Motojiro Yoshihara

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi Acute genetic manipulation of neuronal activity for the functional dissection of neural circuits-a dream come true for the pioneers of behavioral genetics
    Moto Yoshihara
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 4321, USA
    J Neurogenet 26:43-52. 2012
  2. ncbi Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1
    Motojiro Yoshihara
    Picower Institute for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:14869-74. 2010
  3. ncbi Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment
    Bill Adolfsen
    The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Cell Biol 166:249-60. 2004
  4. ncbi Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth
    Motojiro Yoshihara
    Picower Institute for Learning and Memory, Department of Biology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 310:858-63. 2005
  5. ncbi The synaptotagmins: calcium sensors for vesicular trafficking
    Motojiro Yoshihara
    The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuroscientist 10:566-74. 2004
  6. ncbi Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release
    Motojiro Yoshihara
    Picower Center for Learning and Memory, Cambridge, MA, USA
    Neuron 36:897-908. 2002
  7. ncbi Presynaptic N-type calcium channels regulate synaptic growth
    Gabrielle E Rieckhof
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 278:41099-108. 2003
  8. ncbi Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease
    Wyan Ching Mimi Lee
    Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:3224-9. 2004
  9. ncbi Is synaptotagmin the calcium sensor?
    Motojiro Yoshihara
    Picower Center for Learning and Memory and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Opin Neurobiol 13:315-23. 2003

Research Grants

  1. Molecular Mechanism of Synaptic Plasticity
    Motojiro Yoshihara; Fiscal Year: 2010

Collaborators

  • J Troy Littleton
  • Kei Ito
  • Wyan Ching Mimi Lee
  • Bill Adolfsen
  • Gabrielle E Rieckhof
  • Sudipta Saraswati
  • Wyan-Ching Mimi Lee
  • Zhuo Guan

Detail Information

Publications9

  1. ncbi Acute genetic manipulation of neuronal activity for the functional dissection of neural circuits-a dream come true for the pioneers of behavioral genetics
    Moto Yoshihara
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 4321, USA
    J Neurogenet 26:43-52. 2012
    ..This methodology opened a new avenue to dissect functions of neural circuits to make dreams of the pioneers into reality...
  2. ncbi Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1
    Motojiro Yoshihara
    Picower Institute for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:14869-74. 2010
    ..These results suggest that the tandem C2 domains of Syt 1 play independent roles in neurotransmission, as Ca(2+) binding to C2A suppresses asynchronous release, whereas Ca(2+) binding to C2B mediates synchronous fusion...
  3. ncbi Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment
    Bill Adolfsen
    The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Cell Biol 166:249-60. 2004
    ..In addition, the identification of a postsynaptic synaptotagmin suggests calcium-dependent membrane-trafficking functions on both sides of the synapse...
  4. ncbi Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth
    Motojiro Yoshihara
    Picower Institute for Learning and Memory, Department of Biology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 310:858-63. 2005
    ..Postsynaptic Ca2+ influx also stimulates local synaptic differentiation and growth through Syt 4-mediated retrograde signals in a synapse-specific manner...
  5. ncbi The synaptotagmins: calcium sensors for vesicular trafficking
    Motojiro Yoshihara
    The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuroscientist 10:566-74. 2004
    ..This suggests an intriguing possibility that syt 4 may mediate a postsynaptic vesicle trafficking pathway, providing a molecular basis for an evolutionarily conserved bidirectional vesicular trafficking communication system at synapses...
  6. ncbi Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release
    Motojiro Yoshihara
    Picower Center for Learning and Memory, Cambridge, MA, USA
    Neuron 36:897-908. 2002
    ..These results indicate that synaptotagmin is the major Ca(2+) sensor for evoked release and functions to trigger synchronous fusion in response to Ca(2+), while suppressing asynchronous release...
  7. ncbi Presynaptic N-type calcium channels regulate synaptic growth
    Gabrielle E Rieckhof
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 278:41099-108. 2003
    ..Linking presynaptic voltage-gated calcium entry to downstream calcium-sensitive synaptic growth regulators provides an efficient activity-dependent mechanism for modifying synaptic strength...
  8. ncbi Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease
    Wyan Ching Mimi Lee
    Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:3224-9. 2004
    ..Our findings indicate that nonnuclear events induced by cytoplasmic huntingtin aggregation play a central role in the progressive neurodegeneration observed in Huntington's disease...
  9. ncbi Is synaptotagmin the calcium sensor?
    Motojiro Yoshihara
    Picower Center for Learning and Memory and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Opin Neurobiol 13:315-23. 2003
    ..Biochemical and genetic studies suggest that lipid and SNARE interactions underlie synaptotagmin's ability to mediate the incredible speed of vesicle fusion that is the hallmark of fast synaptic transmission...

Research Grants2

  1. Molecular Mechanism of Synaptic Plasticity
    Motojiro Yoshihara; Fiscal Year: 2010
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