Affiliation: University of Washington
- Integrating open-source technologies to build low-cost information systems for improved access to public health dataQian Yi
Center for Public Health Informatics, University of Washington, Seattle, Washington, USA
Int J Health Geogr 7:29. 2008....
- Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibriumChristopher S Carlson
Department of Genome Sciences, University of Washington, Seattle, WA, 98195, USA
Am J Hum Genet 74:106-20. 2004..We demonstrate that, although common variation tends to be shared between populations, tagSNPs should be selected separately for populations with different ancestries...
- Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populationsDana C Crawford
Department of Genome Sciences, University of Washington, Seattle 98195 7730, USA
Am J Hum Genet 74:610-22. 2004....
- Sequence diversity, natural selection and linkage disequilibrium in the human T cell receptor alpha/delta locusRachel Mackelprang
Department of Genome Sciences, University of Washington, 357730, Seattle, WA, 98195 7730, USA
Hum Genet 119:255-66. 2006..Furthermore, we explore signatures of natural selection across V genes. We find evidence of strong directional selection at this locus as evidenced by unusually high values of Fst...
- Allelic spectrum of the natural variation in CRPDana C Crawford
Department of Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195 7730, USA
Hum Genet 119:496-504. 2006..Collectively, these data suggest that several different types re-sequencing and genotyping approaches may be required to fully understand the complete spectrum of alleles that impact human phenotypes...
- LPA and PLG sequence variation and kringle IV-2 copy number in two populationsDana C Crawford
Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
Hum Hered 66:199-209. 2008..African-descent populations have, on average, higher levels of Lp(a), suggesting other genetic factors contribute to Lp(a) level variability across populations...
- Integrating host genomics with surveillance for invasive bacterial diseasesDana C Crawford
Vanderbilt University, Nashville, Tennessee, USA
Emerg Infect Dis 14:1138-40. 2008..Using nDBS specimens, we resequenced CD46, putative host gene receptor for Neisseria meningitidis, and identified variants associated with susceptibility to this disease...