Research Topics
| Cecelia YatesSummaryAffiliation: University of Pittsburgh SOM Location: Pittsburgh, USN Publications
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Detail Information
Publications
Transplanted fibroblasts prevents dysfunctional repair in a murine CXCR3-deficient scarring modelCecelia C Yates
Department of Pathology and McGowan Institute for Regenerative Medicine, University of Pittsburgh and Pittsburgh VAMC, Pittsburgh, PA 15261, USA
Cell Transplant 21:919-31. 2012..These suggest that the major determinant of healing versus scarring lies with the nature of the matrix. These findings have intriguing implications for rational cellular interventions aimed at promoting wound healing via cell therapy...- Matrix control of scarringCecelia C Yates
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Cell Mol Life Sci 68:1871-81. 2011..This is particularly true of the inducers of scar formation. Here, we present a hypothesis that it is the matrix itself that is a primary driver of scar, rather than being simply the result of other cellular dysregulations... 
Lack of CXC chemokine receptor 3 signaling leads to hypertrophic and hypercellular scarringCecelia C Yates
University of Pittsburgh, Department of Pathology, Pittsburgh, PA 15261, USA
Am J Pathol 176:1743-55. 2010....- IP-10 induces dissociation of newly formed blood vesselsRichard J Bodnar
Pittsburgh Veterans Affairs Medical Center, Pittsburgh, PA 15240, USA
J Cell Sci 122:2064-77. 2009..This is the first direct evidence for an extracellular signaling mechanism through CXCR3 that causes the dissociation of newly formed blood vessels followed by cell death... - Delayed reepithelialization and basement membrane regeneration after wounding in mice lacking CXCR3Cecelia C Yates
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Wound Repair Regen 17:34-41. 2009..These studies further establish the emerging signaling network that involves the CXCR3 chemokine receptor and its ligands as a key regulator of wound repair... - ELR-negative CXC chemokine CXCL11 (IP-9/I-TAC) facilitates dermal and epidermal maturation during wound repairCecelia C Yates
Department of Pathology, University of Pittsburgh and Pittsburgh Veteran s Administration Medical Center, Pittsburgh, Pennsylvania 15261, USA
Am J Pathol 173:643-52. 2008..We conclude that IP-9 is a key ligand in the CXCR3 signaling system for wound repair, promoting re-epithelialization and modulating the maturation of the superficial dermis... - Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptorCecelia C Yates
Department of Pathology, University of Pittsburgh and Pittsburgh VAMC, Pittsburgh, Pennsylvania 15261, USA
Am J Pathol 171:484-95. 2007..These studies establish a pathophysiologic role for CXCR3 and its ligand during wound repair... - The effect of multifunctional polymer-based gels on wound healing in full thickness bacteria-contaminated mouse skin wound modelsCecelia C Yates
Department of Pathology, University of Pittsburgh, S713 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Biomaterials 28:3977-86. 2007..These preclinical studies show that the anti-microbial polymer gel not only supports but also accelerates healing of bacterially contaminated wounds... 
IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpainRichard J Bodnar
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261 0001, USA
Circ Res 98:617-25. 2006..This provides a means by which late wound repair signals limit the angiogenesis driven early in the wound response process...- An IP-10 (CXCL10)-derived peptide inhibits angiogenesisCecelia C Yates-Binder
Tuskegee University, Center for Cancer Research, Tuskegee, Alabama, United States of America
PLoS ONE 7:e40812. 2012..IP-10p provides a novel therapeutic agent that inhibits endothelial cell function thus, allowing for the modulation of angiogenesis...