Leland J Yee

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection
    L J Yee
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Genes Immun 10:365-72. 2009
  2. ncbi Inducible nitric oxide synthase gene (NOS2A) haplotypes and the outcome of hepatitis C virus infection
    L J Yee
    Hepatology Division, Imperial College Faculty of Medicine at St Mary s Hospital, London, UK
    Genes Immun 5:183-7. 2004
  3. ncbi Host genetic determinants in hepatitis C virus infection
    L J Yee
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Genes Immun 5:237-45. 2004
  4. ncbi Polymorphism in the human major histocompatibility complex and early viral decline during treatment of chronic hepatitis C
    Leland J Yee
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Antimicrob Agents Chemother 53:615-21. 2009
  5. ncbi Myxovirus-1 and protein kinase haplotypes and fibrosis in chronic hepatitis C virus
    Leland J Yee
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Hepatology 46:74-83. 2007
  6. ncbi Associations between serum lipids and hepatitis C antiviral treatment efficacy
    Darmendra Ramcharran
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Hepatology 52:854-63. 2010
  7. ncbi Host genetics, steatosis and insulin resistance among African Americans and Caucasian Americans with hepatitis C virus genotype-1 infection
    A Danielle Iuliano
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Intervirology 52:49-56. 2009
  8. ncbi Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR
    S Knapp
    Hepatology Section, Faculty of Medicine, Imperial College of Science, Medicine and Technology at St Mary s Hospital, London, UK
    Genes Immun 4:411-9. 2003
  9. ncbi Association of CTLA4 polymorphisms with sustained response to interferon and ribavirin therapy for chronic hepatitis C virus infection
    Leland J Yee
    Program in Epidemiology of Infection and Immunity, Department of Epidemiology, School of Public Health, University of Alabama at Birmingham Liver Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Infect Dis 187:1264-71. 2003
  10. ncbi Interleukin 10 polymorphisms as predictors of sustained response in antiviral therapy for chronic hepatitis C infection
    L J Yee
    Program in Epidemiology of Infection and Immunity, Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 35294 0022, USA
    Hepatology 33:708-12. 2001

Collaborators

Detail Information

Publications15

  1. ncbi Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection
    L J Yee
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Genes Immun 10:365-72. 2009
    ..Our findings provide additional support for the potential importance of genetic variation in the IL-6 gene and the response to HCV therapy...
  2. ncbi Inducible nitric oxide synthase gene (NOS2A) haplotypes and the outcome of hepatitis C virus infection
    L J Yee
    Hepatology Division, Imperial College Faculty of Medicine at St Mary s Hospital, London, UK
    Genes Immun 5:183-7. 2004
    ..268) or sustained response (P>0.171). Combinations of haplotypes 1/4 were more likely to respond to interferon monotherapy in comparison of initial responders to nonresponders (OR=2.25; 95% CI: 1.05-5.68; P=0.0275)...
  3. ncbi Host genetic determinants in hepatitis C virus infection
    L J Yee
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Genes Immun 5:237-45. 2004
    ..Replication studies are needed for many of these associations, as well as biological data on the function of many of these polymorphisms...
  4. ncbi Polymorphism in the human major histocompatibility complex and early viral decline during treatment of chronic hepatitis C
    Leland J Yee
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Antimicrob Agents Chemother 53:615-21. 2009
    ..018), in CA carriers for Cw*03 (2.99; P = 0.046), and in CA noncarriers for DQA1*04 (2.66; P = 0.018) or DQB1*0402 (2.65; P = 0.018). MHC alleles are associated with the viral decline during the first 28 days of peginterferon therapy...
  5. ncbi Myxovirus-1 and protein kinase haplotypes and fibrosis in chronic hepatitis C virus
    Leland J Yee
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Hepatology 46:74-83. 2007
    ..CONCLUSION: In addition to other factors, polymorphisms in cytokine genes may play a role in the progression of HCV-related fibrosis; however, further studies are needed...
  6. ncbi Associations between serum lipids and hepatitis C antiviral treatment efficacy
    Darmendra Ramcharran
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Hepatology 52:854-63. 2010
    ..The results of this study are compatible with proposed biological mechanisms of HCV entry, replication, and secretion, and may underscore new potential therapeutic targets for HCV eradication...
  7. ncbi Host genetics, steatosis and insulin resistance among African Americans and Caucasian Americans with hepatitis C virus genotype-1 infection
    A Danielle Iuliano
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Intervirology 52:49-56. 2009
    ..These results could imply that some IL10,LEPR and TGF-beta1 polymorphisms may modify an association between steatosis and IR...
  8. ncbi Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR
    S Knapp
    Hepatology Section, Faculty of Medicine, Imperial College of Science, Medicine and Technology at St Mary s Hospital, London, UK
    Genes Immun 4:411-9. 2003
    ..45-5.24; P=0.002). Further associations were found with a CGG trinucleotide repeat in the 5'UTR region of the PKR gene. Polymorphisms in the interferon-induced genes, MxA, OAS-1 and PKR appear thus associated with HCV outcome...
  9. ncbi Association of CTLA4 polymorphisms with sustained response to interferon and ribavirin therapy for chronic hepatitis C virus infection
    Leland J Yee
    Program in Epidemiology of Infection and Immunity, Department of Epidemiology, School of Public Health, University of Alabama at Birmingham Liver Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Infect Dis 187:1264-71. 2003
    ..0095) and the -318C-49G haplotype. CTLA4 49G in exon 1 alone and in a haplotype with -318C promoter is associated with sustained IFNalpha+R response in white patients with HCV genotype 1 infection...
  10. ncbi Interleukin 10 polymorphisms as predictors of sustained response in antiviral therapy for chronic hepatitis C infection
    L J Yee
    Program in Epidemiology of Infection and Immunity, Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 35294 0022, USA
    Hepatology 33:708-12. 2001
    ..In conclusion, homozygosity for -592A, -819T or the extended haplotype (108bp) - (-2575T) - (-2763C) - (-1082A) - (-819T) - (-592A) is associated with SR to IFN + R...
  11. ncbi HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma
    M Tevfik Dorak
    Department of Epidemiology and Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    J Med Virol 76:302-10. 2005
    ..Alternatively, the relationship might hold a clue to the predilection of KS for men because that haplotype harbors the mutant form of the 21-hydroxylase gene...
  12. ncbi C-C chemokine receptor 2 and C-C chemokine receptor 5 genotypes in patients treated for chronic hepatitis C virus infection
    M Tevfik Dorak
    Department of Epidemiology and International Health, School of Public Health, Comprehensive Cancer Center, University of Alabama at Birmingham, 35294 0022, USA
    Immunol Res 26:167-75. 2002
    ..016). Differential receptor expression due to E/E homozygosity in HCV infection remains to be confirmed...
  13. ncbi Antinuclear antibodies (ANA) in chronic hepatitis C virus infection: correlates of positivity and clinical relevance
    L J Yee
    London School of Hygiene and Tropical Medicine, London, UK
    J Viral Hepat 11:459-64. 2004
    ..Our observation of increased plasma cells in ANA+ biopsies might suggest B-cell polyclonal activity with a secondary clinical manifestation of increased serum immunoglobulins...
  14. ncbi Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infection
    Branwen J Hennig
    The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK
    Liver Int 27:1134-43. 2007
    ..IL-22, an IL-10 homologue, shares the IL-10RB receptor chain with IL-10 and has antiviral properties. We investigated the possible role of polymorphisms in the IL-10RA and IL-22 genes in hepatitis C disease pathogenesis...
  15. ncbi 24 weeks of interferon-ribavirin therapy should not routinely be given to all hepatitis C patients
    D J van Leeuwen
    Am J Gastroenterol 97:497-8. 2002