Research Topics
| Shao Yao YingSummaryAffiliation: University of Southern California Country: USA Publications
Research Grants
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Detail Information
Publications
Transcriptional control of Shh/Ptc1 signaling in embryonic developmentShi Lung Lin
Department of Cell and Neurobiology, BMT 403, 1333 San Pablo Street, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Gene 367:56-65. 2006..Based on previous bioinformatics and the present experimental findings, we successfully established an in vivo signaling model for the Shh/Ptc1-directed embryonic feather morphogenesis...- Current perspectives in intronic micro RNAs (miRNAs)Shao Yao Ying
Department of Cell and Neurobiology, Keck School of Medicine, BMT 403, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
J Biomed Sci 13:5-15. 2006..Taken together, the model of intronic miRNA-mediated transgenic animals provides a tool to investigate the mechanism of miRNA-associated diseases in vivo and will shed light on miRNA-related therapies... - The MicroRNAShao Yao Ying
Department of Cell and Neurobiology, University of Southern California, Los Angeles, CA, USA
Methods Mol Biol 936:1-19. 2013..The biogenesis and identification of miRNAs, potential applications, and future directions for research are presented in this chapter, hopefully providing a guideline for further miRNA and gene function studies... - Gene expression in precursor cells of prostate cancer associated with activin by combination of subtractive hybridization and microarray technologiesShao Yao Ying
Department of Cell and Neurobiology, Keck School of Medicine, BMT 401, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90089 9112, USA
Biochem Biophys Res Commun 313:104-9. 2004..The evaluation of candidate genes that emerge from these experiments provides a rational approach to investigate those genes significant in evolution from PIN to prostate carcinoma... - Complementary DNA libraries: an overviewShao Yao Ying
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Mol Biotechnol 27:245-52. 2004..It is anticipated that the high-quality cDNA libraries so generated would facilitate studies involving genechips and the microarray, differential display, subtractive hybridization, gene cloning, and peptide library generation... - Intron-derived microRNAs--fine tuning of gene functionsShao Yao Ying
Department of Cell and Neurobiology, Keck School of Medicine, BMT 401, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033 9112, USA
Gene 342:25-8. 2004..This review describes that the miRNAs derived from introns can suppress intracellular RNA homologues and regulate the gene function... - Intronic microRNAsShao Yao Ying
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033 9112, USA
Biochem Biophys Res Commun 326:515-20. 2005.... 
MicroRNA: fine-tunes the function of genes in zebrafishShao Yao Ying
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, BMT 403, Los Angeles, CA 90033, USA
Biochem Biophys Res Commun 335:1-4. 2005..The Pol-II-mediated intronic miRNA is a useful tool to validate the function of computer-predicated miRNAs in zebrafish and mice...- The microRNA (miRNA): overview of the RNA genes that modulate gene functionShao Yao Ying
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, BMT 403, Los Angeles, CA, 90033, USA
Mol Biotechnol 38:257-68. 2008..The biogenesis and identification of miRNAs, potential applications, and future directions for research are presented, hopefully providing a guideline for further miRNA and gene function studies... - Asymmetry of intronic pre-miRNA structures in functional RISC assemblyShi Lung Lin
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, BMT 403, Los Angeles, CA 90033, USA
Gene 356:32-8. 2005..These findings suggest that the miRISC assembly is likely different from the RISC assembly model of siRNA in zebrafish, providing the first in vivo evidence for asymmetric miRISC assembly... - A novel RNA splicing-mediated gene silencing mechanism potential for genome evolutionShi Lung Lin
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Biochem Biophys Res Commun 310:754-60. 2003..These findings may explain how cells respond to the presence of transgenic introns that are homologous to pre-existing exons during genomic evolution... - Hyaluronan stimulates transformation of androgen-independent prostate cancerShi Lung Lin
Department of Cell and Neurobiology, Keck School of Medicine BMT 403, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
Carcinogenesis 28:310-20. 2007..These findings reveal a novel signal transduction mechanism for matrix-mediated cancer transformation and metastasis in hormone-refractory CaP... - Truncated Bcl-2, a potential pre-metastatic marker in prostate cancerJen ming Huang
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, BMT 401, 1333 San Pablo Street, Los Angeles, CA 90033, USA
Biochem Biophys Res Commun 306:912-7. 2003..These findings suggest that Bcl-2psi may be a potential pre-metastatic marker for detection, diagnosis, and therapy during the initiation of metastasis in prostate cancer... 
Intron-mediated RNA interference, intronic microRNAs, and applicationsShao Yao Ying
Department of Cell, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Methods Mol Biol 629:205-37. 2010..These findings suggest an important miRNA-mediated gene regulatory system, which fine-tunes a variety of cellular and developmental events through the mechanism of RNAi-like gene silencing...- Androgen receptor regulates CD168 expression and signaling in prostate cancerShi Lung Lin
Department of Cell and Neurobiology, Keck School of Medicine, BMT 403, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
Carcinogenesis 29:282-90. 2008.... - Intron-mediated RNA interference and microRNA (miRNA)Shi Lung Lin
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, BMT 403, 1333 San Pablo Street, Los Angeles, CA 90033, USA
Front Biosci 13:2216-30. 2008..Here, we show for the first time that intron-derived miRNAs are able to induce RNA interference in many cells demonstrating the evolutionary preservation of this post-transcriptional regulatory system in vivo... - Loss of mir-146a function in hormone-refractory prostate cancerShi Lung Lin
Department of Cell and Neurobiology, Keck School of Medicine, BMT 403, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
RNA 14:417-24. 2008.... - Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like stateShi Lung Lin
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
RNA 14:2115-24. 2008.... - Gene silencing in vitro and in vivo using intronic microRNAsShi-Lung Lin
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Methods Mol Biol 342:295-312. 2006..These miRNA-mediated animal models provide artificial means to reproduce the mechanisms of miRNA-induced disease in vivo and will shed further light on miRNA-related therapies... - Subtractive cloning of differential genes using RNA-PCRShao-Yao Ying
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, USA
Methods Mol Biol 221:253-9. 2003 - Isolation and identification of gene-specific microRNAsShi-Lung Lin
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Methods Mol Biol 342:313-20. 2006..According to this proof- of-principle method, we now have the knowledge to design pre-miRNA inserts that are more efficient and effective for the intronic miRNA-expressing system... - mRNA/cDNA library construction using RNA-polymerase cycling reactionShi-Lung Lin
Epiclone Inc, San Diego, CA, USA
Methods Mol Biol 221:129-43. 2003 - Subtractive hybridization for the identification of differentially expressed genes using uracil-dNA glycosylase and mung-bean nucleaseTsen-Yin Lin
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, USA
Methods Mol Biol 221:239-51. 2003 - Transgene-like animal models using intronic microRNAsShi-Lung Lin
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Methods Mol Biol 342:321-34. 2006.... - The microRNA: overview of the RNA gene that modulates gene functionsShao-Yao Ying
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Methods Mol Biol 342:1-18. 2006..The biogenesis and identification of miRNAs, potential applications, and future directions for research are presented in this chapter, hopefully providing a guideline for further miRNA and gene function studies... - MiRNA targets of prostate cancerJia Han Deng
Department of Cell and Neurobiology, University of Southern California, Los Angeles, CA, USA
Methods Mol Biol 936:357-69. 2013..Studies of PC-specific miRNAs show potential for their utilization in the prevention, diagnosis, and treatment of PC to more effectively target tumor growth and provide patients with better therapeutic options... - A novel role of miR-302/367 in reprogrammingChih Hao Kuo
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States
Biochem Biophys Res Commun 417:11-6. 2012..The development of this miR-302/367-mediated iPSC (termed mirPSC) may provide tools to deal with the obstacles facing some current iPSC reprogramming methods. The mechanism by which miR-302/367 induce iPSC reprogramming is proposed... - Intron-mediated RNA interference and microRNA biogenesisShao Yao Ying
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Methods Mol Biol 487:387-413. 2009..These findings suggest an intracellular miRNA-mediated gene regulatory system, fine-tuning the degradation of protein-coding messenger RNAs... - Isolation and identification of gene-specific microRNAsShi Lung Lin
Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA, USA
Methods Mol Biol 936:271-8. 2013..According to this proven-of-principle method, we now have full knowledge to design pre-miRNA inserts that are more efficient and effective for the intronic miRNA-expressing systems... - Transgene-like animal models using intronic microRNAsShi Lung Lin
Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA, USA
Methods Mol Biol 936:279-94. 2013.... - Identify intronic microRNA with bioinformaticsChih Hao Kuo
Department of Cell and Neurobiology, University of Southern California, Los Angeles, CA, USA
Methods Mol Biol 936:77-82. 2013..This information is critical for studying the gene-gene interaction via miRNA, and facilitates the study of miRNA in gene expression regulation... - Gene silencing in vitro and in vivo using intronic microRNAsShi Lung Lin
Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA, USA
Methods Mol Biol 936:209-29. 2013..These miRNA-mediated animal models provide artificial means to reproduce the mechanisms of miRNA-induced disease in vivo and will shed further light on miRNA-related therapies... - Mechanism and method for generating tumor-free iPS cells using intronic microRNA miR-302 inductionShi Lung Lin
Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA, USA
Methods Mol Biol 936:295-312. 2013..In this chapter, we reviewed the mechanism underlying miR-302-mediated tumor suppression and then applied this mechanism to generate tumor-free iPSCs. The same strategy can also be used to prevent ESC tumorigenicity... - Advances in MicroRNA-Mediated Reprogramming TechnologyChih Hao Kuo
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, BMT 403, Los Angeles, CA 90033, USA
Stem Cells Int 2012:823709. 2012..This paper discusses the possible underlying mechanism for miRNA-mediated somatic cell reprogramming and the approaches used by different groups to induce iPSCs with miRNAs... - MicroRNA protocols. PerspectivesShao-Yao Ying
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Methods Mol Biol 342:351-8. 2006..This chapter offers some perspective, with emphasis on areas that can be further developed... - Assessment of the quality of mRNA libraries by agarose gel electrophoresisTsen-Yin Lin
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, USA
Methods Mol Biol 221:155-9. 2003 - Complementary DNA libraries: an overviewShao-Yao Ying
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, USA
Methods Mol Biol 221:1-12. 2003 - Future perspectivesShao-Yao Ying
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, USA
Methods Mol Biol 221:311-29. 2003 - Regulation of cell proliferation, apoptosis, and carcinogenesis by activinYe-Guang Chen
Division of Biomedical Sciences, University of California, Riverside, California 92521, USA
Exp Biol Med (Maywood) 227:75-87. 2002.... - Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesisYe-Guang Chen
State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, People's Republic of China
Exp Biol Med (Maywood) 231:534-44. 2006..This review focuses on the recent progress on activin-receptor interactions, regulations of activin signaling by ligand-binding proteins, receptor-binding proteins, and nucleocytoplasmic shuttling of Smad proteins... - Combinational therapy for potential HIV-1 eradication and vaccinationShi Lung Lin
Department of Gene Medicine, Epiclone Inc, Alhambra, CA 91801, USA
Int J Oncol 24:81-8. 2004..These findings promise to provide an immediate therapy in both acute and chronic HIV infections as well as a potential vaccination strategy for AIDS eradication...
Research Grants
- Novel Molecular Profiling of Prostate Cancer SignaturesShao Yao Ying; Fiscal Year: 2006..These results may pave the way for a precise gene-chip diagnosis of stage-specific markers of human prostate cancer. ..