CHARLES YOST

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint A new look at the respiratory stimulant doxapram
    C Spencer Yost
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, California 94143, USA
    CNS Drug Rev 12:236-49. 2006
  2. ncbi request reprint Update on tandem pore (2P) domain K+ channels
    C Spencer Yost
    Department of Anesthesia and Perioperative Care, University of California, 513 Parnassus Avenue, Room s 261, Box 0542, San Francisco, CA 94143, USA
    Curr Drug Targets 4:347-51. 2003
  3. pmc Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity
    C Spencer Yost
    Department of Anesthesia and Perioperative Care, Medical Sciences Building, 513 Parnassus Avenue, University of California, San Francisco, CA 94143, USA
    Behav Brain Res 193:192-6. 2008
  4. ncbi request reprint The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration
    Joseph F Cotten
    Department of Anesthesia and Perioperative Care, University of California San Francisco, USA
    Anesth Analg 102:779-85. 2006
  5. ncbi request reprint Evaluation of the splanchnic circulation with indocyanine green pharmacokinetics in liver transplant patients
    Claus U Niemann
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0648, USA
    Liver Transpl 8:476-81. 2002
  6. ncbi request reprint Intraoperative hemodynamics and liver function in adult-to-adult living liver donors
    Claus U Niemann
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    Liver Transpl 8:1126-32. 2002
  7. ncbi request reprint Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anesthetics
    Canhui Liu
    Department of Anesthesia and Perioperative Care, 513 Parnassus Ave, Room s 261, Box 0542, San Francisco, CA 94143, USA
    Anesth Analg 99:1715-22, table of contents. 2004
  8. ncbi request reprint Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers
    Robert Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, USA
    Anesth Analg 103:86-91, table of contents. 2006
  9. ncbi request reprint Identification of native rat cerebellar granule cell currents due to background K channel KCNK5 (TASK-2)
    Joseph F Cotten
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, 513 Parnassus Ave, Room s 261, Box 0542, San Francisco, CA 94143, USA
    Brain Res Mol Brain Res 128:112-20. 2004
  10. ncbi request reprint Immunolocalization of TASK-3 (KCNK9) to a subset of cortical neurons in the rat CNS
    Robert Callahan
    Department of Anesthesia and Perioperative Care, University of California, 513 Parnassus Ave, Room s 261, San Francisco, CA 94143 0542, USA
    Biochem Biophys Res Commun 319:525-30. 2004

Research Grants

Collaborators

Detail Information

Publications20

  1. ncbi request reprint A new look at the respiratory stimulant doxapram
    C Spencer Yost
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, California 94143, USA
    CNS Drug Rev 12:236-49. 2006
    ..Although it is unlikely that doxapram will undergo a clinical renaissance based on this new understanding, it represents a significant advance in our knowledge of the control of breathing...
  2. ncbi request reprint Update on tandem pore (2P) domain K+ channels
    C Spencer Yost
    Department of Anesthesia and Perioperative Care, University of California, 513 Parnassus Avenue, Room s 261, Box 0542, San Francisco, CA 94143, USA
    Curr Drug Targets 4:347-51. 2003
    ..Thus, members of this family have emerged as strong candidates for the molecular site of volatile anesthetic action...
  3. pmc Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity
    C Spencer Yost
    Department of Anesthesia and Perioperative Care, Medical Sciences Building, 513 Parnassus Avenue, University of California, San Francisco, CA 94143, USA
    Behav Brain Res 193:192-6. 2008
    ..Additional studies with transgenic animals will help define the overall role of the K(2P) channels in normal neurophysiology and in volatile anesthetic mechanisms...
  4. ncbi request reprint The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration
    Joseph F Cotten
    Department of Anesthesia and Perioperative Care, University of California San Francisco, USA
    Anesth Analg 102:779-85. 2006
    ..Our data indicate that TASK-1 and TASK-3 do not play a role in mediating the immobility produced by halothane, although they are plausible molecular targets for the ventilatory effects of doxapram...
  5. ncbi request reprint Evaluation of the splanchnic circulation with indocyanine green pharmacokinetics in liver transplant patients
    Claus U Niemann
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0648, USA
    Liver Transpl 8:476-81. 2002
    ..This model can be a useful tool to evaluate the effect of pharmacological manipulation of splanchnic hemodynamics...
  6. ncbi request reprint Intraoperative hemodynamics and liver function in adult-to-adult living liver donors
    Claus U Niemann
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    Liver Transpl 8:1126-32. 2002
    ..In addition, we show that functional recovery of the liver is likely to be slower than morphological recovery, and such clinical parameters as coagulation profile may not be a good index of fully restored hepatic function...
  7. ncbi request reprint Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anesthetics
    Canhui Liu
    Department of Anesthesia and Perioperative Care, 513 Parnassus Ave, Room s 261, Box 0542, San Francisco, CA 94143, USA
    Anesth Analg 99:1715-22, table of contents. 2004
    ..These results identify TRESK as a target of volatile anesthetics and suggest a role for this background K channel in mediating the effects of inhaled anesthetics in the central nervous system...
  8. ncbi request reprint Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers
    Robert Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, USA
    Anesth Analg 103:86-91, table of contents. 2006
    ..We recommend that enantioselectivity not be used as a test of relevance for inhaled anesthetic targets...
  9. ncbi request reprint Identification of native rat cerebellar granule cell currents due to background K channel KCNK5 (TASK-2)
    Joseph F Cotten
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, 513 Parnassus Ave, Room s 261, Box 0542, San Francisco, CA 94143, USA
    Brain Res Mol Brain Res 128:112-20. 2004
    ..We conclude that TASK-2 mediates the Type 4 single channel conductance in CGNs as a component of I(K,SO)...
  10. ncbi request reprint Immunolocalization of TASK-3 (KCNK9) to a subset of cortical neurons in the rat CNS
    Robert Callahan
    Department of Anesthesia and Perioperative Care, University of California, 513 Parnassus Ave, Room s 261, San Francisco, CA 94143 0542, USA
    Biochem Biophys Res Commun 319:525-30. 2004
    ..These results provide a more finely detailed picture of TASK-3 expression and indicate a role for TASK-3 in modulating cerebral synaptic transmission and responses to CNS active drugs...
  11. ncbi request reprint Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4
    Anand N Mhatre
    Laboratory of Molecular Genetics, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    J Neurosci Res 75:25-31. 2004
    ....
  12. doi request reprint Molecular biology of background K channels: insights from K(2P) knockout mice
    Marta Sabbadini
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 05442, USA
    J Mol Biol 385:1331-44. 2009
    ..These animals shed new light on the contribution of K(2P) channels to normal and abnormal physiology. In this review, we summarize the published data on these mice to broaden the understanding of the role of K(2P) channel activity...
  13. doi request reprint Anaphylaxis complicating graft reperfusion during orthotopic liver transplantation: a case report
    A Anderson
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94143, USA
    Transplant Proc 42:1967-9. 2010
    ..To our knowledge, this is the first report of anaphylaxis at the time of reperfusion and may provide an explanation for cases of vasoplegic syndrome associated with graft reperfusion...
  14. pmc Regional expression of the anesthetic-activated potassium channel TRESK in the rat nervous system
    SieHyeon Yoo
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, 513 Parnassus Avenue, Room s 261, San Francisco, CA 94143, USA
    Neurosci Lett 465:79-84. 2009
    ..TRESK expression is also high in small and medium sized DRG neurons. These results provide an anatomic basis for identifying functional roles of TRESK in the rat nervous system...
  15. ncbi request reprint Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK
    Bharat Keshavaprasad
    Department of Anesthesia and Perioperative Care, University of California San Francisco, 513 Parnassus Ave, Room s 261, Box 0542, San Francisco, California 94143, USA
    Anesth Analg 101:1042-9, table of contents. 2005
    ..These results identified interspecies differences and similarities in the pharmacology of TRESK. Further characterization of TRESK expression patterns is needed to understand their role in anesthetic mechanisms...
  16. ncbi request reprint Protective effects of TASK-3 (KCNK9) and related 2P K channels during cellular stress
    Canhui Liu
    Severinghaus Anesthesia Laboratory, Department of Anesthesia and Perioperative Care, University of California San Francisco, 513 Parnassus Ave, Room s 261, Box 0542, San Francisco, CA 94143 0542, United States
    Brain Res 1031:164-73. 2005
    ..These results confirm a protective physiologic capability of TASK-3 and related 2P K channels, and suggest agents that enhance their activity, such as volatile anesthetics may intensify these protective effects...
  17. ncbi request reprint Characterization of the interactions between volatile anesthetics and neuromuscular blockers at the muscle nicotinic acetylcholine receptor
    Matthias Paul
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA
    Anesth Analg 95:362-7, table of contents. 2002
    ..Volatile anesthetics increase the potency of NDMRs, possibly by enhancing antagonist affinity at the receptor site. This effect may contribute to the clinically observable enhancement of neuromuscular blockade by volatile anesthetics...
  18. ncbi request reprint Two-pore domain potassium channels: new sites of local anesthetic action and toxicity
    Christoph H Kindler
    Department of Anesthesia, University Hospital, Basel, Switzerland
    Reg Anesth Pain Med 30:260-74. 2005
    ....
  19. ncbi request reprint Amide local anesthetics potently inhibit the human tandem pore domain background K+ channel TASK-2 (KCNK5)
    Christoph H Kindler
    Attending Physician, Department of Anesthesia, University Clinics, Kantonsspital, CH 4031 Basel, Switzerland
    J Pharmacol Exp Ther 306:84-92. 2003
    ..These results show that clinically achievable concentrations of local anesthetics inhibit background K+ channel function and may thereby enhance conduction blockade...
  20. ncbi request reprint Localization of the tandem pore domain K+ channel KCNK5 (TASK-2) in the rat central nervous system
    Anja Gabriel
    Department of Anesthesia and Operative Intensive Care Medicine, University of Koln, 50924, Koln, Germany
    Brain Res Mol Brain Res 98:153-63. 2002
    ..These results suggest a possible involvement of TASK-2 in central mechanisms for controlling cell excitability and in peripheral signal transduction...

Research Grants12

  1. BACKGROUND POTASSIUM CHANNELS AS ANESTHETIC TARGETS
    CHARLES YOST; Fiscal Year: 2007
    ..An understanding of the basic mechanisms underlying anesthesia has the potential to lead to improved anesthetic drugs or techniques. ..
  2. BACKGROUND POTASSIUM CHANNELS AS ANESTHETIC TARGETS
    CHARLES YOST; Fiscal Year: 2003
    ..With these experiments we expect that a more complete understanding of background K+ channels will emerge and their role in mediating the anesthetic state clarified. ..
  3. POTASSIUM CHANNEL ACTIVATION BY VOLATILE ANESTHETICS
    CHARLES YOST; Fiscal Year: 2002
    ..Studies will be carried out in cerebellar granule neurons using whole cell ruptured patch and excised patch techniques on neurons in culture and in thin slices. ..
  4. BACKGROUND POTASSIUM CHANNELS AS ANESTHETIC TARGETS
    CHARLES YOST; Fiscal Year: 2000
    ....