Bradley Yoder

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue
    Amber K O'Connor
    1Department of Cell, Development, and Integrative Biology, University of Alabama at Birmingham Medical School, Birmingham, AL 35294, USA
    Cilia 2:8. 2013
  2. pmc Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruption
    Neeraj Sharma
    Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294, USA
    J Am Soc Nephrol 24:456-64. 2013
  3. pmc Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesis
    Raymond C Pasek
    Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, 1918 University Blvd, Birmingham, AL, 35294, USA
    Cilia 1:20. 2012
  4. ncbi request reprint Role of primary cilia in the pathogenesis of polycystic kidney disease
    Bradley K Yoder
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Am Soc Nephrol 18:1381-8. 2007
  5. ncbi request reprint Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium
    Bradley K Yoder
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    Am J Physiol Renal Physiol 282:F541-52. 2002
  6. ncbi request reprint Molecular pathogenesis of autosomal dominant polycystic kidney disease
    Bradley K Yoder
    University of Alabama at Birmingham, Department of Cell Biology, 1918 University Blvd MCLM652, Birmingham, AL 35294, USA
    Expert Rev Mol Med 8:1-22. 2006
  7. ncbi request reprint The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia
    Bradley K Yoder
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0024, USA
    J Am Soc Nephrol 13:2508-16. 2002
  8. pmc Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease
    Xiaoying Hou
    Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, USA
    J Clin Invest 109:533-40. 2002
  9. pmc The Oak Ridge Polycystic Kidney mouse: modeling ciliopathies of mice and men
    Jonathan M Lehman
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Dev Dyn 237:1960-71. 2008
  10. ncbi request reprint Intraflagellar transport is essential for endochondral bone formation
    Courtney J Haycraft
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    Development 134:307-16. 2007

Research Grants

  1. Cilia and Cystic Kidney Disease
    Bradley Yoder; Fiscal Year: 2009
  2. Cilial dysfunction and pathogenesis of obesity
    Bradley Yoder; Fiscal Year: 2009
  3. Role of Cilia/IFT in Skin and Hair
    Bradley K Yoder; Fiscal Year: 2010
  4. Intraflagellar transport mediated regulation of hedgehog signaling
    Bradley K Yoder; Fiscal Year: 2010
  5. Cilial dysfunction and pathogenesis of obesity
    Bradley K Yoder; Fiscal Year: 2010
  6. Cilia and Cystic Kidney Disease
    Bradley K Yoder; Fiscal Year: 2010
  7. Cilial dysfunction and pathogenesis of obesity
    Bradley K Yoder; Fiscal Year: 2010
  8. Cilial dysfunction and pathogenesis of obesity
    Bradley Yoder; Fiscal Year: 2007
  9. Conserved Mechanisms of Ciliogenesis
    Bradley Yoder; Fiscal Year: 2003
  10. TG737 SIGNALING PATHWAY AND POLYCYSTIC KIDNEY
    Bradley Yoder; Fiscal Year: 2003

Collaborators

Detail Information

Publications44

  1. pmc An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue
    Amber K O'Connor
    1Department of Cell, Development, and Integrative Biology, University of Alabama at Birmingham Medical School, Birmingham, AL 35294, USA
    Cilia 2:8. 2013
    ..Much of what we know about the formation and maintenance of cilia comes from model systems like C. elegans and Chalmydomonas. Studies of mammalian cilia in live tissues have been hampered by difficulty visualizing them...
  2. pmc Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruption
    Neeraj Sharma
    Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294, USA
    J Am Soc Nephrol 24:456-64. 2013
    ..In conclusion, these data suggest that proliferation is unlikely to be the sole mechanism underlying the rapid cystogenesis observed after injury in mice that lose cilia function in adulthood...
  3. pmc Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesis
    Raymond C Pasek
    Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, 1918 University Blvd, Birmingham, AL, 35294, USA
    Cilia 1:20. 2012
    ..abstract:..
  4. ncbi request reprint Role of primary cilia in the pathogenesis of polycystic kidney disease
    Bradley K Yoder
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Am Soc Nephrol 18:1381-8. 2007
    ....
  5. ncbi request reprint Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium
    Bradley K Yoder
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    Am J Physiol Renal Physiol 282:F541-52. 2002
    ..Further characterization of these cells will be important in elucidating the physiological role of renal cilia and in determining their relationship to cystic disease...
  6. ncbi request reprint Molecular pathogenesis of autosomal dominant polycystic kidney disease
    Bradley K Yoder
    University of Alabama at Birmingham, Department of Cell Biology, 1918 University Blvd MCLM652, Birmingham, AL 35294, USA
    Expert Rev Mol Med 8:1-22. 2006
    ....
  7. ncbi request reprint The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia
    Bradley K Yoder
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0024, USA
    J Am Soc Nephrol 13:2508-16. 2002
    ..These data add to a growing body of evidence that suggests that primary cilium plays a key role in normal physiologic functions of renal epithelia and that defects in ciliary function contribute to the pathogenesis of PKD...
  8. pmc Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease
    Xiaoying Hou
    Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, USA
    J Clin Invest 109:533-40. 2002
    ..We therefore propose that the single epithelial cilium is important in the functional differentiation of polarized epithelia and that ciliary dysfunction underlies the PKD phenotype in cpk mice...
  9. pmc The Oak Ridge Polycystic Kidney mouse: modeling ciliopathies of mice and men
    Jonathan M Lehman
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Dev Dyn 237:1960-71. 2008
    ....
  10. ncbi request reprint Intraflagellar transport is essential for endochondral bone formation
    Courtney J Haycraft
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    Development 134:307-16. 2007
    ..Overall these data provide evidence that IFT is essential for normal formation of the appendicular skeleton through disruption of multiple signaling pathways...
  11. doi request reprint Role for primary cilia in the regulation of mouse ovarian function
    Ellen T Johnson
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    Dev Dyn 237:2053-60. 2008
    ..Mammary gland development including the formation of end bud structures resumed in mutant mice that were injected with estradiol. Together the results suggest that cilia are required for ovarian function...
  12. ncbi request reprint Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737(orpk) mutant mice
    Qihong Zhang
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Lab Invest 85:45-64. 2005
    ..These findings are interesting in light of the recently proposed role for polaris, the protein encoded by the Tg737 gene, in the hedgehog pathway and hedgehog signaling in insulin production and glucose homeostasis...
  13. ncbi request reprint Altered pH(i) regulation and Na(+)/HCO3(-) transporter activity in choroid plexus of cilia-defective Tg737(orpk) mutant mouse
    Boglarka Banizs
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Am J Physiol Cell Physiol 292:C1409-16. 2007
    ....
  14. ncbi request reprint Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus
    Boglarka Banizs
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Development 132:5329-39. 2005
    ..These data suggest that cilia function is necessary for regulating ion transport and CSF production, as well as for CSF flow through the ventricles...
  15. ncbi request reprint Ciliary proteins link basal body polarization to planar cell polarity regulation
    Chonnettia Jones
    Department of Cell Biology, Emory University School of Medicine, 615 Michael St, Atlanta, Georgia 30322, USA
    Nat Genet 40:69-77. 2008
    ..Thus, our data uncover a distinct requirement for ciliary genes in basal body positioning and morphological polarization during PCP regulation...
  16. ncbi request reprint Loss of the Tg737 protein results in skeletal patterning defects
    Qihong Zhang
    The University of Alabama at Birmingham, Department of Cell Biology, Birmingham, Alabama 35294, USA
    Dev Dyn 227:78-90. 2003
    ..Collectively, the data argue for a dosage effect of Tg737 on the limb phenotypes and that the polydactyly is independent of Shh misexpression...
  17. pmc An essential role for dermal primary cilia in hair follicle morphogenesis
    Jonathan M Lehman
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Invest Dermatol 129:438-48. 2009
    ..Thus, these data establish cilia as a critical signaling component required for normal hair morphogenesis and suggest that this organelle is needed on cells in the dermis for reception of signals such as sonic hedgehog...
  18. pmc Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease
    James R Davenport
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Curr Biol 17:1586-94. 2007
    ..These data establish that neuronal cilia function in a pathway regulating satiety responses...
  19. pmc Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
    Courtney J Haycraft
    Department of Cell Biology, University of Alabama, Birmingham, Alabama, USA
    PLoS Genet 1:e53. 2005
    ..Thus, our data support a model where cilia have a direct role in Gli processing and Shh signal transduction...
  20. ncbi request reprint Identification of CHE-13, a novel intraflagellar transport protein required for cilia formation
    Courtney J Haycraft
    Department of Cell Biology, University of Alabama at Birmingham Medical Center, Birmingham, AL 35294, USA
    Exp Cell Res 284:251-63. 2003
    ..Overall, our data confirm that CHE-13 is an IFT protein and further that the IFT particle assembles in an ordered process through specific protein-protein interactions...
  21. ncbi request reprint IFTA-2 is a conserved cilia protein involved in pathways regulating longevity and dauer formation in Caenorhabditis elegans
    Jenny C Schafer
    Department of Cell Biology, University of Alabama at Birmingham Medical Center, Birmingham, AL 35294, USA
    J Cell Sci 119:4088-100. 2006
    ..Interestingly, a mammalian IFTA-2 homolog is also found in cilia, raising the possibility that its function has been conserved during evolution...
  22. ncbi request reprint Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells
    Brian J Siroky
    Department of Physiology, Univ of Alabama at Birmingham, Birmingham, AL, USA
    Am J Physiol Renal Physiol 290:F1320-8. 2006
    ....
  23. doi request reprint Utilization of conditional alleles to study the role of the primary cilium in obesity
    Robert A Kesterson
    Department of Genetics, University of Alabama at Birmingham Medical School, Birmingham, Alabama 35294, USA
    Methods Cell Biol 94:163-79. 2009
    ....
  24. ncbi request reprint An incredible decade for the primary cilium: a look at a once-forgotten organelle
    James R Davenport
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    Am J Physiol Renal Physiol 289:F1159-69. 2005
    ..Research focused on addressing this issue will be of critical importance for a further understanding of how ciliary dysfunction can lead to such severe disease and developmental pathologies...
  25. pmc Functional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesis
    Corey L Williams
    Department of Cell Biology, University of Alabama at Birmingham Medical Center, Birmingham, AL 35294, USA
    Mol Biol Cell 19:2154-68. 2008
    ..Together, these data suggest that the human homologues of the novel B9 genes B9D2 and B9D1 will be strong candidate loci for pathologies in human MKS, NPHP, and JBTS...
  26. ncbi request reprint The C. elegans homologs of nephrocystin-1 and nephrocystin-4 are cilia transition zone proteins involved in chemosensory perception
    Marlene E Winkelbauer
    Department of Cell Biology, University of Alabama at Birmingham Medical Center, Birmingham Alabama, 35294, USA
    J Cell Sci 118:5575-87. 2005
    ..These findings suggest that the defects in human NPH patients may not be the result of aberrant ciliogenesis but abnormal cilia-sensory functions...
  27. pmc Normal ciliogenesis requires synergy between the cystic kidney disease genes MKS-3 and NPHP-4
    Corey L Williams
    Department of Cell Biology, University of Alabama at Birmingham Medical Center, Birmingham, Alabama, USA
    J Am Soc Nephrol 21:782-93. 2010
    ..elegans sensilla. Taken together, these data demonstrate the importance of mutational load on the presentation and severity of ciliopathies and expand the understanding of the interactions between ciliopathy genes...
  28. ncbi request reprint Cystic kidney diseases: all roads lead to the cilium
    Qihong Zhang
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Physiology (Bethesda) 19:225-30. 2004
    ..Recent advancements in this field have provided a surprising finding: that many of the proteins associated with cystic kidney disease localize to a nearly forgotten organelle, the primary cilium...
  29. pmc Development of the post-natal growth plate requires intraflagellar transport proteins
    Buer Song
    Department of Pathology, University of Alabama at Birmingham, AL, USA
    Dev Biol 305:202-16. 2007
    ..The results suggest a model in which IFT/cilia act to maintain the columnar organization of the growth plate via the process of chondrocyte rotation...
  30. pmc XBX-1 encodes a dynein light intermediate chain required for retrograde intraflagellar transport and cilia assembly in Caenorhabditis elegans
    Jenny C Schafer
    Department of Cell Biology, University of Alabama at Birmingham Medical Center, 35294, USA
    Mol Biol Cell 14:2057-70. 2003
    ..Our results suggest that the DLIC protein XBX-1 functions together with the CHE-3 dynein in retrograde IFT, downstream of the complex A proteins...
  31. doi request reprint Ciliary dysfunction in developmental abnormalities and diseases
    Neeraj Sharma
    Department of Cell Biology, University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama, USA
    Curr Top Dev Biol 85:371-427. 2008
    ....
  32. ncbi request reprint More than just the postal service: novel roles for IFT proteins in signal transduction
    Bradley K Yoder
    University of Alabama at Birmingham, McCallum Building, Room 652, 1918 University Boulevard, Birmingham Alabama 35294, USA
    Dev Cell 10:541-2. 2006
    ..In a recent issue of Cell, Wang et al. (2006) used a temperature-sensitive IFT mutant to separate flagella assembly from signaling activity, and they show that IFT has a direct role in forming signaling complexes in the flagella...
  33. doi request reprint Generating conditional mutants to analyze ciliary functions: the use of Cre-lox technology to disrupt cilia in specific organs
    Amber K O'Connor
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Methods Cell Biol 93:305-30. 2009
    ....
  34. pmc The primary cilium as a complex signaling center
    Nicolas F Berbari
    Department of Cell Biology, University of Alabama at Birmingham, School of Medicine, Birmingham, AL 35294, USA
    Curr Biol 19:R526-35. 2009
    ..Here, we review many of the recent advances contributing to the ascendancy of the primary cilium and how the extraordinary complexity of this organelle inevitably assures many more exciting future discoveries...
  35. pmc Caenorhabditis elegans DYF-2, an orthologue of human WDR19, is a component of the intraflagellar transport machinery in sensory cilia
    Evgeni Efimenko
    Karolinska Institute, Department of Biosciences and Nutrition, Sodertorn University College, School of Life Sciences, S 14189 Huddinge, Sweden
    Mol Biol Cell 17:4801-11. 2006
    ..Importantly, the mouse orthologue of DYF-2, WDR19, also localizes to cilia, pointing to an important evolutionarily conserved role for this WDR protein in cilia development and function...
  36. ncbi request reprint Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene
    Jin Billy Li
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell 117:541-52. 2004
    ..We show that this novel protein localizes to basal bodies in mouse and C. elegans, is under the regulatory control of daf-19, and is necessary for the generation of both cilia and flagella...
  37. doi request reprint THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
    Pamela V Tran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Genet 40:403-10. 2008
    ..Specifically, the aln mutation uncouples the roles of anterograde and retrograde transport in SHH signaling, suggesting that anterograde IFT is required for GLI activation and that retrograde IFT modulates this event...
  38. ncbi request reprint Mechanoregulation of intracellular Ca2+ concentration is attenuated in collecting duct of monocilium-impaired orpk mice
    Wen Liu
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Physiol Renal Physiol 289:F978-88. 2005
    ..We speculate that this defect in mechano-induced Ca(2+) signaling in orpk mice leads to aberrant structure and function of the collecting duct in ARPKD...
  39. pmc Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles
    Guangshuo Ou
    Center for Genetics and Development, Section of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
    Mol Biol Cell 18:1554-69. 2007
    ....
  40. ncbi request reprint Heightened epithelial Na+ channel-mediated Na+ absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia
    Dragos Olteanu
    Department of Physiology, Univ of Alabama at Birmingham, MCLM 740, 1918 University Blvd, 35294 0005, USA
    Am J Physiol Cell Physiol 290:C952-63. 2006
    ..cilium-competent controls. When the genetic lesion causes loss or malformation of the monocilium, ENaC-driven Na(+) hyperabsorption may explain the rapid emergence of severe hypertension in a majority of patients with ARPKD...
  41. ncbi request reprint Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis
    Albrecht G Kramer-Zucker
    Renal Unit, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Development 132:1907-21. 2005
    ..In Kupffer's vesicle, loss of flow is associated with loss of left-right patterning, indicating that the 'nodal flow' mechanism of generating situs is conserved in non-mammalian vertebrates...
  42. ncbi request reprint The primary cilium in cell signaling and cancer
    Edward J Michaud
    Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA
    Cancer Res 66:6463-7. 2006
    ....
  43. doi request reprint Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines
    Sonja K Nielsen
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Dev Dyn 237:2039-52. 2008
    ..These findings indicate that primary cilia are involved in pancreatic development and postnatal tissue homeostasis...
  44. ncbi request reprint Cilia proteins control cerebellar morphogenesis by promoting expansion of the granule progenitor pool
    Victor V Chizhikov
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 27:9780-9. 2007
    ....

Research Grants31

  1. Cilia and Cystic Kidney Disease
    Bradley Yoder; Fiscal Year: 2009
    ..These data will provide important and novel insights into how disruption of cilia and basal body signaling can cause human disorders such as cystic kidney disease. ..
  2. Cilial dysfunction and pathogenesis of obesity
    Bradley Yoder; Fiscal Year: 2009
    ....
  3. Role of Cilia/IFT in Skin and Hair
    Bradley K Yoder; Fiscal Year: 2010
    ..The focus of this work is to better understand the role of primary cilia in skin and hair follicle biology, which may lead to treatments for skin cancer and hair loss. ..
  4. Intraflagellar transport mediated regulation of hedgehog signaling
    Bradley K Yoder; Fiscal Year: 2010
    ..Thus, the overall objective of this proposal is to conduct a series of experiments that will lead to a better understanding of the molecular role that cilia play in regulating signaling events dictating how the limb forms. ..
  5. Cilial dysfunction and pathogenesis of obesity
    Bradley K Yoder; Fiscal Year: 2010
    ....
  6. Cilia and Cystic Kidney Disease
    Bradley K Yoder; Fiscal Year: 2010
    ..These data will provide important and novel insights into how disruption of cilia and basal body signaling can cause human disorders such as cystic kidney disease. ..
  7. Cilial dysfunction and pathogenesis of obesity
    Bradley K Yoder; Fiscal Year: 2010
    ....
  8. Cilial dysfunction and pathogenesis of obesity
    Bradley Yoder; Fiscal Year: 2007
    ....
  9. Conserved Mechanisms of Ciliogenesis
    Bradley Yoder; Fiscal Year: 2003
    ..abstract_text> ..
  10. TG737 SIGNALING PATHWAY AND POLYCYSTIC KIDNEY
    Bradley Yoder; Fiscal Year: 2003
    ..Overall, results generated from this proposal will give important insight into the biological function of Tg737 and how disruption of the Tg737/polycystin-1 signaling pathway results in the formation of renal cyst. ..
  11. Conserved Mechanisms of Ciliogenesis
    Bradley Yoder; Fiscal Year: 2006
    ..abstract_text> ..
  12. Conserved Mechanisms of Ciliogenesis
    Bradley Yoder; Fiscal Year: 2007
    ..abstract_text> ..
  13. Cilia and Cystic Kidney Disease
    Bradley Yoder; Fiscal Year: 2007
    ..abstract_text> ..
  14. Intraflagellar transport mediated regulation of hedgehog signaling
    Bradley K Yoder; Fiscal Year: 2010
    ..Thus, the overall objective of this proposal is to conduct a series of experiments that will lead to a better understanding of the molecular role that cilia play in regulating signaling events dictating how the limb forms. ..