Research Topics
| Michael YeamanSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Mechanisms of antimicrobial peptide action and resistanceMichael R Yeaman
Division of Infectious Diseases, Harbor University of California Los Angeles Medical Center, Torrance, California, USA
Pharmacol Rev 55:27-55. 2003..From these perspectives, the intention of this review is to illustrate the contemporary structural and functional themes among mechanisms of antimicrobial peptide action and resistance...
Susceptibility to thrombin-induced platelet microbicidal protein is associated with increased fluconazole efficacy against experimental endocarditis due to Candida albicansMichael R Yeaman
Division of Infectious Diseases, St John s Cardiovascular Research Center, Harbor UCLA Research and Education Institute, Torrance, California 90502, USA
Antimicrob Agents Chemother 48:3051-6. 2004..albicans IE in vivo, particularly in tissues in which platelets and tPMP-1 likely play significant roles in host defense...- Antimicrobial peptides versus invasive infectionsM R Yeaman
Division of Infectious Diseases, David Geffen School of Medicine at UCLA, LAC Harbor UCLA Medical Center, Torrance 90502, USA
Curr Top Microbiol Immunol 306:111-52. 2006..In addition, this knowledge may accelerate development of novel anti-infective agents and strategies against pathogens that have become refractory to conventional antimicrobials... - Modular determinants of antimicrobial activity in platelet factor-4 family kinocidinsMichael R Yeaman
Division of Infectious Diseases, LAC Harbor UCLA Medical Center, Torrance, CA 90509, USA
Biochim Biophys Acta 1768:609-19. 2007..Collectively, these results suggest that modular determinants arising from structural components acting independently and cooperatively govern the antimicrobial functions of PF-4 family kinocidins against specific target pathogens... - Synthetic peptides that exert antimicrobial activities in whole blood and blood-derived matricesMichael R Yeaman
Department of Medicine, Division of Infectious Diseases, Harbor UCLA Medical Center, Research and Education Institute at Harbor UCLA, Torrance, California 90502, USA
Antimicrob Agents Chemother 46:3883-91. 2002..Collectively, these findings support the concept that synthetic peptides can be designed to exert potent antimicrobial activities in relevant and complex biological matrices... 
Bacterial-platelet interactions: virulence meets host defenseMichael R Yeaman
Department of Medicine, David Geffen School of Medicine at UCLA, Harbor UCLA Medical Center, 1124 West Carson Street, RB 2, Torrance, CA 90502, USA
Future Microbiol 5:471-506. 2010..From these perspectives, the net consequences of bacterial virulence versus platelet host defenses likely decide initial steps towards the ultimate result of infection versus immunity...- Emerging themes and therapeutic prospects for anti-infective peptidesNannette Y Yount
Divisions of Infectious Diseases and Molecular Medicine, Los Angeles County Harbor UCLA Medical Center, Torrance, California 90509, USA
Annu Rev Pharmacol Toxicol 52:337-60. 2012.... - Platelets in defense against bacterial pathogensMichael R Yeaman
Division of Infectious Diseases, St John s Cardiovascular Research Center, Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, CA 90502, USA
Cell Mol Life Sci 67:525-44. 2010..In these respects, the molecular and cellular roles of platelets in host defense against bacterial pathogens are explored with attention on advances in platelet immunobiology... - Structural correlates of antimicrobial efficacy in IL-8 and related human kinocidinsNannette Y Yount
Division of Infectious Diseases, LAC Harbor UCLA Medical Center, Torrance, CA 90509, USA
Biochim Biophys Acta 1768:598-608. 2007.... - Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal proteinVance G Fowler
Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
J Infect Dis 190:1140-9. 2004..This investigation examined potential associations between PB with key clinical features and several in vitro bacterial genotypic and phenotypic characteristics, in isolates from 1 institution... - In vitro susceptibility to thrombin-induced platelet microbicidal protein is associated with reduced disease progression and complication rates in experimental Staphylococcus aureus endocarditis: microbiological, histopathologic, and echocardiographic anaLeon Iri Kupferwasser
Division of Infectious Diseases, St John s Cardiovascular Research Center and the Research and Education Institute, Torrance, Calif 90502, USA
Circulation 105:746-52. 2002..In the present study, we evaluated the influence of differences in staphylococcal tPMP-susceptibility profiles in vitro on disease severity in experimental IE... - Inhibition of intracellular macromolecular synthesis in Staphylococcus aureus by thrombin-induced platelet microbicidal proteinsYan Qiong Xiong
Department of Medicine, Division of Infectious Diseases, St John s Cardiovascular Research Center, Harbor UCLA Research and Education Institute, Torrance, CA 90502, USA
J Infect Dis 185:348-56. 2002..Collectively, these observations are consistent with the hypothesis that inhibition of specific macromolecular synthesis pathways is integral to the overall staphylocidal mechanism(s) of tPMPs... - Cell wall thickening is not a universal accompaniment of the daptomycin nonsusceptibility phenotype in Staphylococcus aureus: evidence for multiple resistance mechanismsSoo Jin Yang
Los Angeles Biomedical Research Institute, Torrance, California 90502, USA
Antimicrob Agents Chemother 54:3079-85. 2010..These data confirm that CW thickening is neither universal to DAPr S. aureus nor sufficient to yield the DAPr phenotype among S. aureus strains... - Activation and transcriptional interaction between agr RNAII and RNAIII in Staphylococcus aureus in vitro and in an experimental endocarditis modelYan-Qiong Xiong
Division of Infectious Diseases, Harbor-University of California, Los Angeles, USA
J Infect Dis 186:668-77. 2002..These data demonstrate that RNAIII activation in vivo is time and cell density dependent, may be tissue specific, and can occur through RNAII-dependent and -independent mechanisms... - Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug bindingTiffanny Jones
Los Angeles Biomedical Research Institute at Harbor UCLA, 1124 West Carson Street, Bldg RB2, Room 225, Torrance, CA 90502, USA
Antimicrob Agents Chemother 52:269-78. 2008..aureus. Moreover, the cross-resistance to hNP-1 and tPMP-1 may also impact the capacity of these daptomycin-resistant organisms to be cleared from sites of infection, particularly endovascular foci... - Advances in antimicrobial peptide immunobiologyNannette Y Yount
Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA 90509, USA
Biopolymers 84:435-58. 2006..The following discussion highlights such recent developments in antimicrobial peptide immunobiology, with an emphasis on the biophysical aspects of host-defense polypeptide action and mechanisms of microbial resistance... - Enhanced expression of dltABCD is associated with the development of daptomycin nonsusceptibility in a clinical endocarditis isolate of Staphylococcus aureusSoo Jin Yang
Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
J Infect Dis 200:1916-20. 2009..In contrast, we demonstrated enhanced dlt expression coincident with increased positive surface charge and reduced daptomycin binding... - Salicylic acid attenuates virulence in endovascular infections by targeting global regulatory pathways in Staphylococcus aureusLeon Iri Kupferwasser
Division of Infectious Disease, Harbor-UCLA (University of California-Los Angeles, Torrance, California, USA
J Clin Invest 112:222-33. 2003..aureus, by downmodulating key staphylococcal global regulons and structural genes in vivo, thus abrogating relevant virulence phenotypes... - Impacts of sarA and agr in Staphylococcus aureus strain Newman on fibronectin-binding protein A gene expression and fibronectin adherence capacity in vitro and in experimental infective endocarditisYan-Qiong Xiong
Department of Medicine, Division of Infectious Diseases, Harbor-UCLA Research and Education Institute, Torrance, California, USA
Infect Immun 72:1832-6. 2004..Thus, additional regulatory loci contribute to fnbA regulation and fibronectin-binding capacities in S. aureus... - In vitro susceptibility of Staphylococcus aureus to thrombin-induced platelet microbicidal protein-1 (tPMP-1) is influenced by cell membrane phospholipid composition and asymmetryKasturi Mukhopadhyay
The L A Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Microbiology 153:1187-97. 2007..These findings offer new insights into mechanisms of antimicrobial peptide susceptibility and resistance in S. aureus... - SSD1 is integral to host defense peptide resistance in Candida albicansKimberly D Gank
Division of Infectious Diseases, LAC Harbor UCLA Medical Center, Torrance, California 90509, USA
Eukaryot Cell 7:1318-27. 2008..Collectively, these results indicate that SSD1 is integral to C. albicans resistance to host defense peptides, a phenotype that appears to enhance the virulence of this organism in vivo... - Functional and structural diversity in the Als protein family of Candida albicansDonald C Sheppard
St Johns Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Harbor UCLA Research and Education Institute, Torrance, California 90502, USA
J Biol Chem 279:30480-9. 2004..albicans with an array of cell wall proteins capable of recognizing and interacting with a wide range of host constituents during infection... - A synthetic congener modeled on a microbicidal domain of thrombin- induced platelet microbicidal protein 1 recapitulates staphylocidal mechanisms of the native moleculeYan Q Xiong
Department of Medicine, Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, RB 2, Room 231, Torrance, CA 90502, USA
Antimicrob Agents Chemother 50:3786-92. 2006.... - Platelet antistaphylococcal responses occur through P2X1 and P2Y12 receptor-induced activation and kinocidin releaseDarin A Trier
Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA 90509, USA
Infect Immun 76:5706-13. 2008.... - Unifying themes in host defence effector polypeptidesMichael R Yeaman
Division of Infectious Diseases, LAC Harbour UCLA Medical Center, Torrance, California 90509, USA
Nat Rev Microbiol 5:727-40. 2007..Understanding how nature has sustained these host defence molecules with a potent efficacy in the face of dynamic microbial evolution should provide new opportunities to prevent or treat life-threatening infections... - Phenotypic and genotypic characteristics of persistent methicillin-resistant Staphylococcus aureus bacteremia in vitro and in an experimental endocarditis modelYan Q Xiong
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
J Infect Dis 199:201-8. 2009..Persistent MRSA bacteremia (PB) represents an important subset of Staphylococcus aureus infections and correlates with poor clinical outcomes... - Functional interrelationships between cell membrane and cell wall in antimicrobial peptide-mediated killing of Staphylococcus aureusYan Q Xiong
LA Biomedical Research Institute at Harbor UCLA St John s Cardiovascular Research Center, RB 2, 1124 West Carson Street, Torrance, CA 90502, USA
Antimicrob Agents Chemother 49:3114-21. 2005.... - Tumor necrosis factor inhibition and invasive fungal infectionsScott G Filler
St Johns Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Clin Infect Dis 41:S208-12. 2005.... - Platelet microbicidal protein 1: structural themes of a multifunctional antimicrobial peptideNannette Y Yount
David Geffen School of Medicine at UCLA, Division of Infectious Diseases, St John s Cardiovascular Research Center, Research and Education Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Antimicrob Agents Chemother 48:4395-404. 2004.... - Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureusNagendra N Mishra
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles Medical Center, 1124 West Carson St, Torrance, California 90502, USA
Antimicrob Agents Chemother 53:2312-8. 2009.... - Selective reciprocity in antimicrobial activity versus cytotoxicity of hBD-2 and crotamineNannette Y Yount
Division of Infectious Diseases, LAC Harbor University of California, Los Angeles Medical Center, Torrance, CA 90509, USA
Proc Natl Acad Sci U S A 106:14972-7. 2009..These insights may accelerate development of anti-infective or therapeutic peptides that selectively target microbial or abnormal host cells... - Salicylic acid activates sigma factor B by rsbU-dependent and -independent mechanismsMarco Palma
LA Biomedical Research Institute at Harbor-UCLA, 1124 W. Carson Street, Bldg RB2, Room 225, Torrance, CA 90502, USA
J Bacteriol 188:5896-903. 2006.... - Regulation of Staphylococcus aureus alpha-toxin gene (hla) expression by agr, sarA, and sae in vitro and in experimental infective endocarditisYan Q Xiong
Department of Medicine, Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles Medical Center, Torrance, CA, USA
J Infect Dis 194:1267-75. 2006..However, their relative in vivo contributions to hla expression, particularly in endovascular infections, have not been defined... - The antifungal vaccine derived from the recombinant N terminus of Als3p protects mice against the bacterium Staphylococcus aureusBrad Spellberg
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor, University of California at Los Angeles Medical Center, Torrance, California 90502, USA
Infect Immun 76:4574-80. 2008..These data provide the foundation for cross-kingdom vaccine development against S. aureus and Candida, which collectively cause 200,000 bloodstream infections resulting in >/=40,000 to 50,000 deaths annually in the United States alone... - Multidimensional signatures in antimicrobial peptidesNannette Y Yount
Division of Infectious Diseases, Harbor UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
Proc Natl Acad Sci U S A 101:7363-8. 2004.... - Transcriptional responses of candida albicans to epithelial and endothelial cellsHyunsook Park
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
Eukaryot Cell 8:1498-510. 2009.... - Structural congruence among membrane-active host defense polypeptides of diverse phylogenyNannette Y Yount
Division of Infectious Diseases, LAC-Harbor UCLA Medical Center, Torrance, CA 90509, USA
Biochim Biophys Acta 1758:1373-86. 2006.... - The gamma-core motif correlates with antimicrobial activity in cysteine-containing kaliocin-1 originating from transferrinsNannette Y Yount
Division of Infectious Diseases, LAC Harbor UCLA Medical Center, Torrance, CA 90509, USA
Biochim Biophys Acta 1768:2862-72. 2007.... - Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cellsQuynh T Phan
Department of Medicine, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California, United States of America
PLoS Biol 5:e64. 2007..These results uncover the first known fungal invasin and provide evidence that C. albicans Als3 is a molecular mimic of human cadherins... - Efficacy of the anti-Candida rAls3p-N or rAls1p-N vaccines against disseminated and mucosal candidiasisBrad J Spellberg
Department of Medicine, Los Angeles Biomedical Research Institute at Harbor University of California, Los Angeles UCLA Medical Center, Torrance, Torrance, CA 90502, USA
J Infect Dis 194:256-60. 2006..The rAls3p-N vaccine is a promising new vaccine candidate for further exploration to prevent systemic and mucosal candidal infections... - Regulation of Staphylococcus aureus type 5 capsular polysaccharides by agr and sarA in vitro and in an experimental endocarditis modelWillem van Wamel
Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
Microb Pathog 33:73-9. 2002..In addition, the regulation ofcap5 expression by these global regulators may vary in distinct anatomic niches in vivo... - Antimicrobial peptides from human plateletsYi-Quan Tang
Department of Pathology, College of Medicine, University of California Irvine, 92697, USA
Infect Immun 70:6524-33. 2002..coli. Collectively, these findings suggest a direct antimicrobial role for platelets as they are activated to release peptides in response to trauma or mediators of inflammation... - Staphylococcus aureus menD and hemB mutants are as infective as the parent strains, but the menadione biosynthetic mutant persists within the kidneyDonna M Bates
Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
J Infect Dis 187:1654-61. 2003..These data show that SCVs are able to colonize multiple tissues in vivo and that the menD mutation provides the organism with a survival advantage during antimicrobial therapy, compared with its parent strain, in selected target tissues... - Immunocontinuum: perspectives in antimicrobial peptide mechanisms of action and resistanceNannette Y Yount
Los Angeles Biomedical Research Center at Harbor-UCLA, Medical Center, CA 90059, USA
Protein Pept Lett 12:49-67. 2005..The following discussion highlights recent advances that offer greater understanding of the mechanisms of action and resistance of antimicrobial peptides... - DltABCD- and MprF-mediated cell envelope modifications of Staphylococcus aureus confer resistance to platelet microbicidal proteins and contribute to virulence in a rabbit endocarditis modelChristopher Weidenmaier
Cellular and Molecular Microbiology Division, Medical Microbiology and Hygiene Department, , , Germany
Infect Immun 73:8033-8. 2005..These data underscore the importance of resistance to distinct CAPs and of teichoic acid-dependent EC interactions in the context of endovascular infection pathogenesis... - Transposon disruption of the complex I NADH oxidoreductase gene (snoD) in Staphylococcus aureus is associated with reduced susceptibility to the microbicidal activity of thrombin-induced platelet microbicidal protein 1Arnold S Bayer
Department of Medical Microbiology and Immunology, University of Wisconsin, 1300 University Avenue, Biochemistry Building, Room 250, Madison, WI 53706, USA
J Bacteriol 188:211-22. 2006..aureus nuo orthologue). These novel findings indicate that disruption of a complex I enzyme locus can confer reduced in vitro susceptibility to tPMP-1 in S. aureus... - Beneficial influence of platelets on antibiotic efficacy in an in vitro model of Staphylococcus aureus-induced endocarditisRenee Claude Mercier
College of Pharmacy MSC09 5360, 1 University of New Mexico, Albuquerque, NM 87131 0001, USA
Antimicrob Agents Chemother 48:2551-7. 2004.... - Reduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) functionGeorge Sakoulas
Westchester Medical Center, New York Medical College, Valhalla, New York 10595, USA
Antimicrob Agents Chemother 49:2687-92. 2005..In vitro, these events were associated with defective lysis and reduced susceptibility to tPMP. The precise mechanism(s) underlying these findings is the subject of current investigations... - Lack of wall teichoic acids in Staphylococcus aureus leads to reduced interactions with endothelial cells and to attenuated virulence in a rabbit model of endocarditisChristopher Weidenmaier
Cellular and Molecular Microbiology Division, Medical Microbiology and Hygiene Department, , , Germany
J Infect Dis 191:1771-7. 2005..001). We conclude that WTA is an important factor in the induction and progression of endovascular S. aureus infection, likely through a specific interaction with endothelial cells...
Research Grants
- MICROBICIDAL PROTEINS FROM PLATELETSMichael Yeaman; Fiscal Year: 2009..In turn, these insights will accelerate development of novel strategies to prevent or treat serious infections, particularly those caused by antibiotic-resistant pathogens. ..
- CORE FACILITY RESEARCH PEPTIDE SYNTHESIZERMichael Yeaman; Fiscal Year: 2001..Therefore, the proposed instrument will significantly enhance the efficiency and diversity of SPPS required for NIH-sponsored and hypothesis-driven research. ..
- MICROBICIDAL PROTEINS FROM PLATELETSMichael R Yeaman; Fiscal Year: 2010..In turn, these insights will accelerate development of novel strategies to prevent or treat serious infections, particularly those caused by antibiotic-resistant pathogens. ..
- Novel Context-Activated Protide Anti-InfectivesMichael Yeaman; Fiscal Year: 2007..These advances would represent major breakthroughs in the prevention and treatment of these common and increasingly difficult-to-treat infections. ..
- MICROBICIDAL PROTEINS FROM PLATELETSMichael Yeaman; Fiscal Year: 2007..In turn, these insights will accelerate development of novel strategies to prevent or treat serious infections, particularly those caused by antibiotic-resistant pathogens. ..
- DETERMINANTS IN PLATELET MICROBICIDAL PROTEINSMichael Yeaman; Fiscal Year: 2004..Thus, these studies will significantly advance our understanding of antimicrobial host defense, and may yield new modes for its amplification. ..