Research Topics
Genomes and Genes
Species | Jin YeSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Hepatitis C virus: a new class of virus associated with particles derived from very low-density lipoproteinsJin Ye
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Arterioscler Thromb Vasc Biol 32:1099-103. 2012..These observations suggest that HCV may belong to a novel class of viruses that is associated with VLDL. Understanding the relationship between HCV and VLDL metabolism may reveal new strategies to treat HCV infection...- Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virusJin Ye
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
PLoS Pathog 3:e108. 2007..The potential application of drugs that alter host cholesterol metabolism in treating HCV infection is also discussed... - Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranesYukio Ikeda
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Biol Chem 284:34889-900. 2009..These data suggest that p97 recruits proteasomes to polytopic ER proteins even before they are extracted from membranes... 
Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptakeYi Gong
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Cell Metab 3:15-24. 2006..When the new Insig-1 and cholesterol converge on Scap, Scap/SREBP binds to Insig-1, preventing ubiquitination. The Insig-1/Scap/SREBP complex accumulates in the ER, ready for liberation when the cell is again sterol deprived...- Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination stepJoon No Lee
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 283:33772-83. 2008..The current study provides a molecular mechanism for regulation of proteasome-mediated ER protein degradation at a postubiquitination step... - Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78Joon No Lee
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 281:39308-15. 2006.... - Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasisYi Gong
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 103:6154-9. 2006..These studies identify a single amino acid residue that is crucial for the function of Insig proteins in regulating cholesterol homeostasis in mammalian cells... - Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cellsHongbing Yao
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 283:849-54. 2008..Treatment of cells with small interfering RNA targeting ACSL3 also inhibited secretion of HCV from Huh7-derived cells. These results identify ACSL3 as a new enzymatic target to limit VLDL secretion and HCV infection... - Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replicationChunfu Wang
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Mol Cell 18:425-34. 2005..The current data indicate that geranylgeranylated FBL2 binds to NS5A in a reaction crucial for HCV RNA replication... - The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cellsBray Denard
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Cell Host Microbe 10:65-74. 2011..Our results indicate that CREB3L1 may play an important role in limiting virus spread by inhibiting proliferation of virus-infected cells... - Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesisJoon No Lee
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 107:21424-9. 2010..These results suggest that Ubxd8 acts as a brake that limits TG synthesis, and this brake is released when its structure is altered by exposure to unsaturated FAs... - Epigenetic silencing of antiviral genes renders clones of Huh-7 cells permissive for hepatitis C virus replicationQiuyue Chen
Department of Molecular Genetics, University of Texas Southwestern, Medical Center, Dallas, Texas, USA
J Virol 87:659-65. 2013..Our results demonstrate that understanding the mechanism through which subclones of Huh-7 cells become permissive for HCV replication is crucial for studying their interaction with HCV... - Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysinesJoon No Lee
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 103:4958-63. 2006..The current studies indicate that the degradation of ubiquitinated Insigs is controlled by serine residues flanking the sites of ubiquitination... - Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteinsHua Huang
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 104:5848-53. 2007..These results provide a possible explanation for the restriction of HCV production to the liver and suggest new cellular targets for treatment of HCV infection... - Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin EHua Huang
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 104:18666-70. 2007.... - Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylationJin Ye
Departments of Molecular Genetics and Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 100:15865-70. 2003..Inhibition of its geranylgeranylation affords a therapeutic strategy for treatment of HCV infection... - Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1Bray Denard
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, United States
elife 1:e00090. 2012..These results suggest that measurement of CREB3L1 expression may be a useful biomarker in identifying cancer cells sensitive to doxorubicin.DOI:http://dx.doi.org/10.7554/eLife.00090.001... - Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1Joon No Lee
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Biol Chem 279:45257-65. 2004..The current study demonstrates that animal cells, in response to either hypotonic shock or ER stress, can bypass the cholesterol inhibition of SREBP processing, an effect that is attributable to the rapid turnover of Insig-1... - Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductaseYvonne Lange
Department of Pathology, Rush University Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
J Biol Chem 283:1445-55. 2008..On the other hand, 27-hydroxycholesterol, rather than cholesterol itself or biosynthetic precursors of cholesterol, stimulates the rapid inactivation of HMGR in response to high levels of cholesterol... - Scrambling of phospholipids activates red cell membrane cholesterolYvonne Lange
Department of Pathology, Rush University Medical Center, Chicago, Illinois 60612, USA
Biochemistry 46:2233-8. 2007..Given that phospholipid scrambling is important in blood coagulation and apoptosis, the concomitant activation of cell surface cholesterol could contribute to these and other pathophysiological signaling processes... - Activation of membrane cholesterol by displacement from phospholipidsYvonne Lange
Department of Pathology, Rush University Medical Center, Chicago, Illinois 60612, USA
J Biol Chem 280:36126-31. 2005..We also describe simple screens using red cells in a microtiter well format to identify intercalating agents that increase or decrease the activity of membrane cholesterol... - How cholesterol homeostasis is regulated by plasma membrane cholesterol in excess of phospholipidsYvonne Lange
Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA
Proc Natl Acad Sci U S A 101:11664-7. 2004..Cholesterol-sensitive elements therein respond by nulling the active plasma membrane pool, thereby keeping the cholesterol matched to the other plasma membrane lipids... - Probing red cell membrane cholesterol movement with cyclodextrinTheodore L Steck
Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, USA
Biophys J 83:2118-25. 2002..e., with a half-time of <1 s at 37 degrees C... - Dynamics of lysosomal cholesterol in Niemann-Pick type C and normal human fibroblastsYvonne Lange
Department of Pathology, Rush Presbyterian St Luke s Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
J Lipid Res 43:198-204. 2002..We conclude that the large pool of endolysosomal cholesterol in NPC and amphiphile-treated fibroblasts is dynamic and that its turnover, as in normal cells, is dependent on microtubules... - Effect of protein kinase C on endoplasmic reticulum cholesterolYvonne Lange
Department of Pathology, Rush Presbyterian St Luke s Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA
Biochem Biophys Res Commun 290:488-93. 2002..These findings suggest that multiple protein kinase C isoforms participate in the regulation of ER cholesterol and therefore in cholesterol homeostasis...
Research Grants
- Regulated Intramembrane Proteolysis of CREB3L1 in Innate Antiviral ResponseJin Ye; Fiscal Year: 2010..Thus, understanding the CREB3L1-mediated antiviral pathway, which apparently is interferon-independent, may reveal much needed new strategies to treat HCV infection. ..