Michael Yeaman

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Context mediates antimicrobial efficacy of kinocidin congener peptide RP-1
    Nannette Y Yount
    Division of Infectious Diseases, Los Angeles County Harbor University of California Los Angeles Medical Center, Torrance, California, United States of America
    PLoS ONE 6:e26727. 2011
  2. ncbi request reprint Mechanisms of antimicrobial peptide action and resistance
    Michael R Yeaman
    Division of Infectious Diseases, Harbor University of California Los Angeles Medical Center, Torrance, California, USA
    Pharmacol Rev 55:27-55. 2003
  3. pmc Modular determinants of antimicrobial activity in platelet factor-4 family kinocidins
    Michael R Yeaman
    Division of Infectious Diseases, LAC Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Biochim Biophys Acta 1768:609-19. 2007
  4. doi request reprint Emerging themes and therapeutic prospects for anti-infective peptides
    Nannette Y Yount
    Divisions of Infectious Diseases and Molecular Medicine, Los Angeles County Harbor UCLA Medical Center, Torrance, California 90509, USA
    Annu Rev Pharmacol Toxicol 52:337-60. 2012
  5. pmc Susceptibility to thrombin-induced platelet microbicidal protein is associated with increased fluconazole efficacy against experimental endocarditis due to Candida albicans
    Michael R Yeaman
    Division of Infectious Diseases, St John s Cardiovascular Research Center, Harbor UCLA Research and Education Institute, Torrance, California 90502, USA
    Antimicrob Agents Chemother 48:3051-6. 2004
  6. pmc Platelets in defense against bacterial pathogens
    Michael R Yeaman
    Division of Infectious Diseases, St John s Cardiovascular Research Center, Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, CA 90502, USA
    Cell Mol Life Sci 67:525-44. 2010
  7. doi request reprint Bacterial-platelet interactions: virulence meets host defense
    Michael R Yeaman
    Department of Medicine, David Geffen School of Medicine at UCLA, Harbor UCLA Medical Center, 1124 West Carson Street, RB 2, Torrance, CA 90502, USA
    Future Microbiol 5:471-506. 2010
  8. ncbi request reprint Antimicrobial peptides versus invasive infections
    M R Yeaman
    Division of Infectious Diseases, David Geffen School of Medicine at UCLA, LAC Harbor UCLA Medical Center, Torrance 90502, USA
    Curr Top Microbiol Immunol 306:111-52. 2006
  9. pmc Synthetic peptides that exert antimicrobial activities in whole blood and blood-derived matrices
    Michael R Yeaman
    Department of Medicine, Division of Infectious Diseases, Harbor UCLA Medical Center, Research and Education Institute at Harbor UCLA, Torrance, California 90502, USA
    Antimicrob Agents Chemother 46:3883-91. 2002
  10. ncbi request reprint Structural correlates of antimicrobial efficacy in IL-8 and related human kinocidins
    Nannette Y Yount
    Division of Infectious Diseases, LAC Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Biochim Biophys Acta 1768:598-608. 2007

Research Grants

  1. MICROBICIDAL PROTEINS FROM PLATELETS
    Michael Yeaman; Fiscal Year: 2009
  2. CORE FACILITY RESEARCH PEPTIDE SYNTHESIZER
    Michael Yeaman; Fiscal Year: 2001
  3. MICROBICIDAL PROTEINS FROM PLATELETS
    Michael R Yeaman; Fiscal Year: 2010
  4. MICROBICIDAL PROTEINS FROM PLATELETS
    Michael Yeaman; Fiscal Year: 2006
  5. DETERMINANTS IN PLATELET MICROBICIDAL PROTEINS
    Michael Yeaman; Fiscal Year: 2001
  6. Novel Context-Activated Protide Anti-Infectives
    Michael Yeaman; Fiscal Year: 2007
  7. MICROBICIDAL PROTEINS FROM PLATELETS
    Michael Yeaman; Fiscal Year: 2007
  8. DETERMINANTS IN PLATELET MICROBICIDAL PROTEINS
    Michael Yeaman; Fiscal Year: 2000
  9. DETERMINANTS IN PLATELET MICROBICIDAL PROTEINS
    Michael Yeaman; Fiscal Year: 2004
  10. DETERMINANTS IN PLATELET MICROBICIDAL PROTEINS
    Michael Yeaman; Fiscal Year: 2003

Collaborators

Detail Information

Publications50

  1. pmc Context mediates antimicrobial efficacy of kinocidin congener peptide RP-1
    Nannette Y Yount
    Division of Infectious Diseases, Los Angeles County Harbor University of California Los Angeles Medical Center, Torrance, California, United States of America
    PLoS ONE 6:e26727. 2011
    ....
  2. ncbi request reprint Mechanisms of antimicrobial peptide action and resistance
    Michael R Yeaman
    Division of Infectious Diseases, Harbor University of California Los Angeles Medical Center, Torrance, California, USA
    Pharmacol Rev 55:27-55. 2003
    ..From these perspectives, the intention of this review is to illustrate the contemporary structural and functional themes among mechanisms of antimicrobial peptide action and resistance...
  3. pmc Modular determinants of antimicrobial activity in platelet factor-4 family kinocidins
    Michael R Yeaman
    Division of Infectious Diseases, LAC Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Biochim Biophys Acta 1768:609-19. 2007
    ..Collectively, these results suggest that modular determinants arising from structural components acting independently and cooperatively govern the antimicrobial functions of PF-4 family kinocidins against specific target pathogens...
  4. doi request reprint Emerging themes and therapeutic prospects for anti-infective peptides
    Nannette Y Yount
    Divisions of Infectious Diseases and Molecular Medicine, Los Angeles County Harbor UCLA Medical Center, Torrance, California 90509, USA
    Annu Rev Pharmacol Toxicol 52:337-60. 2012
    ....
  5. pmc Susceptibility to thrombin-induced platelet microbicidal protein is associated with increased fluconazole efficacy against experimental endocarditis due to Candida albicans
    Michael R Yeaman
    Division of Infectious Diseases, St John s Cardiovascular Research Center, Harbor UCLA Research and Education Institute, Torrance, California 90502, USA
    Antimicrob Agents Chemother 48:3051-6. 2004
    ..albicans IE in vivo, particularly in tissues in which platelets and tPMP-1 likely play significant roles in host defense...
  6. pmc Platelets in defense against bacterial pathogens
    Michael R Yeaman
    Division of Infectious Diseases, St John s Cardiovascular Research Center, Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, CA 90502, USA
    Cell Mol Life Sci 67:525-44. 2010
    ..In these respects, the molecular and cellular roles of platelets in host defense against bacterial pathogens are explored with attention on advances in platelet immunobiology...
  7. doi request reprint Bacterial-platelet interactions: virulence meets host defense
    Michael R Yeaman
    Department of Medicine, David Geffen School of Medicine at UCLA, Harbor UCLA Medical Center, 1124 West Carson Street, RB 2, Torrance, CA 90502, USA
    Future Microbiol 5:471-506. 2010
    ..From these perspectives, the net consequences of bacterial virulence versus platelet host defenses likely decide initial steps towards the ultimate result of infection versus immunity...
  8. ncbi request reprint Antimicrobial peptides versus invasive infections
    M R Yeaman
    Division of Infectious Diseases, David Geffen School of Medicine at UCLA, LAC Harbor UCLA Medical Center, Torrance 90502, USA
    Curr Top Microbiol Immunol 306:111-52. 2006
    ..In addition, this knowledge may accelerate development of novel anti-infective agents and strategies against pathogens that have become refractory to conventional antimicrobials...
  9. pmc Synthetic peptides that exert antimicrobial activities in whole blood and blood-derived matrices
    Michael R Yeaman
    Department of Medicine, Division of Infectious Diseases, Harbor UCLA Medical Center, Research and Education Institute at Harbor UCLA, Torrance, California 90502, USA
    Antimicrob Agents Chemother 46:3883-91. 2002
    ..Collectively, these findings support the concept that synthetic peptides can be designed to exert potent antimicrobial activities in relevant and complex biological matrices...
  10. ncbi request reprint Structural correlates of antimicrobial efficacy in IL-8 and related human kinocidins
    Nannette Y Yount
    Division of Infectious Diseases, LAC Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Biochim Biophys Acta 1768:598-608. 2007
    ....
  11. ncbi request reprint Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein
    Vance G Fowler
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 190:1140-9. 2004
    ..This investigation examined potential associations between PB with key clinical features and several in vitro bacterial genotypic and phenotypic characteristics, in isolates from 1 institution...
  12. ncbi request reprint In vitro susceptibility to thrombin-induced platelet microbicidal protein is associated with reduced disease progression and complication rates in experimental Staphylococcus aureus endocarditis: microbiological, histopathologic, and echocardiographic ana
    Leon Iri Kupferwasser
    Division of Infectious Diseases, St John s Cardiovascular Research Center and the Research and Education Institute, Torrance, Calif 90502, USA
    Circulation 105:746-52. 2002
    ..In the present study, we evaluated the influence of differences in staphylococcal tPMP-susceptibility profiles in vitro on disease severity in experimental IE...
  13. ncbi request reprint Inhibition of intracellular macromolecular synthesis in Staphylococcus aureus by thrombin-induced platelet microbicidal proteins
    Yan Qiong Xiong
    Department of Medicine, Division of Infectious Diseases, St John s Cardiovascular Research Center, Harbor UCLA Research and Education Institute, Torrance, CA 90502, USA
    J Infect Dis 185:348-56. 2002
    ..Collectively, these observations are consistent with the hypothesis that inhibition of specific macromolecular synthesis pathways is integral to the overall staphylocidal mechanism(s) of tPMPs...
  14. pmc Cell wall thickening is not a universal accompaniment of the daptomycin nonsusceptibility phenotype in Staphylococcus aureus: evidence for multiple resistance mechanisms
    Soo Jin Yang
    Los Angeles Biomedical Research Institute, Torrance, California 90502, USA
    Antimicrob Agents Chemother 54:3079-85. 2010
    ..These data confirm that CW thickening is neither universal to DAPr S. aureus nor sufficient to yield the DAPr phenotype among S. aureus strains...
  15. ncbi request reprint Activation and transcriptional interaction between agr RNAII and RNAIII in Staphylococcus aureus in vitro and in an experimental endocarditis model
    Yan Qiong Xiong
    Division of Infectious Diseases, Harbor University of California, Los Angeles, USA
    J Infect Dis 186:668-77. 2002
    ..These data demonstrate that RNAIII activation in vivo is time and cell density dependent, may be tissue specific, and can occur through RNAII-dependent and -independent mechanisms...
  16. pmc Impacts of sarA and agr in Staphylococcus aureus strain Newman on fibronectin-binding protein A gene expression and fibronectin adherence capacity in vitro and in experimental infective endocarditis
    Yan Qiong Xiong
    Department of Medicine, Division of Infectious Diseases, Harbor UCLA Research and Education Institute, Torrance, California, USA
    Infect Immun 72:1832-6. 2004
    ..Thus, additional regulatory loci contribute to fnbA regulation and fibronectin-binding capacities in S. aureus...
  17. pmc Enhanced expression of dltABCD is associated with the development of daptomycin nonsusceptibility in a clinical endocarditis isolate of Staphylococcus aureus
    Soo Jin Yang
    Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
    J Infect Dis 200:1916-20. 2009
    ..In contrast, we demonstrated enhanced dlt expression coincident with increased positive surface charge and reduced daptomycin binding...
  18. ncbi request reprint Advances in antimicrobial peptide immunobiology
    Nannette Y Yount
    Division of Infectious Diseases, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Biopolymers 84:435-58. 2006
    ..The following discussion highlights such recent developments in antimicrobial peptide immunobiology, with an emphasis on the biophysical aspects of host-defense polypeptide action and mechanisms of microbial resistance...
  19. pmc Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding
    Tiffanny Jones
    Los Angeles Biomedical Research Institute at Harbor UCLA, 1124 West Carson Street, Bldg RB2, Room 225, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 52:269-78. 2008
    ..aureus. Moreover, the cross-resistance to hNP-1 and tPMP-1 may also impact the capacity of these daptomycin-resistant organisms to be cleared from sites of infection, particularly endovascular foci...
  20. pmc Salicylic acid attenuates virulence in endovascular infections by targeting global regulatory pathways in Staphylococcus aureus
    Leon Iri Kupferwasser
    Division of Infectious Disease, Harbor UCLA University of California Los Angeles, Torrance, California, USA
    J Clin Invest 112:222-33. 2003
    ..aureus, by downmodulating key staphylococcal global regulons and structural genes in vivo, thus abrogating relevant virulence phenotypes...
  21. pmc A synthetic congener modeled on a microbicidal domain of thrombin- induced platelet microbicidal protein 1 recapitulates staphylocidal mechanisms of the native molecule
    Yan Q Xiong
    Department of Medicine, Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, RB 2, Room 231, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 50:3786-92. 2006
    ....
  22. ncbi request reprint In vitro susceptibility of Staphylococcus aureus to thrombin-induced platelet microbicidal protein-1 (tPMP-1) is influenced by cell membrane phospholipid composition and asymmetry
    Kasturi Mukhopadhyay
    The L A Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    Microbiology 153:1187-97. 2007
    ..These findings offer new insights into mechanisms of antimicrobial peptide susceptibility and resistance in S. aureus...
  23. ncbi request reprint Unifying themes in host defence effector polypeptides
    Michael R Yeaman
    Division of Infectious Diseases, LAC Harbour UCLA Medical Center, Torrance, California 90509, USA
    Nat Rev Microbiol 5:727-40. 2007
    ..Understanding how nature has sustained these host defence molecules with a potent efficacy in the face of dynamic microbial evolution should provide new opportunities to prevent or treat life-threatening infections...
  24. pmc SSD1 is integral to host defense peptide resistance in Candida albicans
    Kimberly D Gank
    Division of Infectious Diseases, LAC Harbor UCLA Medical Center, Torrance, California 90509, USA
    Eukaryot Cell 7:1318-27. 2008
    ..Collectively, these results indicate that SSD1 is integral to C. albicans resistance to host defense peptides, a phenotype that appears to enhance the virulence of this organism in vivo...
  25. pmc Phenotypic and genotypic characteristics of persistent methicillin-resistant Staphylococcus aureus bacteremia in vitro and in an experimental endocarditis model
    Yan Q Xiong
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
    J Infect Dis 199:201-8. 2009
    ..Persistent MRSA bacteremia (PB) represents an important subset of Staphylococcus aureus infections and correlates with poor clinical outcomes...
  26. pmc Platelet antistaphylococcal responses occur through P2X1 and P2Y12 receptor-induced activation and kinocidin release
    Darin A Trier
    Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Infect Immun 76:5706-13. 2008
    ....
  27. ncbi request reprint Tumor necrosis factor inhibition and invasive fungal infections
    Scott G Filler
    St Johns Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Clin Infect Dis 41:S208-12. 2005
    ....
  28. ncbi request reprint Functional and structural diversity in the Als protein family of Candida albicans
    Donald C Sheppard
    St Johns Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Harbor UCLA Research and Education Institute, Torrance, California 90502, USA
    J Biol Chem 279:30480-9. 2004
    ..albicans with an array of cell wall proteins capable of recognizing and interacting with a wide range of host constituents during infection...
  29. pmc Functional interrelationships between cell membrane and cell wall in antimicrobial peptide-mediated killing of Staphylococcus aureus
    Yan Q Xiong
    LA Biomedical Research Institute at Harbor UCLA St John s Cardiovascular Research Center, RB 2, 1124 West Carson Street, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 49:3114-21. 2005
    ....
  30. pmc Salicylic acid activates sigma factor B by rsbU-dependent and -independent mechanisms
    Marco Palma
    LA Biomedical Research Institute at Harbor UCLA, 1124 W Carson Street, Bldg RB2, Room 225, Torrance, CA 90502, USA
    J Bacteriol 188:5896-903. 2006
    ....
  31. pmc Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureus
    Nagendra N Mishra
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles Medical Center, 1124 West Carson St, Torrance, California 90502, USA
    Antimicrob Agents Chemother 53:2312-8. 2009
    ....
  32. pmc Platelet microbicidal protein 1: structural themes of a multifunctional antimicrobial peptide
    Nannette Y Yount
    David Geffen School of Medicine at UCLA, Division of Infectious Diseases, St John s Cardiovascular Research Center, Research and Education Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 48:4395-404. 2004
    ....
  33. pmc Selective reciprocity in antimicrobial activity versus cytotoxicity of hBD-2 and crotamine
    Nannette Y Yount
    Division of Infectious Diseases, LAC Harbor University of California, Los Angeles Medical Center, Torrance, CA 90509, USA
    Proc Natl Acad Sci U S A 106:14972-7. 2009
    ..These insights may accelerate development of anti-infective or therapeutic peptides that selectively target microbial or abnormal host cells...
  34. pmc The antifungal vaccine derived from the recombinant N terminus of Als3p protects mice against the bacterium Staphylococcus aureus
    Brad Spellberg
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor, University of California at Los Angeles Medical Center, Torrance, California 90502, USA
    Infect Immun 76:4574-80. 2008
    ..aureus and Candida, which collectively cause 200,000 bloodstream infections resulting in >/=40,000 to 50,000 deaths annually in the United States alone...
  35. ncbi request reprint Regulation of Staphylococcus aureus alpha-toxin gene (hla) expression by agr, sarA, and sae in vitro and in experimental infective endocarditis
    Yan Q Xiong
    Department of Medicine, Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles Medical Center, Torrance, CA, USA
    J Infect Dis 194:1267-75. 2006
    ..However, their relative in vivo contributions to hla expression, particularly in endovascular infections, have not been defined...
  36. pmc Transcriptional responses of candida albicans to epithelial and endothelial cells
    Hyunsook Park
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
    Eukaryot Cell 8:1498-510. 2009
    ....
  37. pmc Multidimensional signatures in antimicrobial peptides
    Nannette Y Yount
    Division of Infectious Diseases, Harbor UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
    Proc Natl Acad Sci U S A 101:7363-8. 2004
    ....
  38. ncbi request reprint Structural congruence among membrane-active host defense polypeptides of diverse phylogeny
    Nannette Y Yount
    Division of Infectious Diseases, LAC Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Biochim Biophys Acta 1758:1373-86. 2006
    ....
  39. ncbi request reprint The gamma-core motif correlates with antimicrobial activity in cysteine-containing kaliocin-1 originating from transferrins
    Nannette Y Yount
    Division of Infectious Diseases, LAC Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Biochim Biophys Acta 1768:2862-72. 2007
    ....
  40. pmc Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells
    Quynh T Phan
    Department of Medicine, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California, United States of America
    PLoS Biol 5:e64. 2007
    ..These results uncover the first known fungal invasin and provide evidence that C. albicans Als3 is a molecular mimic of human cadherins...
  41. ncbi request reprint Efficacy of the anti-Candida rAls3p-N or rAls1p-N vaccines against disseminated and mucosal candidiasis
    Brad J Spellberg
    Department of Medicine, Los Angeles Biomedical Research Institute at Harbor University of California, Los Angeles UCLA Medical Center, Torrance, Torrance, CA 90502, USA
    J Infect Dis 194:256-60. 2006
    ..The rAls3p-N vaccine is a promising new vaccine candidate for further exploration to prevent systemic and mucosal candidal infections...
  42. pmc Transposon disruption of the complex I NADH oxidoreductase gene (snoD) in Staphylococcus aureus is associated with reduced susceptibility to the microbicidal activity of thrombin-induced platelet microbicidal protein 1
    Arnold S Bayer
    Department of Medical Microbiology and Immunology, University of Wisconsin, 1300 University Avenue, Biochemistry Building, Room 250, Madison, WI 53706, USA
    J Bacteriol 188:211-22. 2006
    ..aureus nuo orthologue). These novel findings indicate that disruption of a complex I enzyme locus can confer reduced in vitro susceptibility to tPMP-1 in S. aureus...
  43. ncbi request reprint Regulation of Staphylococcus aureus type 5 capsular polysaccharides by agr and sarA in vitro and in an experimental endocarditis model
    Willem van Wamel
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Microb Pathog 33:73-9. 2002
    ..In addition, the regulation ofcap5 expression by these global regulators may vary in distinct anatomic niches in vivo...
  44. pmc Antimicrobial peptides from human platelets
    Yi Quan Tang
    Department of Pathology, College of Medicine, University of California Irvine, 92697, USA
    Infect Immun 70:6524-33. 2002
    ..coli. Collectively, these findings suggest a direct antimicrobial role for platelets as they are activated to release peptides in response to trauma or mediators of inflammation...
  45. ncbi request reprint Staphylococcus aureus menD and hemB mutants are as infective as the parent strains, but the menadione biosynthetic mutant persists within the kidney
    Donna M Bates
    Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Infect Dis 187:1654-61. 2003
    ..These data show that SCVs are able to colonize multiple tissues in vivo and that the menD mutation provides the organism with a survival advantage during antimicrobial therapy, compared with its parent strain, in selected target tissues...
  46. pmc Reduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) function
    George Sakoulas
    Westchester Medical Center, New York Medical College, Valhalla, New York 10595, USA
    Antimicrob Agents Chemother 49:2687-92. 2005
    ..In vitro, these events were associated with defective lysis and reduced susceptibility to tPMP. The precise mechanism(s) underlying these findings is the subject of current investigations...
  47. ncbi request reprint Lack of wall teichoic acids in Staphylococcus aureus leads to reduced interactions with endothelial cells and to attenuated virulence in a rabbit model of endocarditis
    Christopher Weidenmaier
    Cellular and Molecular Microbiology Division, Medical Microbiology and Hygiene Department, University of Tubingen, 72076 Tubingen, Germany
    J Infect Dis 191:1771-7. 2005
    ..001). We conclude that WTA is an important factor in the induction and progression of endovascular S. aureus infection, likely through a specific interaction with endothelial cells...
  48. pmc Beneficial influence of platelets on antibiotic efficacy in an in vitro model of Staphylococcus aureus-induced endocarditis
    Renee Claude Mercier
    College of Pharmacy MSC09 5360, 1 University of New Mexico, Albuquerque, NM 87131 0001, USA
    Antimicrob Agents Chemother 48:2551-7. 2004
    ....
  49. ncbi request reprint Immunocontinuum: perspectives in antimicrobial peptide mechanisms of action and resistance
    Nannette Y Yount
    Los Angeles Biomedical Research Center at Harbor UCLA, Medical Center, CA 90059, USA
    Protein Pept Lett 12:49-67. 2005
    ..The following discussion highlights recent advances that offer greater understanding of the mechanisms of action and resistance of antimicrobial peptides...
  50. pmc DltABCD- and MprF-mediated cell envelope modifications of Staphylococcus aureus confer resistance to platelet microbicidal proteins and contribute to virulence in a rabbit endocarditis model
    Christopher Weidenmaier
    Cellular and Molecular Microbiology Division, Medical Microbiology and Hygiene Department, University of Tubingen, 72076 Tubingen, Germany
    Infect Immun 73:8033-8. 2005
    ..These data underscore the importance of resistance to distinct CAPs and of teichoic acid-dependent EC interactions in the context of endovascular infection pathogenesis...

Research Grants13

  1. MICROBICIDAL PROTEINS FROM PLATELETS
    Michael Yeaman; Fiscal Year: 2009
    ..In turn, these insights will accelerate development of novel strategies to prevent or treat serious infections, particularly those caused by antibiotic-resistant pathogens. ..
  2. CORE FACILITY RESEARCH PEPTIDE SYNTHESIZER
    Michael Yeaman; Fiscal Year: 2001
    ..Therefore, the proposed instrument will significantly enhance the efficiency and diversity of SPPS required for NIH-sponsored and hypothesis-driven research. ..
  3. MICROBICIDAL PROTEINS FROM PLATELETS
    Michael R Yeaman; Fiscal Year: 2010
    ..In turn, these insights will accelerate development of novel strategies to prevent or treat serious infections, particularly those caused by antibiotic-resistant pathogens. ..
  4. MICROBICIDAL PROTEINS FROM PLATELETS
    Michael Yeaman; Fiscal Year: 2006
    ..In turn, these insights will accelerate development of novel strategies to prevent or treat serious infections, particularly those caused by antibiotic-resistant pathogens. ..
  5. DETERMINANTS IN PLATELET MICROBICIDAL PROTEINS
    Michael Yeaman; Fiscal Year: 2001
    ..Thus, these studies will significantly advance our understanding of antimicrobial host defense, and may yield new modes for its amplification. ..
  6. Novel Context-Activated Protide Anti-Infectives
    Michael Yeaman; Fiscal Year: 2007
    ..These advances would represent major breakthroughs in the prevention and treatment of these common and increasingly difficult-to-treat infections. ..
  7. MICROBICIDAL PROTEINS FROM PLATELETS
    Michael Yeaman; Fiscal Year: 2007
    ..In turn, these insights will accelerate development of novel strategies to prevent or treat serious infections, particularly those caused by antibiotic-resistant pathogens. ..
  8. DETERMINANTS IN PLATELET MICROBICIDAL PROTEINS
    Michael Yeaman; Fiscal Year: 2000
    ..Thus, these studies will significantly advance our understanding of antimicrobial host defense, and may yield new modes for its amplification. ..
  9. DETERMINANTS IN PLATELET MICROBICIDAL PROTEINS
    Michael Yeaman; Fiscal Year: 2004
    ..Thus, these studies will significantly advance our understanding of antimicrobial host defense, and may yield new modes for its amplification. ..
  10. DETERMINANTS IN PLATELET MICROBICIDAL PROTEINS
    Michael Yeaman; Fiscal Year: 2003
    ..Thus, these studies will significantly advance our understanding of antimicrobial host defense, and may yield new modes for its amplification. ..
  11. DETERMINANTS IN PLATELET MICROBICIDAL PROTEINS
    Michael Yeaman; Fiscal Year: 2002
    ..Thus, these studies will significantly advance our understanding of antimicrobial host defense, and may yield new modes for its amplification. ..