Research Topics
Genomes and Genes | Yerem YeghiazariansSummaryAffiliation: University of California Country: USA Publications
| Collaborators
|
Detail Information
Publications
Myocardial improvement with human embryonic stem cell-derived cardiomyocytes enriched by p38MAPK inhibitionYerem Yeghiazarians
Department of Medicine, University of California, San Francisco, California 94143 1346, USA
Cytotherapy 14:223-31. 2012....
Cytokine combination therapy with long-acting erythropoietin and granulocyte colony stimulating factor improves cardiac function but is not superior than monotherapy in a mouse model of acute myocardial infarctionYerem Yeghiazarians
Division of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, California 94143 0103, USA
J Card Fail 16:669-78. 2010..We first established the optimal and clinically applicable dosages of these drugs in mobilizing hematopoietic stem cells (HSC), and then tested the efficacy of monotherapy and combination therapy post-MI...- Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapyYerem Yeghiazarians
Department of Medicine, University of California San Francisco, 94143 0103, USA
Mol Ther 17:1250-6. 2009..Intact cells are not necessary and death of implanted cells may be a major component of the benefit... - Cytokine combination therapy with erythropoietin and granulocyte colony stimulating factor in a porcine model of acute myocardial infarctionFranca S Angeli
Division of Cardiology, Department of Medicine, University of California, 505 Parnassus Avenue, L 523, Box 0103, San Francisco, CA 94143 0103, USA
Cardiovasc Drugs Ther 24:409-20. 2010..We investigated the impact of prolonged combination therapy with EPO and GCSF on cardiac function, infarct size, and vascular density after MI in a porcine model... - Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injuryJianqin Ye
Division of Cardiology, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 7:e30329. 2012..Cardiospheres (CSs) have been proposed to have cardiac regenerative properties; however, their cellular composition and how they may be influenced by the tissue milieu remains unclear... - Treatment of pulmonary arterial hypertension with circulating angiogenic cellsRachel Mirsky
Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
Am J Physiol Lung Cell Mol Physiol 301:L12-9. 2011..Future studies should be geared toward either earlier therapeutic time points with varying doses of unmodified CACs or genetically modified cells as a means of delivery of factors to the pulmonary arterial circulation... - Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery diseaseChristian Heiss
Division of Cardiology, University of California San Francisco, San Francisco, California, USA
J Am Coll Cardiol 56:218-24. 2010.... - A comparison of echocardiography to invasive measurement in the evaluation of pulmonary arterial hypertension in a rat modelJuha W Koskenvuo
Division of Cardiology, Department of Medicine, University of California, 505 Parnassus Avenue, Box 0103, San Francisco, CA 94143, USA
Int J Cardiovasc Imaging 26:509-18. 2010..These non-invasive parameters may be used to replace invasive measurements in detecting successful disease induction and to complement invasive data in the evaluation of PAH severity in a rat model... - Granulocyte colony stimulating factor in myocardial infarction with low ejection fractionFranca S Angeli
Division of Cardiology, Department of Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0103, USA
Cytokine 51:278-85. 2010..We investigated the safety and efficacy of GCSF therapy in a porcine model of ischemia-reperfusion with left ventricle ejection fraction of <45% using a clinically relevant dosing and timing regimen... - Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide productionChristian Heiss
Division of Cardiology, Department of Medicine, University of California, San Francisco, California 94143 0103, USA
J Am Coll Cardiol 51:1760-71. 2008..This study sought to analyze the effects of acute secondhand smoke (SHS) exposure on the number and function of endothelial progenitor cells (EPCs) over 24 h... - Timing of bone marrow cell therapy is more important than repeated injections after myocardial infarctionYan Zhang
Division of Cardiology, Department of Medicine, University of California San Francisco, CA 94143 0103, USA
Cardiovasc Pathol 20:204-12. 2011..Bone marrow cell treatment has been proposed as a therapy for myocardial infarction, but the optimal timing and number of injections remain unknown... - Nitric oxide synthase expression and functional response to nitric oxide are both important modulators of circulating angiogenic cell response to angiogenic stimuliChristian Heiss
Division of Cardiology, University of California, San Francisco, San Francisco, CA 94143 0124, USA
Arterioscler Thromb Vasc Biol 30:2212-8. 2010..The role of nitric oxide (NO) in CAC function is poorly understood. We hypothesized that CAC migration toward angiogenic signals is modulated by both NO synthase (NOS) expression and functional response to NO... - Evidence of diminished coronary flow in pulmonary hypertension: explaining angina pectoris in this patient group?Juha W Koskenvuo
Division of Cardiology, Department of Medicine, University of California, San Francisco, USA
Clin Physiol Funct Imaging 31:477-84. 2011..The role of pulmonary artery dilatation, septal wall motion abnormality, cardiac output or diastolic blood pressure in determining coronary blood flow (CBF) during PH was determined... - Prolonged therapy with erythropoietin is safe and prevents deterioration of left ventricular systolic function in a porcine model of myocardial infarctionFranca S Angeli
Division of Cardiology, Department of Medicine, University of California, San Francisco, CA 94143 0103, USA
J Card Fail 16:579-89. 2010..Erythropoietin (EPO) has generated interest as a novel therapy after myocardial infarction (MI), but the safety and efficacy of prolonged therapy have not been studied in a large animal model of reperfused MI... - Increased CD62e(+) endothelial microparticle levels predict poor outcome in pulmonary hypertension patientsNicolas Amabile
Department of Medicine, Division of Cardiology, University of California at San Francisco, San Francisco, California, USA
J Heart Lung Transplant 28:1081-6. 2009..We hypothesized that the levels of circulating EMPs and LMPs could predict outcome in these patients... - Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approachesJunya Takagawa
Department of Medicine, Division of Cardiology, University of California, San Francisco, 513 Parnassus Ave, Rm S1136, Box 0124, San Francisco, CA 94143 0124, USA
J Appl Physiol 102:2104-11. 2007.... - Timed inhibition of p38MAPK directs accelerated differentiation of human embryonic stem cells into cardiomyocytesMeenakshi Gaur
Department of Medicine, University of California, San Francisco, California, USA
Cytotherapy 12:807-17. 2010..As others have shown that p38 mitogen-activated protein kinase (p38MAPK) directs neurogenesis from mouse embryonic stem cells, we investigated whether the p38MAPK inhibitor, SB203580, might influence hCM differentiation... - Left ventricular remodeling after myocardial infarction: characterization of a swine model on beta-blocker therapyFranca S Angeli
Division of Cardiology, Department of Medicine, University of California, San Francisco, California, USA
Comp Med 59:272-9. 2009..These findings suggest a dynamic pattern of remodeling over time in a closed-chest ischemia-reperfusion swine model of acute MI on beta-blocker therapy and may guide future studies... - Fractionation of mouse bone-marrow cells limits functional efficacy in non-reperfused mouse model of acute myocardial infarctionJuha W Koskenvuo
Division of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
Ann Med 44:829-35. 2012.... 
Validation of the wall motion score and myocardial performance indexes as novel techniques to assess cardiac function in mice after myocardial infarctionYan Zhang
Division of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0124, USA
Am J Physiol Heart Circ Physiol 292:H1187-92. 2007..These novel parameters provide additional noninvasive assessment of regional and global LV function in mice after MI...- Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction: differences between mice and manAndrew J Boyle
Department of Medicine, Division of Cardiology, University of California San Francisco, USA
J Transl Med 9:150. 2011..It remains unknown if they are produced by, and released from, the heart in order to attract stem cells to repair the damaged myocardium... - Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagyAndrew J Boyle
Department of Medicine, Division of Cardiology, University of California San Francisco, San Francisco, CA 94143, United States
Exp Gerontol 46:549-59. 2011..In conclusion, we describe the functional, structural and genetic changes in murine hearts as they first develop cardiomyopathy of aging... - Sterile radial artery granuloma after transradial cardiac catheterizationChristian Zellner
Division of Cardiology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
Cardiovasc Revasc Med 12:187-9. 2011..The clinical presentation was suggestive of an infected pseudoaneurysm. Awareness of this entity may help clinicians avoid unnecessary surgical procedures, as these granulomata are transient self-limiting reactions... - Multivessel coronary artery disease predicts mortality, length of stay, and pressor requirements after liver transplantationCelina M Yong
Division of Cardiology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
Liver Transpl 16:1242-8. 2010..This study provides preliminary evidence showing that there may be significant prognostic value in coronary angiography as a part of the pretransplant workup... - Topical nitroglycerin and lidocaine locally vasodilate the radial artery without affecting systemic blood pressure: a dose-finding phase I studyDavid T Majure
Department of Medicine, Division of Cardiology, University of California San Francisco, San Francisco, CA 94143, USA
J Crit Care 27:532.e9-13. 2012..We performed this study to determine if topical nitroglycerin and/or nitroglycerin plus topical lidocaine increases RAD without affecting systemic blood pressure... - Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory responseXiaoyin Wang
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
Sci Transl Med 3:100ra90. 2011..Our findings offer an explanation of why human trials have not matched the success of rodent experiments and suggest potential strategies to improve the success of clinical autologous BMC therapy... - In vivo measurement of flow-mediated vasodilation in living rats using high-resolution ultrasoundChristian Heiss
Division of Cardiology, Department of Medicine, University of California, San Francisco 94143 0124, USA
Am J Physiol Heart Circ Physiol 294:H1086-93. 2008..To our knowledge, this is the first integrative physiological model to reproducibly study FMD of conduit arteries in living rats... - Circulating endothelial microparticle levels predict hemodynamic severity of pulmonary hypertensionNicolas Amabile
Division of Cardiology, Department of Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0103, USA
Am J Respir Crit Care Med 177:1268-75. 2008..Endothelial MPs are a biological marker of dysfunctional endothelium. Vascular remodeling and endothelial dysfunction are involved in pulmonary hypertension (PH)... - Sterile radial artery granuloma after transradial procedures: a unique and avoidable complicationChristian Zellner
Department of Medicine, University of California, San Francisco, CA, USA
Catheter Cardiovasc Interv 76:673-6. 2010..2010 Wiley-Liss, Inc... - CD45-positive cells are not an essential component in cardiosphere formationJianqin Ye
Department of Medicine, Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA
Cell Tissue Res 351:201-5. 2013..0001). Purified CD45(+) cells from CS-forming cells did not form CSs in culture. Thus, BM-derived CD45(+) cells including BM progenitors are neither necessary nor sufficient for CS formation... - Injection of human bone marrow and mononuclear cell extract into infarcted mouse hearts results in functional improvementFranca S Angeli
Division of Cardiology, Department of Medicine, University of California, San Francisco, USA
Open Cardiovasc Med J 6:38-43. 2012..It is not clear if these results are translatable to extracts from human BMC (hBMC) or mononuclear cells (hMNC), which would have significant clinical implications... - Closure of a para-valvular aortic leak: with the use of 2 AMPLATZER devices and real-time 2- and 3-dimensional transesophageal echocardiographyKurt S Hoffmayer
Division of Cardiology, Department of Medicine, University of California, San Francisco San Francisco, California 94143, USA
Tex Heart Inst J 38:81-4. 2011..The early outcome of the procedure was favorable and without sequelae. To our knowledge, this is the 1st report of the closing of an aortic paravalvular leak with the use of 2 closure devices and real-time echocardiographic guidance... - Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cellsChristian Heiss
Department of Medicine, Division of Cardiology, University of California, San Francisco, San Francisco, California 94143 0124, USA
J Cell Physiol 215:366-73. 2008..These data suggest that PTN may mediate its pro-angiogenic effects by increasing the local number of not only endothelial cells but also early EPCs at angiogenic sites... - Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiographyMatthew L Springer
Division of Cardiology, Department of Medicine, University of California, San Francisco, California 94143 0124, USA
Am J Physiol Heart Circ Physiol 289:H1307-14. 2005..The use of this system will allow more precise cellular implantation into the mouse myocardium by accurately guiding injections to desired locations, confirming successful implantation of cells, in a clinically relevant time frame... - Peripheral arterial function in infants and young children with one-ventricle physiology and hypoxemiaShobha Natarajan
Division of Pediatric Cardiology, University of California San Francisco, San Francisco, CA, USA
Am J Cardiol 103:862-6. 2009.... - Safety of cardiac catheterization in patients with end-stage liver disease awaiting liver transplantationMadan Sharma
Division of Cardiology, University of California, San Francisco, San Francisco, California, USA corrected
Am J Cardiol 103:742-6. 2009..In conclusion, despite severe coagulopathy, left-sided cardiac catheterization may be performed safely in this patient population, with correction of coagulopathy and meticulous attention to procedural technique... - Roles of matrix metalloproteinases in flow-induced outward vascular remodelingRyo Ota
Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94110, USA
J Cereb Blood Flow Metab 29:1547-58. 2009..These data revealed that MMPs, especially MMP-9, are critical in flow-induced outward vascular remodeling... - Another kind of broken heartCharles S Smith
Division of Cardiology, Department of Medicine, University of California San Francisco Medical Center, CA 94143-0124, USA
Am J Med 121:687-90. 2008 - A murine model of isolated cardiac steatosis leads to cardiomyopathyDENIS J GLENN
Department of Medicine and Diabetes Center, University of California at San Francisco, San Francisco, CA 94143 0540, USA
Hypertension 57:216-22. 2011..These findings suggest that triglyceride accumulation, in the absence of systemic metabolic derangement, results in cardiac dysfunction and decreased mitochondrial biogenesis... - Left ventricular rupture due to HIV-associated T-cell lymphomaEhrin J Armstrong
Division of Cardiology, University of California, San Francisco 94143, California, USA
Tex Heart Inst J 37:457-60. 2010..We conclude that noncoronary causes of chest pain, including direct myocardial infiltration, should be considered in immunocompromised patients with lymphoma... - Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophySongcang Chen
Diabetes Center UCSF, San Francisco, CA 94143 0540, USA
Circulation 124:1838-47. 2011..Using Cre-Lox technology we have selectively deleted the vitamin D receptor (VDR) gene in the cardiac myocyte in an effort to better understand the role of vitamin D in regulating myocyte structure and function... - Atherosclerotic renal artery stenosis--diagnosis and treatmentDavid Lao
Division of Cardiology, University of California San Francisco, San Francisco, CA 94143 0103, USA
Mayo Clin Proc 86:649-57. 2011.... - Rotational vs. standard coronary angiography: an image content analysisJoel A Garcia
Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Catheter Cardiovasc Interv 73:753-61. 2009..To evaluate the clinical utility of images acquired from rotational coronary angiographic (RA) acquisitions compared to standard "fixed" coronary angiography (SA)... - Anomalous origin of the left coronary artery from the pulmonary artery: a case series and brief reviewAndrew C Lee
Division of Cardiology, University of California, San Francisco, CA 94143, USA
Congenit Heart Dis 1:111-5. 2006..We review the pathophysiology of this rare congenital anomaly and discuss some of the signs, symptoms, and diagnostic tests that can help diagnose this unusual condition in adults... - Determination of adequate coronary stent expansion using StentBoost, a novel fluoroscopic image processing techniqueJacob M Mishell
Division of Cardiology, Department of Medicine, University of California, San Francisco, California, USA
Catheter Cardiovasc Interv 69:84-93. 2007..We tested the hypothesis that the use of motion-corrected fluoroscopic images results in enhanced coronary stent visualization and improved detection of inadequate stent expansion... - Phonocardiographic timing of third and fourth heart sounds during acute myocardial infarctionIan S Harris
Division of Cardiology, Department of Medicine, University of California-San Francisco Medical Center, San Francisco, CA 94143-0124, USA
J Electrocardiol 39:305-9. 2006..In this report, the sequence of these events is discussed, and the literature is reviewed... - Is it time to burst the "balloon" for high-risk patients?Sukesh C Burjonroppa
Cardiology Division, Heart and Vascular Center, UCSF, San Francisco, CA 94143, USA
J Invasive Cardiol 19:347-8. 2007