Minkyung Yi

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. pmc Trans-complementation of an NS2 defect in a late step in hepatitis C virus (HCV) particle assembly and maturation
    Minkyung Yi
    Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, USA
    PLoS Pathog 5:e1000403. 2009
  2. pmc NS3 helicase domains involved in infectious intracellular hepatitis C virus particle assembly
    Yinghong Ma
    Center for Hepatitis Research, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 1073, USA
    J Virol 82:7624-39. 2008
  3. doi request reprint Antiviral suppression vs restoration of RIG-I signaling by hepatitis C protease and polymerase inhibitors
    Yuqiong Liang
    Center for Hepatitis Research, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas 77555 1073, USA
    Gastroenterology 135:1710-1718.e2. 2008
  4. pmc Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122
    Rohit K Jangra
    Center for Hepatitis Research, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555 0610, USA
    J Virol 84:6615-25. 2010
  5. pmc Efficiency of E2-p7 processing modulates production of infectious hepatitis C virus
    Saravanabalaji Shanmugam
    Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA
    J Virol 87:11255-66. 2013
  6. pmc Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chimeric hepatitis C virus
    Minkyung Yi
    Center for Hepatitis Research, Institute for Human Infections and Immunity, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 1019, USA
    J Virol 81:629-38. 2007
  7. pmc Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells
    Minkyung Yi
    Center for Hepatitis Research, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1019, USA
    Proc Natl Acad Sci U S A 103:2310-5. 2006
  8. ncbi request reprint Screening for hepatitis C virus antiviral activity with a cell-based secreted alkaline phosphatase reporter replicon system
    Nigel Bourne
    Department of Pediatrics, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0436, USA
    Antiviral Res 67:76-82. 2005
  9. pmc Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor
    Yan Yang
    Center for Hepatitis Research, Institute for Human Infections and Immunity, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1019, USA
    Proc Natl Acad Sci U S A 104:7253-8. 2007
  10. doi request reprint Genotype 1a HCV (H77S) infection system
    Minkyung Yi
    Center for Hepatitis Research, Institute for Human Infections and the Department of Microbiology and Immunology, University of Texas Galveston, TX, USA
    Methods Mol Biol 510:337-46. 2009

Collaborators

Detail Information

Publications28

  1. pmc Trans-complementation of an NS2 defect in a late step in hepatitis C virus (HCV) particle assembly and maturation
    Minkyung Yi
    Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, USA
    PLoS Pathog 5:e1000403. 2009
    ..In aggregate, these results indicate that NS2 functions in trans, in a late-post assembly maturation step, perhaps in concert with NS5A, to confer infectivity to the HCV particle...
  2. pmc NS3 helicase domains involved in infectious intracellular hepatitis C virus particle assembly
    Yinghong Ma
    Center for Hepatitis Research, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 1073, USA
    J Virol 82:7624-39. 2008
    ..These data reveal a previously unsuspected role for the NS3 helicase in early virion morphogenesis and provide a new perspective on HCV assembly...
  3. doi request reprint Antiviral suppression vs restoration of RIG-I signaling by hepatitis C protease and polymerase inhibitors
    Yuqiong Liang
    Center for Hepatitis Research, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas 77555 1073, USA
    Gastroenterology 135:1710-1718.e2. 2008
    ..This study quantitatively assessed the rescue of IRF-3 signaling by NS3/4A inhibitors, compared with in vitro antiviral activity...
  4. pmc Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122
    Rohit K Jangra
    Center for Hepatitis Research, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555 0610, USA
    J Virol 84:6615-25. 2010
    ..miR-122 is thus likely to act at an additional step in the virus life cycle...
  5. pmc Efficiency of E2-p7 processing modulates production of infectious hepatitis C virus
    Saravanabalaji Shanmugam
    Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA
    J Virol 87:11255-66. 2013
    ..In conclusion, these results imply that effective release of E2 and p7 from the precursor E2-p7 promotes HCV production by enhancing NS2-associated virus assembly complex formation near LD. ..
  6. pmc Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chimeric hepatitis C virus
    Minkyung Yi
    Center for Hepatitis Research, Institute for Human Infections and Immunity, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 1019, USA
    J Virol 81:629-38. 2007
    ..We conclude that interactions between NS2 and E1 and p7 as well as between NS2 and NS3 are essential for virus assembly and/or release and that each of these viral proteins plays an important role in this process...
  7. pmc Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells
    Minkyung Yi
    Center for Hepatitis Research, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1019, USA
    Proc Natl Acad Sci U S A 103:2310-5. 2006
    ..The ability of this genotype 1a virus to infect cultured cells will substantially benefit antiviral and vaccine discovery programs...
  8. ncbi request reprint Screening for hepatitis C virus antiviral activity with a cell-based secreted alkaline phosphatase reporter replicon system
    Nigel Bourne
    Department of Pediatrics, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0436, USA
    Antiviral Res 67:76-82. 2005
    ..We have found excellent agreement between the SEAP and RT-PCR assays. This phased system provides an efficient and cost-effective screen for compounds with antiviral activity against HCV...
  9. pmc Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor
    Yan Yang
    Center for Hepatitis Research, Institute for Human Infections and Immunity, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1019, USA
    Proc Natl Acad Sci U S A 104:7253-8. 2007
    ..The unique requirement for mitochondrial localization of 3ABC underscores the importance of mitochondria to host control of virus infections within the liver...
  10. doi request reprint Genotype 1a HCV (H77S) infection system
    Minkyung Yi
    Center for Hepatitis Research, Institute for Human Infections and the Department of Microbiology and Immunology, University of Texas Galveston, TX, USA
    Methods Mol Biol 510:337-46. 2009
    ..Although significantly less efficient than JFH-1 RNA, H77S RNA produces moderate titers of cell culture-infectious virus when transfected into Huh-7 cells...
  11. pmc DDX6 (Rck/p54) is required for efficient hepatitis C virus replication but not for internal ribosome entry site-directed translation
    Rohit K Jangra
    Center for Hepatitis Research, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555 0610, USA
    J Virol 84:6810-24. 2010
    ..Thus, DDX6 helicase activity is essential for efficient HCV replication, reflecting essential roles for DDX6 in HCV genome amplification and/or maintenance of cellular homeostasis...
  12. pmc Hepatitis C virus NS2 protein serves as a scaffold for virus assembly by interacting with both structural and nonstructural proteins
    Yinghong Ma
    Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 0610, USA
    J Virol 85:86-97. 2011
    ..p7 may play an accessory role by regulating NS2 membrane topology, which is important for NS2-mediated protein interactions and therefore NS2 function...
  13. pmc Identification of a conserved RNA replication element (cre) within the 3Dpol-coding sequence of hepatoviruses
    Yan Yang
    Center for Hepatitis Research, 4 104 Blocker Medical Research Bldg, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1073, USA
    J Virol 82:10118-28. 2008
    ....
  14. pmc Adaptive mutations producing efficient replication of genotype 1a hepatitis C virus RNA in normal Huh7 cells
    Minkyung Yi
    Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555 1019, USA
    J Virol 78:7904-15. 2004
    ....
  15. ncbi request reprint p21-activated kinase 1 is activated through the mammalian target of rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in human hepatoma cells
    Hisashi Ishida
    Center for Hepatitis Research, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas 77555 1018, USA
    J Biol Chem 282:11836-48. 2007
    ..Taken together, the data indicate that p70 S6 kinase activates PAK1 and contributes to phosphatidylinositol 3-kinase- and ERK-mediated regulation of HCV RNA replication...
  16. pmc Evolution of a Cell Culture-Derived Genotype 1a Hepatitis C Virus (H77S.2) during Persistent Infection with Chronic Hepatitis in a Chimpanzee
    Minkyung Yi
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA
    J Virol 88:3678-94. 2014
    ....
  17. ncbi request reprint "Strong reasons make strong actions"--The antiviral efficacy of NS3/4A protease inhibitors
    Stanley M Lemon
    Center for Hepatitis Research, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA
    Hepatology 41:671-4. 2005
  18. pmc In vitro selection of a neutralization-resistant hepatitis C virus escape mutant
    Meital Gal-Tanamy
    Center for Hepatitis Research, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1073, USA
    Proc Natl Acad Sci U S A 105:19450-5. 2008
    ....
  19. ncbi request reprint Subgenomic hepatitis C virus replicons inducing expression of a secreted enzymatic reporter protein
    Minkyung Yi
    Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, 77555 1019, USA
    Virology 304:197-210. 2002
    ..Using this reporter system, we have demonstrated significant differences in the response to interferon alpha-2b in cell lines containing replicons derived from these two strains of HCV...
  20. pmc 3' nontranslated RNA signals required for replication of hepatitis C virus RNA
    Minkyung Yi
    Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555 1019, USA
    J Virol 77:3557-68. 2003
    ....
  21. ncbi request reprint Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA
    Catherine L Jopling
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Science 309:1577-81. 2005
    ..Therefore, miR-122 is likely to facilitate replication of the viral RNA, suggesting that miR-122 may present a target for antiviral intervention...
  22. pmc Hepatitis C virus: propagation, quantification, and storage
    Minkyung Yi
    The University of Texas Medical Branch at Galveston, Galveston, Texas, USA
    Curr Protoc Microbiol . 2010
    ....
  23. pmc Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells
    Masanori Ikeda
    Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555 1019, USA
    J Virol 76:2997-3006. 2002
    ..We conclude that RNA derived from this documented infectious molecular clone has a unique capacity for replication in Huh7 cells in the absence of additional cell culture-adaptive mutations...
  24. pmc Structure-function analysis of the 3' stem-loop of hepatitis C virus genomic RNA and its role in viral RNA replication
    Minkyung Yi
    Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555 1019, USA
    RNA 9:331-45. 2003
    ..These features of stem-loop I are likely to facilitate recognition of the 3' end of the viral RNA by the viral RNA replicase...
  25. pmc Replication of subgenomic hepatitis A virus RNAs expressing firefly luciferase is enhanced by mutations associated with adaptation of virus to growth in cultured cells
    Minkyung Yi
    Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555 1019, USA
    J Virol 76:1171-80. 2002
    ....
  26. pmc Mutagenesis analysis of the rGTP-specific binding site of hepatitis C virus RNA-dependent RNA polymerase
    Zhaohui Cai
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, 800 Rose St, MN477, Lexington, KY 40536 0298, USA
    J Virol 79:11607-17. 2005
    ..Collectively, these findings demonstrate that the rGTP-specific binding site of the HCV NS5B is not required for in vitro RdRp activity but is important for HCV RNA replication in vivo...
  27. pmc Conserved C-terminal threonine of hepatitis C virus NS3 regulates autoproteolysis and prevents product inhibition
    Wenyan Wang
    Department of Structural Chemistry, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Virol 78:700-9. 2004
    ....
  28. ncbi request reprint Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations
    Minkyung Yi
    Center for Hepatitis Research, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston 77555 1019, USA
    J Biol Chem 281:8205-15. 2006
    ....

Research Grants5

  1. Function of NS2 in Hepatitis C Virus Assembly and Release
    Minkyung Yi; Fiscal Year: 2010
    ....
  2. Replication Elements in the 5' End of the HCV Genome
    Minkyung Yi; Fiscal Year: 2004
    ..abstract_text> ..
  3. Functions of NS3 in HCV RNA Replication
    Minkyung Yi; Fiscal Year: 2006
    ..abstract_text> ..
  4. Function of NS2 in Hepatitis C Virus Assembly and Release
    Minkyung Yi; Fiscal Year: 2009
    ....