Research Topics
Species | Minkyung YiSummaryAffiliation: University of Texas Medical Branch Country: USA Publications
Research Grants
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Detail Information
Publications
Trans-complementation of an NS2 defect in a late step in hepatitis C virus (HCV) particle assembly and maturationMinkyung Yi
Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, USA
PLoS Pathog 5:e1000403. 2009..In aggregate, these results indicate that NS2 functions in trans, in a late-post assembly maturation step, perhaps in concert with NS5A, to confer infectivity to the HCV particle...- NS3 helicase domains involved in infectious intracellular hepatitis C virus particle assemblyYinghong Ma
Center for Hepatitis Research, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 1073, USA
J Virol 82:7624-39. 2008..These data reveal a previously unsuspected role for the NS3 helicase in early virion morphogenesis and provide a new perspective on HCV assembly... 
Antiviral suppression vs restoration of RIG-I signaling by hepatitis C protease and polymerase inhibitorsYuqiong Liang
Center for Hepatitis Research, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas 77555 1073, USA
Gastroenterology 135:1710-1718.e2. 2008..This study quantitatively assessed the rescue of IRF-3 signaling by NS3/4A inhibitors, compared with in vitro antiviral activity...- Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122Rohit K Jangra
Center for Hepatitis Research, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555 0610, USA
J Virol 84:6615-25. 2010..miR-122 is thus likely to act at an additional step in the virus life cycle... - Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chimeric hepatitis C virusMinkyung Yi
Center for Hepatitis Research, Institute for Human Infections and Immunity, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 1019, USA
J Virol 81:629-38. 2007..We conclude that interactions between NS2 and E1 and p7 as well as between NS2 and NS3 are essential for virus assembly and/or release and that each of these viral proteins plays an important role in this process... 
Screening for hepatitis C virus antiviral activity with a cell-based secreted alkaline phosphatase reporter replicon systemNigel Bourne
Department of Pediatrics, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0436, USA
Antiviral Res 67:76-82. 2005..We have found excellent agreement between the SEAP and RT-PCR assays. This phased system provides an efficient and cost-effective screen for compounds with antiviral activity against HCV...- Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cellsMinkyung Yi
Center for Hepatitis Research, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-1019, USA
Proc Natl Acad Sci U S A 103:2310-5. 2006..The ability of this genotype 1a virus to infect cultured cells will substantially benefit antiviral and vaccine discovery programs... - DDX6 (Rck/p54) is required for efficient hepatitis C virus replication but not for internal ribosome entry site-directed translationRohit K Jangra
Center for Hepatitis Research, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555 0610, USA
J Virol 84:6810-24. 2010..Thus, DDX6 helicase activity is essential for efficient HCV replication, reflecting essential roles for DDX6 in HCV genome amplification and/or maintenance of cellular homeostasis... - Hepatitis C virus NS2 protein serves as a scaffold for virus assembly by interacting with both structural and nonstructural proteinsYinghong Ma
Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 0610, USA
J Virol 85:86-97. 2011..p7 may play an accessory role by regulating NS2 membrane topology, which is important for NS2-mediated protein interactions and therefore NS2 function... - Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursorYan Yang
Center for Hepatitis Research, Institute for Human Infections and Immunity, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1019, USA
Proc Natl Acad Sci U S A 104:7253-8. 2007..The unique requirement for mitochondrial localization of 3ABC underscores the importance of mitochondria to host control of virus infections within the liver... - Genotype 1a HCV (H77S) infection systemMinkyung Yi
Center for Hepatitis Research, Institute for Human Infections and the Department of Microbiology and Immunology, University of Texas Galveston, TX, USA
Methods Mol Biol 510:337-46. 2009..Although significantly less efficient than JFH-1 RNA, H77S RNA produces moderate titers of cell culture-infectious virus when transfected into Huh-7 cells... - p21-activated kinase 1 is activated through the mammalian target of rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in human hepatoma cellsHisashi Ishida
Center for Hepatitis Research, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas 77555 1018, USA
J Biol Chem 282:11836-48. 2007..Taken together, the data indicate that p70 S6 kinase activates PAK1 and contributes to phosphatidylinositol 3-kinase- and ERK-mediated regulation of HCV RNA replication... - Adaptive mutations producing efficient replication of genotype 1a hepatitis C virus RNA in normal Huh7 cellsMinkyung Yi
Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, USA
J Virol 78:7904-15. 2004.... - Identification of a conserved RNA replication element (cre) within the 3Dpol-coding sequence of hepatovirusesYan Yang
Center for Hepatitis Research, 4 104 Blocker Medical Research Bldg, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1073, USA
J Virol 82:10118-28. 2008.... - In vitro selection of a neutralization-resistant hepatitis C virus escape mutantMeital Gal-Tanamy
Center for Hepatitis Research, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1073, USA
Proc Natl Acad Sci U S A 105:19450-5. 2008.... - 3' nontranslated RNA signals required for replication of hepatitis C virus RNAMinkyung Yi
Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555-1019, USA
J Virol 77:3557-68. 2003.... - Subgenomic hepatitis C virus replicons inducing expression of a secreted enzymatic reporter proteinMinkyung Yi
Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, 77555-1019, USA
Virology 304:197-210. 2002..Using this reporter system, we have demonstrated significant differences in the response to interferon alpha-2b in cell lines containing replicons derived from these two strains of HCV... - "Strong reasons make strong actions"--The antiviral efficacy of NS3/4A protease inhibitorsStanley M Lemon
Center for Hepatitis Research, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA
Hepatology 41:671-4. 2005 - Hepatitis C virus: propagation, quantification, and storageMinkyung Yi
The University of Texas Medical Branch at Galveston, Galveston, Texas, USA
Curr Protoc Microbiol . 2010.... - Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNACatherine L Jopling
Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
Science 309:1577-81. 2005..Therefore, miR-122 is likely to facilitate replication of the viral RNA, suggesting that miR-122 may present a target for antiviral intervention... - Structure-function analysis of the 3' stem-loop of hepatitis C virus genomic RNA and its role in viral RNA replicationMinkyung Yi
Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555-1019, USA
RNA 9:331-45. 2003..These features of stem-loop I are likely to facilitate recognition of the 3' end of the viral RNA by the viral RNA replicase... - Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cellsMasanori Ikeda
Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555-1019, USA
J Virol 76:2997-3006. 2002..We conclude that RNA derived from this documented infectious molecular clone has a unique capacity for replication in Huh7 cells in the absence of additional cell culture-adaptive mutations... - Replication of subgenomic hepatitis A virus RNAs expressing firefly luciferase is enhanced by mutations associated with adaptation of virus to growth in cultured cellsMinkyung Yi
Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555-1019, USA
J Virol 76:1171-80. 2002.... - Mutagenesis analysis of the rGTP-specific binding site of hepatitis C virus RNA-dependent RNA polymeraseZhaohui Cai
Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, 800 Rose St, MN477, Lexington, KY 40536-0298, USA
J Virol 79:11607-17. 2005..Collectively, these findings demonstrate that the rGTP-specific binding site of the HCV NS5B is not required for in vitro RdRp activity but is important for HCV RNA replication in vivo... - Conserved C-terminal threonine of hepatitis C virus NS3 regulates autoproteolysis and prevents product inhibitionWenyan Wang
Department of Structural Chemistry, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA
J Virol 78:700-9. 2004.... - Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutationsMinkyung Yi
Center for Hepatitis Research, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston 77555-1019, USA
J Biol Chem 281:8205-15. 2006....
Research Grants
- Function of NS2 in Hepatitis C Virus Assembly and ReleaseMinkyung Yi; Fiscal Year: 2010....
- Replication Elements in the 5' End of the HCV GenomeMinkyung Yi; Fiscal Year: 2004..abstract_text> ..
- Functions of NS3 in HCV RNA ReplicationMinkyung Yi; Fiscal Year: 2006..abstract_text> ..