R S Yeung

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Multiple roles of the tuberous sclerosis complex genes
    Raymond S Yeung
    Department of Surgery, University of Washington, Seattle, Washington, USA
    Genes Chromosomes Cancer 38:368-75. 2003
  2. ncbi request reprint Genetic identification of a locus, Mot1, that affects renal tumor size in the rat
    R S Yeung
    Department of Surgery, University of Washington, Seattle, Washington 98195, USA
    Genomics 78:108-12. 2001
  3. pmc Subependymal astrocytic hamartomas in the Eker rat model of tuberous sclerosis
    R S Yeung
    Division of Medical Sciences, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Am J Pathol 151:1477-86. 1997
  4. ncbi request reprint Lessons from the Eker rat model: from cage to bedside
    Raymond S Yeung
    Department of Surgery, University of Washington, Seattle, WA 98195, USA
    Curr Mol Med 4:799-806. 2004
  5. ncbi request reprint Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis
    L D Aicher
    Departments of Surgery, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 276:21017-21. 2001
  6. ncbi request reprint The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis
    G H Xiao
    Divisions of Medical, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 272:6097-100. 1997
  7. ncbi request reprint Assignment of 22 loci in the rat by somatic hybrid and linkage analysis
    R S Yeung
    Fox Chase Cancer Center, Department of Surgical Oncology, Philadelphia, Pennsylvania 19111
    Mamm Genome 4:585-8. 1993
  8. ncbi request reprint The Vpreb1 and comt genes are closely linked and sublocalized to rat chromosome 11q23
    R S Yeung
    Division of Medical Sciences, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mamm Genome 7:246-7. 1996
  9. pmc Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors
    E P Henske
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Am J Pathol 151:1639-47. 1997
  10. ncbi request reprint The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19
    R S Yeung
    Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111
    Oncogene 8:3465-8. 1993

Research Grants

  1. Pathogenesis of TSC2-Related Tumors
    Raymond Yeung; Fiscal Year: 2006
  2. In Vivo Studies of TSC-Related Tumorigenesis
    Raymond Yeung; Fiscal Year: 2007
  3. Pathogenesis of TSC2-Related Tumors
    Raymond Yeung; Fiscal Year: 2007
  4. CANCER SUSCEPTIBILITY IN AN ANIMAL MODEL
    Raymond Yeung; Fiscal Year: 2004
  5. PATHOGENESIS OF TSCE-RELATED TUMORS IN THE EKER RAT
    Raymond Yeung; Fiscal Year: 2001
  6. Pathogenesis of TSC2-Related Tumors
    Raymond Yeung; Fiscal Year: 2010

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Multiple roles of the tuberous sclerosis complex genes
    Raymond S Yeung
    Department of Surgery, University of Washington, Seattle, Washington, USA
    Genes Chromosomes Cancer 38:368-75. 2003
    ..Despite much experimental work, the mechanisms of these genes have remained elusive until recently. This review summarizes some of the current concepts in our understanding of the biological and biochemical function of the TSC genes...
  2. ncbi request reprint Genetic identification of a locus, Mot1, that affects renal tumor size in the rat
    R S Yeung
    Department of Surgery, University of Washington, Seattle, Washington 98195, USA
    Genomics 78:108-12. 2001
    ..01). Comparative genomics suggest that the Mot1 region is represented by human chromosomes 15q and 20pq. Our results provide the first evidence of a modifier gene affecting the Tsc2 pathway in the progression of renal tumorigenesis...
  3. pmc Subependymal astrocytic hamartomas in the Eker rat model of tuberous sclerosis
    R S Yeung
    Division of Medical Sciences, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Am J Pathol 151:1477-86. 1997
    ..This genetically-defined rodent model may be useful in elucidating the molecular and developmental basis of the subependymal giant cell astrocytoma in humans...
  4. ncbi request reprint Lessons from the Eker rat model: from cage to bedside
    Raymond S Yeung
    Department of Surgery, University of Washington, Seattle, WA 98195, USA
    Curr Mol Med 4:799-806. 2004
    ..The focus of our review is to highlight the contribution of the Eker rat towards understanding the Tsc2 signaling pathways in tumorigenesis and evaluating potential therapeutics in the pre-clinical setting...
  5. ncbi request reprint Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis
    L D Aicher
    Departments of Surgery, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 276:21017-21. 2001
    ..These findings suggest that phosphorylation may be a key regulatory mechanism controlling TSC1-TSC2 function...
  6. ncbi request reprint The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis
    G H Xiao
    Divisions of Medical, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 272:6097-100. 1997
    ..Re-expression of tuberin in TSC2 mutant cells reduced the rate of fluid-phase endocytosis. These findings suggest that tuberin functions as a Rab5GAP in vivo to negatively regulate Rab5-GTP activity in endocytosis...
  7. ncbi request reprint Assignment of 22 loci in the rat by somatic hybrid and linkage analysis
    R S Yeung
    Fox Chase Cancer Center, Department of Surgical Oncology, Philadelphia, Pennsylvania 19111
    Mamm Genome 4:585-8. 1993
    ..Results of this study further support the extensive conservation of synteny between the rat and mouse and, to a lesser degree, between rat and human...
  8. ncbi request reprint The Vpreb1 and comt genes are closely linked and sublocalized to rat chromosome 11q23
    R S Yeung
    Division of Medical Sciences, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mamm Genome 7:246-7. 1996
  9. pmc Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors
    E P Henske
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Am J Pathol 151:1639-47. 1997
    ..These results support a two-hit tumor suppressor model for the pathogenesis of SEGAs and angiomyolipomas. The vascular elements of angiomyolipomas and the giant cells of SEGAs may be reactive rather than neoplastic...
  10. ncbi request reprint The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19
    R S Yeung
    Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111
    Oncogene 8:3465-8. 1993
    ..Deletions of chromosome 16q have been found in several human neoplasias (including breast, ovarian, hepatic, and prostatic cancers) which is in support of an involvement of RB2 in human cancer as a tumor suppressor gene...
  11. pmc Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10
    R S Yeung
    Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111
    Proc Natl Acad Sci U S A 90:8038-42. 1993
    ..Our result suggested that the human homolog of the RC gene may reside on human chromosome 16, not known to be altered commonly in human RC...
  12. ncbi request reprint Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles
    T L Plank
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 58:4766-70. 1998
    ..If altered vesicular trafficking leads to tumorigenesis in tuberous sclerosis, TSC1 and TSC2 may have a novel mechanism of tumor suppression...
  13. ncbi request reprint Internal mammary lymph node drainage patterns in patients with breast cancer documented by breast lymphoscintigraphy
    D R Byrd
    Department of General Surgery, University of Washington Medical Center, Seattle 98195, USA
    Ann Surg Oncol 8:234-40. 2001
    ..The purpose of this study was to identify the frequency of IMN drainage in patients undergoing breast lymphoscintigraphy and sentinel lymph node dissection (SLND)...
  14. ncbi request reprint The tuberin-hamartin complex negatively regulates beta-catenin signaling activity
    Baldwin C Mak
    Department of Surgery, University of Washington, School of Medicine, Seattle, Washington 98195, USA
    J Biol Chem 278:5947-51. 2003
    ..Our data suggest that hamartin and tuberin negatively regulate beta-catenin stability and activity by participating in the beta-catenin degradation complex...
  15. ncbi request reprint The tuberous sclerosis complex genes in tumor development
    Baldwin C Mak
    Department of Surgery, University of Washington, Seattle, Washington 98195, USA
    Cancer Invest 22:588-603. 2004
    ..Rapamycin, a specific mTOR inhibitor, has potent antitumoral activities in preclinical models of TSC and is currently undergoing phase I/II clinical studies...
  16. doi request reprint Adverse events after radiofrequency ablation of unresectable liver tumors: a single-center experience
    Oliver B Lao
    Department of Surgery, University of Washington, Seattle, WA 98195, USA
    Am J Surg 198:76-82. 2009
    ..Radiofrequency ablation (RFA) is a relatively new modality to treat liver tumors that is being incorporated into practice despite the fact that its risk profile has not been well described...
  17. ncbi request reprint Identification of tuberous sclerosis 2 messenger RNA splice variants that are conserved and differentially expressed in rat and human tissues
    G H Xiao
    Division of Medical Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cell Growth Differ 6:1185-91. 1995
    ..These splice variants are highly conserved in the human gene, suggesting a possible functional role of these Tsc2 isoforms in various cell regulatory and developmental processes...
  18. ncbi request reprint Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin
    Yuji Yamamoto
    Department of Surgery, University of Washington, 1959 NE Pacific St, Box 356410, Seattle, WA 98195, USA
    Arch Biochem Biophys 404:210-7. 2002
    ..Our data suggest that hamartin and tuberin are multicompartmental proteins that partially reside in caveolin-1-enriched structures and potentially affect their signaling...
  19. ncbi request reprint Tuberous sclerosis as an underlying basis for infantile spasm
    Raymond S Yeung
    Department of Surgery, University of Washington, Seattle, Washington 98195, USA
    Int Rev Neurobiol 49:315-32. 2002
    ..These approaches, with their unique advantages and disadvantages, will be helpful in gaining insights into the development of cortical tubers and their electrophysiologic consequences...
  20. ncbi request reprint Tuberin is a component of lipid rafts and mediates caveolin-1 localization: role of TSC2 in post-Golgi transport
    Kathryn A Jones
    Department of Surgery, University of Washington, Seattle, WA 98195, USA
    Exp Cell Res 295:512-24. 2004
    ..The presence of mislocalized proteins in Tsc2-/- cells may contribute to the abnormal signaling and cellular phenotype of tuberous sclerosis...
  21. pmc Aberrant beta-catenin signaling in tuberous sclerosis
    Baldwin C Mak
    Department of Surgery, University of Washington, 1959 NE Pacific St, Box 356410, Seattle, WA 98195, USA
    Am J Pathol 167:107-16. 2005
    ..Collectively, our data provide further evidence that beta-catenin signaling plays a role in TSC pathogenesis in vivo and suggest a novel role of GSK3 in modulating the TSC1/TSC2 complex through TSC1 phosphorylation...
  22. ncbi request reprint Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
    Heidi L Kenerson
    Department of Surgery, University of Washington, Seattle 98195, USA
    Cancer Res 62:5645-50. 2002
    ..Our data provide in vivo evidence that the mTOR pathway is aberrantly activated in TSC renal pathology and that treatment with rapamycin appears effective in the preclinical setting...
  23. ncbi request reprint Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)
    Elena A Goncharova
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, 421 Curie Boulevard, 847 BRB II III, Philadelphia, PA 19104, USA
    J Biol Chem 277:30958-67. 2002
    ..These data demonstrate that tuberin negatively regulates the activity of S6 and p70S6K specifically, and suggest a potential mechanism for abnormal cell growth in LAM...
  24. ncbi request reprint Axillary web syndrome after axillary dissection
    A H Moskovitz
    Department of Surgery, Surgical Oncology Section, Bio-Clinical Breast Care Program, University of Washington, Box 356410, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Am J Surg 181:434-9. 2001
    ..More limited axillary surgery, with less lymphovenous disruption, might reduce the severity and incidence of this syndrome, although SLND does not eliminate its occurrence...
  25. pmc Laparoscopic liver resection
    Edgar J Figueredo
    Center for Videoendoscopic Surgery, Department of General Surgery, University of Washington, Seattle, USA
    Medscape J Med 10:68. 2008
  26. ncbi request reprint The role of tumor ablation in bridging patients to liver transplantation
    E William Johnson
    Department of Surgery, University of Washington School of Medicine, Seattle 98195, USA
    Arch Surg 139:825-9; discussion 829-30. 2004
    ..Treatment of hepatocellular carcinoma before liver transplantation can curb local tumor progression and thereby prolong patients' transplantation eligibility...
  27. ncbi request reprint Effects of rapamycin in the Eker rat model of tuberous sclerosis complex
    Heidi Kenerson
    Department of Surgery, University of Washington, 1959 NE Pacific Street, Box 356410, Seattle, WA 98195, USA
    Pediatr Res 57:67-75. 2005
    ..Our data also suggest the role of a rapamycin-insensitive pathway during tumor initiation...
  28. pmc The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake
    Xiuyun Jiang
    Department of Surgery, Box 356410, University of Washington, 1959 NE Pacific, Seattle, WA 98195, USA
    Am J Pathol 172:1748-56. 2008
    ..Together, these data show that mTORC1 activity is insufficient for increased glycolysis in tumors and that constitutive mTOR activity negatively regulates glucose transporter trafficking...
  29. pmc Activation of the mTOR pathway in sporadic angiomyolipomas and other perivascular epithelioid cell neoplasms
    Heidi Kenerson
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Hum Pathol 38:1361-71. 2007
    ..This suggests the possibility that mTOR inhibitors such as rapamycin may be therapeutic for this class of disease...
  30. ncbi request reprint Regulation of microtubule-dependent protein transport by the TSC2/mammalian target of rapamycin pathway
    Xiuyun Jiang
    Department of Surgery, University of Washington, Seattle, Washington 98195, USA
    Cancer Res 66:5258-69. 2006
    ..Together, these findings highlight a novel role of the TSC2/mTOR pathway in regulating microtubule-dependent protein transport...
  31. pmc The loss of tuberin promotes cell invasion through the ß-catenin pathway
    Elizabeth A Barnes
    University of Washington, Department of Surgery, Seattle, Washington 98195, USA
    Am J Respir Cell Mol Biol 43:617-27. 2010
    ....
  32. ncbi request reprint Morphology of cerebral lesions in the Eker rat model of tuberous sclerosis
    H Jurgen Wenzel
    Department of Neurological Surgery, University of California at Davis, 1 Shields Avenue, Davis, CA 95616, USA
    Acta Neuropathol 108:97-108. 2004
    ..Both normal-appearing and dysmorphic neurons, as well as cells in the hamartomas, exhibited immunopositivity for tuberin, the protein product of the TSC2 gene...
  33. ncbi request reprint Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
    Han C Dan
    Department of Pathology, Molecular Oncology, and Drug Discovery Programs, University of South Florida College of Medicine, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 277:35364-70. 2002
    ..Our results indicate that tuberin is a direct physiological substrate of Akt and that phosphorylation of tuberin by PI3K/Akt is a major mechanism controlling hamartin-tuberin function...
  34. ncbi request reprint Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
    Xinsheng Gao
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
    Nat Cell Biol 4:699-704. 2002
    ..Our studies identify Tsc1 and Tsc2 as regulators of the amino acid-TOR pathway and provide a new paradigm for how proteins involved in nutrient sensing function as tumour suppressors...
  35. doi request reprint Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Rac1 activation
    Tsukasa Suzuki
    Department of Applied Biology and Chemistry, Tokyo University of Agriculture, 1 1 1 Sakuragaoka, Setagaya Ku, Tokyo 156 8502, Japan
    Biochem Biophys Res Commun 368:132-7. 2008
    ..These results indicate that loss-of-function mutated tuberin can activate Rac1 and thereby increase ROS production...

Research Grants23

  1. Pathogenesis of TSC2-Related Tumors
    Raymond Yeung; Fiscal Year: 2006
    ..The results of these experiments will enable us to better understand the pathogenesis of tumor development and their clinical sequelae in tuberous sclerosis and related disorders. ..
  2. In Vivo Studies of TSC-Related Tumorigenesis
    Raymond Yeung; Fiscal Year: 2007
    ..Our long-term goal is to exploit the mechanisms of these pathways in the development of clinical therapy for TSC-related disorders. ..
  3. Pathogenesis of TSC2-Related Tumors
    Raymond Yeung; Fiscal Year: 2007
    ..However, the contribution and mechanism of mTOR in the pathogenesis of these tumors remains poorly understood. Over the last funding period, a wealth of genetic and biochemical studies have identified a ..
  4. CANCER SUSCEPTIBILITY IN AN ANIMAL MODEL
    Raymond Yeung; Fiscal Year: 2004
    ..Appreciation of these 'modifier' genes will impart new knowledge about the interplay between genes and environment during the development of complex diseases such as cancer. ..
  5. PATHOGENESIS OF TSCE-RELATED TUMORS IN THE EKER RAT
    Raymond Yeung; Fiscal Year: 2001
    ..Creating this network of information about tuberin and its interacting proteins will facilitate our long-term objective of identifying therapeutic targets that will benefit those who suffer from these devastating diseases. ..
  6. Pathogenesis of TSC2-Related Tumors
    Raymond Yeung; Fiscal Year: 2010
    ..Microtubules are critical to many cellular functions and have been a target of chemotherapeutic agents in cancer therapy. ..