Lei Yin

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha
    Lei Yin
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:11614-9. 2010
  2. ncbi request reprint The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1
    Jing Wang
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Biol Chem 281:33842-8. 2006
  3. ncbi request reprint Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways
    Lei Yin
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 318:1786-9. 2007
  4. pmc Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha
    Nan Wu
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 23:2201-9. 2009
  5. ncbi request reprint Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock
    Lei Yin
    Division of Endocrinology, Diabetes, and Metabolism, and University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Science 311:1002-5. 2006
  6. ncbi request reprint The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene
    Lei Yin
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia 19104 6149, USA
    Mol Endocrinol 19:1452-9. 2005

Collaborators

Detail Information

Publications6

  1. pmc E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha
    Lei Yin
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:11614-9. 2010
    ..Thus, Arf-bp1 and Pam are novel regulators of circadian gene expression that target Rev-erb alpha for degradation...
  2. ncbi request reprint The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1
    Jing Wang
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Biol Chem 281:33842-8. 2006
    ..Thus, our results suggest that Rev-erb alpha is a major determinant of the circadian PAI-1 expression and a potential modulator of the morning susceptibility to myocardial infarction...
  3. ncbi request reprint Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways
    Lei Yin
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 318:1786-9. 2007
    ..Thus, Rev-erbalpha serves as a heme sensor that coordinates the cellular clock, glucose homeostasis, and energy metabolism...
  4. pmc Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha
    Nan Wu
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 23:2201-9. 2009
    ..Thus, Rev-erbalpha modulates the synthesis of its own ligand in a negative feedback pathway that maintains heme levels and regulates cellular energy metabolism...
  5. ncbi request reprint Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock
    Lei Yin
    Division of Endocrinology, Diabetes, and Metabolism, and University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Science 311:1002-5. 2006
    ..Control of Rev-erbalpha protein stability is thus a critical component of the peripheral clock and a biological target of lithium therapy...
  6. ncbi request reprint The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene
    Lei Yin
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia 19104 6149, USA
    Mol Endocrinol 19:1452-9. 2005
    ..These data demonstrate a new function for the N-CoR/HDAC3 complex in regulating the expression of genes involved in circadian rhythm by functioning as corepressor for Rev-erbalpha...