Research Topics
Species | CHARLES YOSTSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Publications
A new look at the respiratory stimulant doxapramC Spencer Yost
Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, California 94143, USA
CNS Drug Rev 12:236-49. 2006..Although it is unlikely that doxapram will undergo a clinical renaissance based on this new understanding, it represents a significant advance in our knowledge of the control of breathing...- Update on tandem pore (2P) domain K+ channelsC Spencer Yost
Department of Anesthesia and Perioperative Care, University of California, 513 Parnassus Avenue, Room s 261, Box 0542, San Francisco, CA 94143, USA
Curr Drug Targets 4:347-51. 2003..Thus, members of this family have emerged as strong candidates for the molecular site of volatile anesthetic action... 
Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivityC Spencer Yost
Department of Anesthesia and Perioperative Care, Medical Sciences Building, 513 Parnassus Avenue, University of California, San Francisco, CA 94143, USA
Behav Brain Res 193:192-6. 2008..Additional studies with transgenic animals will help define the overall role of the K(2P) channels in normal neurophysiology and in volatile anesthetic mechanisms...- The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentrationJoseph F Cotten
Department of Anesthesia and Perioperative Care, University of California San Francisco, USA
Anesth Analg 102:779-85. 2006..Our data indicate that TASK-1 and TASK-3 do not play a role in mediating the immobility produced by halothane, although they are plausible molecular targets for the ventilatory effects of doxapram... - Evaluation of the splanchnic circulation with indocyanine green pharmacokinetics in liver transplant patientsClaus U Niemann
Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0648, USA
Liver Transpl 8:476-81. 2002..This model can be a useful tool to evaluate the effect of pharmacological manipulation of splanchnic hemodynamics... - Intraoperative hemodynamics and liver function in adult-to-adult living liver donorsClaus U Niemann
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
Liver Transpl 8:1126-32. 2002..In addition, we show that functional recovery of the liver is likely to be slower than morphological recovery, and such clinical parameters as coagulation profile may not be a good index of fully restored hepatic function... - Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anestheticsCanhui Liu
Department of Anesthesia and Perioperative Care, 513 Parnassus Ave, Room S-261, Box 0542, San Francisco, CA 94143, USA
Anesth Analg 99:1715-22, table of contents. 2004..These results identify TRESK as a target of volatile anesthetics and suggest a role for this background K channel in mediating the effects of inhaled anesthetics in the central nervous system... - Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomersRobert Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, USA
Anesth Analg 103:86-91, table of contents. 2006..We recommend that enantioselectivity not be used as a test of relevance for inhaled anesthetic targets... - Identification of native rat cerebellar granule cell currents due to background K channel KCNK5 (TASK-2)Joseph F Cotten
Department of Anesthesia and Perioperative Care, University of California, San Francisco, 513 Parnassus Ave, Room S-261, Box 0542, San Francisco, CA 94143, USA
Brain Res Mol Brain Res 128:112-20. 2004..We conclude that TASK-2 mediates the Type 4 single channel conductance in CGNs as a component of I(K,SO)... - Immunolocalization of TASK-3 (KCNK9) to a subset of cortical neurons in the rat CNSRobert Callahan
Department of Anesthesia and Perioperative Care, University of California, 513 Parnassus Ave, Room s 261, San Francisco, CA 94143 0542, USA
Biochem Biophys Res Commun 319:525-30. 2004..These results provide a more finely detailed picture of TASK-3 expression and indicate a role for TASK-3 in modulating cerebral synaptic transmission and responses to CNS active drugs... - Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4Anand N Mhatre
Laboratory of Molecular Genetics, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
J Neurosci Res 75:25-31. 2004.... 
Molecular biology of background K channels: insights from K(2P) knockout miceMarta Sabbadini
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 05442, USA
J Mol Biol 385:1331-44. 2009..These animals shed new light on the contribution of K(2P) channels to normal and abnormal physiology. In this review, we summarize the published data on these mice to broaden the understanding of the role of K(2P) channel activity...- Anaphylaxis complicating graft reperfusion during orthotopic liver transplantation: a case reportA Anderson
Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94143, USA
Transplant Proc 42:1967-9. 2010..To our knowledge, this is the first report of anaphylaxis at the time of reperfusion and may provide an explanation for cases of vasoplegic syndrome associated with graft reperfusion... - Regional expression of the anesthetic-activated potassium channel TRESK in the rat nervous systemSieHyeon Yoo
Department of Anesthesia and Perioperative Care, University of California, San Francisco, 513 Parnassus Avenue, Room s 261, San Francisco, CA 94143, USA
Neurosci Lett 465:79-84. 2009..TRESK expression is also high in small and medium sized DRG neurons. These results provide an anatomic basis for identifying functional roles of TRESK in the rat nervous system... - Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESKBharat Keshavaprasad
Department of Anesthesia and Perioperative Care, University of California San Francisco, 513 Parnassus Ave, Room S-261, Box 0542, San Francisco, California 94143, USA
Anesth Analg 101:1042-9, table of contents. 2005..In particular, we found stereospecific differences in response to isoflurane by the rodent TRESKs but not by human TRESK. TRESK may be a target site for the mechanism of action of volatile anesthetics... - Protective effects of TASK-3 (KCNK9) and related 2P K channels during cellular stressCanhui Liu
Severinghaus Anesthesia Laboratory, Department of Anesthesia and Perioperative Care, University of California San Francisco, 513 Parnassus Ave, Room S-261, Box 0542, San Francisco, CA 94143-0542, United States
Brain Res 1031:164-73. 2005..These results confirm a protective physiologic capability of TASK-3 and related 2P K channels, and suggest agents that enhance their activity, such as volatile anesthetics may intensify these protective effects... - Characterization of the interactions between volatile anesthetics and neuromuscular blockers at the muscle nicotinic acetylcholine receptorMatthias Paul
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA
Anesth Analg 95:362-7, table of contents. 2002..IMPLICATIONS: Isoflurane and sevoflurane enhance the receptor blocking effects of nondepolarizing muscle relaxants on nicotinic acetylcholine receptors... - Two-pore domain potassium channels: new sites of local anesthetic action and toxicityChristoph H Kindler
Department of Anesthesia, University Hospital, Basel, Switzerland
Reg Anesth Pain Med 30:260-74. 2005.... - Amide local anesthetics potently inhibit the human tandem pore domain background K+ channel TASK-2 (KCNK5)Christoph H Kindler
Attending Physician, Department of Anesthesia, University Clinics, Kantonsspital, CH 4031 Basel, Switzerland
J Pharmacol Exp Ther 306:84-92. 2003..These results show that clinically achievable concentrations of local anesthetics inhibit background K+ channel function and may thereby enhance conduction blockade... - Localization of the tandem pore domain K+ channel KCNK5 (TASK-2) in the rat central nervous systemAnja Gabriel
Department of Anesthesia and Operative Intensive Care Medicine, University of Koln, 50924, Koln, Germany
Brain Res Mol Brain Res 98:153-63. 2002..These results suggest a possible involvement of TASK-2 in central mechanisms for controlling cell excitability and in peripheral signal transduction...
Research Grants
- BACKGROUND POTASSIUM CHANNELS AS ANESTHETIC TARGETSCHARLES YOST; Fiscal Year: 2007..An understanding of the basic mechanisms underlying anesthesia has the potential to lead to improved anesthetic drugs or techniques. ..
- BACKGROUND POTASSIUM CHANNELS AS ANESTHETIC TARGETSCHARLES YOST; Fiscal Year: 2003..With these experiments we expect that a more complete understanding of background K+ channels will emerge and their role in mediating the anesthetic state clarified. ..
- POTASSIUM CHANNEL ACTIVATION BY VOLATILE ANESTHETICSCHARLES YOST; Fiscal Year: 2002..Studies will be carried out in cerebellar granule neurons using whole cell ruptured patch and excised patch techniques on neurons in culture and in thin slices. ..
- BACKGROUND POTASSIUM CHANNELS AS ANESTHETIC TARGETSCHARLES YOST; Fiscal Year: 2000....