Ian A York

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance
    Ian A York
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 103:9202-7. 2006
  2. ncbi request reprint The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues
    Ian A York
    Department of Pathology, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    Nat Immunol 3:1177-84. 2002
  3. ncbi request reprint A mutant cell with a novel defect in MHC class I quality control
    Ian A York
    Department of Pathology, University of Massachusetts Medical Center, Worcester, 01655, USA
    J Immunol 174:6839-46. 2005
  4. ncbi request reprint Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation
    Ian A York
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 177:1434-43. 2006
  5. ncbi request reprint Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections
    Charles F Towne
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Immunol 180:1704-12. 2008
  6. pmc Characterizing the specificity and cooperation of aminopeptidases in the cytosol and endoplasmic reticulum during MHC class I antigen presentation
    Arron Hearn
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 184:4725-32. 2010
  7. ncbi request reprint Analysis of the role of bleomycin hydrolase in antigen presentation and the generation of CD8 T cell responses
    Charles F Towne
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 178:6923-30. 2007
  8. doi request reprint Analysis of the role of tripeptidyl peptidase II in MHC class I antigen presentation in vivo
    Masahiro Kawahara
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 183:6069-77. 2009
  9. ncbi request reprint The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation
    Ian A York
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunity 18:429-40. 2003
  10. ncbi request reprint Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation
    Charles F Towne
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 175:6605-14. 2005

Collaborators

Detail Information

Publications15

  1. pmc Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance
    Ian A York
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 103:9202-7. 2006
    ..Moreover, peptide trimming and the resulting abundance of peptide-MHC complexes are dominant factors in establishing immunodominance...
  2. ncbi request reprint The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues
    Ian A York
    Department of Pathology, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    Nat Immunol 3:1177-84. 2002
    ..However, after interferon-gamma treatment, which causes proteasomes to produce more NH2-extended antigenic precursors, ERAP1 increased the supply of peptides for MHC class I antigen presentation...
  3. ncbi request reprint A mutant cell with a novel defect in MHC class I quality control
    Ian A York
    Department of Pathology, University of Massachusetts Medical Center, Worcester, 01655, USA
    J Immunol 174:6839-46. 2005
    ..The 4S8.12 cells provide strong genetic evidence for a novel component in the MHC class I pathway. This as-yet unidentified gene is important in early assembly of primate, but not mouse, MHC class I complexes...
  4. ncbi request reprint Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation
    Ian A York
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 177:1434-43. 2006
    ..Moreover, these findings reveal that three sequential proteolytic steps (by proteasomes, TPPII, and then ER aminopepsidase 1) are required for the generation of a subset of epitopes...
  5. ncbi request reprint Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections
    Charles F Towne
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Immunol 180:1704-12. 2008
    ....
  6. pmc Characterizing the specificity and cooperation of aminopeptidases in the cytosol and endoplasmic reticulum during MHC class I antigen presentation
    Arron Hearn
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 184:4725-32. 2010
    ..Because N-terminal trimming has different specificity in the cytosol and ER, the cleavage of peptides in both of these compartments serves to broaden the repertoire of sequences that are presented...
  7. ncbi request reprint Analysis of the role of bleomycin hydrolase in antigen presentation and the generation of CD8 T cell responses
    Charles F Towne
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 178:6923-30. 2007
    ..Therefore, BH does influence presentation of some Ags, although its role is largely redundant with other aminopeptidases...
  8. doi request reprint Analysis of the role of tripeptidyl peptidase II in MHC class I antigen presentation in vivo
    Masahiro Kawahara
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 183:6069-77. 2009
    ....
  9. ncbi request reprint The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation
    Ian A York
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunity 18:429-40. 2003
    ..TOP therefore plays an important role in vivo in degrading peptides released by proteasomes and is a significant factor limiting the extent of antigen presentation...
  10. ncbi request reprint Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation
    Charles F Towne
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 175:6605-14. 2005
    ..These data demonstrate that LAP is not an essential enzyme for generating most MHC class I-presented peptides and reveal redundancy in the function of cellular aminopeptidases...
  11. pmc The specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum
    Arron Hearn
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 183:5526-36. 2009
    ..These data define key determinants in the specificity of Ag processing...
  12. ncbi request reprint Post-proteasomal antigen processing for major histocompatibility complex class I presentation
    Kenneth L Rock
    Department of Pathology, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    Nat Immunol 5:670-7. 2004
    ..Thus, the extent of antigen presentation depends on the balance between several proteolytic processes that may generate or destroy epitopes...
  13. pmc Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1
    Tina T Nguyen
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Struct Mol Biol 18:604-13. 2011
    ..ERAP1's unique structural elements suggest how a generic aminopeptidase structure has been adapted for the specialized function of trimming antigenic precursors...
  14. ncbi request reprint Protein degradation and the generation of MHC class I-presented peptides
    Kenneth L Rock
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Adv Immunol 80:1-70. 2002
    ....
  15. ncbi request reprint An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides
    Tomo Saric
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 3:1169-76. 2002
    ..Like other proteins involved in antigen presentation, ERAP1 is induced by interferon-gamma. When overexpressed in vivo, we found that ERAP1 stimulates the processing and presentation of an antigenic precursor in the ER...