Shao Yao Ying

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Transcriptional control of Shh/Ptc1 signaling in embryonic development
    Shi Lung Lin
    Department of Cell and Neurobiology, BMT 403, 1333 San Pablo Street, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Gene 367:56-65. 2006
  2. ncbi request reprint Current perspectives in intronic micro RNAs (miRNAs)
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, BMT 403, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    J Biomed Sci 13:5-15. 2006
  3. pmc Advances in MicroRNA-Mediated Reprogramming Technology
    Chih Hao Kuo
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, BMT 403, Los Angeles, CA 90033, USA
    Stem Cells Int 2012:823709. 2012
  4. ncbi request reprint The MicroRNA
    Shao Yao Ying
    Department of Cell and Neurobiology, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 936:1-19. 2013
  5. ncbi request reprint Gene expression in precursor cells of prostate cancer associated with activin by combination of subtractive hybridization and microarray technologies
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, BMT 401, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90089 9112, USA
    Biochem Biophys Res Commun 313:104-9. 2004
  6. ncbi request reprint Intronic microRNAs
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033 9112, USA
    Biochem Biophys Res Commun 326:515-20. 2005
  7. ncbi request reprint Intron-derived microRNAs--fine tuning of gene functions
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, BMT 401, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033 9112, USA
    Gene 342:25-8. 2004
  8. ncbi request reprint Complementary DNA libraries: an overview
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Mol Biotechnol 27:245-52. 2004
  9. pmc MicroRNA: fine-tunes the function of genes in zebrafish
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, BMT 403, Los Angeles, CA 90033, USA
    Biochem Biophys Res Commun 335:1-4. 2005
  10. ncbi request reprint The microRNA (miRNA): overview of the RNA genes that modulate gene function
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, BMT 403, Los Angeles, CA, 90033, USA
    Mol Biotechnol 38:257-68. 2008

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Transcriptional control of Shh/Ptc1 signaling in embryonic development
    Shi Lung Lin
    Department of Cell and Neurobiology, BMT 403, 1333 San Pablo Street, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Gene 367:56-65. 2006
    ..Based on previous bioinformatics and the present experimental findings, we successfully established an in vivo signaling model for the Shh/Ptc1-directed embryonic feather morphogenesis...
  2. ncbi request reprint Current perspectives in intronic micro RNAs (miRNAs)
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, BMT 403, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    J Biomed Sci 13:5-15. 2006
    ..Taken together, the model of intronic miRNA-mediated transgenic animals provides a tool to investigate the mechanism of miRNA-associated diseases in vivo and will shed light on miRNA-related therapies...
  3. pmc Advances in MicroRNA-Mediated Reprogramming Technology
    Chih Hao Kuo
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, BMT 403, Los Angeles, CA 90033, USA
    Stem Cells Int 2012:823709. 2012
    ..This paper discusses the possible underlying mechanism for miRNA-mediated somatic cell reprogramming and the approaches used by different groups to induce iPSCs with miRNAs...
  4. ncbi request reprint The MicroRNA
    Shao Yao Ying
    Department of Cell and Neurobiology, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 936:1-19. 2013
    ..The biogenesis and identification of miRNAs, potential applications, and future directions for research are presented in this chapter, hopefully providing a guideline for further miRNA and gene function studies...
  5. ncbi request reprint Gene expression in precursor cells of prostate cancer associated with activin by combination of subtractive hybridization and microarray technologies
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, BMT 401, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90089 9112, USA
    Biochem Biophys Res Commun 313:104-9. 2004
    ..The evaluation of candidate genes that emerge from these experiments provides a rational approach to investigate those genes significant in evolution from PIN to prostate carcinoma...
  6. ncbi request reprint Intronic microRNAs
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033 9112, USA
    Biochem Biophys Res Commun 326:515-20. 2005
    ....
  7. ncbi request reprint Intron-derived microRNAs--fine tuning of gene functions
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, BMT 401, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033 9112, USA
    Gene 342:25-8. 2004
    ..This review describes that the miRNAs derived from introns can suppress intracellular RNA homologues and regulate the gene function...
  8. ncbi request reprint Complementary DNA libraries: an overview
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Mol Biotechnol 27:245-52. 2004
    ..It is anticipated that the high-quality cDNA libraries so generated would facilitate studies involving genechips and the microarray, differential display, subtractive hybridization, gene cloning, and peptide library generation...
  9. pmc MicroRNA: fine-tunes the function of genes in zebrafish
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, BMT 403, Los Angeles, CA 90033, USA
    Biochem Biophys Res Commun 335:1-4. 2005
    ..The Pol-II-mediated intronic miRNA is a useful tool to validate the function of computer-predicated miRNAs in zebrafish and mice...
  10. ncbi request reprint The microRNA (miRNA): overview of the RNA genes that modulate gene function
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, BMT 403, Los Angeles, CA, 90033, USA
    Mol Biotechnol 38:257-68. 2008
    ..The biogenesis and identification of miRNAs, potential applications, and future directions for research are presented, hopefully providing a guideline for further miRNA and gene function studies...
  11. pmc Asymmetry of intronic pre-miRNA structures in functional RISC assembly
    Shi Lung Lin
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, BMT 403, Los Angeles, CA 90033, USA
    Gene 356:32-8. 2005
    ..These findings suggest that the miRISC assembly is likely different from the RISC assembly model of siRNA in zebrafish, providing the first in vivo evidence for asymmetric miRISC assembly...
  12. ncbi request reprint Subtractive hybridization for the identification of differentially expressed genes using uracil-dNA glycosylase and mung-bean nuclease
    Tsen Yin Lin
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Methods Mol Biol 221:239-51. 2003
  13. ncbi request reprint Subtractive cloning of differential genes using RNA-PCR
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Methods Mol Biol 221:253-9. 2003
  14. ncbi request reprint A novel RNA splicing-mediated gene silencing mechanism potential for genome evolution
    Shi Lung Lin
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Biochem Biophys Res Commun 310:754-60. 2003
    ..These findings may explain how cells respond to the presence of transgenic introns that are homologous to pre-existing exons during genomic evolution...
  15. ncbi request reprint Hyaluronan stimulates transformation of androgen-independent prostate cancer
    Shi Lung Lin
    Department of Cell and Neurobiology, Keck School of Medicine BMT 403, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    Carcinogenesis 28:310-20. 2007
    ..These findings reveal a novel signal transduction mechanism for matrix-mediated cancer transformation and metastasis in hormone-refractory CaP...
  16. ncbi request reprint Gene silencing in vitro and in vivo using intronic microRNAs
    Shi Lung Lin
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 342:295-312. 2006
    ..These miRNA-mediated animal models provide artificial means to reproduce the mechanisms of miRNA-induced disease in vivo and will shed further light on miRNA-related therapies...
  17. ncbi request reprint Truncated Bcl-2, a potential pre-metastatic marker in prostate cancer
    Jen ming Huang
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, BMT 401, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    Biochem Biophys Res Commun 306:912-7. 2003
    ..These findings suggest that Bcl-2psi may be a potential pre-metastatic marker for detection, diagnosis, and therapy during the initiation of metastasis in prostate cancer...
  18. doi request reprint Intron-mediated RNA interference, intronic microRNAs, and applications
    Shao Yao Ying
    Department of Cell, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 629:205-37. 2010
    ..These findings suggest an important miRNA-mediated gene regulatory system, which fine-tunes a variety of cellular and developmental events through the mechanism of RNAi-like gene silencing...
  19. ncbi request reprint Transgene-like animal models using intronic microRNAs
    Shi Lung Lin
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 342:321-34. 2006
    ....
  20. ncbi request reprint mRNA/cDNA library construction using RNA-polymerase cycling reaction
    Shi Lung Lin
    Epiclone Inc, San Diego, CA, USA
    Methods Mol Biol 221:129-43. 2003
  21. ncbi request reprint Intron-mediated RNA interference and microRNA (miRNA)
    Shi Lung Lin
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, BMT 403, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    Front Biosci 13:2216-30. 2008
    ..Here, we show for the first time that intron-derived miRNAs are able to induce RNA interference in many cells demonstrating the evolutionary preservation of this post-transcriptional regulatory system in vivo...
  22. ncbi request reprint Transgene-like animal models using intronic microRNAs
    Shi Lung Lin
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA, USA
    Methods Mol Biol 936:279-94. 2013
    ....
  23. ncbi request reprint Androgen receptor regulates CD168 expression and signaling in prostate cancer
    Shi Lung Lin
    Department of Cell and Neurobiology, Keck School of Medicine, BMT 403, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    Carcinogenesis 29:282-90. 2008
    ....
  24. pmc Loss of mir-146a function in hormone-refractory prostate cancer
    Shi Lung Lin
    Department of Cell and Neurobiology, Keck School of Medicine, BMT 403, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    RNA 14:417-24. 2008
    ....
  25. ncbi request reprint The microRNA: overview of the RNA gene that modulates gene functions
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 342:1-18. 2006
    ..The biogenesis and identification of miRNAs, potential applications, and future directions for research are presented in this chapter, hopefully providing a guideline for further miRNA and gene function studies...
  26. ncbi request reprint MiRNA targets of prostate cancer
    Jia Han Deng
    Department of Cell and Neurobiology, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 936:357-69. 2013
    ..Studies of PC-specific miRNAs show potential for their utilization in the prevention, diagnosis, and treatment of PC to more effectively target tumor growth and provide patients with better therapeutic options...
  27. ncbi request reprint Mechanism and method for generating tumor-free iPS cells using intronic microRNA miR-302 induction
    Shi Lung Lin
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA, USA
    Methods Mol Biol 936:295-312. 2013
    ..In this chapter, we reviewed the mechanism underlying miR-302-mediated tumor suppression and then applied this mechanism to generate tumor-free iPSCs. The same strategy can also be used to prevent ESC tumorigenicity...
  28. ncbi request reprint MicroRNA protocols. Perspectives
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 342:351-8. 2006
    ..This chapter offers some perspective, with emphasis on areas that can be further developed...
  29. ncbi request reprint Gene silencing in vitro and in vivo using intronic microRNAs
    Shi Lung Lin
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA, USA
    Methods Mol Biol 936:209-29. 2013
    ..These miRNA-mediated animal models provide artificial means to reproduce the mechanisms of miRNA-induced disease in vivo and will shed further light on miRNA-related therapies...
  30. ncbi request reprint Isolation and identification of gene-specific microRNAs
    Shi Lung Lin
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA, USA
    Methods Mol Biol 936:271-8. 2013
    ..According to this proven-of-principle method, we now have full knowledge to design pre-miRNA inserts that are more efficient and effective for the intronic miRNA-expressing systems...
  31. ncbi request reprint Isolation and identification of gene-specific microRNAs
    Shi Lung Lin
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 342:313-20. 2006
    ..According to this proof- of-principle method, we now have the knowledge to design pre-miRNA inserts that are more efficient and effective for the intronic miRNA-expressing system...
  32. pmc Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state
    Shi Lung Lin
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    RNA 14:2115-24. 2008
    ....
  33. ncbi request reprint Identify intronic microRNA with bioinformatics
    Chih Hao Kuo
    Department of Cell and Neurobiology, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 936:77-82. 2013
    ..This information is critical for studying the gene-gene interaction via miRNA, and facilitates the study of miRNA in gene expression regulation...
  34. doi request reprint A novel role of miR-302/367 in reprogramming
    Chih Hao Kuo
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States
    Biochem Biophys Res Commun 417:11-6. 2012
    ..The development of this miR-302/367-mediated iPSC (termed mirPSC) may provide tools to deal with the obstacles facing some current iPSC reprogramming methods. The mechanism by which miR-302/367 induce iPSC reprogramming is proposed...
  35. doi request reprint Intron-mediated RNA interference and microRNA biogenesis
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 487:387-413. 2009
    ..These findings suggest an intracellular miRNA-mediated gene regulatory system, fine-tuning the degradation of protein-coding messenger RNAs...
  36. ncbi request reprint Assessment of the quality of mRNA libraries by agarose gel electrophoresis
    Tsen Yin Lin
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Methods Mol Biol 221:155-9. 2003
  37. doi request reprint MicroRNA-mediated somatic cell reprogramming
    Chih Hao Kuo
    Department of Cell and Neurobiology Keck School of Medicine, BMT 403 University of Southern California Los Angeles, CA 90033, USA
    J Cell Biochem 114:275-81. 2013
    ..Based on the pivotal role of microRNAs in embryogenesis and somatic cell reprogramming, studies in this area must continue in order to gain a better understanding of the role of microRNAs in stem cells regulation and activity...
  38. ncbi request reprint Future perspectives
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Methods Mol Biol 221:311-29. 2003
  39. ncbi request reprint Complementary DNA libraries: an overview
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Methods Mol Biol 221:1-12. 2003
  40. ncbi request reprint Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis
    Ye Guang Chen
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, People s Republic of China
    Exp Biol Med (Maywood) 231:534-44. 2006
    ..This review focuses on the recent progress on activin-receptor interactions, regulations of activin signaling by ligand-binding proteins, receptor-binding proteins, and nucleocytoplasmic shuttling of Smad proteins...
  41. ncbi request reprint Regulation of cell proliferation, apoptosis, and carcinogenesis by activin
    Ye Guang Chen
    Division of Biomedical Sciences, University of California, Riverside, California 92521, USA
    Exp Biol Med (Maywood) 227:75-87. 2002
    ....
  42. ncbi request reprint Combinational therapy for potential HIV-1 eradication and vaccination
    Shi Lung Lin
    Department of Gene Medicine, Epiclone Inc, Alhambra, CA 91801, USA
    Int J Oncol 24:81-8. 2004
    ..These findings promise to provide an immediate therapy in both acute and chronic HIV infections as well as a potential vaccination strategy for AIDS eradication...

Research Grants5

  1. Novel Molecular Profiling of Prostate Cancer Signatures
    Shao Yao Ying; Fiscal Year: 2002
    ..These results may pave the way for a precise gene-chip diagnosis of stage-specific markers of human prostate cancer. ..
  2. Novel Molecular Profiling of Prostate Cancer Signatures
    Shao Yao Ying; Fiscal Year: 2003
    ..These results may pave the way for a precise gene-chip diagnosis of stage-specific markers of human prostate cancer. ..
  3. Novel Molecular Profiling of Prostate Cancer Signatures
    Shao Yao Ying; Fiscal Year: 2004
    ..These results may pave the way for a precise gene-chip diagnosis of stage-specific markers of human prostate cancer. ..
  4. Novel Molecular Profiling of Prostate Cancer Signatures
    Shao Yao Ying; Fiscal Year: 2005
    ..These results may pave the way for a precise gene-chip diagnosis of stage-specific markers of human prostate cancer. ..
  5. Novel Molecular Profiling of Prostate Cancer Signatures
    Shao Yao Ying; Fiscal Year: 2006
    ..These results may pave the way for a precise gene-chip diagnosis of stage-specific markers of human prostate cancer. ..