Leman Yel

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Arsenic trioxide induces apoptosis via the mitochondrial pathway by upregulating the expression of Bax and Bim in human B cells
    Abdullah Baysan
    Cellular and Molecular Immunology Laboratory, Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
    Int J Oncol 30:313-8. 2007
  2. pmc Selective IgA deficiency
    Leman Yel
    University of California, Irvine, Irvine, CA, USA
    J Clin Immunol 30:10-6. 2010
  3. ncbi request reprint Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondria
    Leman Yel
    Department of Medicine, University of California, Irvine, CA 92697, USA
    Int J Mol Med 16:971-7. 2005
  4. ncbi request reprint Severe T- and B-cell immune deficiency associated with malignant thymoma
    Leman Yel
    Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, California 92697, USA
    Ann Allergy Asthma Immunol 91:501-5. 2003
  5. ncbi request reprint Cellular immunodeficiency and autoimmunity in long-term mineral oil administration
    Leman Yel
    Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, California 92697, USA
    Ann Allergy Asthma Immunol 92:88-91. 2004
  6. ncbi request reprint Clinical and immunological features in IgM deficiency
    Leman Yel
    Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92697, USA
    Int Arch Allergy Immunol 150:291-8. 2009
  7. ncbi request reprint Arsenic trioxide induces apoptosis in peripheral blood T lymphocyte subsets by inducing oxidative stress: a role of Bcl-2
    Sudhir Gupta
    Cellular and Molecular Immunology Laboratory, Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA
    Mol Cancer Ther 2:711-9. 2003
  8. ncbi request reprint Characterization of naïve, memory and effector CD8+ T cells: effect of age
    Sudhir Gupta
    Division of Basic and Clinical Immunology, Medical Sciences C C 240, University of California, Irvine, CA 92697 4069, USA
    Exp Gerontol 39:545-50. 2004
  9. ncbi request reprint A role of fas-associated death domain (FADD) in increased apoptosis in aged humans
    Sudhir Gupta
    Molecular Biology and Cellular Immunology Laboratories, Division of Basic and Clinical Immunology, University of California, Irvine, Irvine, California 92697, USA
    J Clin Immunol 24:24-9. 2004
  10. pmc Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions
    Hong Zan
    Institute for Immunology, 3028 Hewitt Hall, University of California, Irvine, CA 92697 4120, United States
    Mol Immunol 48:610-22. 2011

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Arsenic trioxide induces apoptosis via the mitochondrial pathway by upregulating the expression of Bax and Bim in human B cells
    Abdullah Baysan
    Cellular and Molecular Immunology Laboratory, Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
    Int J Oncol 30:313-8. 2007
    ..Altogether, these data indicate that As2O3 induces apoptosis in B cells, regardless of Bcl-2 expression, via the mitochondrial pathway by enhancing oxidative stress...
  2. pmc Selective IgA deficiency
    Leman Yel
    University of California, Irvine, Irvine, CA, USA
    J Clin Immunol 30:10-6. 2010
    ..Despite this critical role, there may be some compensatory mechanisms that would prevent disease manifestations in some IgA-deficient individuals...
  3. ncbi request reprint Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondria
    Leman Yel
    Department of Medicine, University of California, Irvine, CA 92697, USA
    Int J Mol Med 16:971-7. 2005
    ..Finally, caspase-9 and caspase-3 were activated in the absence of caspase-8 activation. Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironment...
  4. ncbi request reprint Severe T- and B-cell immune deficiency associated with malignant thymoma
    Leman Yel
    Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, California 92697, USA
    Ann Allergy Asthma Immunol 91:501-5. 2003
    ..Typically, thymic tumors are benign, and gradually developing immunodeficiency consists of hypogammaglobulinemia with low B-cell counts and an inverted CD4+/CD8+ T-cell ratio due to excessive CD8+ T cells...
  5. ncbi request reprint Cellular immunodeficiency and autoimmunity in long-term mineral oil administration
    Leman Yel
    Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, California 92697, USA
    Ann Allergy Asthma Immunol 92:88-91. 2004
    ..Infection, ulceration, subcutaneous nodules, and autoimmune activation are among the known adverse effects. Immunodeficiency has not been previously reported in association with mineral oil injection...
  6. ncbi request reprint Clinical and immunological features in IgM deficiency
    Leman Yel
    Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92697, USA
    Int Arch Allergy Immunol 150:291-8. 2009
    ..Patients with IgM deficiency may exhibit various clinical manifestations. However, IgM deficiency still remains to be explored with regard to diagnosis and treatment...
  7. ncbi request reprint Arsenic trioxide induces apoptosis in peripheral blood T lymphocyte subsets by inducing oxidative stress: a role of Bcl-2
    Sudhir Gupta
    Cellular and Molecular Immunology Laboratory, Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA
    Mol Cancer Ther 2:711-9. 2003
    ..These data indicate that As(2)O(3) induces apoptosis in T cells by enhancing oxidative stress and that Bcl-2 appears to play a major role in As(2)O(3)-induced apoptosis...
  8. ncbi request reprint Characterization of naïve, memory and effector CD8+ T cells: effect of age
    Sudhir Gupta
    Division of Basic and Clinical Immunology, Medical Sciences C C 240, University of California, Irvine, CA 92697 4069, USA
    Exp Gerontol 39:545-50. 2004
    ..In this article, we have further defined naïve, central memory, effector memory, and effector CD8+ T cells in humans and their changes in aged humans...
  9. ncbi request reprint A role of fas-associated death domain (FADD) in increased apoptosis in aged humans
    Sudhir Gupta
    Molecular Biology and Cellular Immunology Laboratories, Division of Basic and Clinical Immunology, University of California, Irvine, Irvine, California 92697, USA
    J Clin Immunol 24:24-9. 2004
    ..These data suggest that FADD plays an important role in increased apoptosis in aged lymphocytes signaled via TNF-R...
  10. pmc Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions
    Hong Zan
    Institute for Immunology, 3028 Hewitt Hall, University of California, Irvine, CA 92697 4120, United States
    Mol Immunol 48:610-22. 2011
    ..Rather, it was associated with significantly reduced frequency of DSBs. Thus, our findings determine a role for EndoG in the generation of S region DSBs and CSR...
  11. ncbi request reprint Effect of age on molecular signaling of TNF-alpha-induced apoptosis in human lymphocytes
    Sudhir Gupta
    Laboratories of Cellular and Molecular Immunology and Molecular Biology Division of Basic and Clinical Immunology, Medical Sciences I, C 240, University of California, Irvine, CA 92697, USA
    Mech Ageing Dev 124:503-9. 2003
    ..T cells and T cell subsets from aged humans are more sensitive to TNF-alpha-induced apoptosis, which appears to be due to both an increased apoptotic signaling and decreased survival signals...
  12. ncbi request reprint Health-related quality of life and treatment satisfaction in North American patients with primary immunedeficiency diseases receiving subcutaneous IgG self-infusions at home
    Uwe Nicolay
    Section of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
    J Clin Immunol 26:65-72. 2006
    ..Treatment satisfaction was significantly improved in Group A. The preference for the subcutaneous route and for home therapy was respectively 81% and 90% in Group A. In Group B, 69% preferred the subcutaneous route and 92% home therapy...
  13. ncbi request reprint Defective anti-polysaccharide antibody response in patients with ataxia-telangiectasia
    Ozden Sanal
    Department of Molecular Biology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 46:208-13. 2004
    ..Our results suggest that the extent and severity of the recurrent sinopulmonary infections may depend not only on the immunological defects but also on other ATM-dependent physiological responses...
  14. ncbi request reprint Antibody response to a seven-valent pneumococcal conjugated vaccine in patients with ataxia-telangiectasia
    Ozden Sanal
    Immunology Division, Ihsan Dogramaci Children s Hospital, Hacettepe University, 06100 Ankara, Turkey
    J Clin Immunol 24:411-7. 2004
    ..In conclusion, A-T patients failed to respond to one dose of PCV7 vaccine. Two or more doses of conjugated vaccine may be required to recruit the help of T lymphocytes in A-T patients...
  15. ncbi request reprint Griscelli disease: genotype-phenotype correlation in an array of clinical heterogeneity
    Ozden Sanal
    Hacettepe University, Ihsan Dogramaci Children s Hospital, Immunology Division, Ankara, Turkey
    J Clin Immunol 22:237-43. 2002
    ..This genotype-phenotype correlation suggests that the natural course of the disease and outcome is dictated by the site and type of the genetic mutation...