Research Topics
Species | Mark H YazerSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
What a difference 2 nucleotides make: a short review of ABO geneticsMark H Yazer
Institute for Transfusion Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Transfus Med Rev 19:200-9. 2005..A short section on the techniques of ABO allele investigation describes some of the current methodologies used in both research and clinical laboratories...- Immune hemolysis following ABO-mismatched stem cell or solid organ transplantationMark H Yazer
Division of Transfusion Medicine, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Curr Opin Hematol 14:664-70. 2007..Limitations in donor availability for stem cell or organ transplantation require that ABO-incompatible donors be used. Crossing ABO lines can have immune consequences characterized by immediate or delayed hemolysis... 
ABO-mismatched transfusions are not over-represented in febrile non-haemolytic transfusion reactions to plateletsM H Yazer
The Institute For Transfusion Medicine, Pittsburgh, PA, USA
Vox Sang 102:175-7. 2012..ABO-mismatched PLT transfusions do not appear to be aetiological agents of FNHTR in a population routinely receiving both ABO-identical and ABO-mismatched transfusions...- Blood grouping discrepancies between ABO genotype and phenotype caused by O allelesMark H Yazer
The Institute For Transfusion Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Curr Opin Hematol 15:618-24. 2008..Although an analysis of the ABO gene can be helpful in establishing the nature of the subtype phenotype, numerous confounding factors exist that can lead to a discrepancy between the genotype and the observed phenotype... - Does a febrile reaction to platelets predispose recipients to red blood cell alloimmunization?Mark H Yazer
Institute for Transfusion Medicine, Pittsburgh, PA 15213, USA
Transfusion 49:1070-5. 2009.... - The role of the elution in antibody investigationsMark H Yazer
Department of Pathology, University of Pittsburgh, and The Institute for Transfusion Medicine, Pittsburgh, Pennsylvania, USA
Transfusion 49:2395-9. 2009..This study questioned how frequently elutions contributed novel serologic information under our reference laboratory's current policy or whether elutions should be performed in more selective serologic conditions... - Detection of anti-D in D- recipients transfused with D+ red blood cellsMark H Yazer
The Institute for Transfusion Medicine and Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Transfusion 47:2197-201. 2007..The relatively low sensitization rate in oncology patients transfused with D+ platelets is well documented. A study of the alloimmunization rate of primarily nononcology D- recipients transfused with D+ RBCs was undertaken... - Cryoprecipitate prepared from plasma frozen within 24 hours after phlebotomy contains acceptable levels of fibrinogen and VIIICMark H Yazer
Institute for Transfusion Medicine, Pittsburgh, Pennsylvania, USA
Transfusion 50:1014-8. 2010.... - The cis-AB blood group phenotype: fundamental lessons in glycobiologyMark H Yazer
The Institute for Transfusion Medicine and Department of Pathology, University of Pittsburgh, PA 15213, USA
Transfus Med Rev 20:207-17. 2006..By correctly identifying the cis-AB phenotype, the blood bank can be of assistance to a clinician faced with a patient with what appears to be a genetically impossible ABO blood group... - Coagulation factor levels in plasma frozen within 24 hours of phlebotomy over 5 days of storage at 1 to 6 degrees CMark H Yazer
Institute for Transfusion Medicine and the Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Transfusion 48:2525-30. 2008..This study was performed to investigate the levels of clotting factors in thawed plasma (TP) prepared from FP24 during 5 days of storage at 1 to 6 degrees C... - Kinetic studies on Korean serum cis-AB enzymes reveal diminished A and B transferase activitiesM H Yazer
The Institute for Transfusion Medicine and Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Vox Sang 89:161-7. 2005..We have identified a large cohort of Korean cis-AB blood donors and studied the N-acetylgalactosaminyltransferase (glycosyltransferase A, GTA) and galactosyltransferase (glycosyltransferase B, GTB) activity of their cis-AB serum enzymes... - The importance of disordered loops in ABO glycosyltransferasesMark H Yazer
Institute for Transfusion Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Transfus Med Rev 19:210-6. 2005..In this review, we describe the nature of various disordered regions in glycosyltransferase structures from bacteria to human beings... - Use of a pH meter for bacterial screening of whole blood plateletsMark H Yazer
Institute for Transfusion Medicine and Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Transfusion 45:1133-7. 2005..The use of pH screening of whole-blood PLTs (WBPs) was evaluated with a pH meter at the time of issue as a surrogate test for bacterial contamination... - Investigation into A antigen expression on O2 heterozygous group O-labeled red blood cell unitsMark H Yazer
Institute for Transfusion Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Transfusion 48:1650-7. 2008..While reports vary, O2 has been proposed to encode weakly functional A-glycosyltransferase (GTA). The main objective of this study was to evaluate if GTA activity is detectable in O2 donors... - Amino-acid substitution in the disordered loop of blood group B-glycosyltransferase enzyme causes weak B phenotypeMark H Yazer
Institute for Transfusion Medicine and Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Transfusion 45:1178-82. 2005..Another patient has been identified with a 556G>A B(w) allele and the kinetics of the resulting mutant glycosyltransferase were studied... 
Hepatic function after genetically engineered pig liver transplantation in baboonsBurcin Ekser
Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Transplantation 90:483-93. 2010..If "bridging" to allo-transplantation (Tx) is to be achieved by a pig liver xenograft, adequate hepatic function needs to be assured...- Receipt of older RBCs does not predispose D-negative recipients to anti-D alloimmunizationMark H Yazer
The Institute for Transfusion Medicine and the Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Am J Clin Pathol 134:443-7. 2010..02); median ages of the D-positive RBCs were 16 vs 14 days, respectively (P = .21). There was no association between the age of transfused RBCs and the likelihood of anti-D alloimmunization... - Incomplete pretransfusion testing leads to surgical delaysBrian McWilliams
Department of Pathology, The Institute For Transfusion Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Transfusion 52:2139-44; quiz 2145. 2012..The maximum surgical blood ordering schedule (MSBOS) indicates which patients require preoperative transfusion testing. We determined the number of times surgical delays were caused due to the lack of completed pretransfusion testing... - Enhanced detection of blood bank sample collection errors with a centralized patient databaseDuncan MacIvor
Department of Pathology, University of Pittsburgh, and The Institute for Transfusion Medicine, Pittsburgh, Pennsylvania, USA
Transfusion 49:40-3. 2009..We hypothesized that having access to patient historical ABO types from anywhere in the CTS system can identify WBIT errors and prevent mistransfusions... - A comparison of hemolysis and red cell mechanical fragility in blood collected with different cell salvage suction devicesMark H Yazer
Institute for Transfusion Medicine, The Department of Pathology, and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Transfusion 48:1188-91. 2008..This study compared a constant-suction-pressure system with a device that is expected to minimize hemolysis by automatically varying the suction pressure... - Clinical studies of the effect of blood storage on patient outcomesDarrell J Triulzi
Division of Transfusion Medicine, Department of Pathology, University of Pittsburgh, PA, USA
Transfus Apher Sci 43:95-106. 2010..These studies do however provide equipoise to support the ethical conduct of the large, definitive randomized clinical trials which are now underway... - What every physician should know about transfusion reactionsSuzanne Bakdash
Department of Pathology, University of Pittsburgh and the Institute for Transfusion Medicine, Pittsburgh PA, USA
CMAJ 177:141-7. 2007 - Case report and literature review: transient Inab phenotype and an agglutinating anti-IFC in a patient with a gastrointestinal problemMark H Yazer
Institute for Transfusion Medicine and Department of Pathology, University of Pittsburgh, Pennsylvania, USA
Transfusion 46:1537-42. 2006..The cause of the transient depression in CD55 protein (and thus Cromer system antigens) and appearance of anti-IFC remains unknown, as does the relationship between the patient's GI system abnormalities and these serologic findings... - Use of the RQI test for bacterial screening of whole blood plateletsMark H Yazer
Department of Pathology, University of Pittsburgh, PA, USA
Am J Clin Pathol 133:564-8. 2010..The specificity and positive predictive value of the RQI test were 99.85% and 14.3%, respectively. The specificity and positive predictive value of the RQI test were higher than pH testing, leading to less waste of sterile WBP pools... - Complications following an unnecessary peri-operative plasma transfusion and literature reviewJay S Raval
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA The Institute for Transfusion Medicine, Pittsburgh, PA, USA
Korean J Hematol 47:298-301. 2012.... - Changes in mechanical fragility and free hemoglobin levels after processing salvaged cardiopulmonary bypass circuit blood with a modified ultrafiltration deviceSarah K Harm
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Extra Corpor Technol 44:21-5. 2012..001. Although percent hemolysis was increased following processing with the MUF device, the total amount of PFHb and RBC sublethal injury were not increased. The clinical significance of these findings needs to be determined... - Transfusion-associated circulatory overload after plasma transfusionChristina Narick
Department of Pathology, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA
Transfusion 52:160-5. 2012..We sought to determine the rate of TACO caused by plasma transfusion... - Hemolysis and red blood cell mechanical fragility in shed blood after total knee arthroplastyJohn T Ley
Department of Anesthesiology, Magee Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Transfusion 52:34-8. 2012..This study compared the characteristics of the returned RBCs collected using two different devices: one that washes and one that does not wash the collected RBCs... - Modification of suction-induced hemolysis during cell salvageJonathan H Waters
Department of Anesthesiology, Magee Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Anesth Analg 104:684-7. 2007..In this study, we attempted to determine the influence of suction pressure on the efficiency of cell salvage and to identify methods for minimizing the impact of suction on salvaged blood... - Changes in hematologic indices in caucasian and non-caucasian pregnant women in the United StatesSarah K Harm
Department of Pathology, University of Pittsburgh Medical Center, University of Pittsburgh, PA, USA
Korean J Hematol 47:136-41. 2012.... - The impact of suctioning RBCs from a simulated operative site on mechanical fragility and hemolysisJay S Raval
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Korean J Hematol 46:31-5. 2011.... - Significant association between ABO blood group and pancreatic cancerJulia B Greer
The Institute For Transfusion Medicine, 3636 Blvd of the Allies, Pittsburgh, PA 15213, USA
World J Gastroenterol 16:5588-91. 2010..To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States... - Extended coagulation profiles of healthy baboons and of baboons rejecting GT-KO pig heart graftsMohamed Ezzelarab
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
Xenotransplantation 13:522-8. 2006..ii) Antibody-mediated rejection of GT-KO pig hearts in baboons can be associated with laboratory and clinical evidence of DIC... - The volume of returned red blood cells in a large blood salvage program: where does it all go?Jonathan H Waters
Department of Anesthesiology, Magee Womens Hospital, Pittsburgh, Pennsylvania 15213, USA
Transfusion 51:2126-32. 2011..We analyzed the trends in the volume of returned RBCs by our blood salvage program across a 12-hospital regional health care system over a 5-year period... - The blood bank "black box" debunked: pretransfusion testing explainedMark H Yazer
Institute for Transfusion Medicine, Department of Pathology, University of Pittsburgh, Pittsburgh, Penn, USA
CMAJ 174:29-32. 2006 - On the complexity of D antigen typing: a handy decision tree in the age of molecular blood group diagnosticsWilly A Flegel
Institute for Transfusion Medicine, University Hospital Ulm, Germany
J Obstet Gynaecol Can 29:746-52. 2007..We demonstrate how molecular tests of the RHD gene can and should be used in resolving serological discrepancies, in particular in pregnant women... - The effect of prestorage WBC reduction on the rates of febrile nonhemolytic transfusion reactions to platelet concentrates and RBCMark H Yazer
Department of Laboratory Medicine and Pathology, University of Alberta and Capital Health Transfusion Service, Edmonton, Canada
Transfusion 44:10-5. 2004..Prestorage WBC reduction should abrogate the accumulation of these cytokines reducing the number of FNHTRs...