Qi Long Ying

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
    Qi Long Ying
    Institute for Stem Cell Research, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JQ, United Kingdom
    Nat Biotechnol 21:183-6. 2003
  2. ncbi Changing potency by spontaneous fusion
    Qi Long Ying
    Centre for Genome Research, University of Edinburgh, The King s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK
    Nature 416:545-8. 2002
  3. ncbi Defined conditions for neural commitment and differentiation
    Qi Long Ying
    Institute for Stem Cell Research, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh, Scotland, EH9 3JQ, UK
    Methods Enzymol 365:327-41. 2003
  4. doi The ground state of embryonic stem cell self-renewal
    Qi Long Ying
    Center for Stem Cell and Regenerative Medicine, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, ZNI 529, Los Angeles, California 90033, USA
    Nature 453:519-23. 2008
  5. ncbi Derivation and propagation of embryonic stem cells in serum- and feeder-free culture
    Jennifer Nichols
    Centre Development in Stem Cell Biology, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK
    Methods Mol Biol 329:91-8. 2006
  6. pmc Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1
    Shoudong Ye
    1 Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA 2 Department of Biochemistry and Molecular Biology, Shanghai Medical School and Key Laboratory of Molecular Medicine, Ministry of Education, Fudan University, Shanghai, PR China
    EMBO J 32:2548-60. 2013
  7. pmc STAT3 phosphorylation at tyrosine 705 and serine 727 differentially regulates mouse ESC fates
    Guanyi Huang
    Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Stem Cells 32:1149-60. 2014
  8. pmc Klf2 and Tfcp2l1, Two Wnt/β-Catenin Targets, Act Synergistically to Induce and Maintain Naive Pluripotency
    Dongbo Qiu
    Guangdong Provincial Key Laboratory of Liver Disease, Cell gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou 510630, PRC Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, University of Southern California, Los Angeles, CA 90033, USA
    Stem Cell Reports 5:314-22. 2015
  9. pmc Induced neural stem cells generated from rat fibroblasts
    Guangjun Xi
    Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Cell and Neurobiology, University of Southern California, Los Angeles, CA 90033, USA Department of Neurology, Wuxi People s Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China
    Genomics Proteomics Bioinformatics 11:312-9. 2013
  10. pmc Signaling pathways in induced naïve pluripotency
    Shoudong Ye
    Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei 230601, PR China Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Curr Opin Genet Dev 28:10-5. 2014

Collaborators

Detail Information

Publications14

  1. ncbi Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
    Qi Long Ying
    Institute for Stem Cell Research, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JQ, United Kingdom
    Nat Biotechnol 21:183-6. 2003
    ..This system provides a platform for defining the molecular machinery of neural commitment and optimizing the efficiency of neuronal and glial cell production from pluripotent mammalian stem cells...
  2. ncbi Changing potency by spontaneous fusion
    Qi Long Ying
    Centre for Genome Research, University of Edinburgh, The King s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK
    Nature 416:545-8. 2002
    ..We propose that transdetermination consequent to cell fusion 10 could underlie many observations otherwise attributed to an intrinsic plasticity of tissue stem cells 9...
  3. ncbi Defined conditions for neural commitment and differentiation
    Qi Long Ying
    Institute for Stem Cell Research, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh, Scotland, EH9 3JQ, UK
    Methods Enzymol 365:327-41. 2003
    ....
  4. doi The ground state of embryonic stem cell self-renewal
    Qi Long Ying
    Center for Stem Cell and Regenerative Medicine, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, ZNI 529, Los Angeles, California 90033, USA
    Nature 453:519-23. 2008
    ..This property may account for their latent tumorigenicity. The delineation of minimal requirements for self-renewal now provides a defined platform for the precise description and dissection of the pluripotent state...
  5. ncbi Derivation and propagation of embryonic stem cells in serum- and feeder-free culture
    Jennifer Nichols
    Centre Development in Stem Cell Biology, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK
    Methods Mol Biol 329:91-8. 2006
    ..This chapter describes a simple protocol for efficient derivation and maintenance of ES cells from embryos of the 129 and C57B1/6 strains of mice...
  6. pmc Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1
    Shoudong Ye
    1 Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA 2 Department of Biochemistry and Molecular Biology, Shanghai Medical School and Key Laboratory of Molecular Medicine, Ministry of Education, Fudan University, Shanghai, PR China
    EMBO J 32:2548-60. 2013
    ..Our study provides an expanded understanding of the current model of ground-state pluripotency. ..
  7. pmc STAT3 phosphorylation at tyrosine 705 and serine 727 differentially regulates mouse ESC fates
    Guanyi Huang
    Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Stem Cells 32:1149-60. 2014
    ..Moreover, loss of pS727 sufficed LIF to reprogram epiblast stem cells to naïve pluripotency, suggesting a dynamic equilibrium of STAT3 pY705 and pS727 in the control of mESC fate...
  8. pmc Klf2 and Tfcp2l1, Two Wnt/β-Catenin Targets, Act Synergistically to Induce and Maintain Naive Pluripotency
    Dongbo Qiu
    Guangdong Provincial Key Laboratory of Liver Disease, Cell gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou 510630, PRC Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, University of Southern California, Los Angeles, CA 90033, USA
    Stem Cell Reports 5:314-22. 2015
    ..Our study therefore establishes the pivotal role of Klf2 and Tfcp2l1 in mediating ESC self-renewal promoted by Wnt/β-catenin signaling...
  9. pmc Induced neural stem cells generated from rat fibroblasts
    Guangjun Xi
    Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Cell and Neurobiology, University of Southern California, Los Angeles, CA 90033, USA Department of Neurology, Wuxi People s Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China
    Genomics Proteomics Bioinformatics 11:312-9. 2013
    ..The generation and long-term maintenance of iNS cells could have wide and momentous implications. ..
  10. pmc Signaling pathways in induced naïve pluripotency
    Shoudong Ye
    Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei 230601, PR China Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Curr Opin Genet Dev 28:10-5. 2014
    ..Understanding how these pathways induce and maintain naïve pluripotency will likely lead to the generation of germline-competent naïve ESCs/iPSCs from humans and animals phylogenetically close to humans. ..
  11. pmc Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal
    Hoon Kim
    1 Department of Cell and Neurobiology, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA 2
    Nat Commun 4:2403. 2013
    ..Our results elucidate a new role for β-catenin in stem cell self-renewal that is independent of its transcriptional activity and will have broad implications in understanding the molecular regulation of stem cell fate. ..
  12. pmc p53 promotes inflammation-associated hepatocarcinogenesis by inducing HMGB1 release
    He Xin Yan
    Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200433, China Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA Electronic address
    J Hepatol 59:762-8. 2013
    ..Here we aim at exploring the mechanism linking p53 activation and hepatic inflammation during hepatocarcinogenesis...
  13. pmc Germline competent embryonic stem cells derived from rat blastocysts
    Ping Li
    Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cell 135:1299-310. 2008
    ..Establishment of authentic rat ES cells will make possible sophisticated genetic manipulation to create models for the study of human diseases...
  14. pmc Niche-independent symmetrical self-renewal of a mammalian tissue stem cell
    Luciano Conti
    Institute for Stem Cell Research, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 3:e283. 2005
    ..These homogenous cultures will enable delineation of molecular mechanisms that define a tissue-specific stem cell and allow direct comparison with pluripotent ES cells...