Motojiro Yoshihara

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Acute genetic manipulation of neuronal activity for the functional dissection of neural circuits-a dream come true for the pioneers of behavioral genetics
    Moto Yoshihara
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 4321, USA
    J Neurogenet 26:43-52. 2012
  2. pmc Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1
    Motojiro Yoshihara
    Picower Institute for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:14869-74. 2010
  3. pmc Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment
    Bill Adolfsen
    The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Cell Biol 166:249-60. 2004
  4. ncbi request reprint Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth
    Motojiro Yoshihara
    Picower Institute for Learning and Memory, Department of Biology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 310:858-63. 2005
  5. ncbi request reprint The synaptotagmins: calcium sensors for vesicular trafficking
    Motojiro Yoshihara
    The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuroscientist 10:566-74. 2004
  6. pmc A large-scale behavioral screen to identify neurons controlling motor programs in the Drosophila brain
    Thomas F Flood
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts
    G3 (Bethesda) 3:1629-37. 2013
  7. ncbi request reprint Presynaptic N-type calcium channels regulate synaptic growth
    Gabrielle E Rieckhof
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 278:41099-108. 2003
  8. ncbi request reprint Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release
    Motojiro Yoshihara
    Picower Center for Learning and Memory, Cambridge, MA, USA
    Neuron 36:897-908. 2002
  9. pmc Regulation of postsynaptic retrograde signaling by presynaptic exosome release
    Ceren Korkut
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Neuron 77:1039-46. 2013
  10. pmc Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease
    Wyan Ching Mimi Lee
    Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:3224-9. 2004

Research Grants

  1. Molecular Mechanism of Synaptic Plasticity
    Motojiro Yoshihara; Fiscal Year: 2010
  2. Molecular Mechanism of Synaptic Plasticity
    Motojiro Yoshihara; Fiscal Year: 2009

Collaborators

  • J Troy Littleton
  • Kei Ito
  • Kate Koles
  • Thomas F Flood
  • Ceren Korkut
  • Michael Gorczyca
  • Wyan Ching Mimi Lee
  • Bill Adolfsen
  • Gabrielle E Rieckhof
  • Vivian Budnik
  • James Ashley
  • Benjamin White
  • Cassandra Brewer
  • Shinya Iguchi
  • Yihang Li
  • Benjamin H White
  • Sudipta Saraswati
  • Zhuo Guan

Detail Information

Publications13

  1. pmc Acute genetic manipulation of neuronal activity for the functional dissection of neural circuits-a dream come true for the pioneers of behavioral genetics
    Moto Yoshihara
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 4321, USA
    J Neurogenet 26:43-52. 2012
    ..This methodology opened a new avenue to dissect functions of neural circuits to make dreams of the pioneers into reality...
  2. pmc Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1
    Motojiro Yoshihara
    Picower Institute for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:14869-74. 2010
    ..These results suggest that the tandem C2 domains of Syt 1 play independent roles in neurotransmission, as Ca(2+) binding to C2A suppresses asynchronous release, whereas Ca(2+) binding to C2B mediates synchronous fusion...
  3. pmc Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment
    Bill Adolfsen
    The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Cell Biol 166:249-60. 2004
    ..In addition, the identification of a postsynaptic synaptotagmin suggests calcium-dependent membrane-trafficking functions on both sides of the synapse...
  4. ncbi request reprint Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth
    Motojiro Yoshihara
    Picower Institute for Learning and Memory, Department of Biology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 310:858-63. 2005
    ..Postsynaptic Ca2+ influx also stimulates local synaptic differentiation and growth through Syt 4-mediated retrograde signals in a synapse-specific manner...
  5. ncbi request reprint The synaptotagmins: calcium sensors for vesicular trafficking
    Motojiro Yoshihara
    The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuroscientist 10:566-74. 2004
    ..This suggests an intriguing possibility that syt 4 may mediate a postsynaptic vesicle trafficking pathway, providing a molecular basis for an evolutionarily conserved bidirectional vesicular trafficking communication system at synapses...
  6. pmc A large-scale behavioral screen to identify neurons controlling motor programs in the Drosophila brain
    Thomas F Flood
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts
    G3 (Bethesda) 3:1629-37. 2013
    ..Through follow-up studies starting from this screen, we expect to find key components of the neural circuits underlying specific behaviors, thus providing a new avenue for their functional analysis. ..
  7. ncbi request reprint Presynaptic N-type calcium channels regulate synaptic growth
    Gabrielle E Rieckhof
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 278:41099-108. 2003
    ..Linking presynaptic voltage-gated calcium entry to downstream calcium-sensitive synaptic growth regulators provides an efficient activity-dependent mechanism for modifying synaptic strength...
  8. ncbi request reprint Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release
    Motojiro Yoshihara
    Picower Center for Learning and Memory, Cambridge, MA, USA
    Neuron 36:897-908. 2002
    ..These results indicate that synaptotagmin is the major Ca(2+) sensor for evoked release and functions to trigger synchronous fusion in response to Ca(2+), while suppressing asynchronous release...
  9. pmc Regulation of postsynaptic retrograde signaling by presynaptic exosome release
    Ceren Korkut
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Neuron 77:1039-46. 2013
    ..Thus, by transferring an essential component of retrograde signaling through exosomes, presynaptic cells enable retrograde signaling...
  10. pmc Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease
    Wyan Ching Mimi Lee
    Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:3224-9. 2004
    ..Our findings indicate that nonnuclear events induced by cytoplasmic huntingtin aggregation play a central role in the progressive neurodegeneration observed in Huntington's disease...
  11. ncbi request reprint Is synaptotagmin the calcium sensor?
    Motojiro Yoshihara
    Picower Center for Learning and Memory and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Opin Neurobiol 13:315-23. 2003
    ..Biochemical and genetic studies suggest that lipid and SNARE interactions underlie synaptotagmin's ability to mediate the incredible speed of vesicle fusion that is the hallmark of fast synaptic transmission...
  12. pmc A single pair of interneurons commands the Drosophila feeding motor program
    Thomas F Flood
    Deptartment of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 499:83-7. 2013
    ..Our results demonstrate that Fdg neurons operate firmly within the sensorimotor watershed, downstream of sensory and metabolic cues and at the top of the feeding motor hierarchy, to execute the decision to feed. ..

Research Grants2

  1. Molecular Mechanism of Synaptic Plasticity
    Motojiro Yoshihara; Fiscal Year: 2010
    ..abstract_text> ..
  2. Molecular Mechanism of Synaptic Plasticity
    Motojiro Yoshihara; Fiscal Year: 2009
    ..abstract_text> ..