Esther M Yoo
Affiliation: University of California
- Differences in N-glycan structures found on recombinant IgA1 and IgA2 produced in murine myeloma and CHO cell linesEsther M Yoo
Department of Microbiology, University of California, Los Angeles, CA, USA
MAbs 2:320-34. 2010..These data underscore the importance of choosing the appropriate cell line for the production of glycoproteins with therapeutic potential...
- Characterization of IgA and IgM binding and internalization by surface-expressed human Fcα/μ receptorEsther M Yoo
Department of Microbiology, Immunology and Molecular Genetics and the Molecular Biology Institute, University of California, Los Angeles, Box 957364, 615 Charles Young Drive East, Los Angeles, CA 90095, USA
Mol Immunol 48:1818-26. 2011..In addition, we demonstrate that IgA can be rapidly internalized by human Fcα/μR in the presence of cross-linking antibody...
- Human IgG2 can form covalent dimersEsther M Yoo
Department of Microbiology, Immunology, and Molecular Genetics and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
J Immunol 170:3134-8. 2003..Cyanogen bromide cleavage analysis suggests that one or more Cys residues in the gamma 2 hinge are involved in dimer assembly. The potential role of IgG2 dimers in immunity against carbohydrate Ags is discussed...
- IgA: an immune glycoproteinEsther M Yoo
Department of Microbiology, Immunology and Molecular Genetics, University of California, 609 Charles E Young Drive, Los Angeles, CA 90095, USA
Clin Immunol 116:3-10. 2005..In addition, changes in IgA glycosylation are associated with immune pathology. A thorough understanding of the contributions of the glycans to IgA immune protection will aid in the design of clinically suitable antibodies...
- Myeloma expression systemsEsther M Yoo
Department of Microbiology, Immunology and Molecular Genetics and the Molecular Biology Institute, University of California Los Angeles, 611 S Charles Young Drive, Los Angeles, CA 90095, USA
J Immunol Methods 261:1-20. 2002..In addition, novel proteins in which antibodies are fused to non-immunoglobulin sequences as well as secretory IgA have been produced in myeloma cells...
- Human immunoglobulin G2 (IgG2) and IgG4, but not IgG1 or IgG3, protect mice against Cryptococcus neoformans infectionDavid O Beenhouwer
Division of Infectious Diseases, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Infect Immun 75:1424-35. 2007..Therefore, our findings have significant implications for humanization of the mouse IgG1 currently in clinical trials for cryptococcal meningitis and for the design of antibody therapeutics to treat other infectious diseases as well...