Mark H Yazer

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint What a difference 2 nucleotides make: a short review of ABO genetics
    Mark H Yazer
    Institute for Transfusion Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Transfus Med Rev 19:200-9. 2005
  2. ncbi request reprint Immune hemolysis following ABO-mismatched stem cell or solid organ transplantation
    Mark H Yazer
    Division of Transfusion Medicine, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Curr Opin Hematol 14:664-70. 2007
  3. pmc The impact of suctioning RBCs from a simulated operative site on mechanical fragility and hemolysis
    Jay S Raval
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Korean J Hematol 46:31-5. 2011
  4. pmc Complications following an unnecessary peri-operative plasma transfusion and literature review
    Jay S Raval
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA The Institute for Transfusion Medicine, Pittsburgh, PA, USA
    Korean J Hematol 47:298-301. 2012
  5. pmc The how's and why's of evidence based plasma therapy
    Mark H Yazer
    The Institute For Transfusion Medicine, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Korean J Hematol 45:152-7. 2010
  6. ncbi request reprint Trends in RBC ordering and use after implementing adaptive alerts in the electronic computerized physician order entry system
    Brian McWilliams
    The Institute For Transfusion Medicine, 3636 Blvd of the Allies, Pittsburgh, PA 15213
    Am J Clin Pathol 141:534-41. 2014
  7. ncbi request reprint Evaluation of real-time clinical decision support systems for platelet and cryoprecipitate orders
    Ryan A Collins
    The Institute For Transfusion Medicine, 3636 Blvd of the Allies, Pittsburgh, PA 15213 E mail
    Am J Clin Pathol 141:78-84. 2014
  8. ncbi request reprint ABO-mismatched transfusions are not over-represented in febrile non-haemolytic transfusion reactions to platelets
    M H Yazer
    The Institute For Transfusion Medicine, Pittsburgh, PA, USA
    Vox Sang 102:175-7. 2012
  9. ncbi request reprint The role of the elution in antibody investigations
    Mark H Yazer
    Department of Pathology, University of Pittsburgh, and The Institute for Transfusion Medicine, Pittsburgh, Pennsylvania, USA
    Transfusion 49:2395-9. 2009
  10. ncbi request reprint Coagulation factor levels in plasma frozen within 24 hours of phlebotomy over 5 days of storage at 1 to 6 degrees C
    Mark H Yazer
    Institute for Transfusion Medicine and the Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Transfusion 48:2525-30. 2008

Collaborators

Detail Information

Publications49

  1. ncbi request reprint What a difference 2 nucleotides make: a short review of ABO genetics
    Mark H Yazer
    Institute for Transfusion Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Transfus Med Rev 19:200-9. 2005
    ..A short section on the techniques of ABO allele investigation describes some of the current methodologies used in both research and clinical laboratories...
  2. ncbi request reprint Immune hemolysis following ABO-mismatched stem cell or solid organ transplantation
    Mark H Yazer
    Division of Transfusion Medicine, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Curr Opin Hematol 14:664-70. 2007
    ..Limitations in donor availability for stem cell or organ transplantation require that ABO-incompatible donors be used. Crossing ABO lines can have immune consequences characterized by immediate or delayed hemolysis...
  3. pmc The impact of suctioning RBCs from a simulated operative site on mechanical fragility and hemolysis
    Jay S Raval
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Korean J Hematol 46:31-5. 2011
    ....
  4. pmc Complications following an unnecessary peri-operative plasma transfusion and literature review
    Jay S Raval
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA The Institute for Transfusion Medicine, Pittsburgh, PA, USA
    Korean J Hematol 47:298-301. 2012
    ....
  5. pmc The how's and why's of evidence based plasma therapy
    Mark H Yazer
    The Institute For Transfusion Medicine, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Korean J Hematol 45:152-7. 2010
    ..This review will discuss the various plasma products that are available and present some of the current literature on the clinical uses of plasma...
  6. ncbi request reprint Trends in RBC ordering and use after implementing adaptive alerts in the electronic computerized physician order entry system
    Brian McWilliams
    The Institute For Transfusion Medicine, 3636 Blvd of the Allies, Pittsburgh, PA 15213
    Am J Clin Pathol 141:534-41. 2014
    ..An alert appeared if the patient's hemoglobin (Hb) level was above the threshold determined by the selected indication (adaptive alerts)...
  7. ncbi request reprint Evaluation of real-time clinical decision support systems for platelet and cryoprecipitate orders
    Ryan A Collins
    The Institute For Transfusion Medicine, 3636 Blvd of the Allies, Pittsburgh, PA 15213 E mail
    Am J Clin Pathol 141:78-84. 2014
    ..To evaluate cryoprecipitate and platelet ordering practices after the implementation of real-time clinical decision support systems (CDSSs) in a computerized physician order entry (CPOE) system...
  8. ncbi request reprint ABO-mismatched transfusions are not over-represented in febrile non-haemolytic transfusion reactions to platelets
    M H Yazer
    The Institute For Transfusion Medicine, Pittsburgh, PA, USA
    Vox Sang 102:175-7. 2012
    ..ABO-mismatched PLT transfusions do not appear to be aetiological agents of FNHTR in a population routinely receiving both ABO-identical and ABO-mismatched transfusions...
  9. ncbi request reprint The role of the elution in antibody investigations
    Mark H Yazer
    Department of Pathology, University of Pittsburgh, and The Institute for Transfusion Medicine, Pittsburgh, Pennsylvania, USA
    Transfusion 49:2395-9. 2009
    ..This study questioned how frequently elutions contributed novel serologic information under our reference laboratory's current policy or whether elutions should be performed in more selective serologic conditions...
  10. ncbi request reprint Coagulation factor levels in plasma frozen within 24 hours of phlebotomy over 5 days of storage at 1 to 6 degrees C
    Mark H Yazer
    Institute for Transfusion Medicine and the Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Transfusion 48:2525-30. 2008
    ..This study was performed to investigate the levels of clotting factors in thawed plasma (TP) prepared from FP24 during 5 days of storage at 1 to 6 degrees C...
  11. ncbi request reprint Does a febrile reaction to platelets predispose recipients to red blood cell alloimmunization?
    Mark H Yazer
    Institute for Transfusion Medicine, Pittsburgh, PA 15213, USA
    Transfusion 49:1070-5. 2009
    ....
  12. ncbi request reprint Cryoprecipitate prepared from plasma frozen within 24 hours after phlebotomy contains acceptable levels of fibrinogen and VIIIC
    Mark H Yazer
    Institute for Transfusion Medicine, Pittsburgh, Pennsylvania, USA
    Transfusion 50:1014-8. 2010
    ....
  13. ncbi request reprint Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles
    Mark H Yazer
    The Institute For Transfusion Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Hematol 15:618-24. 2008
    ..Although an analysis of the ABO gene can be helpful in establishing the nature of the subtype phenotype, numerous confounding factors exist that can lead to a discrepancy between the genotype and the observed phenotype...
  14. ncbi request reprint Detection of anti-D in D- recipients transfused with D+ red blood cells
    Mark H Yazer
    The Institute for Transfusion Medicine and Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Transfusion 47:2197-201. 2007
    ..The relatively low sensitization rate in oncology patients transfused with D+ platelets is well documented. A study of the alloimmunization rate of primarily nononcology D- recipients transfused with D+ RBCs was undertaken...
  15. ncbi request reprint Use of a pH meter for bacterial screening of whole blood platelets
    Mark H Yazer
    Institute for Transfusion Medicine and Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Transfusion 45:1133-7. 2005
    ..The use of pH screening of whole-blood PLTs (WBPs) was evaluated with a pH meter at the time of issue as a surrogate test for bacterial contamination...
  16. ncbi request reprint The cis-AB blood group phenotype: fundamental lessons in glycobiology
    Mark H Yazer
    The Institute for Transfusion Medicine and Department of Pathology, University of Pittsburgh, PA 15213, USA
    Transfus Med Rev 20:207-17. 2006
    ..By correctly identifying the cis-AB phenotype, the blood bank can be of assistance to a clinician faced with a patient with what appears to be a genetically impossible ABO blood group...
  17. ncbi request reprint The importance of disordered loops in ABO glycosyltransferases
    Mark H Yazer
    Institute for Transfusion Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Transfus Med Rev 19:210-6. 2005
    ..In this review, we describe the nature of various disordered regions in glycosyltransferase structures from bacteria to human beings...
  18. ncbi request reprint Kinetic studies on Korean serum cis-AB enzymes reveal diminished A and B transferase activities
    M H Yazer
    The Institute for Transfusion Medicine and Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Vox Sang 89:161-7. 2005
    ..We have identified a large cohort of Korean cis-AB blood donors and studied the N-acetylgalactosaminyltransferase (glycosyltransferase A, GTA) and galactosyltransferase (glycosyltransferase B, GTB) activity of their cis-AB serum enzymes...
  19. pmc Stationary versus agitated storage of whole blood during acute normovolemic hemodilution
    Shu Yang Lu
    From the Department of Anesthesiology, University of Pittsburgh School of Medicine Department of Pathology, University of Pittsburgh, and The Institute for Transfusion Medicine, Pittsburgh, Pennsylvania Departments of Immunology and Laboratory Medicine, University of Florida College of Medicine, Shands Hospital, Gainesville, Florida Department of Biostatistics, University of Pittsburgh Graduate School of Public Health Departments of Anesthesiology and Bioengineering, University of Pittsburgh School of Medicine and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
    Anesth Analg 118:264-8. 2014
    ..We hypothesized that gentle agitation of WB throughout storage would improve the coagulation properties of the WB at the time of reinfusion...
  20. ncbi request reprint Investigation into A antigen expression on O2 heterozygous group O-labeled red blood cell units
    Mark H Yazer
    Institute for Transfusion Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Transfusion 48:1650-7. 2008
    ..While reports vary, O2 has been proposed to encode weakly functional A-glycosyltransferase (GTA). The main objective of this study was to evaluate if GTA activity is detectable in O2 donors...
  21. ncbi request reprint Amino-acid substitution in the disordered loop of blood group B-glycosyltransferase enzyme causes weak B phenotype
    Mark H Yazer
    Institute for Transfusion Medicine and Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Transfusion 45:1178-82. 2005
    ..Another patient has been identified with a 556G>A B(w) allele and the kinetics of the resulting mutant glycosyltransferase were studied...
  22. ncbi request reprint Incomplete pretransfusion testing leads to surgical delays
    Brian McWilliams
    Department of Pathology, The Institute For Transfusion Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Transfusion 52:2139-44; quiz 2145. 2012
    ..The maximum surgical blood ordering schedule (MSBOS) indicates which patients require preoperative transfusion testing. We determined the number of times surgical delays were caused due to the lack of completed pretransfusion testing...
  23. pmc Hepatic function after genetically engineered pig liver transplantation in baboons
    Burcin Ekser
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 90:483-93. 2010
    ..If "bridging" to allo-transplantation (Tx) is to be achieved by a pig liver xenograft, adequate hepatic function needs to be assured...
  24. ncbi request reprint Receipt of older RBCs does not predispose D-negative recipients to anti-D alloimmunization
    Mark H Yazer
    The Institute for Transfusion Medicine and the Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Clin Pathol 134:443-7. 2010
    ..02); median ages of the D-positive RBCs were 16 vs 14 days, respectively (P = .21). There was no association between the age of transfused RBCs and the likelihood of anti-D alloimmunization...
  25. pmc Stored platelet functionality is not decreased after warming with a fluid warmer
    Gerhardt Konig
    Department of Anesthesiology, Magee Womens Hospital, 300 Halket St, Suite 3510, Pittsburgh, PA 15213
    Anesth Analg 117:575-8. 2013
    ..Our goal in this pilot study was to determine whether the warming of stored PLTs had any effect on their function...
  26. ncbi request reprint Routine use of a rapid test to detect bacteria at the time of issue for nonleukoreduced, whole blood-derived platelets
    Sarah K Harm
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transfusion 53:843-50. 2013
    ..We report the experience of using the PGD test on whole blood-derived PLTs (WBPs) at two large centralized transfusion services (CTS)...
  27. ncbi request reprint Effectiveness of a real-time clinical decision support system for computerized physician order entry of plasma orders
    Mark H Yazer
    Department of Pathology, University of Pittsburgh
    Transfusion 53:3120-7. 2013
    ....
  28. ncbi request reprint Enhanced detection of blood bank sample collection errors with a centralized patient database
    Duncan MacIvor
    Department of Pathology, University of Pittsburgh, and The Institute for Transfusion Medicine, Pittsburgh, Pennsylvania, USA
    Transfusion 49:40-3. 2009
    ..We hypothesized that having access to patient historical ABO types from anywhere in the CTS system can identify WBIT errors and prevent mistransfusions...
  29. ncbi request reprint Hemolysis and red blood cell mechanical fragility in shed blood after total knee arthroplasty
    John T Ley
    Department of Anesthesiology, Magee Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Transfusion 52:34-8. 2012
    ..This study compared the characteristics of the returned RBCs collected using two different devices: one that washes and one that does not wash the collected RBCs...
  30. ncbi request reprint Modification of suction-induced hemolysis during cell salvage
    Jonathan H Waters
    Department of Anesthesiology, Magee Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Anesth Analg 104:684-7. 2007
    ..In this study, we attempted to determine the influence of suction pressure on the efficiency of cell salvage and to identify methods for minimizing the impact of suction on salvaged blood...
  31. ncbi request reprint Case report and literature review: transient Inab phenotype and an agglutinating anti-IFC in a patient with a gastrointestinal problem
    Mark H Yazer
    Institute for Transfusion Medicine and Department of Pathology, University of Pittsburgh, Pennsylvania, USA
    Transfusion 46:1537-42. 2006
    ..Although typically inherited, an acquired and transient form of the Inab phenotype also exists. A patient with the triad of transient Inab phenotype, a direct-agglutinating anti-IFC, and gastrointestinal (GI) abnormalities is reported...
  32. ncbi request reprint Clinical studies of the effect of blood storage on patient outcomes
    Darrell J Triulzi
    Division of Transfusion Medicine, Department of Pathology, University of Pittsburgh, PA, USA
    Transfus Apher Sci 43:95-106. 2010
    ..These studies do however provide equipoise to support the ethical conduct of the large, definitive randomized clinical trials which are now underway...
  33. ncbi request reprint Use of the RQI test for bacterial screening of whole blood platelets
    Mark H Yazer
    Department of Pathology, University of Pittsburgh, PA, USA
    Am J Clin Pathol 133:564-8. 2010
    ..The specificity and positive predictive value of the RQI test were 99.85% and 14.3%, respectively. The specificity and positive predictive value of the RQI test were higher than pH testing, leading to less waste of sterile WBP pools...
  34. pmc What every physician should know about transfusion reactions
    Suzanne Bakdash
    Department of Pathology, University of Pittsburgh and the Institute for Transfusion Medicine, Pittsburgh PA, USA
    CMAJ 177:141-7. 2007
  35. ncbi request reprint A comparison of hemolysis and red cell mechanical fragility in blood collected with different cell salvage suction devices
    Mark H Yazer
    Institute for Transfusion Medicine, The Department of Pathology, and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Transfusion 48:1188-91. 2008
    ..This study compared a constant-suction-pressure system with a device that is expected to minimize hemolysis by automatically varying the suction pressure...
  36. ncbi request reprint Implementation of a simple electronic transfusion alert system decreases inappropriate ordering of packed red blood cells and plasma in a multi-hospital health care system
    Matthew Smith
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, United States
    Transfus Apher Sci 51:53-8. 2014
    ....
  37. ncbi request reprint Effect of blood bank storage on the rheological properties of male and female donor red blood cells
    Amanda Daly
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA
    Clin Hemorheol Microcirc 56:337-45. 2014
    ..The decrease in RBC deformability during blood bank storage may reduce tissue perfusion and RBC lifespan in patients receiving blood bank RBCs. ..
  38. pmc Significant association between ABO blood group and pancreatic cancer
    Julia B Greer
    The Institute For Transfusion Medicine, 3636 Blvd of the Allies, Pittsburgh, PA 15213, USA
    World J Gastroenterol 16:5588-91. 2010
    ..To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States...
  39. ncbi request reprint Addition of ascorbic acid solution to stored murine red blood cells increases posttransfusion recovery and decreases microparticles and alloimmunization
    Sean R Stowell
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia Puget Sound Blood Center Research Institute, Seattle, Washington William G Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio Department of Pathology, University of Pittsburgh and the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania
    Transfusion 53:2248-57. 2013
    ..One component of the RBC storage lesion is the accumulation of oxidative damage. We tested the hypothesis that adding a chemical antioxidant (ascorbic acid) to stored RBCs would improve the quality of the stored RBCs...
  40. ncbi request reprint Changes in mechanical fragility and free hemoglobin levels after processing salvaged cardiopulmonary bypass circuit blood with a modified ultrafiltration device
    Sarah K Harm
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Extra Corpor Technol 44:21-5. 2012
    ..001. Although percent hemolysis was increased following processing with the MUF device, the total amount of PFHb and RBC sublethal injury were not increased. The clinical significance of these findings needs to be determined...
  41. ncbi request reprint Transfusion-associated circulatory overload after plasma transfusion
    Christina Narick
    Department of Pathology, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA
    Transfusion 52:160-5. 2012
    ..We sought to determine the rate of TACO caused by plasma transfusion...
  42. ncbi request reprint Clinical validation of risk stratification criteria for peripartum hemorrhage
    Andrew J Dilla
    University of Pittsburgh School of Medicine, Department of Anesthesiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Obstet Gynecol 122:120-6. 2013
    ..To determine whether the California Maternal Quality Care Collaborative risk groups predicted the risk of peripartum hemorrhage and to determine which women should have peripartum pretransfusion testing performed...
  43. pmc The effect of salvaged blood on coagulation function as measured by thromboelastography
    Gerhardt Konig
    Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Transfusion 53:1235-9. 2013
    ....
  44. pmc Changes in hematologic indices in caucasian and non-caucasian pregnant women in the United States
    Sarah K Harm
    Department of Pathology, University of Pittsburgh Medical Center, University of Pittsburgh, PA, USA
    Korean J Hematol 47:136-41. 2012
    ....
  45. pmc The blood bank "black box" debunked: pretransfusion testing explained
    Mark H Yazer
    Institute for Transfusion Medicine, Department of Pathology, University of Pittsburgh, Pittsburgh, Penn, USA
    CMAJ 174:29-32. 2006
  46. ncbi request reprint The volume of returned red blood cells in a large blood salvage program: where does it all go?
    Jonathan H Waters
    Department of Anesthesiology, Magee Womens Hospital, Pittsburgh, Pennsylvania 15213, USA
    Transfusion 51:2126-32. 2011
    ..We analyzed the trends in the volume of returned RBCs by our blood salvage program across a 12-hospital regional health care system over a 5-year period...
  47. ncbi request reprint Extended coagulation profiles of healthy baboons and of baboons rejecting GT-KO pig heart grafts
    Mohamed Ezzelarab
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Xenotransplantation 13:522-8. 2006
    ..Studies have investigated the coagulation profile in baboons post-xenotransplantation (XTx), but an extended coagulation profile of healthy baboons pre-XTx has not been reported...
  48. ncbi request reprint On the complexity of D antigen typing: a handy decision tree in the age of molecular blood group diagnostics
    Willy A Flegel
    Institute for Transfusion Medicine, University Hospital Ulm, Germany
    J Obstet Gynaecol Can 29:746-52. 2007
    ..We demonstrate how molecular tests of the RHD gene can and should be used in resolving serological discrepancies, in particular in pregnant women...
  49. ncbi request reprint The effect of prestorage WBC reduction on the rates of febrile nonhemolytic transfusion reactions to platelet concentrates and RBC
    Mark H Yazer
    Department of Laboratory Medicine and Pathology, University of Alberta and Capital Health Transfusion Service, Edmonton, Canada
    Transfusion 44:10-5. 2004
    ..Prestorage WBC reduction should abrogate the accumulation of these cytokines reducing the number of FNHTRs...