  19. pmc Comparative effectiveness of sphincter-sparing surgery versus abdominoperineal resection in rectal cancer: patient-reported outcomes in National Surgical Adjuvant Breast and Bowel Project randomized trial R-04
    Marcia M Russell
    National Surgical Adjuvant Breast and Bowel Project NSABP Operations and Biostatistical Centers, Pittsburgh, PA David Geffen School of Medicine at UCLA, VA Greater Los Angeles Healthcare System, Los Angeles, CA UCLA Schools of Medicine and Public Health and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA University of Pittsburgh Graduate School of Public Health Department of Biostatistics, Pittsburgh, PA UCLA, Los Angeles, CA Kaiser Permanente Oncology Clinical Trials, Northern California, Vallejo, CA Southeast Cancer Control Consortium CCOP, Goldsboro, NC University of Pittsburgh Medical Center, Pittsburgh, PA Missouri Valley Cancer Consortium CCOP, Omaha, NE Beaumont Hospital System, Royal Oak, MI Florida Cancer Specialists, Sarasota, FL Montana Cancer Consortium, Billings, MT Helen F Graham Cancer Center, Newark, DE Glendale Memorial Hospital and Health Center, Glendale, CA Allegheny Cancer Center at Allegheny General Hospital, Pittsburgh, PA
    Ann Surg 261:144-8. 2015
    ..We hypothesized that patients who underwent abdominoperineal resection (APR) would have a poorer quality of life than those who underwent sphincter-sparing surgery (SSS)...
  20. pmc Mutation profiling and microsatellite instability in stage II and III colon cancer: an assessment of their prognostic and oxaliplatin predictive value
    Patrick G Gavin
    National Surgical Adjuvant Breast and Bowel Project, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15212, USA
    Clin Cancer Res 18:6531-41. 2012
    ..The purpose of this study was to examine the prognostic and oxaliplatin predictive value of mismatch repair (MMR) status and common hot spot mutations, which we previously identified in stage II and III colon cancer...
  21. ncbi request reprint Health-related quality of life in axillary node-negative, estrogen receptor-negative breast cancer patients undergoing AC versus CMF chemotherapy: findings from the National Surgical Adjuvant Breast and Bowel Project B-23
    Stephanie R Land
    NSABP Biostatistical Center, Pittsburgh, USA Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
    Breast Cancer Res Treat 86:153-64. 2004
    ..QOL information was considered especially relevant given the possibility that the two chemotherapy regimens would prove equivalent in terms of clinical outcome...
  22. ncbi request reprint Real-world performance of HER2 testing--National Surgical Adjuvant Breast and Bowel Project experience
    Soonmyung Paik
    National Surgical Adjuvant Breast and Bowel Project NSABP Operation Center, Pittsburgh, PA 15212, USA
    J Natl Cancer Inst 94:852-4. 2002
    ..This report provides a snapshot of the quality of HER2 assays performed in laboratories nationwide...