S Yende

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Interplay between sepsis and chronic health
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA Electronic address
    Trends Mol Med 20:234-8. 2014
  2. pmc Epidemiology of severe sepsis
    Florian B Mayr
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Center University of Pittsburgh Pittsburgh, PA USA Department of Critical Care Medicine University of Pittsburgh, Pittsburgh, PA USA Department of Medicine University of Pittsburgh Pittsburgh, PA USA
    Virulence 5:4-11. 2014
  3. pmc The effects of age on inflammatory and coagulation-fibrinolysis response in patients hospitalized for pneumonia
    Sachin Kale
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e13852. 2010
  4. pmc Revisiting Mars and Venus: understanding gender differences in critical illness
    Michael C Reade
    Department of Intensive Care Medicine, Austin Hospital and University of Melbourne, Melbourne, VIC 3084, Australia
    Crit Care 15:180. 2011
  5. pmc Protocol-directed care in the ICU: making a future generation of intensivists less knowledgeable?
    Erik Diringer
    University of Pittsburgh Department of Critical Care Medicine, Pittsburgh, PA 15261, USA
    Crit Care 16:307. 2012
  6. pmc The influence of pre-existing diabetes mellitus on the host immune response and outcome of pneumonia: analysis of two multicentre cohort studies
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Thorax 65:870-7. 2010
  7. pmc Understanding the potential role of statins in pneumonia and sepsis
    Sachin Yende
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 39:1871-8. 2011
  8. pmc Elevated hemostasis markers after pneumonia increases one-year risk of all-cause and cardiovascular deaths
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e22847. 2011
  9. pmc Understanding genetics of sepsis: will new technology help?
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Crit Care 13:141. 2009
  10. ncbi request reprint Influence of comorbid conditions on long-term mortality after pneumonia in older people
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 55:518-25. 2007

Detail Information

Publications29

  1. pmc Interplay between sepsis and chronic health
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA Electronic address
    Trends Mol Med 20:234-8. 2014
    ..Here we review the epidemiologic studies examining the interplay between sepsis and chronic health and propose a conceptual model, which has implications for preclinical and human study design. ..
  2. pmc Epidemiology of severe sepsis
    Florian B Mayr
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Center University of Pittsburgh Pittsburgh, PA USA Department of Critical Care Medicine University of Pittsburgh, Pittsburgh, PA USA Department of Medicine University of Pittsburgh Pittsburgh, PA USA
    Virulence 5:4-11. 2014
    ..People of older age, male gender, black race, and preexisting chronic health conditions are particularly prone to develop severe sepsis; hence prevention strategies should be targeted at these vulnerable populations in future studies. ..
  3. pmc The effects of age on inflammatory and coagulation-fibrinolysis response in patients hospitalized for pneumonia
    Sachin Kale
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e13852. 2010
    ..To determine whether inflammatory and hemostasis response in patients hospitalized for pneumonia varies by age and whether these differences explain higher mortality in the elderly...
  4. pmc Revisiting Mars and Venus: understanding gender differences in critical illness
    Michael C Reade
    Department of Intensive Care Medicine, Austin Hospital and University of Melbourne, Melbourne, VIC 3084, Australia
    Crit Care 15:180. 2011
    ..However, if true gender effects can be identified, examination of their biological or psychosocial causes will be warranted...
  5. pmc Protocol-directed care in the ICU: making a future generation of intensivists less knowledgeable?
    Erik Diringer
    University of Pittsburgh Department of Critical Care Medicine, Pittsburgh, PA 15261, USA
    Crit Care 16:307. 2012
    ..Clinical Protocols and Trainee Knowledge About Mechanical Ventilation. JAMA. 2011; 306(9):935-941. PubMed PMID: 21900133 This is available on http://www.pubmed.gov..
  6. pmc The influence of pre-existing diabetes mellitus on the host immune response and outcome of pneumonia: analysis of two multicentre cohort studies
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Thorax 65:870-7. 2010
    ..Although diabetes mellitus is implicated in susceptibility to infection, the association of diabetes with the subsequent course and outcome is unclear...
  7. pmc Understanding the potential role of statins in pneumonia and sepsis
    Sachin Yende
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 39:1871-8. 2011
    ..To examine the association of statin use with clinical outcomes and circulating biomarkers in community-acquired pneumonia and sepsis...
  8. pmc Elevated hemostasis markers after pneumonia increases one-year risk of all-cause and cardiovascular deaths
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e22847. 2011
    ....
  9. pmc Understanding genetics of sepsis: will new technology help?
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Crit Care 13:141. 2009
    ..Careful attention should be paid to different aspects of study design and analyses as large, multicenter cohorts are assembled for genome-wide association studies...
  10. ncbi request reprint Influence of comorbid conditions on long-term mortality after pneumonia in older people
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 55:518-25. 2007
    ..To test the hypothesis that increased long-term mortality after hospitalization for community-acquired pneumonia (CAP) is independent of comorbid conditions...
  11. pmc Diabetes and sepsis outcomes--it is not all bad news
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Crit Care 13:117. 2009
    ..Their main conclusion was that diabetes patients, relative to non-diabetics, were less likely to develop respiratory failure and more likely to develop renal failure during the course of sepsis...
  12. pmc Preinfection systemic inflammatory markers and risk of hospitalization due to pneumonia
    Sachin Yende
    Department of Critical Care Medicine, 3550 Terrace Street, Pittsburgh PA 15261, USA
    Am J Respir Crit Care Med 172:1440-6. 2005
    ..Elevated proinflammatory cytokines are associated with severity of pneumonia, but the role of preinfection cytokine levels in the predisposition to pneumonia in humans is less clear...
  13. pmc Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjects
    S Yende
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, PA 15238, USA
    Thorax 61:10-6. 2006
    ..Inflammatory markers are increased in chronic obstructive pulmonary disease (COPD) and are hypothesised to play an important part in muscle dysfunction and exercise intolerance...
  14. pmc 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia
    Sachin Yende
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 176:1129-37. 2007
    ..Whether variation within the PAI-1 gene is associated with increased susceptibility to infection is unknown...
  15. pmc Genetics and proteomics: deciphering gene association studies in critical illness
    Sachin Yende
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care 10:227. 2006
    ....
  16. pmc Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival
    Raghavan Murugan
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 77:527-35. 2010
    ..29) was also present in those never admitted to an intensive care unit. Hence acute kidney injury is common even among patients with non-severe pneumonia and is associated with higher immune response and an increased risk of death...
  17. pmc The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    FASEB J 23:2403-11. 2009
    ..These data indicate that polymorphisms associated with higher MIF expression may have a beneficial effect in community-acquired pneumonia...
  18. pmc Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Respir Crit Care Med 177:1242-7. 2008
    ..Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown...
  19. pmc Differences in immune response may explain lower survival among older men with pneumonia
    Michael C Reade
    Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 37:1655-62. 2009
    ..We assessed if sex-related survival difference following community-acquired pneumonia (CAP) is due to differences in clinical characteristics, quality of care, or immune response...
  20. pmc Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis
    Florian B Mayr
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA
    JAMA 303:2495-503. 2010
    ..Severe sepsis, defined as infection complicated by acute organ dysfunction, occurs more frequently and leads to more deaths in black than in white individuals. The optimal approach to minimize these disparities is unclear...
  21. pmc Do hospitals provide lower quality of care to black patients for pneumonia?
    Florian B Mayr
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 38:759-65. 2010
    ..We examined racial differences in emergency department and intensive care unit care processes to determine whether differences persist after adjusting for case-mix and variation in care across hospitals...
  22. ncbi request reprint Genetic polymorphisms that predict outcome and need for treatment in cardiovascular disease
    Sachin Yende
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 12:420-5. 2006
    ..The focus is on risk of complications or differences in management, rather than only susceptibility to cardiovascular disease itself...
  23. ncbi request reprint Clinical relevance of angiotensin-converting enzyme gene polymorphisms to predict risk of mechanical ventilation after coronary artery bypass graft surgery
    Sachin Yende
    Physician Research Network SY, Methodist Healthcare Memphis, Memphis, TN, USA
    Crit Care Med 32:922-7. 2004
    ..Therefore, we examined interactions between these polymorphisms...
  24. ncbi request reprint Association of tumor necrosis factor gene polymorphisms and prolonged mechanical ventilation after coronary artery bypass surgery
    Sachin Yende
    Methodist Healthcare University Hospital, Memphis, TN, USA
    Crit Care Med 31:133-40. 2003
    ....
  25. ncbi request reprint Impact of cytokine gene polymorphisms on outcomes of coronary artery bypass graft surgery
    Sachin Yende
    Methodist Healthcare and University of Tennessee, Memphis, TN 38104, USA
    Chest 121:86S. 2002
  26. ncbi request reprint Role of toll-like receptor 4 mutations in gram-negative septic shock
    Sachin Yende
    Arch Intern Med 162:2496; author reply 2496. 2002