Jin Ye

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Roles of regulated intramembrane proteolysis in virus infection and antiviral immunity
    Jin Ye
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9046, USA Electronic address
    Biochim Biophys Acta 1828:2926-32. 2013
  2. pmc Hepatitis C virus: a new class of virus associated with particles derived from very low-density lipoproteins
    Jin Ye
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Arterioscler Thromb Vasc Biol 32:1099-103. 2012
  3. pmc Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus
    Jin Ye
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Pathog 3:e108. 2007
  4. pmc Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes
    Yukio Ikeda
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 284:34889-900. 2009
  5. ncbi Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake
    Yi Gong
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell Metab 3:15-24. 2006
  6. pmc Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step
    Joon No Lee
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 283:33772-83. 2008
  7. ncbi Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78
    Joon No Lee
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 281:39308-15. 2006
  8. pmc Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis
    Yi Gong
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 103:6154-9. 2006
  9. pmc The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells
    Bray Denard
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Host Microbe 10:65-74. 2011
  10. ncbi Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells
    Hongbing Yao
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 283:849-54. 2008

Collaborators

Detail Information

Publications29

  1. pmc Roles of regulated intramembrane proteolysis in virus infection and antiviral immunity
    Jin Ye
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9046, USA Electronic address
    Biochim Biophys Acta 1828:2926-32. 2013
    ..Understanding this Yin and Yang side of RIP may lead to new strategies to combat viral infection. This article is part of a Special Issue entitled: Intramembrane Proteases. ..
  2. pmc Hepatitis C virus: a new class of virus associated with particles derived from very low-density lipoproteins
    Jin Ye
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Arterioscler Thromb Vasc Biol 32:1099-103. 2012
    ..These observations suggest that HCV may belong to a novel class of viruses that is associated with VLDL. Understanding the relationship between HCV and VLDL metabolism may reveal new strategies to treat HCV infection...
  3. pmc Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus
    Jin Ye
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Pathog 3:e108. 2007
    ..The potential application of drugs that alter host cholesterol metabolism in treating HCV infection is also discussed...
  4. pmc Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes
    Yukio Ikeda
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 284:34889-900. 2009
    ..These data suggest that p97 recruits proteasomes to polytopic ER proteins even before they are extracted from membranes...
  5. ncbi Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake
    Yi Gong
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell Metab 3:15-24. 2006
    ..When the new Insig-1 and cholesterol converge on Scap, Scap/SREBP binds to Insig-1, preventing ubiquitination. The Insig-1/Scap/SREBP complex accumulates in the ER, ready for liberation when the cell is again sterol deprived...
  6. pmc Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step
    Joon No Lee
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 283:33772-83. 2008
    ..The current study provides a molecular mechanism for regulation of proteasome-mediated ER protein degradation at a postubiquitination step...
  7. ncbi Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78
    Joon No Lee
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 281:39308-15. 2006
    ....
  8. pmc Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis
    Yi Gong
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 103:6154-9. 2006
    ..These studies identify a single amino acid residue that is crucial for the function of Insig proteins in regulating cholesterol homeostasis in mammalian cells...
  9. pmc The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells
    Bray Denard
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Host Microbe 10:65-74. 2011
    ..Our results indicate that CREB3L1 may play an important role in limiting virus spread by inhibiting proliferation of virus-infected cells...
  10. ncbi Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells
    Hongbing Yao
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 283:849-54. 2008
    ..Treatment of cells with small interfering RNA targeting ACSL3 also inhibited secretion of HCV from Huh7-derived cells. These results identify ACSL3 as a new enzymatic target to limit VLDL secretion and HCV infection...
  11. ncbi Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication
    Chunfu Wang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cell 18:425-34. 2005
    ..The current data indicate that geranylgeranylated FBL2 binds to NS5A in a reaction crucial for HCV RNA replication...
  12. pmc Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis
    Joon No Lee
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:21424-9. 2010
    ..These results suggest that Ubxd8 acts as a brake that limits TG synthesis, and this brake is released when its structure is altered by exposure to unsaturated FAs...
  13. pmc Epigenetic silencing of antiviral genes renders clones of Huh-7 cells permissive for hepatitis C virus replication
    Qiuyue Chen
    Department of Molecular Genetics, University of Texas Southwestern, Medical Center, Dallas, Texas, USA
    J Virol 87:659-65. 2013
    ..Our results demonstrate that understanding the mechanism through which subclones of Huh-7 cells become permissive for HCV replication is crucial for studying their interaction with HCV...
  14. pmc Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines
    Joon No Lee
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 103:4958-63. 2006
    ..The current studies indicate that the degradation of ubiquitinated Insigs is controlled by serine residues flanking the sites of ubiquitination...
  15. pmc Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins
    Hua Huang
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 104:5848-53. 2007
    ..These results provide a possible explanation for the restriction of HCV production to the liver and suggest new cellular targets for treatment of HCV infection...
  16. pmc Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin E
    Hua Huang
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 104:18666-70. 2007
    ....
  17. ncbi Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1
    Joon No Lee
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 279:45257-65. 2004
    ..The current study demonstrates that animal cells, in response to either hypotonic shock or ER stress, can bypass the cholesterol inhibition of SREBP processing, an effect that is attributable to the rapid turnover of Insig-1...
  18. pmc The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism
    Yingfeng Deng
    Touchstone Diabetes Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 123:455-68. 2013
    ..Our results provide evidence that the Xbp1s/GalE pathway functions as a novel regulatory nexus connecting the UPR to the characteristic postprandial metabolic changes in hepatocytes...
  19. pmc UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids
    Hyeonwoo Kim
    Departments of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Lipid Res 54:2144-52. 2013
    ..These results provide further insights into protein-FA interactions by identifying the UAS domain as a motif interacting with long-chain unsaturated FAs. ..
  20. pmc Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation
    Jin Ye
    Departments of Molecular Genetics and Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 100:15865-70. 2003
    ..Inhibition of its geranylgeranylation affords a therapeutic strategy for treatment of HCV infection...
  21. pmc Sufficient production of geranylgeraniol is required to maintain endotoxin tolerance in macrophages
    Jinyong Kim
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390
    J Lipid Res 54:3430-7. 2013
    ..These results suggest that insufficient production of GGOH in macrophages may cause autoinflammatory diseases. ..
  22. pmc Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1
    Bray Denard
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, United States
    elife 1:e00090. 2012
    ..These results suggest that measurement of CREB3L1 expression may be a useful biomarker in identifying cancer cells sensitive to doxorubicin.DOI:http://dx.doi.org/10.7554/eLife.00090.001...
  23. pmc How cholesterol homeostasis is regulated by plasma membrane cholesterol in excess of phospholipids
    Yvonne Lange
    Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 101:11664-7. 2004
    ..Cholesterol-sensitive elements therein respond by nulling the active plasma membrane pool, thereby keeping the cholesterol matched to the other plasma membrane lipids...
  24. ncbi Activation of membrane cholesterol by displacement from phospholipids
    Yvonne Lange
    Department of Pathology, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Biol Chem 280:36126-31. 2005
    ..We also describe simple screens using red cells in a microtiter well format to identify intercalating agents that increase or decrease the activity of membrane cholesterol...
  25. ncbi Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase
    Yvonne Lange
    Department of Pathology, Rush University Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
    J Biol Chem 283:1445-55. 2008
    ..On the other hand, 27-hydroxycholesterol, rather than cholesterol itself or biosynthetic precursors of cholesterol, stimulates the rapid inactivation of HMGR in response to high levels of cholesterol...
  26. pmc Scrambling of phospholipids activates red cell membrane cholesterol
    Yvonne Lange
    Department of Pathology, Rush University Medical Center, Chicago, Illinois 60612, USA
    Biochemistry 46:2233-8. 2007
    ..Given that phospholipid scrambling is important in blood coagulation and apoptosis, the concomitant activation of cell surface cholesterol could contribute to these and other pathophysiological signaling processes...
  27. ncbi Dynamics of lysosomal cholesterol in Niemann-Pick type C and normal human fibroblasts
    Yvonne Lange
    Department of Pathology, Rush Presbyterian St Luke s Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
    J Lipid Res 43:198-204. 2002
    ..We conclude that the large pool of endolysosomal cholesterol in NPC and amphiphile-treated fibroblasts is dynamic and that its turnover, as in normal cells, is dependent on microtubules...
  28. pmc Probing red cell membrane cholesterol movement with cyclodextrin
    Theodore L Steck
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, USA
    Biophys J 83:2118-25. 2002
    ..e., with a half-time of <1 s at 37 degrees C...
  29. ncbi Effect of protein kinase C on endoplasmic reticulum cholesterol
    Yvonne Lange
    Department of Pathology, Rush Presbyterian St Luke s Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA
    Biochem Biophys Res Commun 290:488-93. 2002
    ..These findings suggest that multiple protein kinase C isoforms participate in the regulation of ER cholesterol and therefore in cholesterol homeostasis...

Research Grants1

  1. Regulated Intramembrane Proteolysis of CREB3L1 in Innate Antiviral Response
    Jin Ye; Fiscal Year: 2010
    ..Thus, understanding the CREB3L1-mediated antiviral pathway, which apparently is interferon-independent, may reveal much needed new strategies to treat HCV infection. ..