Affiliation: University of Pittsburgh SOM
Location: Pittsburgh, USN
Bodnar R, Yates C, Wells A. IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain. Circ Res. 2006;98:617-25 pubmed
..This provides a means by which late wound repair signals limit the angiogenesis driven early in the wound response process. ..
Yates C, Whaley D, Y Chen A, Kulesekaran P, Hebda P, Wells A. ELR-negative CXC chemokine CXCL11 (IP-9/I-TAC) facilitates dermal and epidermal maturation during wound repair. Am J Pathol. 2008;173:643-52 pubmed publisher
..We conclude that IP-9 is a key ligand in the CXCR3 signaling system for wound repair, promoting re-epithelialization and modulating the maturation of the superficial dermis. ..
Bodnar R, Yates C, Rodgers M, Du X, Wells A. IP-10 induces dissociation of newly formed blood vessels. J Cell Sci. 2009;122:2064-77 pubmed publisher
..This is the first direct evidence for an extracellular signaling mechanism through CXCR3 that causes the dissociation of newly formed blood vessels followed by cell death. ..
Yates C, Bodnar R, Wells A. Matrix control of scarring. Cell Mol Life Sci. 2011;68:1871-81 pubmed publisher
..This is particularly true of the inducers of scar formation. Here, we present a hypothesis that it is the matrix itself that is a primary driver of scar, rather than being simply the result of other cellular dysregulations. ..
Yates C, Whaley D, Babu R, Zhang J, Krishna P, Beckman E, et al
. The effect of multifunctional polymer-based gels on wound healing in full thickness bacteria-contaminated mouse skin wound models. Biomaterials. 2007;28:3977-86 pubmed
..These preclinical studies show that the anti-microbial polymer gel not only supports but also accelerates healing of bacterially contaminated wounds. ..
Yates C, Whaley D, Kulasekeran P, Hancock W, Lu B, Bodnar R, et al
. Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor. Am J Pathol. 2007;171:484-95 pubmed
..These studies establish a pathophysiologic role for CXCR3 and its ligand during wound repair. ..
Yates C, Whaley D, Hooda S, Hebda P, Bodnar R, Wells A. Delayed reepithelialization and basement membrane regeneration after wounding in mice lacking CXCR3. Wound Repair Regen. 2009;17:34-41 pubmed publisher
..These studies further establish the emerging signaling network that involves the CXCR3 chemokine receptor and its ligands as a key regulator of wound repair. ..
Yates C, Krishna P, Whaley D, Bodnar R, Turner T, Wells A. Lack of CXC chemokine receptor 3 signaling leads to hypertrophic and hypercellular scarring. Am J Pathol. 2010;176:1743-55 pubmed publisher
Yates C, Whaley D, Wells A. Transplanted fibroblasts prevents dysfunctional repair in a murine CXCR3-deficient scarring model. Cell Transplant. 2012;21:919-31 pubmed publisher
..These suggest that the major determinant of healing versus scarring lies with the nature of the matrix. These findings have intriguing implications for rational cellular interventions aimed at promoting wound healing via cell therapy. ..