Richard Ye

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc A critical role for phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 in endothelial junction disruption and vascular hyperpermeability
    Ram P Naikawadi
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Circ Res 111:1517-27. 2012
  2. pmc Role for the guanine nucleotide exchange factor phosphatidylinositol-3,4,5-trisphosphate-dependent rac exchanger 1 in platelet secretion and aggregation
    Feng Qian
    Department of Pharmacology, University of Illinois College of Medicine, 835 S Wolcott Ave, Chicago, IL 60612, USA
    Arterioscler Thromb Vasc Biol 32:768-77. 2012
  3. pmc Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling
    Andrew Mf Liu
    Division of Life Science and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    BMC Struct Biol 11:17. 2011
  4. ncbi request reprint Regulation of nuclear factor kappaB activation by G-protein-coupled receptors
    R D Ye
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612 7343, USA
    J Leukoc Biol 70:839-48. 2001
  5. pmc International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family
    Richard D Ye
    Department of Pharmacology, University of Illinois College of Medicine, 835 South Wolcott Avenue, M C 868, Chicago, Illinois 60612, USA
    Pharmacol Rev 61:119-61. 2009
  6. ncbi request reprint Reconstitution of chemotactic peptide-induced nicotinamide adenine dinucleotide phosphate (reduced) oxidase activation in transgenic COS-phox cells
    Rong He
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Immunol 173:7462-70. 2004
  7. ncbi request reprint Lysophosphatidylcholine modulates neutrophil oxidant production through elevation of cyclic AMP
    Phoebe Lin
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    J Immunol 174:2981-9. 2005
  8. pmc Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells
    Baoming Nie
    Department of Pharmacology, University of Illinois, Chicago, 60612, United States
    Cell Signal 22:770-82. 2010
  9. ncbi request reprint Neutrophil caveolin-1 expression contributes to mechanism of lung inflammation and injury
    Guochang Hu
    Department of Pharmacology, University of Illinois College of Medicine, 835 South Wolcott Ave, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 294:L178-86. 2008
  10. ncbi request reprint A novel nonpeptide ligand for formyl peptide receptor-like 1
    Masakatsu Nanamori
    Department of Pharmacology, University of Illinois at Chicago, 835 South Wolcott Avenue, M C 868, Chicago, IL 60612, USA
    Mol Pharmacol 66:1213-22. 2004

Collaborators

Detail Information

Publications51

  1. pmc A critical role for phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 in endothelial junction disruption and vascular hyperpermeability
    Ram P Naikawadi
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Circ Res 111:1517-27. 2012
    ..Understanding the upstream pathway may delineate Rac activation mechanisms and its role in maintaining vascular endothelial barrier integrity...
  2. pmc Role for the guanine nucleotide exchange factor phosphatidylinositol-3,4,5-trisphosphate-dependent rac exchanger 1 in platelet secretion and aggregation
    Feng Qian
    Department of Pharmacology, University of Illinois College of Medicine, 835 S Wolcott Ave, Chicago, IL 60612, USA
    Arterioscler Thromb Vasc Biol 32:768-77. 2012
    ..Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger 1 (P-Rex1) was originally identified in neutrophils that regulates phagocyte functions. We sought to examine whether P-Rex1 plays a role in platelet activation...
  3. pmc Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling
    Andrew Mf Liu
    Division of Life Science and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    BMC Struct Biol 11:17. 2011
    ..Using Gα16 as a model, we asked if its recently discovered adaptor protein tetratricopeptide repeat 1 (TPR1) binds to the same region as its canonical effector, phospholipase Cβ (PLCβ)...
  4. ncbi request reprint Regulation of nuclear factor kappaB activation by G-protein-coupled receptors
    R D Ye
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612 7343, USA
    J Leukoc Biol 70:839-48. 2001
    ..Chemokine-induced, GPCR-mediated production of chemokines constitutes an autocrine regulatory mechanism for the growth of certain malignant tumors and enhances the recruitment of leukocytes to sites of inflammation...
  5. pmc International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family
    Richard D Ye
    Department of Pharmacology, University of Illinois College of Medicine, 835 South Wolcott Avenue, M C 868, Chicago, Illinois 60612, USA
    Pharmacol Rev 61:119-61. 2009
    ....
  6. ncbi request reprint Reconstitution of chemotactic peptide-induced nicotinamide adenine dinucleotide phosphate (reduced) oxidase activation in transgenic COS-phox cells
    Rong He
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Immunol 173:7462-70. 2004
    ....
  7. ncbi request reprint Lysophosphatidylcholine modulates neutrophil oxidant production through elevation of cyclic AMP
    Phoebe Lin
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    J Immunol 174:2981-9. 2005
    ..A similar mechanism of inhibition may be used for the control of neutrophil-mediated tissue injury...
  8. pmc Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells
    Baoming Nie
    Department of Pharmacology, University of Illinois, Chicago, 60612, United States
    Cell Signal 22:770-82. 2010
    ..These results demonstrate that in COS(phox) cells, P-Rex1 is a critical component for FPR1-mediated signaling leading to NADPH oxidase activation, and there is a crosstalk between the P-Rex1-Rac pathway and Akt in superoxide generation...
  9. ncbi request reprint Neutrophil caveolin-1 expression contributes to mechanism of lung inflammation and injury
    Guochang Hu
    Department of Pharmacology, University of Illinois College of Medicine, 835 South Wolcott Ave, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 294:L178-86. 2008
    ..Thus caveolin-1 expression in PMNs plays a key role in mediating PMN activation, adhesion, and transendothelial migration and in PMN activation-induced lung inflammation and vascular injury...
  10. ncbi request reprint A novel nonpeptide ligand for formyl peptide receptor-like 1
    Masakatsu Nanamori
    Department of Pharmacology, University of Illinois at Chicago, 835 South Wolcott Avenue, M C 868, Chicago, IL 60612, USA
    Mol Pharmacol 66:1213-22. 2004
    ..Quin-C1 is a prototype of substituted quinazolinones based on which further structural modifications may be made to improve its efficacy and potency for FPRL1...
  11. ncbi request reprint Characterization of two new members of the formyl peptide receptor gene family from 129S6 mice
    Zhen guo Wang
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Gene 299:57-63. 2002
    ..Our data suggest that the expression of Fpr-rs6 and Fpr-rs7 is differentially regulated in mouse despite their high sequence homology...
  12. ncbi request reprint Galpha(q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cells
    Arshad Rahman
    Department of Pharmacology, College of Medicine, The University of Illinois, Chicago, Ill 60612 7343, USA
    Circ Res 91:398-405. 2002
    ..These results support a model in which ligation of PAR-1 induces NF-kappaB activation and ICAM-1 transcription by the engagement of parallel Galphaq/PKC-delta and Gbetagamma/PI3-kinase pathways that converge at Akt...
  13. ncbi request reprint Differential roles of PKC-theta in the regulation of intracellular calcium concentration in primary T cells
    Santhakumar Manicassamy
    Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Mol Biol 355:347-59. 2006
    ..Thus, PKC-theta can both positively and negatively regulate the Ca2+ influx that is critical for NFAT activity...
  14. ncbi request reprint Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R
    Rong He
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago 60012, USA
    Blood 101:1572-81. 2003
    ..The ability of FPRL1/LXA4R to mediate 2 drastically different and opposite functions suggests that it plays a role in the modulation of inflammatory and immune responses...
  15. pmc A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury
    Feng Qian
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL, USA
    EMBO J 28:2896-907. 2009
    ..Collectively, these results show an earlier unrecognized and non-redundant function of MKP5 in restraining p38 MAPK-mediated neutrophil oxidant production, thereby preventing LPS-induced vascular injury...
  16. pmc LIM kinase 1 promotes endothelial barrier disruption and neutrophil infiltration in mouse lungs
    Matvey Gorovoy
    Department of Pharmacology, University of Illinois at Chicago, 909 S Wolcott Ave, Chicago, IL 60612, USA
    Circ Res 105:549-56. 2009
    ..Recently we reported that endotoxin induced activation of RhoA in mice lungs that led to the disruption of endothelial barrier and lung edema formation; however, the molecular mechanism of this phenomenon remained unknown...
  17. pmc Identification of formyl peptides from Listeria monocytogenes and Staphylococcus aureus as potent chemoattractants for mouse neutrophils
    Erica L Southgate
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    J Immunol 181:1429-37. 2008
    ..aureus are approximately 100-fold more potent than fMLF in activating mouse neutrophils. The ability of mFPR1 to detect bacterially derived formyl peptides indicates that this important host defense mechanism is conserved in mice...
  18. ncbi request reprint A critical role of protein kinase C delta activation loop phosphorylation in formyl-methionyl-leucyl-phenylalanine-induced phosphorylation of p47(phox) and rapid activation of nicotinamide adenine dinucleotide phosphate oxidase
    Ni Cheng
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Immunol 179:7720-8. 2007
    ..We conclude that agonist-induced PKCdelta phosphorylation is a novel mechanism for NADPH oxidase activation. The ability to induce PKCdelta phosphorylation may distinguish a full agonist from a partial agonist for superoxide production...
  19. ncbi request reprint Serum amyloid A is an endogenous ligand that differentially induces IL-12 and IL-23
    Rong He
    Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
    J Immunol 177:4072-9. 2006
    ..These results identify SAA as an endogenous ligand that potentially activates the IL-23/IL-17 pathway and present a novel mechanism for regulation of inflammation and immunity by an acute-phase protein...
  20. ncbi request reprint Normal cell surface expression and selective loss of functions resulting from Phe110 to Ser and Cys126 to Trp substitutions in the formyl peptide receptor
    Masakatsu Nanamori
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    Immunol Invest 33:193-212. 2004
    ..Taken together, these results indicate compromised signaling capabilities due to the FPR mutations, but the loss of function is selective and could be partially rescued by mutations at both positions...
  21. ncbi request reprint Regulation of leukocyte degranulation by cGMP-dependent protein kinase and phosphoinositide 3-kinase: potential roles in phosphorylation of target membrane SNARE complex proteins in rat mast cells
    Masakatsu Nanamori
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Immunol 178:416-27. 2007
    ..These results suggest that PKG and PI3K are involved in degranulation, possibly through phosphorylation of target membrane SNAP receptor proteins and their binding proteins...
  22. pmc Ca2+ entry via TRPC channels is necessary for thrombin-induced NF-kappaB activation in endothelial cells through AMP-activated protein kinase and protein kinase Cdelta
    Angela M Bair
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 284:563-74. 2009
    ....
  23. pmc Akt isoforms differentially regulate neutrophil functions
    Jia Chen
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Blood 115:4237-46. 2010
    ..These results demonstrate a predominant role of Akt2 in regulating neutrophil functions and provide evidence for differential activation of the 2 Akt isoforms in neutrophils...
  24. ncbi request reprint Characterization of a mutation in the Phox homology domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide production
    Jia Chen
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 282:30273-84. 2007
    ..Both functions require the association of p40(phox) with p67(phox)...
  25. pmc Activation state-dependent interaction between Galphai and p67phox
    Caroline Marty
    Department of Pharmacology, University of Illinois at Chicago, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    Mol Cell Biol 26:5190-200. 2006
    ..These results provide the first evidence for an interaction between p67phox and an alpha subunit of heterotrimeric G proteins, suggesting a potential role for Galphai in the regulation or activation of NADPH oxidase...
  26. pmc beta-Arrestin1 interacts with the G-protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signalling for NF-kappaB activation
    Ming Yang
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Biochem J 417:287-96. 2009
    ..These results identify novel functions of beta-arrestin1 in binding to the beta1gamma2 subunits of heterotrimeric G-proteins and promoting G(betagamma)-mediated Akt signalling for NF-kappaB activation...
  27. pmc Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway
    Guoying Zhang
    Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
    J Immunol 182:7997-8004. 2009
    ..Taken together, our data indicate that LPS stimulates platelet secretion and potentiates platelet aggregation through a TLR4/MyD88- and cGMP/PKG-dependent pathway...
  28. ncbi request reprint Detection of intact transcription factors in human neutrophils
    Patrick P McDonald
    Department of Pharmacology, Univeristy of Illinois, Chicago, IL, USA
    Methods Mol Biol 412:473-86. 2007
    ..e., undegraded) transcription factors in neutrophils requires special precautions and an alternative protocol, as a result of the huge amounts of endogenous proteases present in these cells. This protocol is the focus of this chapter...
  29. pmc Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2
    Rong L He
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Blood 113:429-37. 2009
    ..Finally, our in vivo studies confirmed that SAA treatment results in a significant increase in plasma G-CSF and neutrophilia, whereas these responses are ablated in G-CSF- or TLR2-deficient mice...
  30. pmc Opposing effects of platelet-activating factor and lyso-platelet-activating factor on neutrophil and platelet activation
    Emily J Welch
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Mol Pharmacol 75:227-34. 2009
    ..These findings identify lysoPAF as a bioactive lipid with opposing functions of PAF and suggest a novel and intrinsic regulatory mechanism for balance of the potent activity of PAF...
  31. ncbi request reprint Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions
    Joseph M Schober
    Department of Pharmacology, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA
    Blood 99:4457-65. 2002
    ..However, unlike fibroblast adhesion to Cyr61, cell surface HSPGs are not absolutely required for this adhesion process...
  32. ncbi request reprint The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis
    Phoebe Lin
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago 60612, USA
    J Biol Chem 278:14379-86. 2003
    ..These results demonstrate the ability of G2A to activate a specific combination of G proteins, and that G2A/LPC-induced apoptosis involves both G alpha(13)- and G alpha(s)-mediated pathways...
  33. pmc Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras
    Caroline Marty
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    Mol Cell Biol 23:3847-58. 2003
    ..Thus, TPR1 is a novel adaptor protein for Ras and selected Galpha proteins that may be involved in protein-protein interaction relating to G-protein signaling...
  34. ncbi request reprint A stimulatory role for cGMP-dependent protein kinase in platelet activation
    Zhenyu Li
    Department of Pharmacology, College of Medicine, University of Illinois, 835 South Wolcott Avenue, Chicago, IL 60612, USA
    Cell 112:77-86. 2003
    ..The cGMP-stimulated platelet responses are biphasic, consisting of an initial transient stimulatory response that promotes platelet aggregation and a subsequent inhibitory response that limits the size of thrombi...
  35. ncbi request reprint Requirement of Gbetagamma and c-Src in D2 dopamine receptor-mediated nuclear factor-kappaB activation
    Ming Yang
    Department of Pharmacology, M C 868, University of Illinois at Chicago, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    Mol Pharmacol 64:447-55. 2003
    ..In addition, the D2R-mediated NF-kappaB activation was enhanced by over-expression of beta-arrestin 1. These results suggest that D2R-mediated NF-kappaB activation requires Gbetagamma and c-Src, and possibly involves beta-arrestin 1...
  36. ncbi request reprint Activation of the small GTPase Rac1 by cGMP-dependent protein kinase
    Yali Hou
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, 1120 15th Street, CB2510, Augusta, GA 30912 2100, USA
    Cell Signal 16:1061-9. 2004
    ..Taken together these data demonstrate a novel PKG-dependent pathway by which the Rac1/Pak1 pathway is activated. Furthermore, we demonstrate that this pathway is central to the activation of p38 MAPK by PKG in these cells...
  37. ncbi request reprint Differential activation of formyl peptide receptor signaling by peptide ligands
    Yoe Sik Bae
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, 790 784, Korea
    Mol Pharmacol 64:841-7. 2003
    ..Our results suggest that WKGMVm and WKRMVm may be useful model for further development of pharmacological agents that selectively activate FPR-mediated functions...
  38. ncbi request reprint A Rho exchange factor mediates fMet-Leu-Phe-induced NF-kappaB activation in human peripheral blood monocytes
    Ling Yu Chen
    Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio 43614, USA
    J Biol Chem 279:7208-12. 2004
    ..These results indicate that guanine nucleotide exchange factor Lbc is a novel signal transducer for RhoA-mediated NF-kappaB activation in human peripheral blood monocytes stimulated with bacterial products...
  39. ncbi request reprint Differential activation of formyl peptide receptor-like 1 by peptide ligands
    Yoe Sik Bae
    Medical Research Center for Cancer Molecular Therapy and Department of Biochemistry, College of Medicine, Dong A University, Seo Gu, Busan, Korea
    J Immunol 171:6807-13. 2003
    ..This study demonstrates that the important chemoattractant receptor, FPRL1, may be differentially modulated by distinct peptide ligands. We also suggest that HRYLPM and HEYLPM may be used to selectively modulate FPRL1...
  40. ncbi request reprint Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling
    Yoe Sik Bae
    Medical Research Center for Cancer Molecular Therapy and Department of Biochemistry, College of Medicine, Dong A University, Busan 602 714, Korea
    J Immunol 173:607-14. 2004
    ..WRW(4) is the first specific FPRL1 antagonist and is expected to be useful in the study of FPRL1 signaling and in the development of drugs against FPRL1-related diseases...
  41. ncbi request reprint Leukocyte inflammatory mediators and lung pathophysiology: an update
    Richard D Ye
    Am J Physiol Lung Cell Mol Physiol 286:L461-2. 2004
  42. ncbi request reprint Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation
    De Yang
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Maryland 21702 1201, USA
    J Leukoc Biol 72:598-607. 2002
    ....
  43. ncbi request reprint Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1
    Caihong Zhou
    National Center for Drug Screening, 189 Guo Shou Jing Road, Shanghai 201203, China
    Mol Pharmacol 72:976-83. 2007
    ..This study represents the first characterization of a nonpeptidic antagonist for FPRL1 and suggests the prospect of using low molecular weight compounds as modulators of chemoattractant receptors in vitro and in vivo...
  44. ncbi request reprint Activation of cGMP-dependent protein kinase by protein kinase C
    Yali Hou
    Department of Biochemistry, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 278:16706-12. 2003
    ..Taken together, these findings outline a novel signal transduction pathway that links PKC stimulation with cyclic nucleotide-independent activation of PKG...
  45. ncbi request reprint The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand binding
    Pangke Yan
    National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
    J Immunol 177:7050-8. 2006
    ..These results demonstrate that CsA is a selective antagonist of FPR and that its inhibition of fMLF-stimulated leukocyte activation is at the level of cognate ligand binding...
  46. ncbi request reprint Stereospecific induction of nuclear factor-kappaB activation by isochamaejasmin
    Qinghai Tian
    The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
    Mol Pharmacol 68:1534-42. 2005
    ..These results provide the first evidence for a potential mechanism of action by S. chamaejasme L., and indicate that structurally similar compounds derived from S. chamaejasme L. may have different pharmacological properties...
  47. ncbi request reprint Identification of functional domains in the formyl peptide receptor-like 1 for agonist-induced cell chemotaxis
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD, USA
    FEBS J 272:769-78. 2005
    ..Considering the potential importance of FPRL1 in inflammation and neurodegenerative diseases, the identification of functional domains in this receptor will provide valuable information for the design of specific receptor antagonists...
  48. ncbi request reprint Differential signaling of formyl peptide receptor-like 1 by Trp-Lys-Tyr-Met-Val-Met-CONH2 or lipoxin A4 in human neutrophils
    Yoe Sik Bae
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, San 31, Hyojadong, Pohang, 790 784, Korea
    Mol Pharmacol 64:721-30. 2003
    ..These results indicate that the activation of FPRL1 by the two different ligands can induce differential cellular signaling and unique functional consequences in human neutrophils...
  49. ncbi request reprint Novel chemoattractant peptides for human leukocytes
    Yoe Sik Bae
    Department of Biochemistry, College of Medicine, Medical Research Center for Cancer Molecular Therapy, Dong A University, Busan 02 714, South Korea
    Biochem Pharmacol 66:1841-51. 2003
    ..These peptides provide previously unavailable tools for study of differential signaling in leukocytes...
  50. doi request reprint PML/RARalpha fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase
    Lingna Li
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Institutes of Medical Sciencies, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Cell Physiol 217:486-93. 2008
    ..PML/RARalpha that bestows NB4 cells various pathological features, paradoxically also endows these cells with the basis for susceptibility to ATO-induced cytotoxcity...
  51. ncbi request reprint Discovery of Trp-Nle-Tyr-Met as a novel agonist for human formyl peptide receptor-like 1
    Hui Xin Wan
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
    Biochem Pharmacol 74:317-26. 2007
    ..The identification of the core sequence of a potent peptide agonist provides a structural basis for future design of peptidomimetics as potential therapeutic agents for FPRL1-related disorders...

Research Grants24

  1. MOLECULAR MECHANISMS OF LEUKOCYTE ACTIVATION
    Richard D Ye; Fiscal Year: 2010
    ..Information derived from these studies is expected to have health benefit by reducing inflammatory tissue injury and the resulting failure of organ functions. ..
  2. Pharmacological Study of G-proteins in Gene Regulation
    Richard Ye; Fiscal Year: 2007
    ..abstract_text> ..
  3. Chemoattractant Regulation of Leukocyte Gene Expression
    Richard Ye; Fiscal Year: 2007
    ..Collectively, these studies are designed to test the central hypothesis that chemoattractant receptors regulate gene expression through differential coupling to G proteins. ..
  4. Molecular Mechanism of Leukocyte Activation
    Richard Ye; Fiscal Year: 2007
    ..Taken together, these studies utilize our experience in FPR research and our newly developed reconstitution assay to investigate the mechanisms underlying an important neutrophil bactericidal function. ..
  5. CHEMOATTRACTANT INDUCED GENE EXPRESSION IN LEUKOCYTES
    Richard Ye; Fiscal Year: 2001
    ....
  6. MOLECULAR MECHANISMS OF LEUKOCYTE ACTIVATION
    Richard Ye; Fiscal Year: 2002
    ....