Affiliation: University of North Carolina
- Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticityKoji Yashiro
Department of Cell and Molecular Physiology, Neuroscience Center, and Neurobiology Curriculum, University of North Carolina, Neuroscience Research Building, Campus Box 7545, 115 Mason Farm Road, Chapel Hill, NC 27599 7545, USA
Neuropharmacology 55:1081-94. 2008..Finally, we use the visual cortex as a model system to illustrate how activity-dependent modifications in the NR2A/NR2B ratio may contribute to the development of cortical functions...
- NMDA receptor antagonists reveal age-dependent differences in the properties of visual cortical plasticityJacqueline De Marchena
Neuroscience Center, Department of Cell and Molecular Physiology, University of North Carolina, 5109E Neuroscience Research Bldg, Campus Box 7545, 115 Mason Farm Rd, Chapel Hill, NC 27599 7545, USA
J Neurophysiol 100:1936-48. 2008..These results indicate that the degree of NMDAR activation required for LTP increases with development, providing insight into a novel underlying mechanism governing the properties of synaptic plasticity...
- Ube3a is required for experience-dependent maturation of the neocortexKoji Yashiro
Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina, USA
Nat Neurosci 12:777-83. 2009..We conclude that Ube3a is necessary for maintaining plasticity during experience-dependent neocortical development and suggest that the loss of neocortical plasticity contributes to deficits associated with Angelman syndrome...
- Behavioral deficits in an Angelman syndrome model: effects of genetic background and ageHsien Sung Huang
Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Behav Brain Res 243:79-90. 2013..Overall, these profiles of abnormal phenotypes can provide behavioral targets for evaluating effects of novel therapeutic strategies relevant to AS...
- Visual deprivation modifies both presynaptic glutamate release and the composition of perisynaptic/extrasynaptic NMDA receptors in adult visual cortexKoji Yashiro
Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Neurosci 25:11684-92. 2005..These differences may help to explain the unique consequences of sensory deprivation on plasticity in the developing versus mature cortex...